Abstract:
:Metabolic syndrome is an increasing health problem, whose pathogenesis may be associated with genetic factors. The main purpose of our study was to assess relationships between MetS and the presence of the FTO rs9939609, the MC4R rs17782313, and the PPAR-γ rs1801282 polymorphisms in 45-60-year-old women. The study included patients from the general population of the Westpomeranian Province (Poland). The mean age was 54.3 ± 4.2 years. The research procedure involved taking structured history, physical examination, anthropometric measurements, and collecting blood for biochemical and genetic analysis. The patients who met the diagnostic criteria for MetS constituted 38.35% of all participants (sample size: 425 patients). The comparison of blood biochemical parameters revealed numerous differences between the women with MetS and those from the control group. Genetic analysis demonstrated that the T allele of the FTO gene was a factor substantially decreasing the incidence of MetS in the study sample (ORT vs. A = 0.734; 95% CI: 0.555 - 0.970; p < 0.05). Other polymorphisms were not directly related to MetS incidence. CONCLUSIONS:1. MetS-related abnormalities are widespread in the population of 45-60-year-old Polish women. Those most common are the elevated serum total cholesterol and LDL levels, increased insulin resistance and BMI scores, as well as visceral obesity. 2. No direct relationships were demonstrated between MetS and the gene polymorphisms analyzed in our study except for the FTO rs9939609, whose A allele and A/A genotype seemed to predispose to metabolic disorders.
journal_name
Aging Disjournal_title
Aging and diseaseauthors
Małgorzata S,Jacek B,Jerzy OA,Piotr C,Anna J,Elżbieta Gdoi
10.14336/AD.2017.1027subject
Has Abstractpub_date
2018-10-01 00:00:00pages
831-842issue
5issn
2152-5250pii
ad-9-5-831journal_volume
9pub_type
杂志文章abstract::In 2011, Hansen discovered the natural antisense transcript (NAT) of the cerebellar degeneration-related protein 1 gene (CDR1), and further described CDR1 NAT as a circular RNA (CircRNA). CDR1 antisense RNA (CDR1as), which is the official name of CDR1 NAT, is conserved and extensively expressed in most eutherian mamma...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0920
更新日期:2020-07-23 00:00:00
abstract::Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients with acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0601
更新日期:2018-06-01 00:00:00
abstract::Hypoxia is an environmental stress at high altitude and underground conditions but it is also present in many chronic age-related diseases, where blood flow into tissues is impaired. The oxygen-sensing system stimulates gene expression protecting tissues against hypoxic insults. Hypoxia stabilizes the expression of hy...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2015.0929
更新日期:2016-03-15 00:00:00
abstract::Age-related hearing loss (ARHL), a degenerative disorder characterized by age-dependent progressive increase in the threshold of auditory sensitivity, affects 40% of people over the age of 65, and it has emerged as an important social and public health problem. Various factors, including genetic and environmental comp...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500150
更新日期:2014-04-01 00:00:00
abstract::Cerebral microbleeds (CMBs), which indicate hemorrhage-prone disease, may associate with hemostatic abnormalities, but the association between CMBs and coagulation function is uncertain. We aimed to examine this possible association. The following coagulation function indicators were evaluated in 85 consecutive ischem...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0715
更新日期:2017-04-01 00:00:00
abstract::Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2013-03-07 00:00:00
abstract::Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of regulatory receptors on the T cell surface contribute to...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-10-01 00:00:00
abstract::There has been increasing interest and research into sarcopenia in community-dwelling older adults since the European Working Group on Sarcopenia in Older People (EWGSOP) agreed a consensus definition in 2010. Sarcopenia has been defined as loss of muscle mass with loss of muscle function (strength or physical perform...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.0315
更新日期:2018-02-01 00:00:00
abstract::Myocardial fibrosis is observed in various cardiovascular diseases and plays a key role in the impairment of cardiac function. Endomyocardial biopsy, as the gold standard for the diagnosis of myocardial fibrosis, has limitations in terms of clinical application. Therefore, biomarkers have been recommended for noninvas...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2020.0604
更新日期:2020-10-01 00:00:00
abstract::Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0929
更新日期:2017-02-01 00:00:00
abstract::Cardiovascular disease is one of the most common causes of death worldwide and the most usual in the western populations. Although it affects both sexes, it is more frequent in males in whom it shortens the average life expectancy. This difference has been attributed to the negative effects of testosterone; however, r...
journal_title:Aging and disease
pub_type:
doi:10.14336/AD.2013.0400381
更新日期:2013-10-07 00:00:00
abstract::Many oncogenes are involved in the progression from low-grade squamous intraepithelial lesions (LSILs) to high-grade squamous intraepithelial lesions (HSILs); which greatly increases the risk of cervical cancer (CC). Thus, a reliable biomarker for risk classification of LSILs is urgently needed. The prolyl isomerase P...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0415
更新日期:2020-02-01 00:00:00
abstract::It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500307
更新日期:2014-10-01 00:00:00
abstract::Aging is associated with increased fat mass and elevated serum leptin levels (hyperleptinemia), causing proinflammation in the kidneys where it plays a primary role in the removal of endogenous leptin from the circulation. Lymphocyte-specific kinase (Lck) is a positive regulator of inflammatory signaling and a potenti...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0218
更新日期:2019-12-01 00:00:00
abstract::Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induc...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500394
更新日期:2013-12-17 00:00:00
abstract::Emerging evidence indicates that the intestinal microbiota could interact with the central nervous system and modulate multiple pathophysiological changes, including the integrity of intestinal barrier and blood-brain barrier, as well as neuroinflammatory response. In the present study, we investigated the potential r...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0106
更新日期:2020-10-01 00:00:00
abstract::Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have pro...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.002
更新日期:2015-08-01 00:00:00
abstract::The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract::Multiple cues from the environment of our indirect and immediate ancestors, which often persist throughout the prenatal period and adulthood, are shaping our phenotypes through either direct, parent-to-child influences, or transgenerational inheritance. These effects are due to gene-environment interactions, which are...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract::DICER1 deficiency in the retinal pigment epithelium (RPE) was associated with the accumulation of Alu transcripts and implicated in geographic atrophy (GA), a form of age-related macular degeneration (AMD), an eye disease leading to blindness in millions of people. Although the exact mechanism of this association is n...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0809
更新日期:2020-07-23 00:00:00
abstract::Advances in pharmacological treatment and effective early myocardial revascularization have -in recent years- led to improved clinical outcomes in patients with acute myocardial infarction (AMI). However, it has been suggested that compared to younger subjects, elderly AMI patients are less likely to receive evidence-...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-04-01 00:00:00
abstract::This population-based retrospective cohort study investigated dementia risk associated with acarbose in patients with type 2 diabetes mellitus by using Taiwan's National Health Insurance database. A cohort of 15,524 matched pairs of ever and never users of acarbose based on propensity score matching was enrolled from ...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0621
更新日期:2020-05-09 00:00:00
abstract::Dimebon (latrepirdine), an old antihistaminic drug, showed divergent results in two large clinical trials in Alzheimer disease (AD), which according to our review might be related to the specific pharmacological properties of the drug and the different patient populations included in both studies. Out of the many phar...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.1014
更新日期:2018-08-01 00:00:00
abstract::Healthy aged individuals are more likely to suffer profound memory impairments following a challenging life event such as a severe bacterial infection, surgery, or an intense psychological stressor, than are younger adults. These peripheral challenges are capable of producing a neuroinflammatory response, (e.g., incre...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Oxidative stress and iron accumulation are tightly associated with neurodegenerative diseases. Mitochondrial ferritin (FtMt) is identified as an iron-storage protein located in the mitochondria, and its role in regulation of iron hemeostasis in neurodegenerative diseases has been reported. However, the role of FtMt in...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.1108
更新日期:2017-07-21 00:00:00
abstract::Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in senile plaque and neurofibrillary tangles, are strongly intertwined with oxidative stress, which is considered one of the common effectors of the ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0903
更新日期:2018-08-01 00:00:00
abstract::Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical ...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0521
更新日期:2020-03-09 00:00:00
abstract::Longstanding immunological dogma holds that flexible immune recognition, which forms the mechanistic basis of adaptive immunity, is strictly confined to the lymphocyte lineage. In higher vertebrates, flexible immune recognition is represented by recombinatorial antigen receptors of enormous diversity known as immunogl...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
abstract::The immune system declines with aging, leading to an increased susceptibility to infections and higher incidence and progression of autoimmune phenomena and neoplasia. Down syndrome prematurely shows clinical manifestations that are normally seen with aging. This review provides a concise overview of abnormalities in ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract::Microglial activation is an important contributor to the pathogenesis of Parkinson's disease (PD). Microglia are tightly and efficiently regulated by immune checkpoints, including CD200-CD200R1 and CX3CL1-CX3CR1. Understanding the involvement of these checkpoints in disease progression provides important insights into...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0615
更新日期:2020-03-09 00:00:00