Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage.

abstract：:Better understanding of survival factors in amyotrophic lateral sclerosis (ALS) could help physicians and patients schedule therapeutic interventions. We conducted a study to evaluate the predictive factors associated with longer survival and construct prognostic nomogram in ALS patients. A total of 553 ALS patients w...

journal_title：Aging and disease

authors： Wei QQ,Chen Y,Chen X,Cao B,Ou R,Zhang L,Hou Y,Shang H

更新日期：2018-12-04 00:00:00

abstract：:Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative da...

journal_title：Aging and disease

authors： Zhang X,Li L

更新日期：2020-10-01 00:00:00

abstract：:The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was...

journal_title：Aging and disease

authors： Takeuchi H,Uchida HA,Kakio Y,Okuyama Y,Okuyama M,Umebayashi R,Wada K,Sugiyama H,Sugimoto K,Rakugi H,Wada J

更新日期：2018-04-01 00:00:00

abstract：:Many oncogenes are involved in the progression from low-grade squamous intraepithelial lesions (LSILs) to high-grade squamous intraepithelial lesions (HSILs); which greatly increases the risk of cervical cancer (CC). Thus, a reliable biomarker for risk classification of LSILs is urgently needed. The prolyl isomerase P...

journal_title：Aging and disease

authors： Guo YT,Lu Y,Jia YY,Qu HN,Qi D,Wang XQ,Song PY,Jin XS,Xu WH,Dong Y,Liang YY,Quan CS

更新日期：2020-02-01 00:00:00

abstract：:Cisplatin is a commonly used chemotherapeutic drug, used for the treatment of malignant ovarian cancer, but acquired resistance limits its application. There is therefore an overwhelming need to understand the mechanism of cisplatin resistance in ovarian cancer, that is, ovarian cancer cells are insensitive to cisplat...

journal_title：Aging and disease

authors： Ma L,Wang H,Wang C,Su J,Xie Q,Xu L,Yu Y,Liu S,Li S,Xu Y,Li Z

更新日期：2016-05-27 00:00:00

abstract：:Aging is associated with increased fat mass and elevated serum leptin levels (hyperleptinemia), causing proinflammation in the kidneys where it plays a primary role in the removal of endogenous leptin from the circulation. Lymphocyte-specific kinase (Lck) is a positive regulator of inflammatory signaling and a potenti...

journal_title：Aging and disease

authors： Kim DH,Park JW,Jeong HO,Lee B,Chung KW,Lee Y,Jung HJ,Hyun MK,Lee AK,Kim BM,Yu BP,Chung HY

更新日期：2019-12-01 00:00:00

abstract：:Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin' Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 health...

journal_title：Aging and disease

authors： Yu Q,Guo P,Li D,Zuo L,Lian T,Yu S,Hu Y,Liu L,Jin Z,Wang R,Piao Y,Li L,Wang X,Zhang W

更新日期：2018-12-04 00:00:00

abstract：:Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose of this study was to further explore the clinical significance of miR-424 in peripheral immune cells of patients ...

journal_title：Aging and disease

authors： Li G,Ma Q,Wang R,Fan Z,Tao Z,Liu P,Zhao H,Luo Y

更新日期：2018-04-01 00:00:00

abstract：:Cardiovascular disease is one of the most common causes of death worldwide and the most usual in the western populations. Although it affects both sexes, it is more frequent in males in whom it shortens the average life expectancy. This difference has been attributed to the negative effects of testosterone; however, r...

journal_title：Aging and disease

authors： Stamatiou K,Stamatopoulou E,Christopoulos G

更新日期：2013-10-07 00:00:00

abstract：:Cortical atrophy, neuronal loss, beta-amyloid deposition, neuritic plaques, and neurofibrillary tangles are neuropathological key features in the Alzheimer's disease (AD). Antibodies against beta-amyloid, neurotransmitters, microvascular endothelium components and microglial cells have been detected in AD serum sugges...

journal_title：Aging and disease

authors： Giulia P,Michele L,Andrea F,Grazia D,Filomena C,Francesco P,Leandro C,Maria U,Carolina G,Massimiliano C,Antonio G

更新日期：2015-11-24 00:00:00

abstract：:Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induc...

journal_title：Aging and disease

authors： Baugé C,Girard N,Lhuissier E,Bazille C,Boumediene K

更新日期：2013-12-17 00:00:00

abstract：:Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and pa...

journal_title：Aging and disease

authors： Urzua U,Chacon C,Lizama L,Sarmiento S,Villalobos P,Kroxato B,Marcelain K,Gonzalez MJ

更新日期：2017-10-01 00:00:00

abstract：:DICER1 deficiency in the retinal pigment epithelium (RPE) was associated with the accumulation of Alu transcripts and implicated in geographic atrophy (GA), a form of age-related macular degeneration (AMD), an eye disease leading to blindness in millions of people. Although the exact mechanism of this association is n...

journal_title：Aging and disease

authors： Kaarniranta K,Pawlowska E,Szczepanska J,Blasiak J

更新日期：2020-07-23 00:00:00

abstract：:Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of regulatory receptors on the T cell surface contribute to...

journal_title：Aging and disease

authors： Cavanagh MM,Qi Q,Weyand CM,Goronzy JJ

更新日期：2011-10-01 00:00:00

abstract：:The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly unders...

journal_title：Aging and disease

authors： Xu S,Cai Y,Wei Y

更新日期：2013-12-05 00:00:00

abstract：:Aging is the progressive decline of physiological functions necessary for survival and reproduction. In gaining a better understanding of the inevitable aging process, the hope is to preserve, promote, or delay healthy aging through the treatment of common age-associated diseases. Although there are theories that try ...

journal_title：Aging and disease

authors： Jin K

更新日期：2019-06-01 00:00:00

abstract：:Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...

journal_title：Aging and disease

authors： Ray L,Khemka VK,Behera P,Bandyopadhyay K,Pal S,Pal K,Basu D,Chakrabarti S

更新日期：2013-03-07 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...

journal_title：Aging and disease

authors： Zhao Y,Zhang Y,Zhang L,Dong Y,Ji H,Shen L

更新日期：2019-12-01 00:00:00

abstract：:Neurogenesis in the hippocampal dentate gyrus persists throughout the lifespan of mammals, however, the rate of neurogenesis decreases as the animal ages. Although seizures increase neurogenesis in young adult brains, this relationship has not been shown in aged animals. Using doublecortin (DCX) immunocytochemistry, t...

journal_title：Aging and disease

authors： Shapiro LA,Wang L,Upadhyaya P,Ribak CE

更新日期：2011-08-01 00:00:00

abstract：:Sleep duration and quality have been associated with poor physical function, but both the temporality of the association and the independence of sleep duration and quality are unclear. We examined the prospective association of sleep duration and quality with physical function impairment and disability in older adults...

journal_title：Aging and disease

authors： Campanini MZ,Mesas AE,Carnicero-Carreño JA,Rodríguez-Artalejo F,Lopez-Garcia E

更新日期：2019-06-01 00:00:00

abstract：:The immune system declines with aging, leading to an increased susceptibility to infections and higher incidence and progression of autoimmune phenomena and neoplasia. Down syndrome prematurely shows clinical manifestations that are normally seen with aging. This review provides a concise overview of abnormalities in ...

journal_title：Aging and disease

authors： Kusters MA,Verstegen RH,de Vries E

更新日期：2011-12-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-...

journal_title：Aging and disease

authors： Su R,Sun M,Wang W,Zhang J,Zhang L,Zhen J,Qian Y,Zheng Y,Wang X

更新日期：2017-02-01 00:00:00

abstract：:Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical ...

journal_title：Aging and disease

authors： Ma L,Chan P

更新日期：2020-03-09 00:00:00

abstract：:Sepsis is a severe disease frequently occurred in the Intenisive Care Unit (ICU), which has a very high morbidity and mortality, especially in patients aged over 65 years. Owing to the aging effect and the ensuing deterioration of body function, the elder patients may have atypical responses to sepsis. Diagnosis and p...

journal_title：Aging and disease

authors： Xu D,Liao S,Li P,Zhang Q,Lv Y,Fu X,Yang M,Wang J,Kong L

更新日期：2019-08-01 00:00:00

abstract：:The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...

journal_title：Aging and disease

authors： Vyas NS,Lee Y,Ahn K,Ternouth A,Stahl DR,Al-Chalabi A,Powell JF,Puri BK

更新日期：2012-08-01 00:00:00

abstract：:Microglial activation is an important contributor to the pathogenesis of Parkinson's disease (PD). Microglia are tightly and efficiently regulated by immune checkpoints, including CD200-CD200R1 and CX3CL1-CX3CR1. Understanding the involvement of these checkpoints in disease progression provides important insights into...

journal_title：Aging and disease

authors： Wang L,Liu Y,Yan S,Du T,Fu X,Gong X,Zhou X,Zhang T,Wang X

更新日期：2020-03-09 00:00:00

abstract：:Age-related hearing loss (ARHL), a degenerative disorder characterized by age-dependent progressive increase in the threshold of auditory sensitivity, affects 40% of people over the age of 65, and it has emerged as an important social and public health problem. Various factors, including genetic and environmental comp...

journal_title：Aging and disease

authors： Kim HJ,Oh GS,Choe SK,Kwak TH,Park R,So HS

更新日期：2014-04-01 00:00:00

abstract：:Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract. Histologicall...

journal_title：Aging and disease

authors： He Q,Gao Y,Wang T,Zhou L,Zhou W,Yuan Z

更新日期：2019-04-01 00:00:00

abstract：:Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets histones and many non-histone proteins and participates in various physiological functions. The enzymatic activity of SIRT1 is decreased in patients with Parkinson's disease (PD), which may reduce their ability to resist neuronal damage c...

journal_title：Aging and disease

authors： Li X,Feng Y,Wang XX,Truong D,Wu YC

更新日期：2020-12-01 00:00:00

abstract：:Melatonin is a pleiotropically acting regulator molecule, which influences numerous physiological functions. Its secretion by the pineal gland progressively declines by age. Strong reductions of circulating melatonin are also observed in numerous disorders and diseases, including Alzheimer's disease, various other neu...

journal_title：Aging and disease

authors： Hardeland R

更新日期：2012-04-01 00:00:00