Abstract:
:Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets histones and many non-histone proteins and participates in various physiological functions. The enzymatic activity of SIRT1 is decreased in patients with Parkinson's disease (PD), which may reduce their ability to resist neuronal damage caused by various neurotoxins. As far as we know, SIRT1 can induce autophagy by regulating autophagy related proteins such as AMP-activated protein kinase, light chain 3, mammalian target of rapamycin, and forkhead transcription factor 1. Furthermore, SIRT1 can regulate mitochondrial function and inhibit oxidative stress mainly by maintaining peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in a deacetylated state and thus maintaining a constant level of PGC-1α. Other studies have demonstrated that SIRT1 may play a role in the pathophysiology of PD by regulating neuroinflammation. SIRT1 deacetylases nuclear factor-kappa B and thus reduces its transcriptional activity, inhibits inducible nitric oxide synthase expression, and decreases tumor necrosis factor-alpha and interleukin-6 levels. SIRT1 can also upregulate heat shock protein 70 by deacetylating heat shock factor 1 to increase the degradation of α-synuclein oligomers. Few studies have focused on the relationship between SIRT1 single nucleotide polymorphisms and PD risk, so this topic requires further research. Based on the neuroprotective effects of SIRT1 on PD, many in vitro and in vivo experiments have demonstrated that some SIRT1 activators, notably resveratrol, have potential neuroprotective effects against dopaminergic neuronal damage caused by various neurotoxins. Thus, SIRT1 plays a critical role in PD development and might be a potential target for PD therapy.
journal_name
Aging Disjournal_title
Aging and diseaseauthors
Li X,Feng Y,Wang XX,Truong D,Wu YCdoi
10.14336/AD.2020.0216subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1608-1622issue
6issn
2152-5250pii
ad-11-6-1608journal_volume
11pub_type
杂志文章,评审abstract::Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients with acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) ...
journal_title:Aging and disease
pub_type: 杂志文章
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abstract::Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysa...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0630
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.0611
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journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2010-10-01 00:00:00
abstract::Aging is associated with myriad changes in behavioral performance and brain structure and function. Given this complex interplay of brain and behavior, two streams of findings are reviewed here that show that aging is generally associated with dedifferentiated neural processes, and also changes in functional connectiv...
journal_title:Aging and disease
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
abstract::Cisplatin is a commonly used chemotherapeutic drug, used for the treatment of malignant ovarian cancer, but acquired resistance limits its application. There is therefore an overwhelming need to understand the mechanism of cisplatin resistance in ovarian cancer, that is, ovarian cancer cells are insensitive to cisplat...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0118
更新日期:2016-05-27 00:00:00
abstract::Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induc...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500394
更新日期:2013-12-17 00:00:00
abstract::Age related bone loss predisposes adults to osteoporosis. This is especially true for individuals with spinal cord injury (SCI). The effects of decreased bone loading with older age and paralysis significantly contribute to decreased bone mass and increased risk for fragility fractures. Loading bone via volitional mus...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2013-02-07 00:00:00
abstract::Evidence indicated that inflammatory response and some pattern-recognition receptors play important roles in the occurrence and progression of osteoarthritis. This study is conducted to evaluate the role of RIG-I and its adaptor protein MAVS in the pathogenesis of osteoarthritis. Four SNPs in RIG-I gene and four in MA...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0308
更新日期:2018-02-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0602
更新日期:2018-04-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0920
更新日期:2020-07-23 00:00:00
abstract::Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have pro...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.002
更新日期:2015-08-01 00:00:00
abstract::Dopamine (DA) is one of the major neurotransmitters and participates in a number of functions such as motor coordination, emotions, memory, reward mechanism, neuroendocrine regulation etc. DA exerts its effects through five DA receptors that are subdivided in 2 families: D1-like DA receptors (D1 and D5) and the D2-lik...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2015.0330
更新日期:2015-10-01 00:00:00
abstract::Cardiovascular disease is one of the most common causes of death worldwide and the most usual in the western populations. Although it affects both sexes, it is more frequent in males in whom it shortens the average life expectancy. This difference has been attributed to the negative effects of testosterone; however, r...
journal_title:Aging and disease
pub_type:
doi:10.14336/AD.2013.0400381
更新日期:2013-10-07 00:00:00
abstract::Sepsis is a severe disease frequently occurred in the Intenisive Care Unit (ICU), which has a very high morbidity and mortality, especially in patients aged over 65 years. Owing to the aging effect and the ensuing deterioration of body function, the elder patients may have atypical responses to sepsis. Diagnosis and p...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.1027
更新日期:2019-08-01 00:00:00
abstract::Muscle power is a strong predictor of functional status in the elderly population and is required to perform different daily activities. To compare the effects of different weekly training frequencies on muscle power and muscle quality induced by concurrent training (resistance + aerobic) in previously trained elderly...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0504
更新日期:2016-12-01 00:00:00
abstract::Many oncogenes are involved in the progression from low-grade squamous intraepithelial lesions (LSILs) to high-grade squamous intraepithelial lesions (HSILs); which greatly increases the risk of cervical cancer (CC). Thus, a reliable biomarker for risk classification of LSILs is urgently needed. The prolyl isomerase P...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0415
更新日期:2020-02-01 00:00:00
abstract::Multiple cues from the environment of our indirect and immediate ancestors, which often persist throughout the prenatal period and adulthood, are shaping our phenotypes through either direct, parent-to-child influences, or transgenerational inheritance. These effects are due to gene-environment interactions, which are...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract::Superoxide is a precursor of many free radicals and reactive oxygen species (ROS) in biological systems. It has been shown that superoxide regulates major epigenetic processes of DNA methylation, histone methylation, and histone acetylation. We suggested that superoxide, being a radical anion and a strong nucleophile,...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0924
更新日期:2015-06-01 00:00:00
abstract::Longstanding immunological dogma holds that flexible immune recognition, which forms the mechanistic basis of adaptive immunity, is strictly confined to the lymphocyte lineage. In higher vertebrates, flexible immune recognition is represented by recombinatorial antigen receptors of enormous diversity known as immunogl...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2018.1105
更新日期:2019-12-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.1014
更新日期:2018-08-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0402
更新日期:2020-02-01 00:00:00
abstract::Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0929
更新日期:2017-02-01 00:00:00
abstract::Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations aft...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0619
更新日期:2020-07-23 00:00:00
abstract::Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2013-03-07 00:00:00
abstract::As one of the leading causes of death around the world, suicide is a global public health threat. In the Chinese population, suicides constitute one-fifth of all recorded suicides in the world. Despite the factual data on suicide rates, the understanding of various causal factors behind suicide, including risk and pro...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0223
更新日期:2015-03-10 00:00:00
abstract::The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract::The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.0505
更新日期:2015-11-17 00:00:00
abstract::Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical ...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0521
更新日期:2020-03-09 00:00:00