Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging.

abstract：:Neurogenesis in the hippocampal dentate gyrus persists throughout the lifespan of mammals, however, the rate of neurogenesis decreases as the animal ages. Although seizures increase neurogenesis in young adult brains, this relationship has not been shown in aged animals. Using doublecortin (DCX) immunocytochemistry, t...

journal_title：Aging and disease

authors： Shapiro LA,Wang L,Upadhyaya P,Ribak CE

更新日期：2011-08-01 00:00:00

abstract：:Dimebon (latrepirdine), an old antihistaminic drug, showed divergent results in two large clinical trials in Alzheimer disease (AD), which according to our review might be related to the specific pharmacological properties of the drug and the different patient populations included in both studies. Out of the many phar...

journal_title：Aging and disease

authors： Eckert SH,Gaca J,Kolesova N,Friedland K,Eckert GP,Muller WE

更新日期：2018-08-01 00:00:00

abstract：:The aim of the study is to investigate the diffusion characteristics of Alzheimer's disease (AD) patients using an ultra-high b-values apparent diffusion coefficient (ADC_uh) and diffusion kurtosis imaging (DKI). A total of 31 AD patients and 20 healthy controls (HC) who underwent both MRI examination and clinical ass...

journal_title：Aging and disease

authors： Xue Y,Zhang Z,Wen C,Liu H,Wang S,Li J,Zhuge Q,Chen W,Ye Q

更新日期：2019-10-01 00:00:00

abstract：:The expending of elderly population worldwide has resulted in a dramatic rise in the incidence of chronic diseases such as Alzheimer's disease (AD). Inadequate understanding of the mechanisms underlying AD has hampered the development of efficient tools for definitive diagnosis and curative interventions. Previous stu...

journal_title：Aging and disease

authors： Shao Y,Ouyang Y,Li T,Liu X,Xu X,Li S,Xu G,Le W

更新日期：2020-12-01 00:00:00

abstract：:Healthy aged individuals are more likely to suffer profound memory impairments following a challenging life event such as a severe bacterial infection, surgery, or an intense psychological stressor, than are younger adults. These peripheral challenges are capable of producing a neuroinflammatory response, (e.g., incre...

journal_title：Aging and disease

authors： Barrientos RM,Frank MG,Watkins LR,Maier SF

更新日期：2010-01-01 00:00:00

abstract：:Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations aft...

journal_title：Aging and disease

authors： Schwartz MD,Emerson SG,Punt J,Goff WD

更新日期：2020-07-23 00:00:00

abstract：:The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly unders...

journal_title：Aging and disease

authors： Xu S,Cai Y,Wei Y

更新日期：2013-12-05 00:00:00

abstract：:Although the geroprotectors discovery is a new biomedicine trend and more than 200 compounds can slow aging and increase the lifespan of the model organism, there are still no geroprotectors on the market. The reasons may be partly related to the lack of a unified concept of geroprotector, accepted by the scientific c...

journal_title：Aging and disease

authors： Moskalev A,Chernyagina E,Kudryavtseva A,Shaposhnikov M

更新日期：2017-05-02 00:00:00

abstract：:Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induc...

journal_title：Aging and disease

authors： Baugé C,Girard N,Lhuissier E,Bazille C,Boumediene K

更新日期：2013-12-17 00:00:00

abstract：:Metabolic syndrome is an increasing health problem, whose pathogenesis may be associated with genetic factors. The main purpose of our study was to assess relationships between MetS and the presence of the FTO rs9939609, the MC4R rs17782313, and the PPAR-γ rs1801282 polymorphisms in 45-60-year-old women. The study inc...

journal_title：Aging and disease

authors： Małgorzata S,Jacek B,Jerzy OA,Piotr C,Anna J,Elżbieta G

更新日期：2018-10-01 00:00:00

abstract：:Age related bone loss predisposes adults to osteoporosis. This is especially true for individuals with spinal cord injury (SCI). The effects of decreased bone loading with older age and paralysis significantly contribute to decreased bone mass and increased risk for fragility fractures. Loading bone via volitional mus...

journal_title：Aging and disease

authors： Dolbow JD,Dolbow DR,Gorgey AS,Adler RA,Gater DR

更新日期：2013-02-07 00:00:00

abstract：:Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and pa...

journal_title：Aging and disease

authors： Urzua U,Chacon C,Lizama L,Sarmiento S,Villalobos P,Kroxato B,Marcelain K,Gonzalez MJ

更新日期：2017-10-01 00:00:00

abstract：:The molecular processes of aging are very heterogenic and not fully understood. Studies on rare progeria syndromes, which display an accelerated progression of physiological aging, can help to get a better understanding. Pseudoxanthoma elasticum (PXE) caused by mutations in the ATP-binding cassette sub-family C member...

journal_title：Aging and disease

authors： Tiemann J,Wagner T,Vanakker OM,van Gils M,Cabrera JB,Ibold B,Faust I,Knabbe C,Hendig D

更新日期：2020-05-09 00:00:00

abstract：:In 2011, Hansen discovered the natural antisense transcript (NAT) of the cerebellar degeneration-related protein 1 gene (CDR1), and further described CDR1 NAT as a circular RNA (CircRNA). CDR1 antisense RNA (CDR1as), which is the official name of CDR1 NAT, is conserved and extensively expressed in most eutherian mamma...

journal_title：Aging and disease

authors： Guo Z,Cao Q,Zhao Z,Song C

更新日期：2020-07-23 00:00:00

abstract：:Galectin-3 (Gal-3) is highly expressed in fibrotic tissue related to diverse etiologies. endothelial-to-mesenchymal transition (EndoMT), A less well studied phenomenon serves as a critical process in pulmonary vascular remodeling associated with the development of pulmonary arterial hypertension (PAH). EndoMT is hypot...

journal_title：Aging and disease

authors： Li T,Zha L,Luo H,Li S,Zhao L,He J,Li X,Qi Q,Liu Y,Yu Z

更新日期：2019-08-01 00:00:00

abstract：:The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...

journal_title：Aging and disease

authors： Dai CF,Xie X,Ma YT,Yang YN,Li XM,Fu ZY,Liu F,Chen BD,Gai MT

更新日期：2015-11-17 00:00:00

abstract：:With an increased life expectancy in humans and thus an increase in the number of the elderly population, the frequency of hip fractures will rise as well. Aside from a higher incidence, hip fractures in a geriatric population is a significant problem due to the possible onset of severe and in some cases dramatic comp...

journal_title：Aging and disease

authors： Radosavljevic N,Nikolic D,Lazovic M,Jeremic A

更新日期：2014-06-01 00:00:00

abstract：:Superoxide is a precursor of many free radicals and reactive oxygen species (ROS) in biological systems. It has been shown that superoxide regulates major epigenetic processes of DNA methylation, histone methylation, and histone acetylation. We suggested that superoxide, being a radical anion and a strong nucleophile,...

journal_title：Aging and disease

authors： Afanas'ev I

更新日期：2015-06-01 00:00:00

abstract：:Stroke is the second leading cause of death worldwide. The prognostic influence of body temperature on acute stroke in patients has been recently reported; however, hypothermia has confounded experimental results in animal stroke models. This work aimed to investigate how body temperature could prognose stroke severit...

journal_title：Aging and disease

authors： Hu H,Doll DN,Sun J,Lewis SE,Wimsatt JH,Kessler MJ,Simpkins JW,Ren X

更新日期：2016-01-02 00:00:00

abstract：:Oxidative stress and iron accumulation are tightly associated with neurodegenerative diseases. Mitochondrial ferritin (FtMt) is identified as an iron-storage protein located in the mitochondria, and its role in regulation of iron hemeostasis in neurodegenerative diseases has been reported. However, the role of FtMt in...

journal_title：Aging and disease

authors： Gao G,Zhang N,Wang YQ,Wu Q,Yu P,Shi ZH,Duan XL,Zhao BL,Wu WS,Chang YZ

更新日期：2017-07-21 00:00:00

abstract：:Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose of this study was to further explore the clinical significance of miR-424 in peripheral immune cells of patients ...

journal_title：Aging and disease

authors： Li G,Ma Q,Wang R,Fan Z,Tao Z,Liu P,Zhao H,Luo Y

更新日期：2018-04-01 00:00:00

abstract：:Muscle power is a strong predictor of functional status in the elderly population and is required to perform different daily activities. To compare the effects of different weekly training frequencies on muscle power and muscle quality induced by concurrent training (resistance + aerobic) in previously trained elderly...

journal_title：Aging and disease

authors： Ferrari R,Fuchs SC,Kruel LF,Cadore EL,Alberton CL,Pinto RS,Radaelli R,Schoenell M,Izquierdo M,Tanaka H,Umpierre D

更新日期：2016-12-01 00:00:00

abstract：:Sleep duration and quality have been associated with poor physical function, but both the temporality of the association and the independence of sleep duration and quality are unclear. We examined the prospective association of sleep duration and quality with physical function impairment and disability in older adults...

journal_title：Aging and disease

authors： Campanini MZ,Mesas AE,Carnicero-Carreño JA,Rodríguez-Artalejo F,Lopez-Garcia E

更新日期：2019-06-01 00:00:00

abstract：:Evidence indicated that inflammatory response and some pattern-recognition receptors play important roles in the occurrence and progression of osteoarthritis. This study is conducted to evaluate the role of RIG-I and its adaptor protein MAVS in the pathogenesis of osteoarthritis. Four SNPs in RIG-I gene and four in MA...

journal_title：Aging and disease

authors： Liu J,Tang LY,Wang YG,Lu SY,Zhang EN,Wang ZG,Zhang HX

更新日期：2018-02-01 00:00:00

abstract：:Microglial activation is an important contributor to the pathogenesis of Parkinson's disease (PD). Microglia are tightly and efficiently regulated by immune checkpoints, including CD200-CD200R1 and CX3CL1-CX3CR1. Understanding the involvement of these checkpoints in disease progression provides important insights into...

journal_title：Aging and disease

authors： Wang L,Liu Y,Yan S,Du T,Fu X,Gong X,Zhou X,Zhang T,Wang X

更新日期：2020-03-09 00:00:00

abstract：:Mammalian Sterile20-like (MST) kinases are located upstream in the mitogen-activated protein kinase pathway, and play an important role in cell proliferation, differentiation, renewal, polarization and migration. Generally, five MST kinases exist in mammalian signal transduction pathways, including MST1, MST2, MST3, M...

journal_title：Aging and disease

authors： Chen S,Fang Y,Xu S,Reis C,Zhang J

更新日期：2018-06-01 00:00:00

abstract：:Cerebral microbleeds (CMBs), which indicate hemorrhage-prone disease, may associate with hemostatic abnormalities, but the association between CMBs and coagulation function is uncertain. We aimed to examine this possible association. The following coagulation function indicators were evaluated in 85 consecutive ischem...

journal_title：Aging and disease

authors： Liu J,Wang D,Xiong Y,Liu B,Lin J,Zhang S,Wu B,Wei C,Liu M

更新日期：2017-04-01 00:00:00

abstract：:Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...

journal_title：Aging and disease

authors： Ray L,Khemka VK,Behera P,Bandyopadhyay K,Pal S,Pal K,Basu D,Chakrabarti S

更新日期：2013-03-07 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...

journal_title：Aging and disease

authors： Zhao Y,Zhang Y,Zhang L,Dong Y,Ji H,Shen L

更新日期：2019-12-01 00:00:00

abstract：:Alzheimer disease (AD) is the most common dementing illness. Metabolic defects in the brain with aging contribute to the pathogenesis of AD. These changes can be found systematically and thus can be used as potential biomarkers. Erythrocytes (RBCs) are passive "reporter cells" that are not well studied in AD. In the p...

journal_title：Aging and disease

authors： Kaminsky YG,Reddy VP,Ashraf GM,Ahmad A,Benberin VV,Kosenko EA,Aliev G

更新日期：2013-10-01 00:00:00