Abstract:
:Cerebral microbleeds (CMBs), which indicate hemorrhage-prone disease, may associate with hemostatic abnormalities, but the association between CMBs and coagulation function is uncertain. We aimed to examine this possible association. The following coagulation function indicators were evaluated in 85 consecutive ischemic stroke patients diagnosed with atrial fibrillation and/or rheumatic heart disease: prothrombintime (PT), activated partial thromboplastin time (APTT), and levels of D-dimer and fibrinogen. Indicators were assessed within 24 h after admission. CMBs were identified based on published criteria by two experienced stroke neurologists working independently. PT, APPT, and levels of D-dimer and fibrinogen were compared between patients with and without CMBs using univariate and multivariate analysis. CMBs were detected in 48 patients (56.5%), and fibrinogen levels in these patients were independently and significantly higher than in patients without CMBs after adjustment (OR 2.16, 95% CI 1.20-3.90, P=0.01), whereas the two types of patients did not differ significantly in PT, APPT, or D-dimer levels. The presence of CMBs in ischemic stroke patients with atrial fibrillation and/or rheumatic heart disease is associated with elevated levels of fibrinogen. Larger prospective studies are needed to verify this association and explore the mechanisms involved.
journal_name
Aging Disjournal_title
Aging and diseaseauthors
Liu J,Wang D,Xiong Y,Liu B,Lin J,Zhang S,Wu B,Wei C,Liu Mdoi
10.14336/AD.2016.0715subject
Has Abstractpub_date
2017-04-01 00:00:00pages
131-135issue
2issn
2152-5250pii
ad-8-2-131journal_volume
8pub_type
杂志文章abstract::The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.0505
更新日期:2015-11-17 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0504
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abstract::Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induc...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500394
更新日期:2013-12-17 00:00:00
abstract::The immune system declines with aging, leading to an increased susceptibility to infections and higher incidence and progression of autoimmune phenomena and neoplasia. Down syndrome prematurely shows clinical manifestations that are normally seen with aging. This review provides a concise overview of abnormalities in ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract::Myocardial fibrosis is observed in various cardiovascular diseases and plays a key role in the impairment of cardiac function. Endomyocardial biopsy, as the gold standard for the diagnosis of myocardial fibrosis, has limitations in terms of clinical application. Therefore, biomarkers have been recommended for noninvas...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2020.0604
更新日期:2020-10-01 00:00:00
abstract::Longstanding immunological dogma holds that flexible immune recognition, which forms the mechanistic basis of adaptive immunity, is strictly confined to the lymphocyte lineage. In higher vertebrates, flexible immune recognition is represented by recombinatorial antigen receptors of enormous diversity known as immunogl...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
abstract::The expending of elderly population worldwide has resulted in a dramatic rise in the incidence of chronic diseases such as Alzheimer's disease (AD). Inadequate understanding of the mechanisms underlying AD has hampered the development of efficient tools for definitive diagnosis and curative interventions. Previous stu...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0217
更新日期:2020-12-01 00:00:00
abstract::Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0929
更新日期:2017-02-01 00:00:00
abstract::Cardiovascular disease is one of the most common causes of death worldwide and the most usual in the western populations. Although it affects both sexes, it is more frequent in males in whom it shortens the average life expectancy. This difference has been attributed to the negative effects of testosterone; however, r...
journal_title:Aging and disease
pub_type:
doi:10.14336/AD.2013.0400381
更新日期:2013-10-07 00:00:00
abstract::There has been increasing interest and research into sarcopenia in community-dwelling older adults since the European Working Group on Sarcopenia in Older People (EWGSOP) agreed a consensus definition in 2010. Sarcopenia has been defined as loss of muscle mass with loss of muscle function (strength or physical perform...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.0315
更新日期:2018-02-01 00:00:00
abstract::The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly unders...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500263
更新日期:2013-12-05 00:00:00
abstract::Age-related hearing loss (ARHL), a degenerative disorder characterized by age-dependent progressive increase in the threshold of auditory sensitivity, affects 40% of people over the age of 65, and it has emerged as an important social and public health problem. Various factors, including genetic and environmental comp...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500150
更新日期:2014-04-01 00:00:00
abstract::Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent yea...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.0829
更新日期:2017-12-01 00:00:00
abstract::The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract::Healthcare-associated pneumonia (HCAP) is a new concept of pneumonia proposed by the American Thoracic Society/Infectious Diseases Society of America in 2005. This category is located between community-acquired pneumonia and hospital-acquired pneumonia with respect to the characteristics of the causative pathogens and...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0127
更新日期:2014-02-08 00:00:00
abstract::Microglial activation is an important contributor to the pathogenesis of Parkinson's disease (PD). Microglia are tightly and efficiently regulated by immune checkpoints, including CD200-CD200R1 and CX3CL1-CX3CR1. Understanding the involvement of these checkpoints in disease progression provides important insights into...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0615
更新日期:2020-03-09 00:00:00
abstract::The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0429
更新日期:2018-04-01 00:00:00
abstract::Superoxide is a precursor of many free radicals and reactive oxygen species (ROS) in biological systems. It has been shown that superoxide regulates major epigenetic processes of DNA methylation, histone methylation, and histone acetylation. We suggested that superoxide, being a radical anion and a strong nucleophile,...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0924
更新日期:2015-06-01 00:00:00
abstract::Aging is associated with myriad changes in behavioral performance and brain structure and function. Given this complex interplay of brain and behavior, two streams of findings are reviewed here that show that aging is generally associated with dedifferentiated neural processes, and also changes in functional connectiv...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations aft...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0619
更新日期:2020-07-23 00:00:00
abstract::Galectin-3 (Gal-3) is highly expressed in fibrotic tissue related to diverse etiologies. endothelial-to-mesenchymal transition (EndoMT), A less well studied phenomenon serves as a critical process in pulmonary vascular remodeling associated with the development of pulmonary arterial hypertension (PAH). EndoMT is hypot...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.1001
更新日期:2019-08-01 00:00:00
abstract::Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have pro...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.002
更新日期:2015-08-01 00:00:00
abstract::It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500307
更新日期:2014-10-01 00:00:00
abstract::Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysa...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0630
更新日期:2018-04-01 00:00:00
abstract::Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and pa...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0110
更新日期:2017-10-01 00:00:00
abstract::Studies comparing chronologically "young" versus "old" humans document age-related decline of classical immunological functions. However, older adults aged ≥65 years have very heterogeneous health phenotypes. A significant number of them are functionally independent and are surviving well into their 8(th)-11(th) decad...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00
abstract::Neurogenesis in the hippocampal dentate gyrus persists throughout the lifespan of mammals, however, the rate of neurogenesis decreases as the animal ages. Although seizures increase neurogenesis in young adult brains, this relationship has not been shown in aged animals. Using doublecortin (DCX) immunocytochemistry, t...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-08-01 00:00:00
abstract::Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract. Histologicall...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.0910
更新日期:2019-04-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in senile plaque and neurofibrillary tangles, are strongly intertwined with oxidative stress, which is considered one of the common effectors of the ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0903
更新日期:2018-08-01 00:00:00
abstract::Aging is associated with increased fat mass and elevated serum leptin levels (hyperleptinemia), causing proinflammation in the kidneys where it plays a primary role in the removal of endogenous leptin from the circulation. Lymphocyte-specific kinase (Lck) is a positive regulator of inflammatory signaling and a potenti...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0218
更新日期:2019-12-01 00:00:00