Extent of cortical involvement in amyotrophic lateral sclerosis--an analysis based on cortical thickness.

abstract：BACKGROUND:Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the central nervous system could lead to disease-specific PTMs detectable in the cerebrospinal fluid (C...

journal_title：BMC neurology

authors： Bäckryd E,Edström S,Gerdle B,Ghafouri B

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Neurocysticercosis (NC) is one of the most frequent parasitic diseases of the central nervous system. Cysticidal drugs, albendazole and praziquantel, are generally effective when parasites localize in the parenchyma. In contrast, parasites lodged in the subarachnoid basal cisterns are less responsive to trea...

journal_title：BMC neurology

authors： Cárdenas G,Carrillo-Mezo R,Jung H,Sciutto E,Hernandez JL,Fleury A

更新日期：2010-03-04 00:00:00

abstract：BACKGROUND:Our objective was to find which additional factors can influence the favorable result in stroke patients after receiving fibrinolytic and/or endovascular treatment, quantified as a more than 30% improvement of the NIHSS score at 7 days. METHODS:This is a retrospective study to find factors that could influe...

journal_title：BMC neurology

authors： Tudor R,Iovanescu G,Reisz D,Cornea A,Potre-Oncu C,Tutelca A,Simu M

更新日期：2020-11-14 00:00:00

abstract：BACKGROUND:This study aims to investigate the clinical value of two kinds of vestibular-evoked myogenic potentials in patients with sudden sensorineural hearing loss (SSNHL). METHODS:A total of 82 patients were divided into two groups: vertigo group and non-vertigo group. All patients underwent examinations for pure t...

journal_title：BMC neurology

authors： Wang Y,Gu ST,Bao XL,Guo JL

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:Migraine is a highly prevalent disorder. The disability provoked by its attacks results in suffering as well as considerable economic and social losses. The objective of migraine acute treatment is to restore the patient to normal function as quickly and consistently as possible. There are numerous drugs ava...

journal_title：BMC neurology

authors： Krymchantowski AV

更新日期：2004-01-28 00:00:00

abstract：BACKGROUND:Ventral intermediate thalamic nucleus (VIM) deep brain stimulation (DBS) is an effective treatment for tremor, but there is limited data on long-term efficacy and mortality after VIM-DBS. Here we report the analysis of patient satisfaction and mortality in all patients treated in our center 1996-2010 with VI...

journal_title：BMC neurology

authors： Børretzen MN,Bjerknes S,Sæhle T,Skjelland M,Skogseid IM,Toft M,Dietrichs E

更新日期：2014-06-05 00:00:00

abstract：BACKGROUND:Intracranial hemorrhage is a rare but potentially severe complication of spinal surgery. Most reported post-operative ICH cases consist of cerebellar hemorrhage. There are fewer reported cases of supratentorial ICH following spinal surgery. CASE PRESENTATION:A 56-year-old woman underwent spinal surgery comp...

journal_title：BMC neurology

authors： Berry B,Ghannam M,Bell C,Ghazaleh S,Boss S,Streib C,Ezzeddine M

更新日期：2018-12-14 00:00:00

abstract：BACKGROUND:Patients frequently fail to receive adequate pain relief from, or are intolerant of, first-line therapies prescribed for neuropathic pain (NeP). This refractory chronic pain causes psychological distress and impacts patient quality of life. Published literature for treatment in refractory patients is sparse ...

journal_title：BMC neurology

authors： Plested M,Budhia S,Gabriel Z

更新日期：2010-11-19 00:00:00

abstract：BACKGROUND:Neuromuscular electrical stimulation (NMES) is commonly used to activate skeletal muscles and reverse muscle atrophy in clinical populations. Clinical recommendations for NMES suggest the use of short pulse widths (100-200 μs) and low-to-moderate pulse frequencies (30-50 Hz). However, this type of NMES cause...

journal_title：BMC neurology

authors： Bochkezanian V,Newton RU,Trajano GS,Vieira A,Pulverenti TS,Blazevich AJ

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Few studies on whether etiologic subtype can predict outcome in mild stroke are available. The study aim to explore the effect of different etiologic subtype on prognosis of these patients. METHODS:We prospectively registered consecutive cases of acute ischemic stroke from September. 01, 2009 to August. 31,...

journal_title：BMC neurology

authors： Hao Z,Liu M,Wang D,Wu B,Tao W,Chang X

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospital stay post ischemic stroke on mortality is unclear. We determined whether the timing of OAC initia...

journal_title：BMC neurology

authors： Palm F,Kraus M,Safer A,Wolf J,Becher H,Grau AJ

更新日期：2014-10-08 00:00:00

abstract：BACKGROUND:Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer's disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise that skin vascular response to iontophoresis of acetylcholine, which is partly determined by the le...

journal_title：BMC neurology

authors： Connelly PJ,Adams F,Tayar ZI,Khan F

更新日期：2019-05-03 00:00:00

abstract：:The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates early in the drug-discovery process, and decreased the proportion of compounds failing in clinical trials for ADMET reasons. This paper reviews the history of ADM...

journal_title：BMC neurology

authors： Tsaioun K,Bottlaender M,Mabondzo A,Alzheimer's Drug Discovery Foundation.

更新日期：2009-06-12 00:00:00

abstract：BACKGROUND:The study aims to assess the therapeutic benefits of motor imagery training in stroke patients with persistent motor weakness. There is evidence to suggest that mental rehearsal of movement can produce effects normally attributed to practising the actual movements. Imagining hand movements could stimulate th...

journal_title：BMC neurology

authors： Ietswaart M,Johnston M,Dijkerman HC,Scott CL,Joice SA,Hamilton S,Macwalter RS

更新日期：2006-10-26 00:00:00

abstract：BACKGROUND:The disease burden of human immunodeficiency virus (HIV)--acquired immunodeficiency syndrome (AIDS) is highest in sub-Saharan Africa but there are few studies on the associated neurocognitive disorders in this region. The objectives of this study were to determine whether Western neuropsychological (NP) meth...

journal_title：BMC neurology

authors： Kanmogne GD,Kuate CT,Cysique LA,Fonsah JY,Eta S,Doh R,Njamnshi DM,Nchindap E,Franklin DR Jr,Ellis RJ,McCutchan JA,Binam F,Mbanya D,Heaton RK,Njamnshi AK

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:Cholinesterase inhibitors can delay the progression of Alzheimer's disease (AD). Several clinical trials of the drug in moderate to severe AD have consistently reported clinically positive effects. A combining effect with psychosocial intervention was reported in mild to moderate AD patients. Since a therape...

journal_title：BMC neurology

authors： Meguro K,Ouchi Y,Akanuma K,Meguro M,Kasai M

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Type 2 Diabetes in Mexico has a high prevalence, 16-87% of patients may experience peripheral neuropathy. Early detection can prevent or halt its progression. The performance of Sudoscan in detecting neuropathy was compared to the Michigan Neuropathy Screening Instrument (MNSI). The aim was to identificate s...

journal_title：BMC neurology

authors： Carbajal-Ramírez A,Hernández-Domínguez JA,Molina-Ayala MA,Rojas-Uribe MM,Chávez-Negrete A

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:Neuromyelitis optica (NMO) includes transverse myelitis, optic neuritis and brain lesions. Recent studies have indicated that the brainstem is an important site of attack in NMO. Longitudinally extensive transverse myelitis (LETM) is an important component of the clinical diagnosis of NMO. The frequency of b...

journal_title：BMC neurology

authors： Asgari N,Skejoe HP,Lillevang ST,Steenstrup T,Stenager E,Kyvik KO

更新日期：2013-04-08 00:00:00

abstract：BACKGROUND:Association of leukoencephalopathy and atypical mycobacteriosis has been rarely reported. We present a case that is relevant for its unusual presentation and because it may shed further light on the pathogenic mechanisms underlying reversible encephalopathies. CASE REPORT:We report the case of a Hispanic 64...

journal_title：BMC neurology

authors： Oliveira MC,Sato DK,Soares-Neto HR,Lucato LT,Callegaro D,Nitrini R,Medeiros RS,Misu T,Fujihara K,Castro LH

更新日期：2015-09-02 00:00:00

abstract：BACKGROUND:Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including central nervous system infections, however, Japanese encephalitis (JE, epidemic encephalitis type B) w...

journal_title：BMC neurology

authors： Jia M,Xiong N,Huang J,Wang Y,Zhang X,Zhang Z,Cao X,Lin Z,Wang T

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:The evidence base for the effectiveness of psychological interventions for patients with dissociative non-epileptic seizures (DS) is currently extremely limited, although data from two small pilot randomised controlled trials (RCTs), including from our group, suggest that Cognitive Behavioural Therapy (CBT) ...

journal_title：BMC neurology

authors： Goldstein LH,Mellers JD,Landau S,Stone J,Carson A,Medford N,Reuber M,Richardson M,McCrone P,Murray J,Chalder T

更新日期：2015-06-27 00:00:00

abstract：BACKGROUND:Parkinson's disease, the second most common neurodegenerative disease, is diagnostically defined by motor impairments, but also includes often under-recognized impairments in cognition, mood, sleep, and the autonomic nervous system. These problems can severely affect individuals' quality of life. In our prio...

journal_title：BMC neurology

authors： Connor K,Cheng E,Siebens HC,Lee ML,Mittman BS,Ganz DA,Vickrey B

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not being able to give informed consent. In some nations, ethics committees will not approve of inclusion in a clinical study via consent of a legal representa...

journal_title：BMC neurology

authors： Hotter B,Ulm L,Hoffmann S,Katan M,Montaner J,Bustamante A,Meisel A

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder of late onset, which is caused by a CAG repeat expansion in the coding region of the ATXN3 gene. This disease presents clinical heterogeneity, which cannot be completely explained by the...

journal_title：BMC neurology

authors： Bettencourt C,Santos C,Coutinho P,Rizzu P,Vasconcelos J,Kay T,Cymbron T,Raposo M,Heutink P,Lima M

更新日期：2011-10-24 00:00:00

abstract：BACKGROUND:Hemifacial spasm (HFS) is a disabling neurological condition. Vascular tortuosity in HFS patients has not been quantified objectively and its relationship with hypertension and posterior fossa volume (PF) is unknown. In a case control magnetic resonance imaging and angiographic (MRI/A) study, we quantified a...

journal_title：BMC neurology

authors： Edmond EC,Sim SX,Li HH,Tan EK,Chan LL

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:The coexistence of distinct neurodegenerative diseases in single cases has recently attracted greater attention. The phenotypic co-occurrence of progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) has been documented in several cases. That said, the clinicopathological comorbidity of...

journal_title：BMC neurology

authors： Fujita K,Matsubara T,Miyamoto R,Sumikura H,Takeuchi T,Maruyama Saladini K,Kawarai T,Nodera H,Udaka F,Kume K,Morino H,Kawakami H,Hasegawa M,Kaji R,Murayama S,Izumi Y

更新日期：2019-07-18 00:00:00

abstract：BACKGROUND:Headache is a common complaint in children and adolescents. Recently, an increased prevalence of headache in children and adolescents has been reported. METHODS:We retrospectively reviewed the medical records of children and adolescents attending the Headache Clinic of Daejeon St. Mary's Hospital during the...

journal_title：BMC neurology

authors： Jeong YJ,Lee YT,Lee IG,Han JY

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:The study of muscle metabolism by near-infrared spectroscopy (NIRS) has been poorly implemented in multiple sclerosis (MS). Aims of the study were to compare resting muscle oxygen consumption (rmVO2) at gastrocnemius in MS patients and in age-matched healthy controls (HC) measured using NIRS, and to evaluate...

journal_title：BMC neurology

authors： Malagoni AM,Felisatti M,Lamberti N,Basaglia N,Manfredini R,Salvi F,Zamboni P,Manfredini F

更新日期：2013-05-29 00:00:00

abstract：BACKGROUND:Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impairment (MCI) and involved in their pathophysiology. METHODS:Plasma samples and clinical data were obt...

journal_title：BMC neurology

authors： Kim SM,Song J,Kim S,Han C,Park MH,Koh Y,Jo SA,Kim YY

更新日期：2011-05-12 00:00:00

abstract：BACKGROUND:Gait ability and cognitive function are interrelated during both normal walking (NW) and dual-task walking (DTW), and gait ability is thus adversely affected by cognitive impairment in both situations. However, this association is insufficiently understood in people with mild cognitive impairment (MCI). Here...

journal_title：BMC neurology

authors： Doi T,Shimada H,Makizako H,Tsutsumimoto K,Uemura K,Anan Y,Suzuki T

更新日期：2014-04-01 00:00:00