Mechanical thrombectomy: can it be safely delivered out of hours in the UK?

Abstract:

BACKGROUND:Mechanical thrombectomy was approved by NICE as a treatment for stroke in 2016. However, most of the evidence is from studies conducted during working hours. Only few centres in the UK perform thrombectomies out-of-hours. The Royal Stoke University Hospital (RSUH) has offered thrombectomies over 24 h (24/7) since 2010. The aim of this service review is to compare the outcomes for patients treated in regular working hours to those treated outside normal working hours within this unit. METHODS:This retrospective service analysis includes all patients treated with mechanical thrombectomy at RSUH since the start of the service in January 2010 to June 2019. Data on key demographics, timings, procedural complications, and long-term outcomes including death and disability at 90 days were collected. In-hours was defined as the time between 8:00-17:00 h, Monday to Friday; out-of-hours was defined as any time outside this period. RESULTS:In total, 516 mechanical thrombectomies were performed in this time period; data were available on 501 of these. Successful recanalization (TICI 2b/3) was achieved in 86% of patients. By 90 days 96 (19%) had died and 234 (47%) were functionally independent (modified Rankin Scale score ≤ 2). 211 (42%) of the procedures were performed in-hours and 290 (58%) out-of-hours. Door-to-CT and door-to-groin times were significantly longer out-of-hours than in-hours, but thrombectomy duration was significantly shorter. There were no significant differences in complications and short- and long-term outcomes. CONCLUSION:Mechanical thrombectomy was delivered safely and effectively 24/7 in this UK hospital, with no difference in clinical outcomes.

journal_name

BMC Neurol

journal_title

BMC neurology

authors

Weddell J,Parr E,Knight S,Muddegowda G,Natarajan I,Chembala J,Ferdinand P,Ahmad N,Pencz Z,Rana S,Warusevitane A,Jadun C,Nayak S,Hashim Z,Augustine A,Sim J,Roffe C

doi

10.1186/s12883-020-01909-8

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

326

issue

1

issn

1471-2377

pii

10.1186/s12883-020-01909-8

journal_volume

20

pub_type

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