Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.

abstract：:Longstanding immunological dogma holds that flexible immune recognition, which forms the mechanistic basis of adaptive immunity, is strictly confined to the lymphocyte lineage. In higher vertebrates, flexible immune recognition is represented by recombinatorial antigen receptors of enormous diversity known as immunogl...

journal_title：Aging and disease

authors： Kaminski WE,Beham AW,Puellmann K

更新日期：2012-10-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-...

journal_title：Aging and disease

authors： Su R,Sun M,Wang W,Zhang J,Zhang L,Zhen J,Qian Y,Zheng Y,Wang X

更新日期：2017-02-01 00:00:00

abstract：:The expending of elderly population worldwide has resulted in a dramatic rise in the incidence of chronic diseases such as Alzheimer's disease (AD). Inadequate understanding of the mechanisms underlying AD has hampered the development of efficient tools for definitive diagnosis and curative interventions. Previous stu...

journal_title：Aging and disease

authors： Shao Y,Ouyang Y,Li T,Liu X,Xu X,Li S,Xu G,Le W

更新日期：2020-12-01 00:00:00

abstract：:Microglial activation is an important contributor to the pathogenesis of Parkinson's disease (PD). Microglia are tightly and efficiently regulated by immune checkpoints, including CD200-CD200R1 and CX3CL1-CX3CR1. Understanding the involvement of these checkpoints in disease progression provides important insights into...

journal_title：Aging and disease

authors： Wang L,Liu Y,Yan S,Du T,Fu X,Gong X,Zhou X,Zhang T,Wang X

更新日期：2020-03-09 00:00:00

abstract：:Hypoxia is an environmental stress at high altitude and underground conditions but it is also present in many chronic age-related diseases, where blood flow into tissues is impaired. The oxygen-sensing system stimulates gene expression protecting tissues against hypoxic insults. Hypoxia stabilizes the expression of hy...

journal_title：Aging and disease

authors： Salminen A,Kaarniranta K,Kauppinen A

更新日期：2016-03-15 00:00:00

abstract：:In 2011, Hansen discovered the natural antisense transcript (NAT) of the cerebellar degeneration-related protein 1 gene (CDR1), and further described CDR1 NAT as a circular RNA (CircRNA). CDR1 antisense RNA (CDR1as), which is the official name of CDR1 NAT, is conserved and extensively expressed in most eutherian mamma...

journal_title：Aging and disease

authors： Guo Z,Cao Q,Zhao Z,Song C

更新日期：2020-07-23 00:00:00

abstract：:Studies comparing chronologically "young" versus "old" humans document age-related decline of classical immunological functions. However, older adults aged ≥65 years have very heterogeneous health phenotypes. A significant number of them are functionally independent and are surviving well into their 8(th)-11(th) decad...

journal_title：Aging and disease

authors： Griffin P,Michel JJ,Huysman K,Logar AJ,Vallejo AN

更新日期：2012-02-01 00:00:00

abstract：:Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical ...

journal_title：Aging and disease

authors： Ma L,Chan P

更新日期：2020-03-09 00:00:00

abstract：:Metabolic syndrome is an increasing health problem, whose pathogenesis may be associated with genetic factors. The main purpose of our study was to assess relationships between MetS and the presence of the FTO rs9939609, the MC4R rs17782313, and the PPAR-γ rs1801282 polymorphisms in 45-60-year-old women. The study inc...

journal_title：Aging and disease

authors： Małgorzata S,Jacek B,Jerzy OA,Piotr C,Anna J,Elżbieta G

更新日期：2018-10-01 00:00:00

abstract：:Aging is a progressive loss of physiological integrity and functionality process which increases susceptibility and mortality to diseases. Vascular aging is a specific type of organic aging. The structure and function changes of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cause of vas...

journal_title：Aging and disease

authors： Ni YQ,Lin X,Zhan JK,Liu YS

更新日期：2020-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...

journal_title：Aging and disease

authors： Zhao Y,Zhang Y,Zhang L,Dong Y,Ji H,Shen L

更新日期：2019-12-01 00:00:00

abstract：:Emerging evidence indicates that the intestinal microbiota could interact with the central nervous system and modulate multiple pathophysiological changes, including the integrity of intestinal barrier and blood-brain barrier, as well as neuroinflammatory response. In the present study, we investigated the potential r...

journal_title：Aging and disease

authors： Han D,Li Z,Liu T,Yang N,Li Y,He J,Qian M,Kuang Z,Zhang W,Ni C,Guo X

更新日期：2020-10-01 00:00:00

abstract：:Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...

journal_title：Aging and disease

authors： Ray L,Khemka VK,Behera P,Bandyopadhyay K,Pal S,Pal K,Basu D,Chakrabarti S

更新日期：2013-03-07 00:00:00

abstract：:Muscle power is a strong predictor of functional status in the elderly population and is required to perform different daily activities. To compare the effects of different weekly training frequencies on muscle power and muscle quality induced by concurrent training (resistance + aerobic) in previously trained elderly...

journal_title：Aging and disease

authors： Ferrari R,Fuchs SC,Kruel LF,Cadore EL,Alberton CL,Pinto RS,Radaelli R,Schoenell M,Izquierdo M,Tanaka H,Umpierre D

更新日期：2016-12-01 00:00:00

abstract：:Better understanding of survival factors in amyotrophic lateral sclerosis (ALS) could help physicians and patients schedule therapeutic interventions. We conducted a study to evaluate the predictive factors associated with longer survival and construct prognostic nomogram in ALS patients. A total of 553 ALS patients w...

journal_title：Aging and disease

authors： Wei QQ,Chen Y,Chen X,Cao B,Ou R,Zhang L,Hou Y,Shang H

更新日期：2018-12-04 00:00:00

abstract：:Alzheimer disease (AD) is the most common dementing illness. Metabolic defects in the brain with aging contribute to the pathogenesis of AD. These changes can be found systematically and thus can be used as potential biomarkers. Erythrocytes (RBCs) are passive "reporter cells" that are not well studied in AD. In the p...

journal_title：Aging and disease

authors： Kaminsky YG,Reddy VP,Ashraf GM,Ahmad A,Benberin VV,Kosenko EA,Aliev G

更新日期：2013-10-01 00:00:00

abstract：:Cisplatin is a commonly used chemotherapeutic drug, used for the treatment of malignant ovarian cancer, but acquired resistance limits its application. There is therefore an overwhelming need to understand the mechanism of cisplatin resistance in ovarian cancer, that is, ovarian cancer cells are insensitive to cisplat...

journal_title：Aging and disease

authors： Ma L,Wang H,Wang C,Su J,Xie Q,Xu L,Yu Y,Liu S,Li S,Xu Y,Li Z

更新日期：2016-05-27 00:00:00

abstract：:Sepsis is a severe disease frequently occurred in the Intenisive Care Unit (ICU), which has a very high morbidity and mortality, especially in patients aged over 65 years. Owing to the aging effect and the ensuing deterioration of body function, the elder patients may have atypical responses to sepsis. Diagnosis and p...

journal_title：Aging and disease

authors： Xu D,Liao S,Li P,Zhang Q,Lv Y,Fu X,Yang M,Wang J,Kong L

更新日期：2019-08-01 00:00:00

abstract：:The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...

journal_title：Aging and disease

authors： Vyas NS,Lee Y,Ahn K,Ternouth A,Stahl DR,Al-Chalabi A,Powell JF,Puri BK

更新日期：2012-08-01 00:00:00

abstract：:This population-based retrospective cohort study investigated dementia risk associated with acarbose in patients with type 2 diabetes mellitus by using Taiwan's National Health Insurance database. A cohort of 15,524 matched pairs of ever and never users of acarbose based on propensity score matching was enrolled from ...

journal_title：Aging and disease

authors： Tseng CH

更新日期：2020-05-09 00:00:00

abstract：:The immune system declines with aging, leading to an increased susceptibility to infections and higher incidence and progression of autoimmune phenomena and neoplasia. Down syndrome prematurely shows clinical manifestations that are normally seen with aging. This review provides a concise overview of abnormalities in ...

journal_title：Aging and disease

authors： Kusters MA,Verstegen RH,de Vries E

更新日期：2011-12-01 00:00:00

abstract：:Sleep duration and quality have been associated with poor physical function, but both the temporality of the association and the independence of sleep duration and quality are unclear. We examined the prospective association of sleep duration and quality with physical function impairment and disability in older adults...

journal_title：Aging and disease

authors： Campanini MZ,Mesas AE,Carnicero-Carreño JA,Rodríguez-Artalejo F,Lopez-Garcia E

更新日期：2019-06-01 00:00:00

abstract：:Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations aft...

journal_title：Aging and disease

authors： Schwartz MD,Emerson SG,Punt J,Goff WD

更新日期：2020-07-23 00:00:00

abstract：:A promising strategy for the prevention of Alzheimer's disease (AD) is the identification of age-related changes that place the brain at risk for the disease. Additionally, AD is associated with chronic dehydration, and one of the significant changes that are known to result in metabolic dysfunction is an increase in ...

journal_title：Aging and disease

authors： Li T,Su T,He Y,Lu J,Mo W,Wei Y,He R

更新日期：2016-10-01 00:00:00

abstract：:Although the geroprotectors discovery is a new biomedicine trend and more than 200 compounds can slow aging and increase the lifespan of the model organism, there are still no geroprotectors on the market. The reasons may be partly related to the lack of a unified concept of geroprotector, accepted by the scientific c...

journal_title：Aging and disease

authors： Moskalev A,Chernyagina E,Kudryavtseva A,Shaposhnikov M

更新日期：2017-05-02 00:00:00

abstract：:The molecular processes of aging are very heterogenic and not fully understood. Studies on rare progeria syndromes, which display an accelerated progression of physiological aging, can help to get a better understanding. Pseudoxanthoma elasticum (PXE) caused by mutations in the ATP-binding cassette sub-family C member...

journal_title：Aging and disease

authors： Tiemann J,Wagner T,Vanakker OM,van Gils M,Cabrera JB,Ibold B,Faust I,Knabbe C,Hendig D

更新日期：2020-05-09 00:00:00

abstract：:Neurogenesis in the hippocampal dentate gyrus persists throughout the lifespan of mammals, however, the rate of neurogenesis decreases as the animal ages. Although seizures increase neurogenesis in young adult brains, this relationship has not been shown in aged animals. Using doublecortin (DCX) immunocytochemistry, t...

journal_title：Aging and disease

authors： Shapiro LA,Wang L,Upadhyaya P,Ribak CE

更新日期：2011-08-01 00:00:00

abstract：:Dopamine (DA) is one of the major neurotransmitters and participates in a number of functions such as motor coordination, emotions, memory, reward mechanism, neuroendocrine regulation etc. DA exerts its effects through five DA receptors that are subdivided in 2 families: D1-like DA receptors (D1 and D5) and the D2-lik...

journal_title：Aging and disease

authors： Rangel-Barajas C,Coronel I,Florán B

更新日期：2015-10-01 00:00:00

abstract：:The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly unders...

journal_title：Aging and disease

authors： Xu S,Cai Y,Wei Y

更新日期：2013-12-05 00:00:00

abstract：:It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...

journal_title：Aging and disease

authors： Famakin BM

更新日期：2014-10-01 00:00:00