Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints.


:Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induce hypertrophy. This may be explained at least in part by alteration of TGFβ signaling pathways in aging chondrocytes. This review focuses on the functions of TGFβ in joints and the regulation of its signaling mediators (receptors, Smads) during aging and osteoarthritis.


Aging Dis


Aging and disease


Baugé C,Girard N,Lhuissier E,Bazille C,Boumediene K




Has Abstract


2013-12-17 00:00:00












  • Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients.

    abstract::The molecular processes of aging are very heterogenic and not fully understood. Studies on rare progeria syndromes, which display an accelerated progression of physiological aging, can help to get a better understanding. Pseudoxanthoma elasticum (PXE) caused by mutations in the ATP-binding cassette sub-family C member...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Tiemann J,Wagner T,Vanakker OM,van Gils M,Cabrera JB,Ibold B,Faust I,Knabbe C,Hendig D

    更新日期:2020-05-09 00:00:00

  • A Novel Immunosuppressor, (5R)-5-Hydroxytriptolide, Alleviates Movement Disorder and Neuroinflammation in a 6-OHDA Hemiparkinsonian Rat Model.

    abstract::Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Su R,Sun M,Wang W,Zhang J,Zhang L,Zhen J,Qian Y,Zheng Y,Wang X

    更新日期:2017-02-01 00:00:00

  • NAD(+) Metabolism in Age-Related Hearing Loss.

    abstract::Age-related hearing loss (ARHL), a degenerative disorder characterized by age-dependent progressive increase in the threshold of auditory sensitivity, affects 40% of people over the age of 65, and it has emerged as an important social and public health problem. Various factors, including genetic and environmental comp...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Kim HJ,Oh GS,Choe SK,Kwak TH,Park R,So HS

    更新日期:2014-04-01 00:00:00

  • The Immune Response to Acute Focal Cerebral Ischemia and Associated Post-stroke Immunodepression: A Focused Review.

    abstract::It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Famakin BM

    更新日期:2014-10-01 00:00:00

  • Age-related defects in erythrocyte 2,3-diphosphoglycerate metabolism in dementia.

    abstract::Alzheimer disease (AD) is the most common dementing illness. Metabolic defects in the brain with aging contribute to the pathogenesis of AD. These changes can be found systematically and thus can be used as potential biomarkers. Erythrocytes (RBCs) are passive "reporter cells" that are not well studied in AD. In the p...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Kaminsky YG,Reddy VP,Ashraf GM,Ahmad A,Benberin VV,Kosenko EA,Aliev G

    更新日期:2013-10-01 00:00:00

  • Prehospital Notification Procedure Improves Stroke Outcome by Shortening Onset to Needle Time in Chinese Urban Area.

    abstract::Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients with acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) ...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Zhang S,Zhang J,Zhang M,Zhong G,Chen Z,Lin L,Lou M

    更新日期:2018-06-01 00:00:00

  • Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging.

    abstract::Aging is a progressive loss of physiological integrity and functionality process which increases susceptibility and mortality to diseases. Vascular aging is a specific type of organic aging. The structure and function changes of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cause of vas...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Ni YQ,Lin X,Zhan JK,Liu YS

    更新日期:2020-02-01 00:00:00

  • Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System.

    abstract::Mammalian Sterile20-like (MST) kinases are located upstream in the mitogen-activated protein kinase pathway, and play an important role in cell proliferation, differentiation, renewal, polarization and migration. Generally, five MST kinases exist in mammalian signal transduction pathways, including MST1, MST2, MST3, M...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Chen S,Fang Y,Xu S,Reis C,Zhang J

    更新日期:2018-06-01 00:00:00

  • Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice.

    abstract::Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and pa...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Urzua U,Chacon C,Lizama L,Sarmiento S,Villalobos P,Kroxato B,Marcelain K,Gonzalez MJ

    更新日期:2017-10-01 00:00:00

  • Healthcare-associated Pneumonia and Aspiration Pneumonia.

    abstract::Healthcare-associated pneumonia (HCAP) is a new concept of pneumonia proposed by the American Thoracic Society/Infectious Diseases Society of America in 2005. This category is located between community-acquired pneumonia and hospital-acquired pneumonia with respect to the characteristics of the causative pathogens and...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Komiya K,Ishii H,Kadota J

    更新日期:2014-02-08 00:00:00

  • The Significance of 8-oxoGsn in Aging-Related Diseases.

    abstract::Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative da...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Zhang X,Li L

    更新日期:2020-10-01 00:00:00

  • Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases.

    abstract::Hypoxia is an environmental stress at high altitude and underground conditions but it is also present in many chronic age-related diseases, where blood flow into tissues is impaired. The oxygen-sensing system stimulates gene expression protecting tissues against hypoxic insults. Hypoxia stabilizes the expression of hy...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Salminen A,Kaarniranta K,Kauppinen A

    更新日期:2016-03-15 00:00:00

  • Hip fractures in a geriatric population - rehabilitation based on patients needs.

    abstract::With an increased life expectancy in humans and thus an increase in the number of the elderly population, the frequency of hip fractures will rise as well. Aside from a higher incidence, hip fractures in a geriatric population is a significant problem due to the possible onset of severe and in some cases dramatic comp...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Radosavljevic N,Nikolic D,Lazovic M,Jeremic A

    更新日期:2014-06-01 00:00:00

  • Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population.

    abstract::The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Dai CF,Xie X,Ma YT,Yang YN,Li XM,Fu ZY,Liu F,Chen BD,Gai MT

    更新日期:2015-11-17 00:00:00

  • Prebiotics Regulation of Intestinal Microbiota Attenuates Cognitive Dysfunction Induced by Surgery Stimulation in APP/PS1 Mice.

    abstract::Emerging evidence indicates that the intestinal microbiota could interact with the central nervous system and modulate multiple pathophysiological changes, including the integrity of intestinal barrier and blood-brain barrier, as well as neuroinflammatory response. In the present study, we investigated the potential r...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Han D,Li Z,Liu T,Yang N,Li Y,He J,Qian M,Kuang Z,Zhang W,Ni C,Guo X

    更新日期:2020-10-01 00:00:00

  • Finding Balance: T cell Regulatory Receptor Expression during Aging.

    abstract::Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of regulatory receptors on the T cell surface contribute to...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Cavanagh MM,Qi Q,Weyand CM,Goronzy JJ

    更新日期:2011-10-01 00:00:00

  • The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations.

    abstract::Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets histones and many non-histone proteins and participates in various physiological functions. The enzymatic activity of SIRT1 is decreased in patients with Parkinson's disease (PD), which may reduce their ability to resist neuronal damage c...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Li X,Feng Y,Wang XX,Truong D,Wu YC

    更新日期:2020-12-01 00:00:00

  • Deficiency of Yes-Associated Protein Induces Cataract in Mice.

    abstract::Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract. Histologicall...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: He Q,Gao Y,Wang T,Zhou L,Zhou W,Yuan Z

    更新日期:2019-04-01 00:00:00

  • Duration and Quality of Sleep and Risk of Physical Function Impairment and Disability in Older Adults: Results from the ENRICA and ELSA Cohorts.

    abstract::Sleep duration and quality have been associated with poor physical function, but both the temporality of the association and the independence of sleep duration and quality are unclear. We examined the prospective association of sleep duration and quality with physical function impairment and disability in older adults...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Campanini MZ,Mesas AE,Carnicero-Carreño JA,Rodríguez-Artalejo F,Lopez-Garcia E

    更新日期:2019-06-01 00:00:00

  • The effects of aging and electrical stimulation exercise on bone after spinal cord injury.

    abstract::Age related bone loss predisposes adults to osteoporosis. This is especially true for individuals with spinal cord injury (SCI). The effects of decreased bone loading with older age and paralysis significantly contribute to decreased bone mass and increased risk for fragility fractures. Loading bone via volitional mus...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Dolbow JD,Dolbow DR,Gorgey AS,Adler RA,Gater DR

    更新日期:2013-02-07 00:00:00

  • Mechanisms of superoxide signaling in epigenetic processes: relation to aging and cancer.

    abstract::Superoxide is a precursor of many free radicals and reactive oxygen species (ROS) in biological systems. It has been shown that superoxide regulates major epigenetic processes of DNA methylation, histone methylation, and histone acetylation. We suggested that superoxide, being a radical anion and a strong nucleophile,...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Afanas'ev I

    更新日期:2015-06-01 00:00:00

  • Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis.

    abstract::Sepsis is a severe disease frequently occurred in the Intenisive Care Unit (ICU), which has a very high morbidity and mortality, especially in patients aged over 65 years. Owing to the aging effect and the ensuing deterioration of body function, the elder patients may have atypical responses to sepsis. Diagnosis and p...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Xu D,Liao S,Li P,Zhang Q,Lv Y,Fu X,Yang M,Wang J,Kong L

    更新日期:2019-08-01 00:00:00

  • Novel Role of Lck in Leptin-Induced Inflammation and Implications for Renal Aging.

    abstract::Aging is associated with increased fat mass and elevated serum leptin levels (hyperleptinemia), causing proinflammation in the kidneys where it plays a primary role in the removal of endogenous leptin from the circulation. Lymphocyte-specific kinase (Lck) is a positive regulator of inflammatory signaling and a potenti...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Kim DH,Park JW,Jeong HO,Lee B,Chung KW,Lee Y,Jung HJ,Hyun MK,Lee AK,Kim BM,Yu BP,Chung HY

    更新日期:2019-12-01 00:00:00

  • The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Zhao Y,Zhang Y,Zhang L,Dong Y,Ji H,Shen L

    更新日期:2019-12-01 00:00:00

  • Geroprotectors: A Unified Concept and Screening Approaches.

    abstract::Although the geroprotectors discovery is a new biomedicine trend and more than 200 compounds can slow aging and increase the lifespan of the model organism, there are still no geroprotectors on the market. The reasons may be partly related to the lack of a unified concept of geroprotector, accepted by the scientific c...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Moskalev A,Chernyagina E,Kudryavtseva A,Shaposhnikov M

    更新日期:2017-05-02 00:00:00

  • Prognostic Nomogram Associated with Longer Survival in Amyotrophic Lateral Sclerosis Patients.

    abstract::Better understanding of survival factors in amyotrophic lateral sclerosis (ALS) could help physicians and patients schedule therapeutic interventions. We conducted a study to evaluate the predictive factors associated with longer survival and construct prognostic nomogram in ALS patients. A total of 553 ALS patients w...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Wei QQ,Chen Y,Chen X,Cao B,Ou R,Zhang L,Hou Y,Shang H

    更新日期:2018-12-04 00:00:00

  • Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway.

    abstract::Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in senile plaque and neurofibrillary tangles, are strongly intertwined with oxidative stress, which is considered one of the common effectors of the ...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Morroni F,Sita G,Graziosi A,Turrini E,Fimognari C,Tarozzi A,Hrelia P

    更新日期:2018-08-01 00:00:00

  • Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities.

    abstract::Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations aft...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Schwartz MD,Emerson SG,Punt J,Goff WD

    更新日期:2020-07-23 00:00:00

  • The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review.

    abstract::Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent yea...

    journal_title:Aging and disease

    pub_type: 杂志文章,评审


    authors: Liang W,Huang X,Chen W

    更新日期:2017-12-01 00:00:00

  • Brain Atrophy, Anti-Smooth Muscle Antibody and Cognitive Impairment: An Association Study.

    abstract::Cortical atrophy, neuronal loss, beta-amyloid deposition, neuritic plaques, and neurofibrillary tangles are neuropathological key features in the Alzheimer's disease (AD). Antibodies against beta-amyloid, neurotransmitters, microvascular endothelium components and microglial cells have been detected in AD serum sugges...

    journal_title:Aging and disease

    pub_type: 杂志文章


    authors: Giulia P,Michele L,Andrea F,Grazia D,Filomena C,Francesco P,Leandro C,Maria U,Carolina G,Massimiliano C,Antonio G

    更新日期:2015-11-24 00:00:00