Abstract:
:In clinical neurology, a comprehensive understanding of consciousness has been regarded as an abstract concept--best left to philosophers. However, times are changing and the need to clinically assess consciousness is increasingly becoming a real-world, practical challenge. Current methods for evaluating altered levels of consciousness are highly reliant on either behavioural measures or anatomical imaging. While these methods have some utility, estimates of misdiagnosis are worrisome (as high as 43%)--clearly this is a major clinical problem. The solution must involve objective, physiologically based measures that do not rely on behaviour. This paper reviews recent advances in physiologically based measures that enable better evaluation of consciousness states (coma, vegetative state, minimally conscious state, and locked in syndrome). Based on the evidence to-date, electroencephalographic and neuroimaging based assessments of consciousness provide valuable information for evaluation of residual function, formation of differential diagnoses, and estimation of prognosis.
journal_name
BMC Neuroljournal_title
BMC neurologyauthors
Gawryluk JR,D'Arcy RC,Connolly JF,Weaver DFdoi
10.1186/1471-2377-10-11subject
Has Abstractpub_date
2010-01-29 00:00:00pages
11issn
1471-2377pii
1471-2377-10-11journal_volume
10pub_type
杂志文章,评审相关文献
BMC Neurology文献大全abstract:BACKGROUND:Muscle fibrosis characterizes degenerated muscles in muscular dystrophies and in late onset myopathies. Fibrotic muscles often exhibit thickening of the extracellular matrix (ECM). The molecular regulation of this process is not fully understood. In oculopharyngeal muscular dystrophy (OPMD), an expansion of ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-13-70
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Progressive Supranuclear Palsy (PSP) is the most frequent form of atypical Parkinsonism. Although there is preliminary evidence for the benefits of gait rehabilitation, balance training and oculomotor exercises in PSP, the quality of reporting of exercise therapies appears mixed. The current investigation ai...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1539-4
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer's disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise that skin vascular response to iontophoresis of acetylcholine, which is partly determined by the le...
journal_title:BMC neurology
pub_type: 临床试验,杂志文章
doi:10.1186/s12883-019-1316-4
更新日期:2019-05-03 00:00:00
abstract:BACKGROUND:Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare autosomal recessive congenital anomaly characterized by horizontal gaze limitation and progressive scoliosis. We investigated the underlying pathogenesis by incorporating diffusion tensor imaging and an electrophysiological study. CASE PRESE...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1081-9
更新日期:2018-05-29 00:00:00
abstract:ASBTRACT:BACKGROUND: There are limited neuroprotective treatment options for patients with aneurysmal subarachnoid hemorrhage (SAH). Cerebrolysin, a brain-specific proposed pleiotropic neuroprotective agent, has been suggested to improve global functional outcomes in ischemic stroke. We investigated the efficacy, safet...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12883-020-01908-9
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:Recovery patterns of upper extremity motor function have been described in several longitudinal studies, but most of these studies have had selected samples, short follow up times or insufficient outcomes on motor function. The general understanding is that improvements in upper extremity occur mainly during...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-56
更新日期:2011-05-25 00:00:00
abstract::Leakage of the blood-brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue where it is exposed to an inflammatory milieu and tissue damage, e.g., demyelination. Once in the CNS, albumin ca...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/s12883-016-0564-9
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:Epidemiology of acute stroke in developing countries differs from that in the developed world, for example, the age at stroke, risk factors, subtypes of stroke and prognosis. Hypertension remains a dominant risk factor and prognostic indicator in patients with stroke in all communities. The risk of stroke is...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-4-1
更新日期:2004-01-06 00:00:00
abstract:BACKGROUND:Anterior spinal cord herniation (aSCH) is a rare cause of myelopathy which may present as pure motor syndrome and mimic other degenerative diseases of the spinal cord. In slowly progressive cases, diagnosis may be impeded by equivocal imaging results and mistaken for evolving upper motor neuron disease. As e...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01891-1
更新日期:2020-08-29 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea is a common sleep disorder in stroke patients. Obstructive sleep apnea is associated with stroke severity and poor functional outcome. Continuous positive airway pressure seems to improve functional recovery in stroke rehabilitation. To date, the effect of continuous positive airway p...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2377-14-36
更新日期:2014-02-25 00:00:00
abstract:BACKGROUND:The COVID-19 pandemic, which broke out in Wuhan in 2019, has become the global health crisis of our time. Elderly patients with certain fundamental diseases are more likely to develop severe cases. The secondary lesion following viral infection have only rarely been reported. CASE PRESENTATION:We here repor...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-02033-3
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:The basal ganglia (BG) are thought to play an important role in the control of eye movements. Accordingly, the broad variety of subtle oculomotor alterations that has been described in Parkinson's disease (PD) are generally attributed to the dysfunction of the BG dopaminergic system. However, the present stu...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-12-5
更新日期:2012-02-29 00:00:00
abstract:BACKGROUND:Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disorder characterised by loss of motor neurons leading to severe weakness and death from respiratory failure within 3-5 years. Riluzole prolongs survival in ALS. A published report has suggested a dramatic effect of lithium carbonate o...
journal_title:BMC neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2377-11-111
更新日期:2011-09-21 00:00:00
abstract:BACKGROUND:Recent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinson's disease (PD). In our previous work, we sequenced the exomes of sixteen patients from eight Chinese PD families using whole exome sequencing technology, consequently three patients from different pedig...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-13-196
更新日期:2013-12-11 00:00:00
abstract:BACKGROUND:Neuromuscular electrical stimulation (NMES) is commonly used to activate skeletal muscles and reverse muscle atrophy in clinical populations. Clinical recommendations for NMES suggest the use of short pulse widths (100-200 μs) and low-to-moderate pulse frequencies (30-50 Hz). However, this type of NMES cause...
journal_title:BMC neurology
pub_type: 临床试验,杂志文章
doi:10.1186/s12883-017-0862-x
更新日期:2017-05-02 00:00:00
abstract:BACKGROUND:Economic costs related to treatment of multiple sclerosis (MS) must be justified by health state, quality of life (QOL) and social participation improvement. This study aims to describe correlations between social participation, economic costs, utility and MS-specific QOL in a sample of patients with MS (pwM...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-14-115
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Epilepsy is a major complication of stroke. We aimed to establish whether there is an association between intravenous thrombolysis, intra-arterial thrombolysis and post stroke seizure (PSS) development. Improved understanding of the relationship between reperfusion therapies and seizure development may impro...
journal_title:BMC neurology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12883-018-1064-x
更新日期:2018-05-03 00:00:00
abstract:BACKGROUND:Detecting and treating neuropsychological deficits after aneurysmatic subarachnoid hemorrhage (aSAH) play a key role in regaining independence; however, detecting deficits relevant to social and professional reintegration has been difficult and optimal timing of assessments remains unclear. Therefore, we eva...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-02003-9
更新日期:2020-11-26 00:00:00
abstract:BACKGROUND:Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is an autosomal recessive inherited disease of metabolic dysfunction clinically characterized by fluctuating proximal muscle weakness, excise intolerance, and dramatic riboflavin responsiveness. Dropped head syndrome can occasionally be observed in...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/s12883-015-0380-7
更新日期:2015-07-24 00:00:00
abstract:BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants for the treatment of depression in patients with Parkinson's Disease (PD) but data on their efficacy are controversial. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials ...
journal_title:BMC neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2377-10-49
更新日期:2010-06-21 00:00:00
abstract:BACKGROUND:Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder of late onset, which is caused by a CAG repeat expansion in the coding region of the ATXN3 gene. This disease presents clinical heterogeneity, which cannot be completely explained by the...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-131
更新日期:2011-10-24 00:00:00
abstract:BACKGROUND:Carotid rete mirabile (RM) is a meshwork of multiple, freely intercommunicating arterioles that reconstitute the absent or hypoplastic segments of the internal carotid artery (ICA). Carotid RM has been reported to be associated with cerebrovascular diseases. However, it is rarely associated with moyamoya-pat...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1277-7
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for producing γ-aminobutyric acid, and it has been suggested that antibodies against GAD play a role in neurological conditions and type 1 diabetes. However, it is not known whether dementia appears as the sole neurological manifestation associate...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-156
更新日期:2011-12-21 00:00:00
abstract:BACKGROUND:DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It plays a crucial role in embryonic development, imprinting and genome stability, cell differentiation. The dysfunction of this group of enzymes can lead to a vari...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1177-2
更新日期:2018-10-20 00:00:00
abstract:BACKGROUND:Cholinesterase inhibitors can delay the progression of Alzheimer's disease (AD). Several clinical trials of the drug in moderate to severe AD have consistently reported clinically positive effects. A combining effect with psychosocial intervention was reported in mild to moderate AD patients. Since a therape...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-014-0243-7
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Central sensitization is thought to be an important contributing factor in many chronic pain disorders. The Central Sensitization Inventory (CSI) is a patient-reported measure frequently used to assess symptoms related to central sensitization. The aims of the study were to translate and cross-culturally ada...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01867-1
更新日期:2020-07-27 00:00:00
abstract:BACKGROUND:Spinal dysraphism with a hamartomatous growth (appendix) of the spinal cord is better known as herniated spinal cord. There are many arguments in favour of considering it a developmental defect. From this point of view, it is a type of neural tube disorder. Neural tube disorders can be caused by multiple fac...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01710-7
更新日期:2020-04-06 00:00:00
abstract:BACKGROUND:The two human cerebral hemispheres are continuously interacting, through excitatory and inhibitory influences and one critical structure subserving this interhemispheric balance is the corpus callosum. Interhemispheric neurophysiological abnormalities and intrahemispheric behavioral impairments have been rep...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-6-21
更新日期:2006-06-21 00:00:00
abstract:BACKGROUND:Balanced Steady State Free Precession (b-SSFP) sequences and the newly developed Fast-Spin-Echo (FSE)-sequences enable an optimized visualization of neurovascular compression (NVC) in patients with trigeminal neuralgia (TN). Arterial conflicts are mostly associated with a favorable outcome of microvascular d...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01860-8
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:Patients with acute stroke are particularly vulnerable to delirium episodes. Although delirium detection is important, no evidence-based recommendations have been established to date on how these patients should be routinely screened for delirium or which tool should be used for this purpose in this populati...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1547-4
更新日期:2019-12-02 00:00:00