Abstract:
:Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent years, a growing body of evidences has shown that baicalin and baicalein could be effective in the treatment of cerebral ischemia. Pharmacokinetic studies have shown that baicalin could penetrate the blood-brain barrier and distribute in cerebral nuclei. Through a variety of in vitro and in vivo models of ischemic neuronal injury, numerous studies have demonstrated that baicalin and baicalein have salutary effect for neuroprotection. Especially, the studies on the pharmacological mechanism showed that baicalin and baicalein have several pharmacological activities, which include antioxidant, anti-apoptotic, anti-inflammatory and anti-excitotoxicity effects, protection of the mitochondria, promoting neuronal protective factors expression and adult neurogenesis effects and many more. This review focuses on the neuroprotective effects of baicalin and baicalein in ischemia or stroke-induced neuronal cell death. We aimed at collecting all important information regarding the neuroprotective effect and its pharmacological mechanism of baicalin and baicalein in various in vivo and in vitro experimental models of ischemic neuronal injury.
journal_name
Aging Disjournal_title
Aging and diseaseauthors
Liang W,Huang X,Chen Wdoi
10.14336/AD.2017.0829subject
Has Abstractpub_date
2017-12-01 00:00:00pages
850-867issue
6issn
2152-5250pii
ad-8-6-850journal_volume
8pub_type
杂志文章,评审abstract::It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500307
更新日期:2014-10-01 00:00:00
abstract::Better understanding of survival factors in amyotrophic lateral sclerosis (ALS) could help physicians and patients schedule therapeutic interventions. We conducted a study to evaluate the predictive factors associated with longer survival and construct prognostic nomogram in ALS patients. A total of 553 ALS patients w...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.1016
更新日期:2018-12-04 00:00:00
abstract::Hypoxia is an environmental stress at high altitude and underground conditions but it is also present in many chronic age-related diseases, where blood flow into tissues is impaired. The oxygen-sensing system stimulates gene expression protecting tissues against hypoxic insults. Hypoxia stabilizes the expression of hy...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2015.0929
更新日期:2016-03-15 00:00:00
abstract::Healthy aged individuals are more likely to suffer profound memory impairments following a challenging life event such as a severe bacterial infection, surgery, or an intense psychological stressor, than are younger adults. These peripheral challenges are capable of producing a neuroinflammatory response, (e.g., incre...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Many oncogenes are involved in the progression from low-grade squamous intraepithelial lesions (LSILs) to high-grade squamous intraepithelial lesions (HSILs); which greatly increases the risk of cervical cancer (CC). Thus, a reliable biomarker for risk classification of LSILs is urgently needed. The prolyl isomerase P...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0415
更新日期:2020-02-01 00:00:00
abstract::Emerging evidence indicates that the intestinal microbiota could interact with the central nervous system and modulate multiple pathophysiological changes, including the integrity of intestinal barrier and blood-brain barrier, as well as neuroinflammatory response. In the present study, we investigated the potential r...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0106
更新日期:2020-10-01 00:00:00
abstract::Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical ...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0521
更新日期:2020-03-09 00:00:00
abstract::The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.0505
更新日期:2015-11-17 00:00:00
abstract::Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients with acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0601
更新日期:2018-06-01 00:00:00
abstract::As one of the leading causes of death around the world, suicide is a global public health threat. In the Chinese population, suicides constitute one-fifth of all recorded suicides in the world. Despite the factual data on suicide rates, the understanding of various causal factors behind suicide, including risk and pro...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0223
更新日期:2015-03-10 00:00:00
abstract::Superoxide is a precursor of many free radicals and reactive oxygen species (ROS) in biological systems. It has been shown that superoxide regulates major epigenetic processes of DNA methylation, histone methylation, and histone acetylation. We suggested that superoxide, being a radical anion and a strong nucleophile,...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0924
更新日期:2015-06-01 00:00:00
abstract::Studies comparing chronologically "young" versus "old" humans document age-related decline of classical immunological functions. However, older adults aged ≥65 years have very heterogeneous health phenotypes. A significant number of them are functionally independent and are surviving well into their 8(th)-11(th) decad...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00
abstract::Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0929
更新日期:2017-02-01 00:00:00
abstract::Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose of this study was to further explore the clinical significance of miR-424 in peripheral immune cells of patients ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0602
更新日期:2018-04-01 00:00:00
abstract::Healthcare-associated pneumonia (HCAP) is a new concept of pneumonia proposed by the American Thoracic Society/Infectious Diseases Society of America in 2005. This category is located between community-acquired pneumonia and hospital-acquired pneumonia with respect to the characteristics of the causative pathogens and...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0127
更新日期:2014-02-08 00:00:00
abstract::Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative da...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.1021
更新日期:2020-10-01 00:00:00
abstract::Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and pa...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0110
更新日期:2017-10-01 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2018.1105
更新日期:2019-12-01 00:00:00
abstract::With an increased life expectancy in humans and thus an increase in the number of the elderly population, the frequency of hip fractures will rise as well. Aside from a higher incidence, hip fractures in a geriatric population is a significant problem due to the possible onset of severe and in some cases dramatic comp...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500177
更新日期:2014-06-01 00:00:00
abstract::Cardiovascular disease is one of the most common causes of death worldwide and the most usual in the western populations. Although it affects both sexes, it is more frequent in males in whom it shortens the average life expectancy. This difference has been attributed to the negative effects of testosterone; however, r...
journal_title:Aging and disease
pub_type:
doi:10.14336/AD.2013.0400381
更新日期:2013-10-07 00:00:00
abstract::Dopamine (DA) is one of the major neurotransmitters and participates in a number of functions such as motor coordination, emotions, memory, reward mechanism, neuroendocrine regulation etc. DA exerts its effects through five DA receptors that are subdivided in 2 families: D1-like DA receptors (D1 and D5) and the D2-lik...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2015.0330
更新日期:2015-10-01 00:00:00
abstract::Microglial activation is an important contributor to the pathogenesis of Parkinson's disease (PD). Microglia are tightly and efficiently regulated by immune checkpoints, including CD200-CD200R1 and CX3CL1-CX3CR1. Understanding the involvement of these checkpoints in disease progression provides important insights into...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0615
更新日期:2020-03-09 00:00:00
abstract::Mammalian Sterile20-like (MST) kinases are located upstream in the mitogen-activated protein kinase pathway, and play an important role in cell proliferation, differentiation, renewal, polarization and migration. Generally, five MST kinases exist in mammalian signal transduction pathways, including MST1, MST2, MST3, M...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.0702
更新日期:2018-06-01 00:00:00
abstract::Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induc...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500394
更新日期:2013-12-17 00:00:00
abstract::The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0429
更新日期:2018-04-01 00:00:00
abstract::Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2013-03-07 00:00:00
abstract::In 2011, Hansen discovered the natural antisense transcript (NAT) of the cerebellar degeneration-related protein 1 gene (CDR1), and further described CDR1 NAT as a circular RNA (CircRNA). CDR1 antisense RNA (CDR1as), which is the official name of CDR1 NAT, is conserved and extensively expressed in most eutherian mamma...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0920
更新日期:2020-07-23 00:00:00
abstract::Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have pro...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.002
更新日期:2015-08-01 00:00:00
abstract::This population-based retrospective cohort study investigated dementia risk associated with acarbose in patients with type 2 diabetes mellitus by using Taiwan's National Health Insurance database. A cohort of 15,524 matched pairs of ever and never users of acarbose based on propensity score matching was enrolled from ...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0621
更新日期:2020-05-09 00:00:00
abstract::Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract. Histologicall...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.0910
更新日期:2019-04-01 00:00:00