Eye movement impairments in Parkinson's disease: possible role of extradopaminergic mechanisms.

abstract：BACKGROUND:The benefit of intravenous thrombolysis (IVT) for acute ischemic stroke is time dependent. Despite great effort, the median door-to-needle time (DNT) was 60 min at the United States stroke centers. We investigated the effect of a simple quality improvement initiative on DNT for IVT. METHODS:This is a single...

journal_title：BMC neurology

authors： Tran D,Zhu Z,Shafie M,Abcede H,Stradling D,Yu W

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:In the pathogenesis of limbic encephalitis other promoting factors besides the pure existence of autoantibodies are increasingly discussed to play a significant role. This is to our knowledge the first described patient in whom the presence of autoantibodies precedes the manifestation of limbic encephalitis ...

journal_title：BMC neurology

authors： Fauser S,Uttner I,Ariño H,Scherbaum WA,Saiz A,Lewerenz J

更新日期：2015-09-30 00:00:00

abstract：BACKGROUND:"Anarchic hand" is a rare condition characterised by non-volitional, goal-directed movements of one arm. We report a case with analysis of structural and functional connectivity. CASE PRESENTATION:A 15 year old girl developed intermittent symptoms of intermanual conflict or anarchic hand as a result of trau...

journal_title：BMC neurology

authors： Basu AP,Taylor PN,Lowther E,Forsyth EO,Blamire AM,Forsyth RJ

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:The clinical features of Alzheimer's disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four diffusion tensor imaging parameters in the white matter of patients with early stage AD, examined thei...

journal_title：BMC neurology

authors： Lee CC,Hsu SW,Huang CW,Chang WN,Chen SF,Wu MK,Chang CC,Hwang LC,Chen PC

更新日期：2017-10-06 00:00:00

abstract：BACKGROUND:Data from different studies suggest a favourable association between pretreatment with statins or hypercholesterolemia and outcome after ischaemic stroke. We examined whether there were differences in in-hospital mortality according to the presence or absence of statin therapy in a large population of first-...

journal_title：BMC neurology

authors： Arboix A,García-Eroles L,Oliveres M,Targa C,Balcells M,Massons J

更新日期：2010-06-18 00:00:00

abstract：BACKGROUND:Nosocomial infection (NI) control is an important issue in neurocritical care due to secondary brain damage and the increased morbidity and mortality of primary acute neurocritical care patients. The primary aim of this study was to determine incidence of nosocomial infections and multidrug-resistant bacteri...

journal_title：BMC neurology

authors： Spatenkova V,Bradac O,Fackova D,Bohunova Z,Suchomel P

更新日期：2018-03-07 00:00:00

abstract：BACKGROUND:Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP is associated with various inflammatory, infectious, and malignant diseases, such as rheumatic arthritis, sarcoidosis, anti-neutrophil cytoplasmic antibody-associated vasculitis, IgG4-rela...

journal_title：BMC neurology

authors： Amano E,Uchida K,Ishihara T,Otsu S,Machida A,Eishi Y

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospital stay post ischemic stroke on mortality is unclear. We determined whether the timing of OAC initia...

journal_title：BMC neurology

authors： Palm F,Kraus M,Safer A,Wolf J,Becher H,Grau AJ

更新日期：2014-10-08 00:00:00

abstract：BACKGROUND:Recent exercise guidelines for people with multiple sclerosis (MS) recommend a minimum of 30 min moderate intensity aerobic exercise and resistance exercise twice per week. This trial compared the secondary outcomes of a combined 10-week guideline based intervention and a Social Cognitive Theory (SCT) educat...

journal_title：BMC neurology

authors： Coote S,Uszynski M,Herring MP,Hayes S,Scarrott C,Newell J,Gallagher S,Larkin A,Motl RW

更新日期：2017-06-24 00:00:00

abstract：BACKGROUND:In adults, the anastomosis between carotid and vertebrobasilar arteries is usually the posterior communicating artery, sometimes the primitive trigeminal artery. In this case, the basilar artery fed the internal carotid artery through the pontine-to-tentorial artery anastomosis after severe stenosis from tra...

journal_title：BMC neurology

authors： Liu X,Li B,Liu Y,Wu H,Zhang H,Dou L,Liu C

更新日期：2020-03-17 00:00:00

abstract：BACKGROUND:DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It plays a crucial role in embryonic development, imprinting and genome stability, cell differentiation. The dysfunction of this group of enzymes can lead to a vari...

journal_title：BMC neurology

authors： Zheng W,Yan Z,He R,Huang Y,Lin A,Huang W,Su Y,Li S,Zhang VW,Xie H

更新日期：2018-10-20 00:00:00

abstract：:The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates early in the drug-discovery process, and decreased the proportion of compounds failing in clinical trials for ADMET reasons. This paper reviews the history of ADM...

journal_title：BMC neurology

authors： Tsaioun K,Bottlaender M,Mabondzo A,Alzheimer's Drug Discovery Foundation.

更新日期：2009-06-12 00:00:00

abstract：BACKGROUND:Balanced Steady State Free Precession (b-SSFP) sequences and the newly developed Fast-Spin-Echo (FSE)-sequences enable an optimized visualization of neurovascular compression (NVC) in patients with trigeminal neuralgia (TN). Arterial conflicts are mostly associated with a favorable outcome of microvascular d...

journal_title：BMC neurology

authors： Müller S,Khadhraoui E,Khanafer A,Psychogios M,Rohde V,Tanrikulu L

更新日期：2020-07-14 00:00:00

abstract：BACKGROUND:The evidence base for the effectiveness of psychological interventions for patients with dissociative non-epileptic seizures (DS) is currently extremely limited, although data from two small pilot randomised controlled trials (RCTs), including from our group, suggest that Cognitive Behavioural Therapy (CBT) ...

journal_title：BMC neurology

authors： Goldstein LH,Mellers JD,Landau S,Stone J,Carson A,Medford N,Reuber M,Richardson M,McCrone P,Murray J,Chalder T

更新日期：2015-06-27 00:00:00

abstract：BACKGROUND:Stroke represents one of the most costly and long-term disabling conditions in adulthood worldwide and there is a need to determine the effectiveness of rehabilitation programs in the late phase after stroke. Limited scientific support exists for training incorporating rhythm and music as well as therapeutic...

journal_title：BMC neurology

authors： Bunketorp Käll L,Lundgren-Nilsson Å,Blomstrand C,Pekna M,Pekny M,Nilsson M

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:There is much discourse in healthcare about the importance of client-centred rehabilitation, however in the realm of community-based therapy post-stroke there has been little investigation into the efficacy of goal-directed practice that reflects patients' valued activities. In addition, the effect of active...

journal_title：BMC neurology

authors： Graven C,Brock K,Hill K,Ames D,Cotton S,Joubert L

更新日期：2011-06-18 00:00:00

abstract：BACKGROUND:Mixed pathology, particularly Alzheimer's disease with cerebrovascular lesions, is reported as the second most common cause of dementia. Research on mixed dementia typically includes people with a primary AD diagnosis and hence, little is known about the effects of co-existing amyloid pathology in people wit...

journal_title：BMC neurology

authors： Dao E,Hsiung GY,Sossi V,Jacova C,Tam R,Dinelle K,Best JR,Liu-Ambrose T

更新日期：2015-10-12 00:00:00

abstract：BACKGROUND:Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated with Parkinson disease (PD), multiple system atrophy (MSA), and pure autonomic failure. nOH can increase the risk of falls due to symptoms that include...

journal_title：BMC neurology

authors： Claassen DO,Adler CH,Hewitt LA,Gibbons C

更新日期：2018-08-25 00:00:00

abstract：BACKGROUND:Past studies found that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But the reason of the concurrency remains unknown. The purpose of this study was to confirm whether angioarchitectural factors relate to the concurrence and which angioarchitectural facto...

journal_title：BMC neurology

authors： Yu T,Liu X,Lin X,Bai C,Zhao J,Zhang J,Zhang L,Wu Z,Wang S,Zhao Y,Meng G

更新日期：2016-09-22 00:00:00

abstract：BACKGROUND:Internal jugular vein stenosis (IJVS), characterized by a series of clinical manifestations, such as head and neck symptoms, visual and ear symptoms, as well as sleep disorder, has been receiving attention in recent years. However, its' etiologies are not fully understood. CASE PRESENTATION:We report a case...

journal_title：BMC neurology

authors： Li M,Sun Y,Chan CC,Fan C,Ji X,Meng R

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Economic costs related to treatment of multiple sclerosis (MS) must be justified by health state, quality of life (QOL) and social participation improvement. This study aims to describe correlations between social participation, economic costs, utility and MS-specific QOL in a sample of patients with MS (pwM...

journal_title：BMC neurology

authors： Kwiatkowski A,Marissal JP,Pouyfaucon M,Vermersch P,Hautecoeur P,Dervaux B

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Among patients with relapsing-remitting multiple sclerosis, relapses are associated with increased disability and decreased quality of life. Relapses are commonly treated with corticosteroids or left untreated. We aimed to better understand patient perceptions of the adequacy of corticosteroids in resolving ...

journal_title：BMC neurology

authors： Nickerson M,Marrie RA

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:Detecting and treating neuropsychological deficits after aneurysmatic subarachnoid hemorrhage (aSAH) play a key role in regaining independence; however, detecting deficits relevant to social and professional reintegration has been difficult and optimal timing of assessments remains unclear. Therefore, we eva...

journal_title：BMC neurology

authors： Walter J,Grutza M,Vogt L,Unterberg A,Zweckberger K

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND:High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity. Our purpose was to investigate the association of adherence to a Mediterranean diet and severity in a prospective hospital register of AIS patient...

journal_title：BMC neurology

authors： Lavados PM,Mazzon E,Rojo A,Brunser AM,Olavarría VV

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid plaques collectively referred to as cerebral amyloidosis, which occurs in the brain commonly among t...

journal_title：BMC neurology

authors： Li JM,Huang LL,Liu F,Tang BS,Yan XX

更新日期：2017-08-25 00:00:00

abstract：BACKGROUND:'Neuromarketing' is a term that has often been used in the media in recent years. These public discussions have generally centered around potential ethical aspects and the public fear of negative consequences for society in general, and consumers in particular. However, positive contributions to the scientif...

journal_title：BMC neurology

authors： Javor A,Koller M,Lee N,Chamberlain L,Ransmayr G

更新日期：2013-02-06 00:00:00

abstract：BACKGROUND:Acute ischemic stroke attack with and without a recent TIA may differ in clinical risk factors, and this may affect treatment outcomes following thrombolytic therapy. We examined whether the odds of exclusion or inclusion for thrombolytic therapy are greater in ischemic stroke with TIA less than 24 h precedi...

journal_title：BMC neurology

authors： Poupore N,Strat D,Mackey T,Snell A,Nathaniel T

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:The use of vestibular rehabilitation principles in the management of gaze and postural stability impairments in people with multiple sclerosis (PwMS) has shown promise in pilot work completed in our lab and in a recently published randomized clinical trial (RCT). However, further work is needed to fully quan...

journal_title：BMC neurology

authors： Loyd BJ,Fangman A,Peterson DS,Gappmaier E,Schubert MC,Thackery A,Dibble L

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:Carotid angioplasty with stenting is a relatively new, increasingly used, less-invasive treatment for the treatment of symptomatic carotid artery stenosis. It is being evaluated in ongoing and nearly finished randomized trials. An important factor in the evaluation of stents is the occurrence of in-stent res...

journal_title：BMC neurology

authors： Nederkoorn PJ,Brown MM

更新日期：2009-07-22 00:00:00

abstract：BACKGROUND:Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular subtypes was not widely investigated. The relationship between molecular phenotype and histological sub...

journal_title：BMC neurology

authors： Tang Q,Lian Y,Yu J,Wang Y,Shi Z,Chen L

更新日期：2017-09-15 00:00:00