Prebiotics Regulation of Intestinal Microbiota Attenuates Cognitive Dysfunction Induced by Surgery Stimulation in APP/PS1 Mice.

abstract：:A temporal framework linking circadian rhythms and clocks to aging rates identifies a specific window of target of rapamycin (TOR) signaling associated with growth hormone (GH) and insulin-like growth factor (IGF-1) (largely exclusive of insulin) in early sleep. IGF-1 signaling is released by growth hormone secretory ...

journal_title：Aging and disease

authors： Rollo CD

更新日期：2010-10-01 00:00:00

abstract：:Healthcare-associated pneumonia (HCAP) is a new concept of pneumonia proposed by the American Thoracic Society/Infectious Diseases Society of America in 2005. This category is located between community-acquired pneumonia and hospital-acquired pneumonia with respect to the characteristics of the causative pathogens and...

journal_title：Aging and disease

authors： Komiya K,Ishii H,Kadota J

更新日期：2014-02-08 00:00:00

abstract：:Liver hypoxia/ischemia injury leads to acute liver injury, delayed graft dysfunction, and failure during liver transplantation. Previous studies showed that autophagy is involved in liver hypoxia/ischemia injury. Our and others' studies have found that the damage-regulated autophagy modulator (DRAM) could induce the a...

journal_title：Aging and disease

authors： Xu J,Zang Y,Liu D,Yang T,Wang J,Wang Y,Liu X,Chen D

更新日期：2019-02-01 00:00:00

abstract：:In 2011, Hansen discovered the natural antisense transcript (NAT) of the cerebellar degeneration-related protein 1 gene (CDR1), and further described CDR1 NAT as a circular RNA (CircRNA). CDR1 antisense RNA (CDR1as), which is the official name of CDR1 NAT, is conserved and extensively expressed in most eutherian mamma...

journal_title：Aging and disease

authors： Guo Z,Cao Q,Zhao Z,Song C

更新日期：2020-07-23 00:00:00

abstract：:Aging is associated with myriad changes in behavioral performance and brain structure and function. Given this complex interplay of brain and behavior, two streams of findings are reviewed here that show that aging is generally associated with dedifferentiated neural processes, and also changes in functional connectiv...

journal_title：Aging and disease

authors： Goh JO

更新日期：2011-01-01 00:00:00

abstract：:Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and pa...

journal_title：Aging and disease

authors： Urzua U,Chacon C,Lizama L,Sarmiento S,Villalobos P,Kroxato B,Marcelain K,Gonzalez MJ

更新日期：2017-10-01 00:00:00

abstract：:Aging is associated with increased fat mass and elevated serum leptin levels (hyperleptinemia), causing proinflammation in the kidneys where it plays a primary role in the removal of endogenous leptin from the circulation. Lymphocyte-specific kinase (Lck) is a positive regulator of inflammatory signaling and a potenti...

journal_title：Aging and disease

authors： Kim DH,Park JW,Jeong HO,Lee B,Chung KW,Lee Y,Jung HJ,Hyun MK,Lee AK,Kim BM,Yu BP,Chung HY

更新日期：2019-12-01 00:00:00

abstract：:This population-based retrospective cohort study investigated dementia risk associated with acarbose in patients with type 2 diabetes mellitus by using Taiwan's National Health Insurance database. A cohort of 15,524 matched pairs of ever and never users of acarbose based on propensity score matching was enrolled from ...

journal_title：Aging and disease

authors： Tseng CH

更新日期：2020-05-09 00:00:00

abstract：:Melatonin is a pleiotropically acting regulator molecule, which influences numerous physiological functions. Its secretion by the pineal gland progressively declines by age. Strong reductions of circulating melatonin are also observed in numerous disorders and diseases, including Alzheimer's disease, various other neu...

journal_title：Aging and disease

authors： Hardeland R

更新日期：2012-04-01 00:00:00

abstract：:It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...

journal_title：Aging and disease

authors： Famakin BM

更新日期：2014-10-01 00:00:00

abstract：:The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...

journal_title：Aging and disease

authors： Dai CF,Xie X,Ma YT,Yang YN,Li XM,Fu ZY,Liu F,Chen BD,Gai MT

更新日期：2015-11-17 00:00:00

abstract：:Cisplatin is a commonly used chemotherapeutic drug, used for the treatment of malignant ovarian cancer, but acquired resistance limits its application. There is therefore an overwhelming need to understand the mechanism of cisplatin resistance in ovarian cancer, that is, ovarian cancer cells are insensitive to cisplat...

journal_title：Aging and disease

authors： Ma L,Wang H,Wang C,Su J,Xie Q,Xu L,Yu Y,Liu S,Li S,Xu Y,Li Z

更新日期：2016-05-27 00:00:00

abstract：:Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract. Histologicall...

journal_title：Aging and disease

authors： He Q,Gao Y,Wang T,Zhou L,Zhou W,Yuan Z

更新日期：2019-04-01 00:00:00

abstract：:Myocardial fibrosis is observed in various cardiovascular diseases and plays a key role in the impairment of cardiac function. Endomyocardial biopsy, as the gold standard for the diagnosis of myocardial fibrosis, has limitations in terms of clinical application. Therefore, biomarkers have been recommended for noninvas...

journal_title：Aging and disease

authors： Ding Y,Wang Y,Zhang W,Jia Q,Wang X,Li Y,Lv S,Zhang J

更新日期：2020-10-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-...

journal_title：Aging and disease

authors： Su R,Sun M,Wang W,Zhang J,Zhang L,Zhen J,Qian Y,Zheng Y,Wang X

更新日期：2017-02-01 00:00:00

abstract：:The aim of the study is to investigate the diffusion characteristics of Alzheimer's disease (AD) patients using an ultra-high b-values apparent diffusion coefficient (ADC_uh) and diffusion kurtosis imaging (DKI). A total of 31 AD patients and 20 healthy controls (HC) who underwent both MRI examination and clinical ass...

journal_title：Aging and disease

authors： Xue Y,Zhang Z,Wen C,Liu H,Wang S,Li J,Zhuge Q,Chen W,Ye Q

更新日期：2019-10-01 00:00:00

abstract：:Muscle power is a strong predictor of functional status in the elderly population and is required to perform different daily activities. To compare the effects of different weekly training frequencies on muscle power and muscle quality induced by concurrent training (resistance + aerobic) in previously trained elderly...

journal_title：Aging and disease

authors： Ferrari R,Fuchs SC,Kruel LF,Cadore EL,Alberton CL,Pinto RS,Radaelli R,Schoenell M,Izquierdo M,Tanaka H,Umpierre D

更新日期：2016-12-01 00:00:00

abstract：:The molecular processes of aging are very heterogenic and not fully understood. Studies on rare progeria syndromes, which display an accelerated progression of physiological aging, can help to get a better understanding. Pseudoxanthoma elasticum (PXE) caused by mutations in the ATP-binding cassette sub-family C member...

journal_title：Aging and disease

authors： Tiemann J,Wagner T,Vanakker OM,van Gils M,Cabrera JB,Ibold B,Faust I,Knabbe C,Hendig D

更新日期：2020-05-09 00:00:00

abstract：:Cerebral microbleeds (CMBs), which indicate hemorrhage-prone disease, may associate with hemostatic abnormalities, but the association between CMBs and coagulation function is uncertain. We aimed to examine this possible association. The following coagulation function indicators were evaluated in 85 consecutive ischem...

journal_title：Aging and disease

authors： Liu J,Wang D,Xiong Y,Liu B,Lin J,Zhang S,Wu B,Wei C,Liu M

更新日期：2017-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in senile plaque and neurofibrillary tangles, are strongly intertwined with oxidative stress, which is considered one of the common effectors of the ...

journal_title：Aging and disease

authors： Morroni F,Sita G,Graziosi A,Turrini E,Fimognari C,Tarozzi A,Hrelia P

更新日期：2018-08-01 00:00:00

abstract：:Metabolic syndrome is an increasing health problem, whose pathogenesis may be associated with genetic factors. The main purpose of our study was to assess relationships between MetS and the presence of the FTO rs9939609, the MC4R rs17782313, and the PPAR-γ rs1801282 polymorphisms in 45-60-year-old women. The study inc...

journal_title：Aging and disease

authors： Małgorzata S,Jacek B,Jerzy OA,Piotr C,Anna J,Elżbieta G

更新日期：2018-10-01 00:00:00

abstract：:Neurogenesis in the hippocampal dentate gyrus persists throughout the lifespan of mammals, however, the rate of neurogenesis decreases as the animal ages. Although seizures increase neurogenesis in young adult brains, this relationship has not been shown in aged animals. Using doublecortin (DCX) immunocytochemistry, t...

journal_title：Aging and disease

authors： Shapiro LA,Wang L,Upadhyaya P,Ribak CE

更新日期：2011-08-01 00:00:00

abstract：:A promising strategy for the prevention of Alzheimer's disease (AD) is the identification of age-related changes that place the brain at risk for the disease. Additionally, AD is associated with chronic dehydration, and one of the significant changes that are known to result in metabolic dysfunction is an increase in ...

journal_title：Aging and disease

authors： Li T,Su T,He Y,Lu J,Mo W,Wei Y,He R

更新日期：2016-10-01 00:00:00

abstract：:Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysa...

journal_title：Aging and disease

authors： Carrera-Bastos P,Picazo Ó,Fontes-Villalba M,Pareja-Galeano H,Lindeberg S,Martínez-Selles M,Lucia A,Emanuele E

更新日期：2018-04-01 00:00:00

abstract：:Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose of this study was to further explore the clinical significance of miR-424 in peripheral immune cells of patients ...

journal_title：Aging and disease

authors： Li G,Ma Q,Wang R,Fan Z,Tao Z,Liu P,Zhao H,Luo Y

更新日期：2018-04-01 00:00:00

abstract：:The expending of elderly population worldwide has resulted in a dramatic rise in the incidence of chronic diseases such as Alzheimer's disease (AD). Inadequate understanding of the mechanisms underlying AD has hampered the development of efficient tools for definitive diagnosis and curative interventions. Previous stu...

journal_title：Aging and disease

authors： Shao Y,Ouyang Y,Li T,Liu X,Xu X,Li S,Xu G,Le W

更新日期：2020-12-01 00:00:00

abstract：:Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have pro...

journal_title：Aging and disease

authors： Chakrabarti S,Khemka VK,Banerjee A,Chatterjee G,Ganguly A,Biswas A

更新日期：2015-08-01 00:00:00

abstract：:The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...

journal_title：Aging and disease

authors： Vyas NS,Lee Y,Ahn K,Ternouth A,Stahl DR,Al-Chalabi A,Powell JF,Puri BK

更新日期：2012-08-01 00:00:00

abstract：:Studies comparing chronologically "young" versus "old" humans document age-related decline of classical immunological functions. However, older adults aged ≥65 years have very heterogeneous health phenotypes. A significant number of them are functionally independent and are surviving well into their 8(th)-11(th) decad...

journal_title：Aging and disease

authors： Griffin P,Michel JJ,Huysman K,Logar AJ,Vallejo AN

更新日期：2012-02-01 00:00:00

abstract：:Aging is a progressive loss of physiological integrity and functionality process which increases susceptibility and mortality to diseases. Vascular aging is a specific type of organic aging. The structure and function changes of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cause of vas...

journal_title：Aging and disease

authors： Ni YQ,Lin X,Zhan JK,Liu YS

更新日期：2020-02-01 00:00:00