Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy.

abstract：BACKGROUND:The medical imaging to differentiate World Health Organization (WHO) grade II (ODG2) from III (ODG3) oligodendrogliomas still remains a challenge. We investigated whether combination of machine leaning with radiomics from conventional T1 contrast-enhanced (T1 CE) and fluid attenuated inversion recovery (FLAI...

journal_title：BMC neurology

authors： Zhao SS,Feng XL,Hu YC,Han Y,Tian Q,Sun YZ,Zhang J,Ge XW,Cheng SC,Li XL,Mao L,Shen SN,Yan LF,Cui GB,Wang W

更新日期：2020-02-07 00:00:00

abstract：BACKGROUND:Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed to synchronous mass activity owing the lack of inhibition. We assume that removal of exactly these frequency components from an auditory stimulus will cause the brain to reorganize ar...

journal_title：BMC neurology

authors： Pantev C,Rudack C,Stein A,Wunderlich R,Engell A,Lau P,Wollbrink A,Shaykevich A

更新日期：2014-03-02 00:00:00

abstract：BACKGROUND:B-mode and Color Doppler ultrasonography (CDUS) are the methods of choice for screening and determining the degree of Carotid artery stenosis. The evaluation of stenosis with calcification may be hampered by a common CDUS artifact known as acoustic shadow (AS). Our objective was to assess the change in relia...

journal_title：BMC neurology

authors： Seyman EE,Bornstein N,Auriel E,Cohen O,Nissel T,Hallevi H

更新日期：2019-07-29 00:00:00

abstract：BACKGROUND:Chest pain as the primary manifestation of epilepsy is extremely rare and has only been reported once to date. CASE PRESENTATION:We herein describe a 47-year-old woman with recurrent chest pain for 3 years. The cause of her chest pain remained elusive despite extensive investigations including comprehensive...

journal_title：BMC neurology

authors： Khoo CS,Lee D,Park KM,In Lee B,Kim SE

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Complications after stroke have been associated with poor outcome. Modern stroke treatment might reduce the occurrence of complications. The aim of this study was to investigate whether the frequency and type of complications during the first week after stroke has changed in patients treated in a stroke unit...

journal_title：BMC neurology

authors： Bovim MR,Askim T,Lydersen S,Fjærtoft H,Indredavik B

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:Non-ataxic symptoms of spinocerebellar ataxias (SCAs) vary widely and often overlap with various types of SCAs. Duration and severity of the disease and genetic background may play a role in such phenotypic diversity. We conducted the study in order to study clinical characteristics of common SCAs in Thailan...

journal_title：BMC neurology

authors： Boonkongchuen P,Pongpakdee S,Jindahra P,Papsing C,Peerapatmongkol P,Wetchaphanphesat S,Paiboonpol S,Dejthevaporn C,Tanprawate S,Nudsasarn A,Jariengprasert C,Muntham D,Ingsathit A,Pulkes T

更新日期：2014-04-05 00:00:00

abstract：BACKGROUND:Complex Regional Pain Syndrome (CRPS) presents as chronic, continuous pain and sensory, autonomic, and motor abnormalities affecting one or more extremities. People with CRPS can also show changes in their perception of and attention to the affected body part and sensory information in the affected side of s...

journal_title：BMC neurology

authors： Halicka M,Vittersø AD,Proulx MJ,Bultitude JH

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Deep brain stimulation of the subthalamic nucleus significantly improves motor function in patients with severe Parkinson's disease. However, the effects on nonmotor aspects remain uncertain. The present study investigated the effects of subthalamic nucleus deep brain stimulation on mood and psychosocial fun...

journal_title：BMC neurology

authors： Kaiser I,Kryspin-Exner I,Brücke T,Volc D,Alesch F

更新日期：2008-11-11 00:00:00

abstract：BACKGROUND:Room tilt illusion (RTI) is a rare symptom of higher vestibular dysfunction, consisting of a transient vertical rotation of the visual scene in the sagittal or coronal plane, most often 90o or 180o, without any alteration in shape, size and color of objects. CASE PRESENTATION:A 63-year-old woman with a hist...

journal_title：BMC neurology

authors： Arntzen K,Alstadhaug KB

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:Chronic low back pain (CLBP) has been shown to be associated with various pathophysiological changes at several level of the sensorimotor system, pointing to a general hypersensitivity in CLBP patients. The aim of the present study was to investigate signs of generalized mechanical pain hypersensitivity in C...

journal_title：BMC neurology

authors： Puta C,Schulz B,Schoeler S,Magerl W,Gabriel B,Gabriel HH,Miltner WH,Weiss T

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbness and leg weakness resulting in decreased productivity and social activity. The majority of sciatic...

journal_title：BMC neurology

authors： Verheijen E,Munts AG,van Haagen O,de Vries D,Dekkers O,van den Hout W,Vleggeert-Lankamp C

更新日期：2019-09-03 00:00:00

abstract：:The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates early in the drug-discovery process, and decreased the proportion of compounds failing in clinical trials for ADMET reasons. This paper reviews the history of ADM...

journal_title：BMC neurology

authors： Tsaioun K,Bottlaender M,Mabondzo A,Alzheimer's Drug Discovery Foundation.

更新日期：2009-06-12 00:00:00

abstract：BACKGROUND:Headache is a common complaint in children and adolescents. Recently, an increased prevalence of headache in children and adolescents has been reported. METHODS:We retrospectively reviewed the medical records of children and adolescents attending the Headache Clinic of Daejeon St. Mary's Hospital during the...

journal_title：BMC neurology

authors： Jeong YJ,Lee YT,Lee IG,Han JY

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the prevalence of sleep problems in a community-based sample of patients with Parkinson's disease (PD) in Norway, and their associated factors. METHODS:176 consecutive PD outpatients (41% females) were included in a study of non-motor symptoms, including sleep proble...

journal_title：BMC neurology

authors： Svensson E,Beiske AG,Loge JH,Beiske KK,Sivertsen B

更新日期：2012-08-10 00:00:00

abstract：BACKGROUND:The X-linked form of Charcot-Marie-Tooth disease type 1 (CMTX1) is an inherited peripheral neuropathy that arises in patients with mutations in the gap-junction beta-1 gene (GJB1). CASE PRESENTATION:Three young male patients from Southern China with pes cavus experienced multiple episodes of transient centr...

journal_title：BMC neurology

authors： Liang Y,Liu J,Cheng D,Wu Y,Mo L,Huang W

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:This study aimed to determine the risk of thromboembolic events in patients with junctional bradycardia(JB). METHODS:We retrospectively reviewed electrocardiograms(ECGs) for 380,682 patients. Those with JB on an ECG at least twice over a ≥3-month interval were included for analysis. We additionally included...

journal_title：BMC neurology

authors： Kim GS,Uhm JS,Kim TH,Lee H,Park J,Park JK,Joung B,Pak HN,Lee MH

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Neuromuscular electrical stimulation (NMES) is commonly used to activate skeletal muscles and reverse muscle atrophy in clinical populations. Clinical recommendations for NMES suggest the use of short pulse widths (100-200 μs) and low-to-moderate pulse frequencies (30-50 Hz). However, this type of NMES cause...

journal_title：BMC neurology

authors： Bochkezanian V,Newton RU,Trajano GS,Vieira A,Pulverenti TS,Blazevich AJ

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Parkinson's disease, the second most common neurodegenerative disease, is diagnostically defined by motor impairments, but also includes often under-recognized impairments in cognition, mood, sleep, and the autonomic nervous system. These problems can severely affect individuals' quality of life. In our prio...

journal_title：BMC neurology

authors： Connor K,Cheng E,Siebens HC,Lee ML,Mittman BS,Ganz DA,Vickrey B

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Patients with ischemic cerebrovascular diseases are more likely to suffer from intracranial aneurysms, and their surgical treatment has a growing controversy in this condition. The current case series was aimed at exploring surgical treatment and perioperative management of intracranial aneurysms in Chinese ...

journal_title：BMC neurology

authors： Zheng Y,Wu C

更新日期：2018-09-14 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (CMV) is an ubiquitous pathogen capable of modulating the host immune system. Immune dysfunction is common during CMV infection and includes autoimmune phenomena. Here we focus on a case of primary CMV infection associated with encephalopathy in a patient with a rudimentary spleen. We d...

journal_title：BMC neurology

authors： Xu X,Bergman P,Willows T,Tammik C,Sund M,Hökfelt T,Söderberg-Naucler C,Varani S

更新日期：2012-09-04 00:00:00

abstract：:An international expert consensus committee recently recommended a brief battery of tests for cognitive evaluation in multiple sclerosis. The Brief International Cognitive Assessment for MS (BICAMS) battery includes tests of mental processing speed and memory. Recognizing that resources for validation will vary intern...

journal_title：BMC neurology

authors： Benedict RH,Amato MP,Boringa J,Brochet B,Foley F,Fredrikson S,Hamalainen P,Hartung H,Krupp L,Penner I,Reder AT,Langdon D

更新日期：2012-07-16 00:00:00

abstract：BACKGROUND:Carotid angioplasty with stenting is a relatively new, increasingly used, less-invasive treatment for the treatment of symptomatic carotid artery stenosis. It is being evaluated in ongoing and nearly finished randomized trials. An important factor in the evaluation of stents is the occurrence of in-stent res...

journal_title：BMC neurology

authors： Nederkoorn PJ,Brown MM

更新日期：2009-07-22 00:00:00

abstract：BACKGROUND:Cognitive impairment and visual deterioration are two key clinical symptoms in MS and affect 50 to 80% of patients. Little is known about the influence of cognitive impairment on visual tests recommended for MS such as low contrast sensitivity testing. Our objective was to investigate whether low contrast se...

journal_title：BMC neurology

authors： Wieder L,Gäde G,Pech LM,Zimmermann H,Wernecke KD,Dörr JM,Bellmann-Strobl J,Paul F,Brandt AU

更新日期：2013-11-08 00:00:00

abstract：BACKGROUND:Patients with vascular Ehlers-Danlos syndrome (EDS) occasionally suffer from arterial dissection. Eagle syndrome, which is caused by an elongated styloid process and also causes arterial dissection, is difficult to diagnose and could sometimes be overlooked. Little is known of the coexistence of these two di...

journal_title：BMC neurology

authors： Ikenouchi H,Takagi M,Nishimura A,Yamaguchi E,Koge J,Saito K,Toyoda K,Koga M

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:A fraction of patients with penetrating artery infarction (PAI) experience progressive motor deficit deterioration (PMD). We sought to investigate the role of high-sensitivity C-reactive protein (hs-CRP) at admission in predicting PMD. METHODS:From January 2015 to September 2018, consecutive patients with P...

journal_title：BMC neurology

authors： Gong P,Liu Y,Huang T,Chen W,Jiang T,Gong Y,Lu M,Wang M,Zhang Y,Zhang X,Deng Q,Zhou J

更新日期：2019-12-29 00:00:00

abstract：BACKGROUND:Friedreich ataxia is a neurological disease originating from an iron-sulfur cluster enzyme deficiency due to impaired iron handling in the mitochondrion, aconitase being particularly affected. As a mean to counteract disease progression, it has been suggested to chelate free mitochondrial iron. Recent years ...

journal_title：BMC neurology

authors： Goncalves S,Paupe V,Dassa EP,Rustin P

更新日期：2008-06-16 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disorder characterised by loss of motor neurons leading to severe weakness and death from respiratory failure within 3-5 years. Riluzole prolongs survival in ALS. A published report has suggested a dramatic effect of lithium carbonate o...

journal_title：BMC neurology

authors： Al-Chalabi A,Shaw PJ,Young CA,Morrison KE,Murphy C,Thornhill M,Kelly J,Steen IN,Leigh PN,UKMND-LiCALS.

更新日期：2011-09-21 00:00:00

abstract：BACKGROUND:In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia. METHODS:Patients presenting with acute cerebral ischemic events were randomly assigned into aspirin (...

journal_title：BMC neurology

authors： Lee SJ,Lee JS,Choi MH,Lee SE,Shin DH,Hong JM

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Rett syndrome is a severe neurodevelopmental disorder that primarily affects females. Typical features include a loss of purposeful hand skills, development of hand stereotypies, loss of spoken language, gait abnormalities, and acquired microcephaly. However, Rett syndrome hasn't been recognized by clinical ...

journal_title：BMC neurology

authors： Lv Y,Liu C,Shi M,Cui L

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Nosocomial infection (NI) control is an important issue in neurocritical care due to secondary brain damage and the increased morbidity and mortality of primary acute neurocritical care patients. The primary aim of this study was to determine incidence of nosocomial infections and multidrug-resistant bacteri...

journal_title：BMC neurology

authors： Spatenkova V,Bradac O,Fackova D,Bohunova Z,Suchomel P

更新日期：2018-03-07 00:00:00