Abstract:
BACKGROUND:A Transient Ischaemic Attack (TIA) bears a high risk of a subsequent ischaemic stroke. Adequate diagnosis of a TIA should be followed immediately by the start of appropriate preventive therapy, including antiplatelets. The diagnosis of a TIA based on symptoms and signs only is notoriously difficult and biomarkers of brain ischaemia might improve the recognition, and target management and prognosis of TIA patients. Our aim is to quantify the added diagnostic value of serum biomarkers of brain ischaemia in patients suspected of TIA. METHODS/DESIGN: STUDY DESIGN:a cross-sectional diagnostic accuracy study with an additional six month follow-up period. STUDY POPULATION:350 patients suspected of TIA in the primary care setting. Patients suspected of a TIA will be recruited by at least 200 general practitioners (GPs) in the catchment area of seven TIA outpatient clinics willing to participate in the study. In all patients a blood sample will be drawn as soon as possible after the patient has contacted the GP, but at least within 72 h after onset of symptoms. Participants will be referred by the GP to the regional TIA outpatient clinic for additional investigations, including brain imaging. The 'definite' diagnosis (reference standard) will be made by a panel consisting of three experienced neurologists who will use all available diagnostic information and the clinical information obtained during the outpatient clinic assessment, and a six month follow-up period. The diagnostic accuracy, and value in addition to signs and symptoms of candidate serum biomarkers will be assessed in terms of discrimination with C statistics, and calibration with plots. We aim to include 350 suspected cases, with 250 patients with indeed definite TIA (or minor stroke) according to the panel. DISCUSSION:We hope to find novel biomarkers that will enable a rapid and accurate diagnosis of TIA. This would largely improve the management and prognosis of such patients. TRIAL REGISTRATION:ClinicalTrials.gov Identifier NCT01954329.
journal_name
BMC Neuroljournal_title
BMC neurologyauthors
Dolmans LS,Rutten FH,El Bartelink ML,Seppenwoolde G,van Delft S,Kappelle LJ,Hoes AWdoi
10.1186/s12883-015-0388-zsubject
Has Abstractpub_date
2015-07-28 00:00:00pages
119issn
1471-2377pii
10.1186/s12883-015-0388-zjournal_volume
15pub_type
杂志文章相关文献
BMC Neurology文献大全abstract:BACKGROUND:Deep brain stimulation of the subthalamic nucleus significantly improves motor function in patients with severe Parkinson's disease. However, the effects on nonmotor aspects remain uncertain. The present study investigated the effects of subthalamic nucleus deep brain stimulation on mood and psychosocial fun...
journal_title:BMC neurology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2377-8-43
更新日期:2008-11-11 00:00:00
abstract::Leakage of the blood-brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue where it is exposed to an inflammatory milieu and tissue damage, e.g., demyelination. Once in the CNS, albumin ca...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/s12883-016-0564-9
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:The cognitive consequences of carbon monoxide (CO) poisoning are well described. However, most studies have been carried out without an ad-hoc group of control subjects. The main aim of this study was to evaluate cognitive and psychiatric outcome after CO exposure during the storm Klaus in the South West of ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-14-153
更新日期:2014-07-21 00:00:00
abstract:BACKGROUND:An Early Supported Discharge (ESD) and rehabilitation from a coordinated team in the home environment is recommended in several high-income countries for patients with mild to moderate symptoms after stroke. Returning home from the hospital takes place very early in Sweden today (12 days post stroke), thus t...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12883-015-0492-0
更新日期:2015-11-16 00:00:00
abstract:BACKGROUND:There is need for a cognitive test battery that can be easily used in clinical practice to detect or monitor cognitive performance in patients with multiple sclerosis (MS). In order to conduct, in this patient group, a preliminary investigation of the validity and utility of a brief computerized battery, the...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-68
更新日期:2011-06-07 00:00:00
abstract:BACKGROUND:The etiologic determinants of stroke in young adults remain a diagnostic challenge in up to one-fourth of cases. Increasing evidences led to consider Fabry's disease (FD) as a possible cause to check up. We aimed at evaluating the prevalence of unrecognized FD in a cohort of patients with juvenile stroke in ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0513-z
更新日期:2015-12-12 00:00:00
abstract:BACKGROUND:Cubital tunnel syndrome is common nerve compression syndrome among peripheral nerve compression diseases. However, the syndrome caused by intraneural ganglion cysts has been rarely reported. Medical approaches, like ultrasound-guided aspiration and open surgical treatment remain to be discussed. CASE PRESEN...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1229-7
更新日期:2018-12-22 00:00:00
abstract:BACKGROUND:Parkinson's disease, the second most common neurodegenerative disease, is diagnostically defined by motor impairments, but also includes often under-recognized impairments in cognition, mood, sleep, and the autonomic nervous system. These problems can severely affect individuals' quality of life. In our prio...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12883-015-0506-y
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:The mechanisms underlying the interictal habituation deficit of cortical visual evoked potentials (VEP) in migraine are not well understood. Abnormal long-term functional plasticity of the visual cortex may play a role and it can be assessed experimentally by light deprivation (LD). METHODS:We have compared...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-91
更新日期:2011-07-27 00:00:00
abstract:BACKGROUND:Mechanical thrombectomy was approved by NICE as a treatment for stroke in 2016. However, most of the evidence is from studies conducted during working hours. Only few centres in the UK perform thrombectomies out-of-hours. The Royal Stoke University Hospital (RSUH) has offered thrombectomies over 24 h (24/7) ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01909-8
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Acceptance and Commitment Therapy (ACT), as a type of behavioral therapy, attempts to respond to changes in people's performance and their relationship to events. ACT can affect sleep quality by providing techniques to enhance the flexibility of patients' thoughts, yet maintaining mindfullness. Therefore, fo...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01883-1
更新日期:2020-08-13 00:00:00
abstract:BACKGROUND:Falls frequency increases with age and particularly in neurogeriatric cohorts. The interplay between eye movements and locomotion may contribute substantially to the occurrence of falls, but is hardly investigated. This paper provides an overview of current approaches to simultaneously measure eye and body m...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0447-5
更新日期:2015-10-09 00:00:00
abstract:BACKGROUND:Lumbo-sacral radiculopathy (LSR) is a common musculoskeletal disorder for which patients seek medical care and referrals for advanced imaging. However, accurate diagnosis remains challenging. Neuropathic pain screening questionnaires, clinical neurological examination and magnetic resonance imaging (MRI) are...
journal_title:BMC neurology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12883-019-1333-3
更新日期:2019-05-30 00:00:00
abstract:BACKGROUND:Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disorder characterised by loss of motor neurons leading to severe weakness and death from respiratory failure within 3-5 years. Riluzole prolongs survival in ALS. A published report has suggested a dramatic effect of lithium carbonate o...
journal_title:BMC neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2377-11-111
更新日期:2011-09-21 00:00:00
abstract:BACKGROUND:Interleukin 36 (IL-36) cytokines belong to the IL-1 family and play an important role in some autoimmune diseases. However, the relationship between IL-36 and neuromyelitis optica spectrum disorders (NMOSD) remains unclear. METHODS:We determined serum IL-36α, IL-36β and IL-36γ levels and assessed correlatio...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1415-2
更新日期:2019-08-05 00:00:00
abstract:BACKGROUND:Recent consensus guidelines recommend pregabalin as a first-tier treatment for painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 mg/d (300 mg dosed BID) versus placebo for relieving DPN-associated neuropathic pain, and assessed its safety using objective measures of ne...
journal_title:BMC neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2377-8-33
更新日期:2008-09-16 00:00:00
abstract:BACKGROUND:French Guiana has the highest incidence of ischemic and hemorrhagic stroke of all French territories. However, there is no further information on the epidemiology and management of stroke in French Guiana. Our goal was to describe the characteristics of patients in French Guiana in order to generate hypothes...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01650-2
更新日期:2020-03-24 00:00:00
abstract:BACKGROUND:Intracranial hemorrhage is a rare but potentially severe complication of spinal surgery. Most reported post-operative ICH cases consist of cerebellar hemorrhage. There are fewer reported cases of supratentorial ICH following spinal surgery. CASE PRESENTATION:A 56-year-old woman underwent spinal surgery comp...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1218-x
更新日期:2018-12-14 00:00:00
abstract:BACKGROUND:Prevalence of degenerative dementias and dementias associated with cerebrovascular disease is increasing. Dementia is one of the most significant public health problem. In recent years, the role of vascular risk factors (hypertension, diabetes mellitus and hypercholesterolemia) and depression has been evalua...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-8-39
更新日期:2008-10-15 00:00:00
abstract:BACKGROUND:Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder of late onset, which is caused by a CAG repeat expansion in the coding region of the ATXN3 gene. This disease presents clinical heterogeneity, which cannot be completely explained by the...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-131
更新日期:2011-10-24 00:00:00
abstract:BACKGROUND:Ropinirole prolonged release (RPR) is a once-daily formulation. However, there may be individual pharmacokinetic differences so that multiple dosing may be preferred in some individuals. This study compares once-daily and twice-daily RPR in patients with Parkinson's disease. METHODS:This study was an open-l...
journal_title:BMC neurology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/1471-2377-13-113
更新日期:2013-09-02 00:00:00
abstract:BACKGROUND:Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer's Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear. METHODS:Adults with chronic treated HIV disease were recruited (n = 43, aged 56.7 ± 7.9; 32% aged 60+; median ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0298-0
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impairment (MCI) and involved in their pathophysiology. METHODS:Plasma samples and clinical data were obt...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-51
更新日期:2011-05-12 00:00:00
abstract:BACKGROUND:The major difficulty in postoperative care in patients after craniotomy is to distinguish the intracranial deficits from the residual effect of general anesthesia. In present study, we used cerebral state index (CSI) monitoring in patients after craniotomy with delayed recovery, and evaluated the prediction ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-15
更新日期:2011-01-27 00:00:00
abstract:BACKGROUND:Infectious basilar artery (BA) aneurysm has been occasionally reported to be generated from meningitis following transcranial operation. However, infectious BA aneurysm formed by intracranial infection after endoscopic endonasal operation has never been reported. CASE PRESENTATION:A 53-year-old man who was ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01673-9
更新日期:2020-03-14 00:00:00
abstract:BACKGROUND:The production of inflammatory cytokines resulting from amyloid β (Aβ) is associated with the initiation of Alzheimer's disease (AD). Atorvastatin (ATV) has been reported to improve AD, however, it is unclear how the anti-inflammatory mechanism is linked with its protection against the impairment of spatial ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-016-0533-3
更新日期:2016-02-04 00:00:00
abstract:BACKGROUND:Recent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinson's disease (PD). In our previous work, we sequenced the exomes of sixteen patients from eight Chinese PD families using whole exome sequencing technology, consequently three patients from different pedig...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-13-196
更新日期:2013-12-11 00:00:00
abstract:BACKGROUND:MS-pathogenesis is known to involve both multiple environmental events, and several independent genetic risk-factors. METHODS:A model of susceptibility is developed and a mathematical analysis undertaken to elucidate the nature of genetic susceptibility to MS and to understand the constraints that are place...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-10-101
更新日期:2010-10-28 00:00:00
abstract:BACKGROUND:While both hypercapnia and hypocapnia are harmful in patients with subarachnoid hemorrhage (SAH), it is unknown whether high-normal PaCO2 values are better than low-normal values. We hypothesized that high-normal PaCO2 values have more detrimental than beneficial effects on outcome. METHODS:Consecutive pati...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-1603-0
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:Epilepsy is a major complication of stroke. We aimed to establish whether there is an association between intravenous thrombolysis, intra-arterial thrombolysis and post stroke seizure (PSS) development. Improved understanding of the relationship between reperfusion therapies and seizure development may impro...
journal_title:BMC neurology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12883-018-1064-x
更新日期:2018-05-03 00:00:00