Deferiprone targets aconitase: implication for Friedreich's ataxia treatment.

abstract：BACKGROUND:Partially thrombosed giant aneurysms at the basilar apex (BA) artery are challenging lesions with a poor prognosis if left untreated. Here we describe a rare case of extensive brain edema after growth of a surgically treated and thrombosed giant basilar apex aneurysm. CASE PRESENTATION:We performed a proxim...

journal_title：BMC neurology

authors： García-Pérez D,Panero I,Eiriz C,Moreno LM,Munarriz PM,Paredes I,Lagares A,Alén JF

更新日期：2020-06-06 00:00:00

abstract：BACKGROUND:Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not being able to give informed consent. In some nations, ethics committees will not approve of inclusion in a clinical study via consent of a legal representa...

journal_title：BMC neurology

authors： Hotter B,Ulm L,Hoffmann S,Katan M,Montaner J,Bustamante A,Meisel A

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:Effective control of (upright) body posture requires a proper representation of body orientation. Stroke patients with pusher syndrome were shown to suffer from severely disturbed perception of own body orientation. They experience their body as oriented 'upright' when actually tilted by nearly 20 degrees to...

journal_title：BMC neurology

authors： Johannsen L,Broetz D,Karnath HO

更新日期：2006-08-23 00:00:00

abstract：BACKGROUND:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a clinically heterogeneous disorder characterized by epileptic seizures, psychosis, dyskinesia, consciousness impairments, and autonomic instability. Symptoms are always various. Sometimes it presents in milder or incomplete forms. We report 4 cases ...

journal_title：BMC neurology

authors： Qin K,Wu W,Huang Y,Xu D,Zhang L,Zheng B,Jiang M,Kou C,Gao J,Li W,Zhang J,Wang S,Luan Y,Yan C,Xu D,Zheng X

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders that occur owing to the abnormalities in type 1 collagen, and is characterized by increased bone fragility and other extraskeletal manifestations. We report the case of a patient who was diagnosed with OI following subarachnoid hemo...

journal_title：BMC neurology

authors： Hirohata T,Miyawaki S,Mizutani A,Iwakami T,Yamada S,Nishido H,Suzuki Y,Miyamoto S,Hoya K,Murakami M,Matsuno A

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:Despite substantial research into the topic and valiant surgical efforts, reconstruction of peripheral nerve injury remains a challenging surgery. This study was conducted to evaluate the effectiveness of axonal regeneration of a transected sciatic nerve through a vein conduit containing degenerated skeletal...

journal_title：BMC neurology

authors： Mohammadi J,Delaviz H,Mohammadi B,Delaviz H,Rad P

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:Susac syndrome (SuS) is a rare condition characterized by a clinical triad of sensorineural hearing loss, branch artery occlusion and encephalopathy. This study reports an increased incidence of SuS in Israel. We describe the clinical characteristics of these patients, diagnostic procedures and the use and s...

journal_title：BMC neurology

authors： Wilf-Yarkoni A,Elkayam O,Aizenstein O,Oron Y,Furer V,Zur D,Goldstein M,Barequet D,Hallevi H,Karni A,Habot-Wilner Z,Regev K

更新日期：2020-09-02 00:00:00

abstract：BACKGROUND:Phase I/II placebo-controlled clinical trials of recombinant Factor VIIa (rFVIIa) suggested that administration of rFVIIa within 4 hours after onset of intracerebral hemorrhage (ICH) is safe, limits ICH growth, and improves outcomes. We sought to determine the cost-effectiveness of rFVIIa for acute ICH treat...

journal_title：BMC neurology

authors： Kissela BM,Eckman MH

更新日期：2008-05-19 00:00:00

abstract：BACKGROUND:The cognitive consequences of carbon monoxide (CO) poisoning are well described. However, most studies have been carried out without an ad-hoc group of control subjects. The main aim of this study was to evaluate cognitive and psychiatric outcome after CO exposure during the storm Klaus in the South West of ...

journal_title：BMC neurology

authors： Pages B,Planton M,Buys S,Lemesle B,Birmes P,Barbeau EJ,Maziero S,Cordier L,Cabot C,Puel M,Genestal M,Chollet F,Pariente J

更新日期：2014-07-21 00:00:00

abstract：BACKGROUND:Association of leukoencephalopathy and atypical mycobacteriosis has been rarely reported. We present a case that is relevant for its unusual presentation and because it may shed further light on the pathogenic mechanisms underlying reversible encephalopathies. CASE REPORT:We report the case of a Hispanic 64...

journal_title：BMC neurology

authors： Oliveira MC,Sato DK,Soares-Neto HR,Lucato LT,Callegaro D,Nitrini R,Medeiros RS,Misu T,Fujihara K,Castro LH

更新日期：2015-09-02 00:00:00

abstract：BACKGROUND:Epidemiology of acute stroke in developing countries differs from that in the developed world, for example, the age at stroke, risk factors, subtypes of stroke and prognosis. Hypertension remains a dominant risk factor and prognostic indicator in patients with stroke in all communities. The risk of stroke is...

journal_title：BMC neurology

authors： Jain S,Namboodri KK,Kumari S,Prabhakar S

更新日期：2004-01-06 00:00:00

abstract：BACKGROUND:Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate. In this study, the temporal profile of ischemic stroke lesion sizes was assessed for more than one year to evaluate the effect of edaravone which m...

journal_title：BMC neurology

authors： Nakase T,Yoshioka S,Suzuki A

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:This study aimed to investigate the prevalence and clinical relevance of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) patients and healthy controls using extra- and intracranial colour Doppler sonography. METHODS:We examined 146 MS patients, presenting with a clinically isol...

journal_title：BMC neurology

authors： Lanzillo R,Mancini M,Liuzzi R,Di Donato O,Salvatore E,Maglio V,Vacca G,Amato L,D'Anna G,Brunetti A,Brescia Morra V

更新日期：2013-02-13 00:00:00

abstract：BACKGROUND:Intracranial hemorrhage is a rare but potentially severe complication of spinal surgery. Most reported post-operative ICH cases consist of cerebellar hemorrhage. There are fewer reported cases of supratentorial ICH following spinal surgery. CASE PRESENTATION:A 56-year-old woman underwent spinal surgery comp...

journal_title：BMC neurology

authors： Berry B,Ghannam M,Bell C,Ghazaleh S,Boss S,Streib C,Ezzeddine M

更新日期：2018-12-14 00:00:00

abstract：BACKGROUND:Deep brain stimulation of the subthalamic nucleus significantly improves motor function in patients with severe Parkinson's disease. However, the effects on nonmotor aspects remain uncertain. The present study investigated the effects of subthalamic nucleus deep brain stimulation on mood and psychosocial fun...

journal_title：BMC neurology

authors： Kaiser I,Kryspin-Exner I,Brücke T,Volc D,Alesch F

更新日期：2008-11-11 00:00:00

abstract：BACKGROUND:Taste disorder is a common symptom in the general population. Several studies have shown that patients with neurological disorders, such as amyotrophic lateral sclerosis and Parkinson's disease, develop taste disturbance. Facial onset sensory and motor neuronopathy (FOSMN) is a rare disease characterized by ...

journal_title：BMC neurology

authors： Ohashi N,Nonami J,Kodaira M,Yoshida K,Sekijima Y

更新日期：2020-02-29 00:00:00

abstract：BACKGROUND:Many Polio survivors have reduced mobility, pain and fatigue, which make access to conventional forms of aerobic exercise difficult. Inactivity leads to increased risk of health problems, many of which are prevalent among Polio survivors. Aerobic exercise programmes in Polio survivors should utilise stable m...

journal_title：BMC neurology

authors： Murray D,Meldrum D,Moloney R,Campion A,Horgan F,Hardiman O

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospital stay post ischemic stroke on mortality is unclear. We determined whether the timing of OAC initia...

journal_title：BMC neurology

authors： Palm F,Kraus M,Safer A,Wolf J,Becher H,Grau AJ

更新日期：2014-10-08 00:00:00

abstract：BACKGROUND:Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed a...

journal_title：BMC neurology

authors： Nakamura Y,Nakajima H,Tani H,Hosokawa T,Ishida S,Kimura F,Kaneko K,Takahashi T,Nakashima I

更新日期：2017-04-19 00:00:00

abstract：BACKGROUND:Spinal dysraphism with a hamartomatous growth (appendix) of the spinal cord is better known as herniated spinal cord. There are many arguments in favour of considering it a developmental defect. From this point of view, it is a type of neural tube disorder. Neural tube disorders can be caused by multiple fac...

journal_title：BMC neurology

authors： Bartels RHMA,Grotenhuis JA,Stegmann APA,Brunner H

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Ramsay Hunt syndrome (RHS) is caused by a reactivation of varicella-zoster virus (VZV) infection, and it is characterized by the symptoms of facial paralysis, otalgia, auricular rash, and/or an oral lesion. Elderly patients or immunocompromised patients, deep pain at the initial visit and no prompt treatment...

journal_title：BMC neurology

authors： Liao YM,Lu HF,Xie P,Zhao Y,Han Q,Zhang QX,Zuo XH,Si YN,Bao HG

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:This multicenter, double-blind, placebo-controlled study assessed the efficacy of rotigotine transdermal patch on apathy and motor symptoms in patients with Parkinson's disease (PD). METHODS:Patients with PD-associated apathy (Unified Parkinson's Disease Rating Scale [UPDRS] I item 4 [motivation] ≥2 and pat...

journal_title：BMC neurology

authors： Hauser RA,Slawek J,Barone P,Dohin E,Surmann E,Asgharnejad M,Bauer L

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impairment (MCI) and involved in their pathophysiology. METHODS:Plasma samples and clinical data were obt...

journal_title：BMC neurology

authors： Kim SM,Song J,Kim S,Han C,Park MH,Koh Y,Jo SA,Kim YY

更新日期：2011-05-12 00:00:00

abstract：BACKGROUND:Decision-making is an essential function of everyday life. Decision-making under explicit risk requires developing advantageous decision strategies based on fixed outcomes (e.g., probabilities of winning or losing a bet). Decision-making and its neural substrates have been rarely studied in MS. We expected p...

journal_title：BMC neurology

authors： Radomski AD,Power C,Purdon SE,Emery DJ,Blevins G,Warren KG,Fujiwara E

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:Rett syndrome (RTT) is a severe neurodevelopmental disorder mainly affecting females. One of the main clinical manifestations is hand stereotypies, which is presumed to based on dysfunction rather than on structural impairment. Reflex interictal discharge precipitated by tapping-lips in electroencephalogram ...

journal_title：BMC neurology

authors： Luo X,Li C,Wang X,Yu X,Jiang J

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Seizures are one of the most important neurologic complications of human immuno-deficiency virus (HIV)-negative cryptococcal meningitis. A better understanding of the risk associated factors can help predict those who will require treatment. METHODS:This 22-year retrospective study enrolled 180 patients. Pr...

journal_title：BMC neurology

authors： Hung CW,Chang WN,Kung CT,Tsai NW,Wang HC,Lin WC,Huang CR,Huang CC,Tsai WC,Chang HW,Su YJ,Lin YJ,Cheng BC,Chang YT,Su CM,Lu CH

更新日期：2014-10-13 00:00:00

abstract：BACKGROUND:Data from different studies suggest a favourable association between pretreatment with statins or hypercholesterolemia and outcome after ischaemic stroke. We examined whether there were differences in in-hospital mortality according to the presence or absence of statin therapy in a large population of first-...

journal_title：BMC neurology

authors： Arboix A,García-Eroles L,Oliveres M,Targa C,Balcells M,Massons J

更新日期：2010-06-18 00:00:00

abstract：BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants for the treatment of depression in patients with Parkinson's Disease (PD) but data on their efficacy are controversial. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials ...

journal_title：BMC neurology

authors： Skapinakis P,Bakola E,Salanti G,Lewis G,Kyritsis AP,Mavreas V

更新日期：2010-06-21 00:00:00

abstract：:In clinical neurology, a comprehensive understanding of consciousness has been regarded as an abstract concept--best left to philosophers. However, times are changing and the need to clinically assess consciousness is increasingly becoming a real-world, practical challenge. Current methods for evaluating altered level...

journal_title：BMC neurology

authors： Gawryluk JR,D'Arcy RC,Connolly JF,Weaver DF

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:Common carotid artery occlusive disease (CCAOD) could form internal carotid artery steal pathways. Based on the diagnostic results of digital subtraction angiography (DSA), head and neck computed tomography angiography (CTA) was used to find the internal carotid artery stealing pathway after CCAOD. METHODS:...

journal_title：BMC neurology

authors： Wang D,Li Z,Zheng X,Cong H,Zhang T,Wang Z,Wang Y,He J

更新日期：2020-09-03 00:00:00