Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone.

abstract：:The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...

journal_title：Aging and disease

authors： Vyas NS,Lee Y,Ahn K,Ternouth A,Stahl DR,Al-Chalabi A,Powell JF,Puri BK

更新日期：2012-08-01 00:00:00

abstract：:Muscle power is a strong predictor of functional status in the elderly population and is required to perform different daily activities. To compare the effects of different weekly training frequencies on muscle power and muscle quality induced by concurrent training (resistance + aerobic) in previously trained elderly...

journal_title：Aging and disease

authors： Ferrari R,Fuchs SC,Kruel LF,Cadore EL,Alberton CL,Pinto RS,Radaelli R,Schoenell M,Izquierdo M,Tanaka H,Umpierre D

更新日期：2016-12-01 00:00:00

abstract：:Better understanding of survival factors in amyotrophic lateral sclerosis (ALS) could help physicians and patients schedule therapeutic interventions. We conducted a study to evaluate the predictive factors associated with longer survival and construct prognostic nomogram in ALS patients. A total of 553 ALS patients w...

journal_title：Aging and disease

authors： Wei QQ,Chen Y,Chen X,Cao B,Ou R,Zhang L,Hou Y,Shang H

更新日期：2018-12-04 00:00:00

abstract：:Stroke is the second leading cause of death worldwide. The prognostic influence of body temperature on acute stroke in patients has been recently reported; however, hypothermia has confounded experimental results in animal stroke models. This work aimed to investigate how body temperature could prognose stroke severit...

journal_title：Aging and disease

authors： Hu H,Doll DN,Sun J,Lewis SE,Wimsatt JH,Kessler MJ,Simpkins JW,Ren X

更新日期：2016-01-02 00:00:00

abstract：:Myocardial fibrosis is observed in various cardiovascular diseases and plays a key role in the impairment of cardiac function. Endomyocardial biopsy, as the gold standard for the diagnosis of myocardial fibrosis, has limitations in terms of clinical application. Therefore, biomarkers have been recommended for noninvas...

journal_title：Aging and disease

authors： Ding Y,Wang Y,Zhang W,Jia Q,Wang X,Li Y,Lv S,Zhang J

更新日期：2020-10-01 00:00:00

abstract：:The aim of the study is to investigate the diffusion characteristics of Alzheimer's disease (AD) patients using an ultra-high b-values apparent diffusion coefficient (ADC_uh) and diffusion kurtosis imaging (DKI). A total of 31 AD patients and 20 healthy controls (HC) who underwent both MRI examination and clinical ass...

journal_title：Aging and disease

authors： Xue Y,Zhang Z,Wen C,Liu H,Wang S,Li J,Zhuge Q,Chen W,Ye Q

更新日期：2019-10-01 00:00:00

abstract：:Alzheimer disease (AD) is the most common dementing illness. Metabolic defects in the brain with aging contribute to the pathogenesis of AD. These changes can be found systematically and thus can be used as potential biomarkers. Erythrocytes (RBCs) are passive "reporter cells" that are not well studied in AD. In the p...

journal_title：Aging and disease

authors： Kaminsky YG,Reddy VP,Ashraf GM,Ahmad A,Benberin VV,Kosenko EA,Aliev G

更新日期：2013-10-01 00:00:00

abstract：:It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...

journal_title：Aging and disease

authors： Famakin BM

更新日期：2014-10-01 00:00:00

abstract：:Cisplatin is a commonly used chemotherapeutic drug, used for the treatment of malignant ovarian cancer, but acquired resistance limits its application. There is therefore an overwhelming need to understand the mechanism of cisplatin resistance in ovarian cancer, that is, ovarian cancer cells are insensitive to cisplat...

journal_title：Aging and disease

authors： Ma L,Wang H,Wang C,Su J,Xie Q,Xu L,Yu Y,Liu S,Li S,Xu Y,Li Z

更新日期：2016-05-27 00:00:00

abstract：:Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...

journal_title：Aging and disease

authors： Ray L,Khemka VK,Behera P,Bandyopadhyay K,Pal S,Pal K,Basu D,Chakrabarti S

更新日期：2013-03-07 00:00:00

abstract：:Aging is a progressive loss of physiological integrity and functionality process which increases susceptibility and mortality to diseases. Vascular aging is a specific type of organic aging. The structure and function changes of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cause of vas...

journal_title：Aging and disease

authors： Ni YQ,Lin X,Zhan JK,Liu YS

更新日期：2020-02-01 00:00:00

abstract：:Although the geroprotectors discovery is a new biomedicine trend and more than 200 compounds can slow aging and increase the lifespan of the model organism, there are still no geroprotectors on the market. The reasons may be partly related to the lack of a unified concept of geroprotector, accepted by the scientific c...

journal_title：Aging and disease

authors： Moskalev A,Chernyagina E,Kudryavtseva A,Shaposhnikov M

更新日期：2017-05-02 00:00:00

abstract：:A promising strategy for the prevention of Alzheimer's disease (AD) is the identification of age-related changes that place the brain at risk for the disease. Additionally, AD is associated with chronic dehydration, and one of the significant changes that are known to result in metabolic dysfunction is an increase in ...

journal_title：Aging and disease

authors： Li T,Su T,He Y,Lu J,Mo W,Wei Y,He R

更新日期：2016-10-01 00:00:00

abstract：:The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly unders...

journal_title：Aging and disease

authors： Xu S,Cai Y,Wei Y

更新日期：2013-12-05 00:00:00

abstract：:Emerging evidence indicates that the intestinal microbiota could interact with the central nervous system and modulate multiple pathophysiological changes, including the integrity of intestinal barrier and blood-brain barrier, as well as neuroinflammatory response. In the present study, we investigated the potential r...

journal_title：Aging and disease

authors： Han D,Li Z,Liu T,Yang N,Li Y,He J,Qian M,Kuang Z,Zhang W,Ni C,Guo X

更新日期：2020-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...

journal_title：Aging and disease

authors： Zhao Y,Zhang Y,Zhang L,Dong Y,Ji H,Shen L

更新日期：2019-12-01 00:00:00

abstract：:Age-related hearing loss (ARHL), a degenerative disorder characterized by age-dependent progressive increase in the threshold of auditory sensitivity, affects 40% of people over the age of 65, and it has emerged as an important social and public health problem. Various factors, including genetic and environmental comp...

journal_title：Aging and disease

authors： Kim HJ,Oh GS,Choe SK,Kwak TH,Park R,So HS

更新日期：2014-04-01 00:00:00

abstract：:Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysa...

journal_title：Aging and disease

authors： Carrera-Bastos P,Picazo Ó,Fontes-Villalba M,Pareja-Galeano H,Lindeberg S,Martínez-Selles M,Lucia A,Emanuele E

更新日期：2018-04-01 00:00:00

abstract：:In 2011, Hansen discovered the natural antisense transcript (NAT) of the cerebellar degeneration-related protein 1 gene (CDR1), and further described CDR1 NAT as a circular RNA (CircRNA). CDR1 antisense RNA (CDR1as), which is the official name of CDR1 NAT, is conserved and extensively expressed in most eutherian mamma...

journal_title：Aging and disease

authors： Guo Z,Cao Q,Zhao Z,Song C

更新日期：2020-07-23 00:00:00

abstract：:Cortical atrophy, neuronal loss, beta-amyloid deposition, neuritic plaques, and neurofibrillary tangles are neuropathological key features in the Alzheimer's disease (AD). Antibodies against beta-amyloid, neurotransmitters, microvascular endothelium components and microglial cells have been detected in AD serum sugges...

journal_title：Aging and disease

authors： Giulia P,Michele L,Andrea F,Grazia D,Filomena C,Francesco P,Leandro C,Maria U,Carolina G,Massimiliano C,Antonio G

更新日期：2015-11-24 00:00:00

abstract：:Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent yea...

journal_title：Aging and disease

authors： Liang W,Huang X,Chen W

更新日期：2017-12-01 00:00:00

abstract：:Multiple cues from the environment of our indirect and immediate ancestors, which often persist throughout the prenatal period and adulthood, are shaping our phenotypes through either direct, parent-to-child influences, or transgenerational inheritance. These effects are due to gene-environment interactions, which are...

journal_title：Aging and disease

authors： Lupu DS,Tint D,Niculescu MD

更新日期：2012-12-01 00:00:00

abstract：:Healthcare-associated pneumonia (HCAP) is a new concept of pneumonia proposed by the American Thoracic Society/Infectious Diseases Society of America in 2005. This category is located between community-acquired pneumonia and hospital-acquired pneumonia with respect to the characteristics of the causative pathogens and...

journal_title：Aging and disease

authors： Komiya K,Ishii H,Kadota J

更新日期：2014-02-08 00:00:00

abstract：:Evidence indicated that inflammatory response and some pattern-recognition receptors play important roles in the occurrence and progression of osteoarthritis. This study is conducted to evaluate the role of RIG-I and its adaptor protein MAVS in the pathogenesis of osteoarthritis. Four SNPs in RIG-I gene and four in MA...

journal_title：Aging and disease

authors： Liu J,Tang LY,Wang YG,Lu SY,Zhang EN,Wang ZG,Zhang HX

更新日期：2018-02-01 00:00:00

abstract：:Many oncogenes are involved in the progression from low-grade squamous intraepithelial lesions (LSILs) to high-grade squamous intraepithelial lesions (HSILs); which greatly increases the risk of cervical cancer (CC). Thus, a reliable biomarker for risk classification of LSILs is urgently needed. The prolyl isomerase P...

journal_title：Aging and disease

authors： Guo YT,Lu Y,Jia YY,Qu HN,Qi D,Wang XQ,Song PY,Jin XS,Xu WH,Dong Y,Liang YY,Quan CS

更新日期：2020-02-01 00:00:00

abstract：:Sleep duration and quality have been associated with poor physical function, but both the temporality of the association and the independence of sleep duration and quality are unclear. We examined the prospective association of sleep duration and quality with physical function impairment and disability in older adults...

journal_title：Aging and disease

authors： Campanini MZ,Mesas AE,Carnicero-Carreño JA,Rodríguez-Artalejo F,Lopez-Garcia E

更新日期：2019-06-01 00:00:00

abstract：:Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract. Histologicall...

journal_title：Aging and disease

authors： He Q,Gao Y,Wang T,Zhou L,Zhou W,Yuan Z

更新日期：2019-04-01 00:00:00

abstract：:Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets histones and many non-histone proteins and participates in various physiological functions. The enzymatic activity of SIRT1 is decreased in patients with Parkinson's disease (PD), which may reduce their ability to resist neuronal damage c...

journal_title：Aging and disease

authors： Li X,Feng Y,Wang XX,Truong D,Wu YC

更新日期：2020-12-01 00:00:00

abstract：:Galectin-3 (Gal-3) is highly expressed in fibrotic tissue related to diverse etiologies. endothelial-to-mesenchymal transition (EndoMT), A less well studied phenomenon serves as a critical process in pulmonary vascular remodeling associated with the development of pulmonary arterial hypertension (PAH). EndoMT is hypot...

journal_title：Aging and disease

authors： Li T,Zha L,Luo H,Li S,Zhao L,He J,Li X,Qi Q,Liu Y,Yu Z

更新日期：2019-08-01 00:00:00

abstract：:Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and pa...

journal_title：Aging and disease

authors： Urzua U,Chacon C,Lizama L,Sarmiento S,Villalobos P,Kroxato B,Marcelain K,Gonzalez MJ

更新日期：2017-10-01 00:00:00