Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints.

Abstract:

:Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induce hypertrophy. This may be explained at least in part by alteration of TGFβ signaling pathways in aging chondrocytes. This review focuses on the functions of TGFβ in joints and the regulation of its signaling mediators (receptors, Smads) during aging and osteoarthritis.

journal_name

Aging Dis

journal_title

Aging and disease

authors

Baugé C,Girard N,Lhuissier E,Bazille C,Boumediene K

doi

10.14336/AD.2014.0500394

subject

Has Abstract

pub_date

2013-12-17 00:00:00

pages

394-405

issue

6

issn

2152-5250

pii

ad-5-6-394

journal_volume

5

pub_type

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