ADDME--Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective.

abstract：BACKGROUND:The WHOQOL-BREF is a frequently used instrument for the assessment of health-related quality of life. Unlike other generic instruments used for the assessment of this construct, little is known about its properties in individuals with headache disorders. The present study examines the reliability and factori...

journal_title：BMC neurology

authors： Brzoska P

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:Cognitive impairment and visual deterioration are two key clinical symptoms in MS and affect 50 to 80% of patients. Little is known about the influence of cognitive impairment on visual tests recommended for MS such as low contrast sensitivity testing. Our objective was to investigate whether low contrast se...

journal_title：BMC neurology

authors： Wieder L,Gäde G,Pech LM,Zimmermann H,Wernecke KD,Dörr JM,Bellmann-Strobl J,Paul F,Brandt AU

更新日期：2013-11-08 00:00:00

abstract：BACKGROUND:Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study, effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia on focal embolic cerebral ischemia have been examined. METHODS:Focal ischemic injury was in...

journal_title：BMC neurology

authors： Wang CX,Yang T,Noor R,Shuaib A

更新日期：2002-04-18 00:00:00

abstract：BACKGROUND:The prognostic impact of preadmission use of calcium channel blockers (CCBs) and beta blockers (BBs) on stroke mortality remains unclear. We aimed to examine whether preadmission use of CCBs or BBs was associated with improved short-term mortality following ischemic stroke, intracerebral hemorrhage (ICH), or...

journal_title：BMC neurology

authors： Sundbøll J,Schmidt M,Horváth-Puhó E,Christiansen CF,Pedersen L,Bøtker HE,Sørensen HT

更新日期：2015-03-07 00:00:00

abstract：BACKGROUND:It has been recently demonstrated that in Frontotemporal Lobar Degeneration (FTLD) memory deficits at presentation are commoner than previously thought. Apolipoprotein E (ApoE) genotype, the major genetic risk factor in sporadic late-onset Alzheimer Disease (AD), modulates cerebral perfusion in late middle-a...

journal_title：BMC neurology

authors： Borroni B,Perani D,Archetti S,Agosti C,Paghera B,Bellelli G,Di Luca M,Padovani A

更新日期：2006-08-24 00:00:00

abstract：BACKGROUND:Study aimed at investigation of pathogenic role and prognostic value of several selected cerebrospinal fluid acute phase factors that can reflect the severity of ischemic brain damage. METHODS:Ninety five acute ischemic stroke patients were investigated. Ischemic region visualized at the twenty fourth hour ...

journal_title：BMC neurology

authors： Beridze M,Sanikidze T,Shakarishvili R,Intskirveli N,Bornstein NM

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Cerebral microvascular abnormality is frequently associated with lacunar and subcortical ischemic lesions. We performed acute and follow-up CT perfusion scans over the first 3 months after ischemic stroke to investigate disturbances of the blood-brain barrier (BBB) and cerebral perfusion in patients with lac...

journal_title：BMC neurology

authors： Yang J,d'Esterre C,Ceruti S,Roversi G,Saletti A,Fainardi E,Lee TY

更新日期：2015-10-22 00:00:00

abstract：BACKGROUND:Assessing primary rehabilitation needs in patients with acquired brain injury is a challenge due to case complexity and the heterogeneity of symptoms after brain injury. The Rehabilitation Complexity Scale-Extended (RCS-E) is an instrument used in assessment of rehabilitation complexity in patients with seve...

journal_title：BMC neurology

authors： Maribo T,Pedersen AR,Jensen J,Nielsen JF

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Autonomic nervous system (ANS) dysfunction is present in up to one third of patients with tetanus. The prognostic value of ANS dysfunction is known in severe tetanus but its value is not well established in mild to moderate tetanus. METHODS:Medical records of all patients admitted with tetanus at two academ...

journal_title：BMC neurology

authors： Wasay M,Khealani BA,Talati N,Shamsi R,Syed NA,Salahuddin N

更新日期：2005-01-31 00:00:00

abstract：BACKGROUND:The use of vestibular rehabilitation principles in the management of gaze and postural stability impairments in people with multiple sclerosis (PwMS) has shown promise in pilot work completed in our lab and in a recently published randomized clinical trial (RCT). However, further work is needed to fully quan...

journal_title：BMC neurology

authors： Loyd BJ,Fangman A,Peterson DS,Gappmaier E,Schubert MC,Thackery A,Dibble L

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:Admission hyperglycemia (HG) has been associated with worse outcomes among acute stroke patients. A better understanding and awareness of the potentially adverse influence of hyperglycemia on the clinical outcome of acute stroke patients would help to provide guidance for acute stroke management and preventi...

journal_title：BMC neurology

authors： Zewde YZ,Mengesha AT,Gebreyes YF,Naess H

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Several studies suggest that perceived psychosocial stress is associated with increased risk of stroke; however results are inconsistent with regard to definitions and measurement of perceived stress, features of individual study design, study conduct and conclusions drawn and no meta-analysis has yet been p...

journal_title：BMC neurology

authors： Booth J,Connelly L,Lawrence M,Chalmers C,Joice S,Becker C,Dougall N

更新日期：2015-11-12 00:00:00

abstract：BACKGROUND:A Transient Ischaemic Attack (TIA) bears a high risk of a subsequent ischaemic stroke. Adequate diagnosis of a TIA should be followed immediately by the start of appropriate preventive therapy, including antiplatelets. The diagnosis of a TIA based on symptoms and signs only is notoriously difficult and bioma...

journal_title：BMC neurology

authors： Dolmans LS,Rutten FH,El Bartelink ML,Seppenwoolde G,van Delft S,Kappelle LJ,Hoes AW

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Ventral intermediate thalamic nucleus (VIM) deep brain stimulation (DBS) is an effective treatment for tremor, but there is limited data on long-term efficacy and mortality after VIM-DBS. Here we report the analysis of patient satisfaction and mortality in all patients treated in our center 1996-2010 with VI...

journal_title：BMC neurology

authors： Børretzen MN,Bjerknes S,Sæhle T,Skjelland M,Skogseid IM,Toft M,Dietrichs E

更新日期：2014-06-05 00:00:00

abstract：BACKGROUND:Our objective was to find which additional factors can influence the favorable result in stroke patients after receiving fibrinolytic and/or endovascular treatment, quantified as a more than 30% improvement of the NIHSS score at 7 days. METHODS:This is a retrospective study to find factors that could influe...

journal_title：BMC neurology

authors： Tudor R,Iovanescu G,Reisz D,Cornea A,Potre-Oncu C,Tutelca A,Simu M

更新日期：2020-11-14 00:00:00

abstract：BACKGROUND:Sturge-Weber syndrome (SWS) is a rare and sporadic congenital neurocutaneous disorder, that is characterized by facial venous capillary malformation (port-wine birthmark), leptomeningeal venous malformation (angiomatosis), glaucoma, and neurologic problems. SWS can comorbid with other disorders in some patie...

journal_title：BMC neurology

authors： Deng L,Wang D,Ruan N,Fu P

更新日期：2019-05-03 00:00:00

abstract：BACKGROUND:Patients often report neurocognitive difficulties after neuroborreliosis (NB). The frequency and extent of cognitive problems in European patients have been studied incompletely. METHODS:Sixty patients received a neurological and neuropsychological work-up 6 months or longer after treatment for proven NB. Q...

journal_title：BMC neurology

authors： Schmidt H,Djukic M,Jung K,Holzgraefe M,Dechent P,von Steinbüchel N,Blocher J,Eiffert H,Schmidt-Samoa C

更新日期：2015-08-19 00:00:00

abstract：BACKGROUND:The autophagic vacuolar myopathies (AVM) are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, an...

journal_title：BMC neurology

authors： Bokuda K,Sugaya K,Tamura S,Miyamoto K,Matsubara S,Komori T

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:Fatigue is a common complaint in multiple sclerosis (MS) and often interferes with daily functioning. Both clinicians and researchers may need to detect high levels of fatigue impact using a time and effort efficient tool. This study evaluates the psychometric properties of a rapid screening instrument for f...

journal_title：BMC neurology

authors： Kos D,Nagels G,D'Hooghe MB,Duportail M,Kerckhofs E

更新日期：2006-08-17 00:00:00

abstract：BACKGROUND:Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed to synchronous mass activity owing the lack of inhibition. We assume that removal of exactly these frequency components from an auditory stimulus will cause the brain to reorganize ar...

journal_title：BMC neurology

authors： Pantev C,Rudack C,Stein A,Wunderlich R,Engell A,Lau P,Wollbrink A,Shaykevich A

更新日期：2014-03-02 00:00:00

abstract：BACKGROUND:Carotid rete mirabile (RM) is a meshwork of multiple, freely intercommunicating arterioles that reconstitute the absent or hypoplastic segments of the internal carotid artery (ICA). Carotid RM has been reported to be associated with cerebrovascular diseases. However, it is rarely associated with moyamoya-pat...

journal_title：BMC neurology

authors： Chen H,Hou K,Wang X,Xu K,Yu J

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO...

journal_title：BMC neurology

authors： Kim HJ,Cho H,Park S,Jang H,Ryu YH,Choi JY,Moon SH,Oh SJ,Oh M,Na DL,Lyoo CH,Kim EJ,Seeley WW,Kim JS,Choi KC,Seo SW

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:While both hypercapnia and hypocapnia are harmful in patients with subarachnoid hemorrhage (SAH), it is unknown whether high-normal PaCO2 values are better than low-normal values. We hypothesized that high-normal PaCO2 values have more detrimental than beneficial effects on outcome. METHODS:Consecutive pati...

journal_title：BMC neurology

authors： Reiff T,Barthel O,Schönenberger S,Mundiyanapurath S

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Lumbo-sacral radiculopathy (LSR) is a common musculoskeletal disorder for which patients seek medical care and referrals for advanced imaging. However, accurate diagnosis remains challenging. Neuropathic pain screening questionnaires, clinical neurological examination and magnetic resonance imaging (MRI) are...

journal_title：BMC neurology

authors： Tawa N,Diener I,Louw Q,Rhoda A

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:The time from injury to surgery (TIS) is critical in the functional recovery of individuals with traumatic acute subdural hematoma (TASDH). However, only few studies have confirmed such notion. METHODS:The data of TASDH patients who were surgically treated in Chia-Yi Christian Hospital between January 2008 ...

journal_title：BMC neurology

authors： Chen SH,Sun JM,Fang WK

更新日期：2020-06-04 00:00:00

abstract：BACKGROUND:B-mode and Color Doppler ultrasonography (CDUS) are the methods of choice for screening and determining the degree of Carotid artery stenosis. The evaluation of stenosis with calcification may be hampered by a common CDUS artifact known as acoustic shadow (AS). Our objective was to assess the change in relia...

journal_title：BMC neurology

authors： Seyman EE,Bornstein N,Auriel E,Cohen O,Nissel T,Hallevi H

更新日期：2019-07-29 00:00:00

abstract：BACKGROUND:Stroke and its risk factors epidemiological survey can help identify individuals at higher risk and therefore promote stroke prevention strategies. The aim of this study was to estimate the current prevalence of stroke and high risk stroke population, and evaluate stroke associated risk factors in southweste...

journal_title：BMC neurology

authors： Yi X,Luo H,Zhou J,Yu M,Chen X,Tan L,Wei W,Li J

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:The genetic epidemiology of ischemic stroke remains relatively unstudied, and information about the genetic epidemiology of ischemic stroke in populations with significant minority representation is currently unavailable. METHODS:The Brain Attack Surveillance in Corpus Christi project (BASIC) is a populatio...

journal_title：BMC neurology

authors： Lisabeth LD,Smith MA,Brown DL,Uchino K,Morgenstern LB

更新日期：2005-10-31 00:00:00

abstract：BACKGROUND:Deep brain stimulation of the subthalamic nucleus significantly improves motor function in patients with severe Parkinson's disease. However, the effects on nonmotor aspects remain uncertain. The present study investigated the effects of subthalamic nucleus deep brain stimulation on mood and psychosocial fun...

journal_title：BMC neurology

authors： Kaiser I,Kryspin-Exner I,Brücke T,Volc D,Alesch F

更新日期：2008-11-11 00:00:00

abstract：BACKGROUND:Cognitive disorders, such as memory disturbances, are often observed following a subarachnoid hemorrhage. We present a very rare case where rupture of a posterior cerebral artery aneurysm caused restricted damage to the hippocampus unilaterally, and caused memory disturbances. CASE PRESENTATION:A 56-year-ol...

journal_title：BMC neurology

authors： Maeshima S,Osawa A,Yamane F,Shimaguchi H,Ochiai I,Yoshihara T,Uemiya N,Kanazawa R,Ishihara S

更新日期：2014-03-07 00:00:00