Abstract:
:Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical frailty to cognitive decline, a complete understanding of the underpinning biological basis of the two disorders remains fragmented. This narrative review discusses insights into the potential roles of chronic inflammation, impaired hypothalamic-pituitary axis stress response, imbalanced energy metabolism, mitochondrial dysfunction, oxidative stress, and neuroendocrine dysfunction linking physical frailty with cognitive decline. We highlight the importance of easier identification of strategic approaches delaying the progression and onset of physical frailty and cognitive decline as well as preventing disability in the older population.
journal_name
Aging Disjournal_title
Aging and diseaseauthors
Ma L,Chan Pdoi
10.14336/AD.2019.0521subject
Has Abstractpub_date
2020-03-09 00:00:00pages
405-418issue
2issn
2152-5250pii
ad-11-2-405journal_volume
11pub_type
杂志文章,评审abstract::Advances in pharmacological treatment and effective early myocardial revascularization have -in recent years- led to improved clinical outcomes in patients with acute myocardial infarction (AMI). However, it has been suggested that compared to younger subjects, elderly AMI patients are less likely to receive evidence-...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
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abstract::Cisplatin is a commonly used chemotherapeutic drug, used for the treatment of malignant ovarian cancer, but acquired resistance limits its application. There is therefore an overwhelming need to understand the mechanism of cisplatin resistance in ovarian cancer, that is, ovarian cancer cells are insensitive to cisplat...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0118
更新日期:2016-05-27 00:00:00
abstract::The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0429
更新日期:2018-04-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.0210
更新日期:2019-02-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0929
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abstract::Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose of this study was to further explore the clinical significance of miR-424 in peripheral immune cells of patients ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0602
更新日期:2018-04-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.0906
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.0702
更新日期:2018-06-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0924
更新日期:2015-06-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.0829
更新日期:2017-12-01 00:00:00
abstract::Cortical atrophy, neuronal loss, beta-amyloid deposition, neuritic plaques, and neurofibrillary tangles are neuropathological key features in the Alzheimer's disease (AD). Antibodies against beta-amyloid, neurotransmitters, microvascular endothelium components and microglial cells have been detected in AD serum sugges...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.1124
更新日期:2015-11-24 00:00:00
abstract::Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in senile plaque and neurofibrillary tangles, are strongly intertwined with oxidative stress, which is considered one of the common effectors of the ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0903
更新日期:2018-08-01 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2018.1105
更新日期:2019-12-01 00:00:00
abstract::Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations aft...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0619
更新日期:2020-07-23 00:00:00
abstract::Healthcare-associated pneumonia (HCAP) is a new concept of pneumonia proposed by the American Thoracic Society/Infectious Diseases Society of America in 2005. This category is located between community-acquired pneumonia and hospital-acquired pneumonia with respect to the characteristics of the causative pathogens and...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0127
更新日期:2014-02-08 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.1001
更新日期:2019-08-01 00:00:00
abstract::Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin' Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 health...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.0819
更新日期:2018-12-04 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-04-01 00:00:00
abstract::Oxidative stress and iron accumulation are tightly associated with neurodegenerative diseases. Mitochondrial ferritin (FtMt) is identified as an iron-storage protein located in the mitochondria, and its role in regulation of iron hemeostasis in neurodegenerative diseases has been reported. However, the role of FtMt in...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.1108
更新日期:2017-07-21 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2020.0216
更新日期:2020-12-01 00:00:00
abstract::Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative da...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.1021
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.1016
更新日期:2018-12-04 00:00:00
abstract::Multiple cues from the environment of our indirect and immediate ancestors, which often persist throughout the prenatal period and adulthood, are shaping our phenotypes through either direct, parent-to-child influences, or transgenerational inheritance. These effects are due to gene-environment interactions, which are...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract::Neurogenesis in the hippocampal dentate gyrus persists throughout the lifespan of mammals, however, the rate of neurogenesis decreases as the animal ages. Although seizures increase neurogenesis in young adult brains, this relationship has not been shown in aged animals. Using doublecortin (DCX) immunocytochemistry, t...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-08-01 00:00:00
abstract::Evidence indicated that inflammatory response and some pattern-recognition receptors play important roles in the occurrence and progression of osteoarthritis. This study is conducted to evaluate the role of RIG-I and its adaptor protein MAVS in the pathogenesis of osteoarthritis. Four SNPs in RIG-I gene and four in MA...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0308
更新日期:2018-02-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.1014
更新日期:2018-08-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract::This population-based retrospective cohort study investigated dementia risk associated with acarbose in patients with type 2 diabetes mellitus by using Taiwan's National Health Insurance database. A cohort of 15,524 matched pairs of ever and never users of acarbose based on propensity score matching was enrolled from ...
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journal_title:Aging and disease
pub_type: 杂志文章
doi:
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