Reperfusion therapy in acute ischemic stroke: dawn of a new era?

abstract：BACKGROUND:Cannabis therapy has been considered an effective treatment for spasticity, although clinical reports of symptom reduction in multiple sclerosis (MS) describe mixed outcomes. Recently introduced therapies of combined Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) extracts have potential for symptom ...

journal_title：BMC neurology

authors： Lakhan SE,Rowland M

更新日期：2009-12-04 00:00:00

abstract：BACKGROUND:Despite substantial research into the topic and valiant surgical efforts, reconstruction of peripheral nerve injury remains a challenging surgery. This study was conducted to evaluate the effectiveness of axonal regeneration of a transected sciatic nerve through a vein conduit containing degenerated skeletal...

journal_title：BMC neurology

authors： Mohammadi J,Delaviz H,Mohammadi B,Delaviz H,Rad P

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:Economic costs related to treatment of multiple sclerosis (MS) must be justified by health state, quality of life (QOL) and social participation improvement. This study aims to describe correlations between social participation, economic costs, utility and MS-specific QOL in a sample of patients with MS (pwM...

journal_title：BMC neurology

authors： Kwiatkowski A,Marissal JP,Pouyfaucon M,Vermersch P,Hautecoeur P,Dervaux B

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Friedreich ataxia is a neurological disease originating from an iron-sulfur cluster enzyme deficiency due to impaired iron handling in the mitochondrion, aconitase being particularly affected. As a mean to counteract disease progression, it has been suggested to chelate free mitochondrial iron. Recent years ...

journal_title：BMC neurology

authors： Goncalves S,Paupe V,Dassa EP,Rustin P

更新日期：2008-06-16 00:00:00

abstract：BACKGROUND:Neuroprotective strategies after cardiopulmonary resuscitation are currently the focus of experimental and clinical research. Levosimendan has been proposed as a promising drug candidate because of its cardioprotective properties, improved haemodynamic effects in vivo and reduced traumatic brain injury in vi...

journal_title：BMC neurology

authors： Roehl AB,Zoremba N,Kipp M,Schiefer J,Goetzenich A,Bleilevens C,Kuehn-Velten N,Tolba R,Rossaint R,Hein M

更新日期：2012-08-24 00:00:00

abstract：BACKGROUND:While both hypercapnia and hypocapnia are harmful in patients with subarachnoid hemorrhage (SAH), it is unknown whether high-normal PaCO2 values are better than low-normal values. We hypothesized that high-normal PaCO2 values have more detrimental than beneficial effects on outcome. METHODS:Consecutive pati...

journal_title：BMC neurology

authors： Reiff T,Barthel O,Schönenberger S,Mundiyanapurath S

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Sturge-Weber syndrome (SWS) is a rare and sporadic congenital neurocutaneous disorder, that is characterized by facial venous capillary malformation (port-wine birthmark), leptomeningeal venous malformation (angiomatosis), glaucoma, and neurologic problems. SWS can comorbid with other disorders in some patie...

journal_title：BMC neurology

authors： Deng L,Wang D,Ruan N,Fu P

更新日期：2019-05-03 00:00:00

abstract：BACKGROUND:B-mode and Color Doppler ultrasonography (CDUS) are the methods of choice for screening and determining the degree of Carotid artery stenosis. The evaluation of stenosis with calcification may be hampered by a common CDUS artifact known as acoustic shadow (AS). Our objective was to assess the change in relia...

journal_title：BMC neurology

authors： Seyman EE,Bornstein N,Auriel E,Cohen O,Nissel T,Hallevi H

更新日期：2019-07-29 00:00:00

abstract：:The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates early in the drug-discovery process, and decreased the proportion of compounds failing in clinical trials for ADMET reasons. This paper reviews the history of ADM...

journal_title：BMC neurology

authors： Tsaioun K,Bottlaender M,Mabondzo A,Alzheimer's Drug Discovery Foundation.

更新日期：2009-06-12 00:00:00

abstract：BACKGROUND:Malignant myoepithelioma is a relatively rare malignant tumor occurring most frequently in the salivary glands. A few isolated cases have been described in other locations, including soft tissue, bone, lung, bronchus, oral cavity, nasopharynx, larynx, and maxillary sinus. Malignant myoepithelioma, however, i...

journal_title：BMC neurology

authors： Hong Y,Guo SX,Chen S,Klebe D,Zhang JM,Wu Q

更新日期：2013-05-04 00:00:00

abstract：BACKGROUND:It has been recently demonstrated that in Frontotemporal Lobar Degeneration (FTLD) memory deficits at presentation are commoner than previously thought. Apolipoprotein E (ApoE) genotype, the major genetic risk factor in sporadic late-onset Alzheimer Disease (AD), modulates cerebral perfusion in late middle-a...

journal_title：BMC neurology

authors： Borroni B,Perani D,Archetti S,Agosti C,Paghera B,Bellelli G,Di Luca M,Padovani A

更新日期：2006-08-24 00:00:00

abstract：BACKGROUND:Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed a...

journal_title：BMC neurology

authors： Nakamura Y,Nakajima H,Tani H,Hosokawa T,Ishida S,Kimura F,Kaneko K,Takahashi T,Nakashima I

更新日期：2017-04-19 00:00:00

abstract：BACKGROUND:Cognitive disorders, such as memory disturbances, are often observed following a subarachnoid hemorrhage. We present a very rare case where rupture of a posterior cerebral artery aneurysm caused restricted damage to the hippocampus unilaterally, and caused memory disturbances. CASE PRESENTATION:A 56-year-ol...

journal_title：BMC neurology

authors： Maeshima S,Osawa A,Yamane F,Shimaguchi H,Ochiai I,Yoshihara T,Uemiya N,Kanazawa R,Ishihara S

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Human serum paraoxonase 1 (PON1) plays a major role in the metabolism of several organophosphorus compounds. The enzyme is encoded by the polymorphic gene PON1, located on chromosome 7q21.3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative ass...

journal_title：BMC neurology

authors： Martínez C,Molina JA,Alonso-Navarro H,Jiménez-Jiménez FJ,Agúndez JA,García-Martín E

更新日期：2010-08-19 00:00:00

abstract：BACKGROUND:There is conflicting information as to whether antiretroviral drugs with better central nervous system (CNS) penetration (neuroHAART) assist in improving neurocognitive function and suppressing cerebrospinal fluid (CSF) HIV RNA. The current review aims to better synthesise existing literature by using an inn...

journal_title：BMC neurology

authors： Cysique LA,Waters EK,Brew BJ

更新日期：2011-11-22 00:00:00

abstract：BACKGROUND:Mixed pathology, particularly Alzheimer's disease with cerebrovascular lesions, is reported as the second most common cause of dementia. Research on mixed dementia typically includes people with a primary AD diagnosis and hence, little is known about the effects of co-existing amyloid pathology in people wit...

journal_title：BMC neurology

authors： Dao E,Hsiung GY,Sossi V,Jacova C,Tam R,Dinelle K,Best JR,Liu-Ambrose T

更新日期：2015-10-12 00:00:00

abstract：BACKGROUND:Delayed post-hypoxic leukoencephalopathy (DPHL) is a demyelinating syndrome characterized by neurological relapse after an initial recovery from hypoxic brain injury. We describe a patient with impaired consciousness following DPHL, concurrent with injury of the ascending reticular activating system (ARAS) s...

journal_title：BMC neurology

authors： Jang SH,Kwon HG

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:We aimed to develop a tool, the hemorrhagic transformation (HT) index (HTI), to predict any HT within 14 days after middle cerebral artery (MCA) stroke onset regardless of the intravenous recombinant tissue plasminogen activator (IV rtPA) use. That is especially important in the light of missing evidence-bas...

journal_title：BMC neurology

authors： Kalinin MN,Khasanova DR,Ibatullin MM

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:The study aims to assess the therapeutic benefits of motor imagery training in stroke patients with persistent motor weakness. There is evidence to suggest that mental rehearsal of movement can produce effects normally attributed to practising the actual movements. Imagining hand movements could stimulate th...

journal_title：BMC neurology

authors： Ietswaart M,Johnston M,Dijkerman HC,Scott CL,Joice SA,Hamilton S,Macwalter RS

更新日期：2006-10-26 00:00:00

abstract：BACKGROUND:Adrenomyeloneuropathy (AMN) is one of several phenotypes of the adrenoleukodystrophy spectrum caused by mutations in the ABCD1 gene on the X chromosome. An inflammatory component is part of the disease complex ranging from severe childhood CNS demyelination to spinal cord and peripheral nerve degeneration. ...

journal_title：BMC neurology

authors： Jønch AE,Danielsen ER,Thomsen C,Meden P,Svenstrup K,Nielsen JE

更新日期：2012-09-26 00:00:00

abstract：BACKGROUND:Patients with ischemic cerebrovascular diseases are more likely to suffer from intracranial aneurysms, and their surgical treatment has a growing controversy in this condition. The current case series was aimed at exploring surgical treatment and perioperative management of intracranial aneurysms in Chinese ...

journal_title：BMC neurology

authors： Zheng Y,Wu C

更新日期：2018-09-14 00:00:00

abstract：BACKGROUND:Among patients with relapsing-remitting multiple sclerosis, relapses are associated with increased disability and decreased quality of life. Relapses are commonly treated with corticosteroids or left untreated. We aimed to better understand patient perceptions of the adequacy of corticosteroids in resolving ...

journal_title：BMC neurology

authors： Nickerson M,Marrie RA

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:Periodic alternating ping-pong gaze (PPG) is a rare disease with few reports. To our knowledge, there was no report on anti GQ1b antibody syndrome accompanied by PPG. This paper reported a case of anti GQ1b antibody syndrome with Bickerstaff's Encephalitis (BBE) overlapping classic Guillain-Barre Syndrome (G...

journal_title：BMC neurology

authors： Han J,Xie Y,Yan H,Cao Y,HongmeiWang,Cao D

更新日期：2019-02-19 00:00:00

abstract：BACKGROUND:Anti-epileptic drugs (AEDs) are frequently prescribed to persons with HIV/AIDS receiving combination antiretroviral therapy (cART) although the extent of AED use and their interactions with cART are uncertain. Herein, AED usage, associated toxicities and immune consequences were investigated. METHODS:HIV re...

journal_title：BMC neurology

authors： Lee K,Vivithanaporn P,Siemieniuk RA,Krentz HB,Maingat F,Gill MJ,Power C

更新日期：2010-06-17 00:00:00

abstract：BACKGROUND:Gait ability and cognitive function are interrelated during both normal walking (NW) and dual-task walking (DTW), and gait ability is thus adversely affected by cognitive impairment in both situations. However, this association is insufficiently understood in people with mild cognitive impairment (MCI). Here...

journal_title：BMC neurology

authors： Doi T,Shimada H,Makizako H,Tsutsumimoto K,Uemura K,Anan Y,Suzuki T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The two human cerebral hemispheres are continuously interacting, through excitatory and inhibitory influences and one critical structure subserving this interhemispheric balance is the corpus callosum. Interhemispheric neurophysiological abnormalities and intrahemispheric behavioral impairments have been rep...

journal_title：BMC neurology

authors： Fecteau S,Lassonde M,Théoret H

更新日期：2006-06-21 00:00:00

abstract：BACKGROUND:Chronic fatigue syndrome (CFS) is a disabling condition that affects approximately 800,000 adult Americans. The pathophysiology remains unknown and there are no diagnostic markers or characteristic physical signs or laboratory abnormalities. Most CFS patients complain of unrefreshing sleep and many of the po...

journal_title：BMC neurology

authors： Unger ER,Nisenbaum R,Moldofsky H,Cesta A,Sammut C,Reyes M,Reeves WC

更新日期：2004-04-19 00:00:00

abstract：BACKGROUND:Partially thrombosed giant aneurysms at the basilar apex (BA) artery are challenging lesions with a poor prognosis if left untreated. Here we describe a rare case of extensive brain edema after growth of a surgically treated and thrombosed giant basilar apex aneurysm. CASE PRESENTATION:We performed a proxim...

journal_title：BMC neurology

authors： García-Pérez D,Panero I,Eiriz C,Moreno LM,Munarriz PM,Paredes I,Lagares A,Alén JF

更新日期：2020-06-06 00:00:00

abstract：BACKGROUND:The mechanisms underlying the interictal habituation deficit of cortical visual evoked potentials (VEP) in migraine are not well understood. Abnormal long-term functional plasticity of the visual cortex may play a role and it can be assessed experimentally by light deprivation (LD). METHODS:We have compared...

journal_title：BMC neurology

authors： Coppola G,Crémers J,Gérard P,Pierelli F,Schoenen J

更新日期：2011-07-27 00:00:00

abstract：BACKGROUND:The available health resources limit the amount of therapy that may be offered to children with cerebral palsy and the amount of training in each session may be insufficient to drive the neuroplastic changes, which are necessary for functional improvements to take place. The aim of this pilot study was to pr...

journal_title：BMC neurology

authors： Bilde PE,Kliim-Due M,Rasmussen B,Petersen LZ,Petersen TH,Nielsen JB

更新日期：2011-03-09 00:00:00