Prehospital Notification Procedure Improves Stroke Outcome by Shortening Onset to Needle Time in Chinese Urban Area.

abstract：:Healthy aged individuals are more likely to suffer profound memory impairments following a challenging life event such as a severe bacterial infection, surgery, or an intense psychological stressor, than are younger adults. These peripheral challenges are capable of producing a neuroinflammatory response, (e.g., incre...

journal_title：Aging and disease

authors： Barrientos RM,Frank MG,Watkins LR,Maier SF

更新日期：2010-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...

journal_title：Aging and disease

authors： Zhao Y,Zhang Y,Zhang L,Dong Y,Ji H,Shen L

更新日期：2019-12-01 00:00:00

abstract：:Muscle power is a strong predictor of functional status in the elderly population and is required to perform different daily activities. To compare the effects of different weekly training frequencies on muscle power and muscle quality induced by concurrent training (resistance + aerobic) in previously trained elderly...

journal_title：Aging and disease

authors： Ferrari R,Fuchs SC,Kruel LF,Cadore EL,Alberton CL,Pinto RS,Radaelli R,Schoenell M,Izquierdo M,Tanaka H,Umpierre D

更新日期：2016-12-01 00:00:00

abstract：:The expending of elderly population worldwide has resulted in a dramatic rise in the incidence of chronic diseases such as Alzheimer's disease (AD). Inadequate understanding of the mechanisms underlying AD has hampered the development of efficient tools for definitive diagnosis and curative interventions. Previous stu...

journal_title：Aging and disease

authors： Shao Y,Ouyang Y,Li T,Liu X,Xu X,Li S,Xu G,Le W

更新日期：2020-12-01 00:00:00

abstract：:Longstanding immunological dogma holds that flexible immune recognition, which forms the mechanistic basis of adaptive immunity, is strictly confined to the lymphocyte lineage. In higher vertebrates, flexible immune recognition is represented by recombinatorial antigen receptors of enormous diversity known as immunogl...

journal_title：Aging and disease

authors： Kaminski WE,Beham AW,Puellmann K

更新日期：2012-10-01 00:00:00

abstract：:Microglial activation is an important contributor to the pathogenesis of Parkinson's disease (PD). Microglia are tightly and efficiently regulated by immune checkpoints, including CD200-CD200R1 and CX3CL1-CX3CR1. Understanding the involvement of these checkpoints in disease progression provides important insights into...

journal_title：Aging and disease

authors： Wang L,Liu Y,Yan S,Du T,Fu X,Gong X,Zhou X,Zhang T,Wang X

更新日期：2020-03-09 00:00:00

abstract：:Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin' Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 health...

journal_title：Aging and disease

authors： Yu Q,Guo P,Li D,Zuo L,Lian T,Yu S,Hu Y,Liu L,Jin Z,Wang R,Piao Y,Li L,Wang X,Zhang W

更新日期：2018-12-04 00:00:00

abstract：:It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...

journal_title：Aging and disease

authors： Famakin BM

更新日期：2014-10-01 00:00:00

abstract：:Advances in pharmacological treatment and effective early myocardial revascularization have -in recent years- led to improved clinical outcomes in patients with acute myocardial infarction (AMI). However, it has been suggested that compared to younger subjects, elderly AMI patients are less likely to receive evidence-...

journal_title：Aging and disease

authors： Carro A,Kaski JC

更新日期：2011-04-01 00:00:00

abstract：:Many oncogenes are involved in the progression from low-grade squamous intraepithelial lesions (LSILs) to high-grade squamous intraepithelial lesions (HSILs); which greatly increases the risk of cervical cancer (CC). Thus, a reliable biomarker for risk classification of LSILs is urgently needed. The prolyl isomerase P...

journal_title：Aging and disease

authors： Guo YT,Lu Y,Jia YY,Qu HN,Qi D,Wang XQ,Song PY,Jin XS,Xu WH,Dong Y,Liang YY,Quan CS

更新日期：2020-02-01 00:00:00

abstract：:Sepsis is a severe disease frequently occurred in the Intenisive Care Unit (ICU), which has a very high morbidity and mortality, especially in patients aged over 65 years. Owing to the aging effect and the ensuing deterioration of body function, the elder patients may have atypical responses to sepsis. Diagnosis and p...

journal_title：Aging and disease

authors： Xu D,Liao S,Li P,Zhang Q,Lv Y,Fu X,Yang M,Wang J,Kong L

更新日期：2019-08-01 00:00:00

abstract：:Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...

journal_title：Aging and disease

authors： Ray L,Khemka VK,Behera P,Bandyopadhyay K,Pal S,Pal K,Basu D,Chakrabarti S

更新日期：2013-03-07 00:00:00

abstract：:Dopamine (DA) is one of the major neurotransmitters and participates in a number of functions such as motor coordination, emotions, memory, reward mechanism, neuroendocrine regulation etc. DA exerts its effects through five DA receptors that are subdivided in 2 families: D1-like DA receptors (D1 and D5) and the D2-lik...

journal_title：Aging and disease

authors： Rangel-Barajas C,Coronel I,Florán B

更新日期：2015-10-01 00:00:00

abstract：:This population-based retrospective cohort study investigated dementia risk associated with acarbose in patients with type 2 diabetes mellitus by using Taiwan's National Health Insurance database. A cohort of 15,524 matched pairs of ever and never users of acarbose based on propensity score matching was enrolled from ...

journal_title：Aging and disease

authors： Tseng CH

更新日期：2020-05-09 00:00:00

abstract：:As one of the leading causes of death around the world, suicide is a global public health threat. In the Chinese population, suicides constitute one-fifth of all recorded suicides in the world. Despite the factual data on suicide rates, the understanding of various causal factors behind suicide, including risk and pro...

journal_title：Aging and disease

authors： Dong X,Chang ES,Zeng P,Simon MA

更新日期：2015-03-10 00:00:00

abstract：:In 2011, Hansen discovered the natural antisense transcript (NAT) of the cerebellar degeneration-related protein 1 gene (CDR1), and further described CDR1 NAT as a circular RNA (CircRNA). CDR1 antisense RNA (CDR1as), which is the official name of CDR1 NAT, is conserved and extensively expressed in most eutherian mamma...

journal_title：Aging and disease

authors： Guo Z,Cao Q,Zhao Z,Song C

更新日期：2020-07-23 00:00:00

abstract：:The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...

journal_title：Aging and disease

authors： Vyas NS,Lee Y,Ahn K,Ternouth A,Stahl DR,Al-Chalabi A,Powell JF,Puri BK

更新日期：2012-08-01 00:00:00

abstract：:Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent yea...

journal_title：Aging and disease

authors： Liang W,Huang X,Chen W

更新日期：2017-12-01 00:00:00

abstract：:Although the geroprotectors discovery is a new biomedicine trend and more than 200 compounds can slow aging and increase the lifespan of the model organism, there are still no geroprotectors on the market. The reasons may be partly related to the lack of a unified concept of geroprotector, accepted by the scientific c...

journal_title：Aging and disease

authors： Moskalev A,Chernyagina E,Kudryavtseva A,Shaposhnikov M

更新日期：2017-05-02 00:00:00

abstract：:The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly unders...

journal_title：Aging and disease

authors： Xu S,Cai Y,Wei Y

更新日期：2013-12-05 00:00:00

abstract：:Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative da...

journal_title：Aging and disease

authors： Zhang X,Li L

更新日期：2020-10-01 00:00:00

abstract：:The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was...

journal_title：Aging and disease

authors： Takeuchi H,Uchida HA,Kakio Y,Okuyama Y,Okuyama M,Umebayashi R,Wada K,Sugiyama H,Sugimoto K,Rakugi H,Wada J

更新日期：2018-04-01 00:00:00

abstract：:The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...

journal_title：Aging and disease

authors： Dai CF,Xie X,Ma YT,Yang YN,Li XM,Fu ZY,Liu F,Chen BD,Gai MT

更新日期：2015-11-17 00:00:00

abstract：:Aging is the progressive decline of physiological functions necessary for survival and reproduction. In gaining a better understanding of the inevitable aging process, the hope is to preserve, promote, or delay healthy aging through the treatment of common age-associated diseases. Although there are theories that try ...

journal_title：Aging and disease

authors： Jin K

更新日期：2019-06-01 00:00:00

abstract：:The aim of the study is to investigate the diffusion characteristics of Alzheimer's disease (AD) patients using an ultra-high b-values apparent diffusion coefficient (ADC_uh) and diffusion kurtosis imaging (DKI). A total of 31 AD patients and 20 healthy controls (HC) who underwent both MRI examination and clinical ass...

journal_title：Aging and disease

authors： Xue Y,Zhang Z,Wen C,Liu H,Wang S,Li J,Zhuge Q,Chen W,Ye Q

更新日期：2019-10-01 00:00:00

abstract：:Stroke is the second leading cause of death worldwide. The prognostic influence of body temperature on acute stroke in patients has been recently reported; however, hypothermia has confounded experimental results in animal stroke models. This work aimed to investigate how body temperature could prognose stroke severit...

journal_title：Aging and disease

authors： Hu H,Doll DN,Sun J,Lewis SE,Wimsatt JH,Kessler MJ,Simpkins JW,Ren X

更新日期：2016-01-02 00:00:00

abstract：:Neurogenesis in the hippocampal dentate gyrus persists throughout the lifespan of mammals, however, the rate of neurogenesis decreases as the animal ages. Although seizures increase neurogenesis in young adult brains, this relationship has not been shown in aged animals. Using doublecortin (DCX) immunocytochemistry, t...

journal_title：Aging and disease

authors： Shapiro LA,Wang L,Upadhyaya P,Ribak CE

更新日期：2011-08-01 00:00:00

abstract：:Melatonin is a pleiotropically acting regulator molecule, which influences numerous physiological functions. Its secretion by the pineal gland progressively declines by age. Strong reductions of circulating melatonin are also observed in numerous disorders and diseases, including Alzheimer's disease, various other neu...

journal_title：Aging and disease

authors： Hardeland R

更新日期：2012-04-01 00:00:00

abstract：:Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations aft...

journal_title：Aging and disease

authors： Schwartz MD,Emerson SG,Punt J,Goff WD

更新日期：2020-07-23 00:00:00

abstract：:Age-related hearing loss (ARHL), a degenerative disorder characterized by age-dependent progressive increase in the threshold of auditory sensitivity, affects 40% of people over the age of 65, and it has emerged as an important social and public health problem. Various factors, including genetic and environmental comp...

journal_title：Aging and disease

authors： Kim HJ,Oh GS,Choe SK,Kwak TH,Park R,So HS

更新日期：2014-04-01 00:00:00