Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints.

abstract：:Stroke is the second leading cause of death worldwide. The prognostic influence of body temperature on acute stroke in patients has been recently reported; however, hypothermia has confounded experimental results in animal stroke models. This work aimed to investigate how body temperature could prognose stroke severit...

journal_title：Aging and disease

authors： Hu H,Doll DN,Sun J,Lewis SE,Wimsatt JH,Kessler MJ,Simpkins JW,Ren X

更新日期：2016-01-02 00:00:00

abstract：:Galectin-3 (Gal-3) is highly expressed in fibrotic tissue related to diverse etiologies. endothelial-to-mesenchymal transition (EndoMT), A less well studied phenomenon serves as a critical process in pulmonary vascular remodeling associated with the development of pulmonary arterial hypertension (PAH). EndoMT is hypot...

journal_title：Aging and disease

authors： Li T,Zha L,Luo H,Li S,Zhao L,He J,Li X,Qi Q,Liu Y,Yu Z

更新日期：2019-08-01 00:00:00

abstract：:Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin' Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 health...

journal_title：Aging and disease

authors： Yu Q,Guo P,Li D,Zuo L,Lian T,Yu S,Hu Y,Liu L,Jin Z,Wang R,Piao Y,Li L,Wang X,Zhang W

更新日期：2018-12-04 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in senile plaque and neurofibrillary tangles, are strongly intertwined with oxidative stress, which is considered one of the common effectors of the ...

journal_title：Aging and disease

authors： Morroni F,Sita G,Graziosi A,Turrini E,Fimognari C,Tarozzi A,Hrelia P

更新日期：2018-08-01 00:00:00

abstract：:A temporal framework linking circadian rhythms and clocks to aging rates identifies a specific window of target of rapamycin (TOR) signaling associated with growth hormone (GH) and insulin-like growth factor (IGF-1) (largely exclusive of insulin) in early sleep. IGF-1 signaling is released by growth hormone secretory ...

journal_title：Aging and disease

authors： Rollo CD

更新日期：2010-10-01 00:00:00

abstract：:Cerebral microbleeds (CMBs), which indicate hemorrhage-prone disease, may associate with hemostatic abnormalities, but the association between CMBs and coagulation function is uncertain. We aimed to examine this possible association. The following coagulation function indicators were evaluated in 85 consecutive ischem...

journal_title：Aging and disease

authors： Liu J,Wang D,Xiong Y,Liu B,Lin J,Zhang S,Wu B,Wei C,Liu M

更新日期：2017-04-01 00:00:00

abstract：:Studies comparing chronologically "young" versus "old" humans document age-related decline of classical immunological functions. However, older adults aged ≥65 years have very heterogeneous health phenotypes. A significant number of them are functionally independent and are surviving well into their 8(th)-11(th) decad...

journal_title：Aging and disease

authors： Griffin P,Michel JJ,Huysman K,Logar AJ,Vallejo AN

更新日期：2012-02-01 00:00:00

abstract：:Cortical atrophy, neuronal loss, beta-amyloid deposition, neuritic plaques, and neurofibrillary tangles are neuropathological key features in the Alzheimer's disease (AD). Antibodies against beta-amyloid, neurotransmitters, microvascular endothelium components and microglial cells have been detected in AD serum sugges...

journal_title：Aging and disease

authors： Giulia P,Michele L,Andrea F,Grazia D,Filomena C,Francesco P,Leandro C,Maria U,Carolina G,Massimiliano C,Antonio G

更新日期：2015-11-24 00:00:00

abstract：:DICER1 deficiency in the retinal pigment epithelium (RPE) was associated with the accumulation of Alu transcripts and implicated in geographic atrophy (GA), a form of age-related macular degeneration (AMD), an eye disease leading to blindness in millions of people. Although the exact mechanism of this association is n...

journal_title：Aging and disease

authors： Kaarniranta K,Pawlowska E,Szczepanska J,Blasiak J

更新日期：2020-07-23 00:00:00

abstract：:The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly unders...

journal_title：Aging and disease

authors： Xu S,Cai Y,Wei Y

更新日期：2013-12-05 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...

journal_title：Aging and disease

authors： Zhao Y,Zhang Y,Zhang L,Dong Y,Ji H,Shen L

更新日期：2019-12-01 00:00:00

abstract：:Sleep duration and quality have been associated with poor physical function, but both the temporality of the association and the independence of sleep duration and quality are unclear. We examined the prospective association of sleep duration and quality with physical function impairment and disability in older adults...

journal_title：Aging and disease

authors： Campanini MZ,Mesas AE,Carnicero-Carreño JA,Rodríguez-Artalejo F,Lopez-Garcia E

更新日期：2019-06-01 00:00:00

abstract：:Oxidative stress and iron accumulation are tightly associated with neurodegenerative diseases. Mitochondrial ferritin (FtMt) is identified as an iron-storage protein located in the mitochondria, and its role in regulation of iron hemeostasis in neurodegenerative diseases has been reported. However, the role of FtMt in...

journal_title：Aging and disease

authors： Gao G,Zhang N,Wang YQ,Wu Q,Yu P,Shi ZH,Duan XL,Zhao BL,Wu WS,Chang YZ

更新日期：2017-07-21 00:00:00

abstract：:The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was...

journal_title：Aging and disease

authors： Takeuchi H,Uchida HA,Kakio Y,Okuyama Y,Okuyama M,Umebayashi R,Wada K,Sugiyama H,Sugimoto K,Rakugi H,Wada J

更新日期：2018-04-01 00:00:00

abstract：:Microglial activation is an important contributor to the pathogenesis of Parkinson's disease (PD). Microglia are tightly and efficiently regulated by immune checkpoints, including CD200-CD200R1 and CX3CL1-CX3CR1. Understanding the involvement of these checkpoints in disease progression provides important insights into...

journal_title：Aging and disease

authors： Wang L,Liu Y,Yan S,Du T,Fu X,Gong X,Zhou X,Zhang T,Wang X

更新日期：2020-03-09 00:00:00

abstract：:Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysa...

journal_title：Aging and disease

authors： Carrera-Bastos P,Picazo Ó,Fontes-Villalba M,Pareja-Galeano H,Lindeberg S,Martínez-Selles M,Lucia A,Emanuele E

更新日期：2018-04-01 00:00:00

abstract：:As one of the leading causes of death around the world, suicide is a global public health threat. In the Chinese population, suicides constitute one-fifth of all recorded suicides in the world. Despite the factual data on suicide rates, the understanding of various causal factors behind suicide, including risk and pro...

journal_title：Aging and disease

authors： Dong X,Chang ES,Zeng P,Simon MA

更新日期：2015-03-10 00:00:00

abstract：:The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...

journal_title：Aging and disease

authors： Vyas NS,Lee Y,Ahn K,Ternouth A,Stahl DR,Al-Chalabi A,Powell JF,Puri BK

更新日期：2012-08-01 00:00:00

abstract：:Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets histones and many non-histone proteins and participates in various physiological functions. The enzymatic activity of SIRT1 is decreased in patients with Parkinson's disease (PD), which may reduce their ability to resist neuronal damage c...

journal_title：Aging and disease

authors： Li X,Feng Y,Wang XX,Truong D,Wu YC

更新日期：2020-12-01 00:00:00

abstract：:Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...

journal_title：Aging and disease

authors： Ray L,Khemka VK,Behera P,Bandyopadhyay K,Pal S,Pal K,Basu D,Chakrabarti S

更新日期：2013-03-07 00:00:00

abstract：:The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...

journal_title：Aging and disease

authors： Dai CF,Xie X,Ma YT,Yang YN,Li XM,Fu ZY,Liu F,Chen BD,Gai MT

更新日期：2015-11-17 00:00:00

abstract：:Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative da...

journal_title：Aging and disease

authors： Zhang X,Li L

更新日期：2020-10-01 00:00:00

abstract：:Mammalian Sterile20-like (MST) kinases are located upstream in the mitogen-activated protein kinase pathway, and play an important role in cell proliferation, differentiation, renewal, polarization and migration. Generally, five MST kinases exist in mammalian signal transduction pathways, including MST1, MST2, MST3, M...

journal_title：Aging and disease

authors： Chen S,Fang Y,Xu S,Reis C,Zhang J

更新日期：2018-06-01 00:00:00

abstract：:Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent yea...

journal_title：Aging and disease

authors： Liang W,Huang X,Chen W

更新日期：2017-12-01 00:00:00

abstract：:Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical ...

journal_title：Aging and disease

authors： Ma L,Chan P

更新日期：2020-03-09 00:00:00

abstract：:It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...

journal_title：Aging and disease

authors： Famakin BM

更新日期：2014-10-01 00:00:00

abstract：:Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have pro...

journal_title：Aging and disease

authors： Chakrabarti S,Khemka VK,Banerjee A,Chatterjee G,Ganguly A,Biswas A

更新日期：2015-08-01 00:00:00

abstract：:Cisplatin is a commonly used chemotherapeutic drug, used for the treatment of malignant ovarian cancer, but acquired resistance limits its application. There is therefore an overwhelming need to understand the mechanism of cisplatin resistance in ovarian cancer, that is, ovarian cancer cells are insensitive to cisplat...

journal_title：Aging and disease

authors： Ma L,Wang H,Wang C,Su J,Xie Q,Xu L,Yu Y,Liu S,Li S,Xu Y,Li Z

更新日期：2016-05-27 00:00:00

abstract：:Age related bone loss predisposes adults to osteoporosis. This is especially true for individuals with spinal cord injury (SCI). The effects of decreased bone loading with older age and paralysis significantly contribute to decreased bone mass and increased risk for fragility fractures. Loading bone via volitional mus...

journal_title：Aging and disease

authors： Dolbow JD,Dolbow DR,Gorgey AS,Adler RA,Gater DR

更新日期：2013-02-07 00:00:00

abstract：:Evidence indicated that inflammatory response and some pattern-recognition receptors play important roles in the occurrence and progression of osteoarthritis. This study is conducted to evaluate the role of RIG-I and its adaptor protein MAVS in the pathogenesis of osteoarthritis. Four SNPs in RIG-I gene and four in MA...

journal_title：Aging and disease

authors： Liu J,Tang LY,Wang YG,Lu SY,Zhang EN,Wang ZG,Zhang HX

更新日期：2018-02-01 00:00:00