Japanese encephalitis accompanied by cerebral venous sinus thrombosis: a case report.

Abstract:

BACKGROUND:Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including central nervous system infections, however, Japanese encephalitis (JE, epidemic encephalitis type B) with CVST has not been reported previously. CASE PRESENTATION:Here, we present a case of JE with CVST in a 17-year-old man. On admission, the patient was initially diagnosed as intracranial infection, and soon after, brain magnetic resonance (MR) imaging (MRI) and MR Venography (MRV) confirmed the diagnosis of CVST. Moreover, the blood JE-specific IgM antibody which proved weakly positive at first, turned positive one week later. Consequently, our patient was diagnosed as CVST accompanied by JE. Anticoagulant and anti-infective therapy were initiated, which eventually lead to gradual recovery of the patient. CONCLUSIONS:To our knowledge, this is the first case report of CVST associated with JE. MRI and MRV represent a prime method for the diagnosis of CVST, while the positivity of JE virus IgM antibody, especially increased antibody levels within a short period, is of great significance to diagnose JE. The early diagnosis and timely treatment of this potentially lethal condition would improve its prognosis significantly.

journal_name

BMC Neurol

journal_title

BMC neurology

authors

Jia M,Xiong N,Huang J,Wang Y,Zhang X,Zhang Z,Cao X,Lin Z,Wang T

doi

10.1186/1471-2377-12-43

subject

Has Abstract

pub_date

2012-06-19 00:00:00

pages

43

issn

1471-2377

pii

1471-2377-12-43

journal_volume

12

pub_type

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