Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer's disease cybrid cells.

abstract：BACKGROUND:THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO...

journal_title：BMC neurology

authors： Kim HJ,Cho H,Park S,Jang H,Ryu YH,Choi JY,Moon SH,Oh SJ,Oh M,Na DL,Lyoo CH,Kim EJ,Seeley WW,Kim JS,Choi KC,Seo SW

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:Patients with Mild Cognitive Impairment (MCI) are at high risk of progression to Alzheimer's dementia. Identifying MCI individuals with high likelihood of conversion to dementia and the associated biosignatures has recently received increasing attention in AD research. Different biosignatures for AD (neuroim...

journal_title：BMC neurology

authors： Ye J,Farnum M,Yang E,Verbeeck R,Lobanov V,Raghavan N,Novak G,DiBernardo A,Narayan VA,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2012-06-25 00:00:00

abstract：BACKGROUND:To describe the clinical phenotype of paroxysmal extreme pain disorder, an autosomal dominant condition in four members in one family with the mutation NM_002977.3:c.3892G > T (p.Val1298Phe) in the SCN9A gene. Clinical examinations and details from members of one Polish family were collected, including age a...

journal_title：BMC neurology

authors： Stępień A,Sałacińska D,Staszewski J,Durka-Kęsy M,Dobrogowski J

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:The X-linked form of Charcot-Marie-Tooth disease type 1 (CMTX1) is an inherited peripheral neuropathy that arises in patients with mutations in the gap-junction beta-1 gene (GJB1). CASE PRESENTATION:Three young male patients from Southern China with pes cavus experienced multiple episodes of transient centr...

journal_title：BMC neurology

authors： Liang Y,Liu J,Cheng D,Wu Y,Mo L,Huang W

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Our objective was to find which additional factors can influence the favorable result in stroke patients after receiving fibrinolytic and/or endovascular treatment, quantified as a more than 30% improvement of the NIHSS score at 7 days. METHODS:This is a retrospective study to find factors that could influe...

journal_title：BMC neurology

authors： Tudor R,Iovanescu G,Reisz D,Cornea A,Potre-Oncu C,Tutelca A,Simu M

更新日期：2020-11-14 00:00:00

abstract：BACKGROUND:Falls frequency increases with age and particularly in neurogeriatric cohorts. The interplay between eye movements and locomotion may contribute substantially to the occurrence of falls, but is hardly investigated. This paper provides an overview of current approaches to simultaneously measure eye and body m...

journal_title：BMC neurology

authors： Srulijes K,Mack DJ,Klenk J,Schwickert L,Ihlen EA,Schwenk M,Lindemann U,Meyer M,Srijana KC,Hobert MA,Brockmann K,Wurster I,Pomper JK,Synofzik M,Schneider E,Ilg U,Berg D,Maetzler W,Becker C

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:Deep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and factors associated with DVT in Asian patients with ischemic stroke. METHODS:Acute ischemic stroke ...

journal_title：BMC neurology

authors： Ha SH,Kim YJ,Heo SH,Chang DI,Kim BJ

更新日期：2020-06-27 00:00:00

abstract：BACKGROUND:The study aims to assess the therapeutic benefits of motor imagery training in stroke patients with persistent motor weakness. There is evidence to suggest that mental rehearsal of movement can produce effects normally attributed to practising the actual movements. Imagining hand movements could stimulate th...

journal_title：BMC neurology

authors： Ietswaart M,Johnston M,Dijkerman HC,Scott CL,Joice SA,Hamilton S,Macwalter RS

更新日期：2006-10-26 00:00:00

abstract：BACKGROUND:The two human cerebral hemispheres are continuously interacting, through excitatory and inhibitory influences and one critical structure subserving this interhemispheric balance is the corpus callosum. Interhemispheric neurophysiological abnormalities and intrahemispheric behavioral impairments have been rep...

journal_title：BMC neurology

authors： Fecteau S,Lassonde M,Théoret H

更新日期：2006-06-21 00:00:00

abstract：BACKGROUND:The disease burden of human immunodeficiency virus (HIV)--acquired immunodeficiency syndrome (AIDS) is highest in sub-Saharan Africa but there are few studies on the associated neurocognitive disorders in this region. The objectives of this study were to determine whether Western neuropsychological (NP) meth...

journal_title：BMC neurology

authors： Kanmogne GD,Kuate CT,Cysique LA,Fonsah JY,Eta S,Doh R,Njamnshi DM,Nchindap E,Franklin DR Jr,Ellis RJ,McCutchan JA,Binam F,Mbanya D,Heaton RK,Njamnshi AK

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:Taste disorder is a common symptom in the general population. Several studies have shown that patients with neurological disorders, such as amyotrophic lateral sclerosis and Parkinson's disease, develop taste disturbance. Facial onset sensory and motor neuronopathy (FOSMN) is a rare disease characterized by ...

journal_title：BMC neurology

authors： Ohashi N,Nonami J,Kodaira M,Yoshida K,Sekijima Y

更新日期：2020-02-29 00:00:00

abstract：BACKGROUND:Vascular cognitive impairment-no dementia (VCIND) refers to the early or mild cognitive impairment induced by cerebral vascular injury. Research shows that serum total homocysteine (tHcy) level is an independent risk factor for cerebral vascular disease and may be closely related to cognitive function.Curren...

journal_title：BMC neurology

authors： Jiang B,Chen Y,Yao G,Yao C,Zhao H,Jia X,Zhang Y,Ge J,Qiu E,Ding C

更新日期：2014-11-30 00:00:00

abstract：BACKGROUND:Migraine is a highly prevalent disorder. The disability provoked by its attacks results in suffering as well as considerable economic and social losses. The objective of migraine acute treatment is to restore the patient to normal function as quickly and consistently as possible. There are numerous drugs ava...

journal_title：BMC neurology

authors： Krymchantowski AV

更新日期：2004-01-28 00:00:00

abstract：BACKGROUND:Alternating hemiplegia of childhood (AHC) is a rare neurological disorder that manifests recurrent attacks of hemiplegia, oculogyric, and choreoathetotic involuntary movements. De novo mutations in ATP1A3 cause three types of neurological diseases: AHC; rapid-onset dystonia-Parkinsonism (RDP); and cerebellar...

journal_title：BMC neurology

authors： Kanemasa H,Fukai R,Sakai Y,Torio M,Miyake N,Lee S,Ono H,Akamine S,Nishiyama K,Sanefuji M,Ishizaki Y,Torisu H,Saitsu H,Matsumoto N,Hara T

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:The partial form of the complex regional pain syndrome of the hand type 1 (CRPS 1), involving only 1 to 3 fingers, is a rare condition first described in 1972. The aim of the study is to define more precisely the diagnosis workup and the prognosis of this clinical entity. METHODS:Retrospective study of CRPS...

journal_title：BMC neurology

authors： Konzelmann M,Deriaz O,Luthi F

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:Anterior spinal cord herniation (aSCH) is a rare cause of myelopathy which may present as pure motor syndrome and mimic other degenerative diseases of the spinal cord. In slowly progressive cases, diagnosis may be impeded by equivocal imaging results and mistaken for evolving upper motor neuron disease. As e...

journal_title：BMC neurology

authors： Regensburger M,Schlachetzki JCM,Klekamp J,Doerfler A,Winkler J

更新日期：2020-08-29 00:00:00

abstract：BACKGROUND:Dopaminergic neuronal loss begins years before motor symptoms appear in Parkinson disease (PD). Thus, reliable biomarkers for early diagnosis and prognosis of PD are an essential pre-requisite to develop disease modifying therapies. Inflammation-derived oxidative stress is postulated to contribute to nigrost...

journal_title：BMC neurology

authors： Rathnayake D,Chang T,Udagama P

更新日期：2019-04-06 00:00:00

abstract：BACKGROUND:Different apoptosis pathways activate caspase-3. In a study involving 27 patients with traumatic brain injury (TBI), higher caspase-3 levels were found in contusion brain tissue resected from non-survivors than from survivors. The objective of this study was to determine whether there is an association in TB...

journal_title：BMC neurology

authors： Lorente L,Martín MM,Argueso M,Ramos L,Solé-Violán J,Riaño-Ruiz M,Jiménez A,Borreguero-León JM

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Stroke increases the risk of cognitive impairment even several years after the stroke event. The exact mechanisms of post-stroke cognitive decline are unclear, but the immunological response to stroke might play a role. The aims of the StrokeCog study are to examine the associations between immunological res...

journal_title：BMC neurology

authors： Drag LL,Mlynash M,Nassar H,Osborn E,Kim DE,Angst MS,Aghaeepour N,Buckwalter M,Lansberg MG

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Spinal cord infarction (SCI) is rarely caused by vertebral artery dissection (VAD), which is an important cause of posterior circulation stroke in young and middle-aged patients. We report the case of a middle-aged patient without obvious risk factors for atherosclerosis who had SCI from right VAD. CASE PRE...

journal_title：BMC neurology

authors： Meng YY,Dou L,Wang CM,Kong DZ,Wei Y,Wu LS,Yang Y,Zhou HW

更新日期：2019-12-12 00:00:00

abstract：BACKGROUND:Internal jugular vein stenosis (IJVS), characterized by a series of clinical manifestations, such as head and neck symptoms, visual and ear symptoms, as well as sleep disorder, has been receiving attention in recent years. However, its' etiologies are not fully understood. CASE PRESENTATION:We report a case...

journal_title：BMC neurology

authors： Li M,Sun Y,Chan CC,Fan C,Ji X,Meng R

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:The benefit of intravenous thrombolysis (IVT) for acute ischemic stroke is time dependent. Despite great effort, the median door-to-needle time (DNT) was 60 min at the United States stroke centers. We investigated the effect of a simple quality improvement initiative on DNT for IVT. METHODS:This is a single...

journal_title：BMC neurology

authors： Tran D,Zhu Z,Shafie M,Abcede H,Stradling D,Yu W

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:Past studies found that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But the reason of the concurrency remains unknown. The purpose of this study was to confirm whether angioarchitectural factors relate to the concurrence and which angioarchitectural facto...

journal_title：BMC neurology

authors： Yu T,Liu X,Lin X,Bai C,Zhao J,Zhang J,Zhang L,Wu Z,Wang S,Zhao Y,Meng G

更新日期：2016-09-22 00:00:00

abstract：BACKGROUND:Association of leukoencephalopathy and atypical mycobacteriosis has been rarely reported. We present a case that is relevant for its unusual presentation and because it may shed further light on the pathogenic mechanisms underlying reversible encephalopathies. CASE REPORT:We report the case of a Hispanic 64...

journal_title：BMC neurology

authors： Oliveira MC,Sato DK,Soares-Neto HR,Lucato LT,Callegaro D,Nitrini R,Medeiros RS,Misu T,Fujihara K,Castro LH

更新日期：2015-09-02 00:00:00

abstract：BACKGROUND:French Guiana has the highest incidence of ischemic and hemorrhagic stroke of all French territories. However, there is no further information on the epidemiology and management of stroke in French Guiana. Our goal was to describe the characteristics of patients in French Guiana in order to generate hypothes...

journal_title：BMC neurology

authors： Rochemont DR,Mimeau E,Misslin-Tritsch C,Papaix-Puech M,Delmas E,Bejot Y,DeToffol B,Fournel I,Nacher M

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:Assessing primary rehabilitation needs in patients with acquired brain injury is a challenge due to case complexity and the heterogeneity of symptoms after brain injury. The Rehabilitation Complexity Scale-Extended (RCS-E) is an instrument used in assessment of rehabilitation complexity in patients with seve...

journal_title：BMC neurology

authors： Maribo T,Pedersen AR,Jensen J,Nielsen JF

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Mechanical thrombectomy was approved by NICE as a treatment for stroke in 2016. However, most of the evidence is from studies conducted during working hours. Only few centres in the UK perform thrombectomies out-of-hours. The Royal Stoke University Hospital (RSUH) has offered thrombectomies over 24 h (24/7) ...

journal_title：BMC neurology

authors： Weddell J,Parr E,Knight S,Muddegowda G,Natarajan I,Chembala J,Ferdinand P,Ahmad N,Pencz Z,Rana S,Warusevitane A,Jadun C,Nayak S,Hashim Z,Augustine A,Sim J,Roffe C

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Gall bladder cancer (GBC) is associated with abdominal pain, lump, nausea, vomiting, and jaundice due to either gall bladder mass or the involved adjacent peritoneal structures. Gall bladder cancer presenting as refractory epilepsy is rare. Here we report a young female GBC patient who presented with an atyp...

journal_title：BMC neurology

authors： Pandey S,Garg RK,Malhotra HS,Uniyal R,Kumar N

更新日期：2019-05-10 00:00:00

abstract：BACKGROUND:The study of muscle metabolism by near-infrared spectroscopy (NIRS) has been poorly implemented in multiple sclerosis (MS). Aims of the study were to compare resting muscle oxygen consumption (rmVO2) at gastrocnemius in MS patients and in age-matched healthy controls (HC) measured using NIRS, and to evaluate...

journal_title：BMC neurology

authors： Malagoni AM,Felisatti M,Lamberti N,Basaglia N,Manfredini R,Salvi F,Zamboni P,Manfredini F

更新日期：2013-05-29 00:00:00

abstract：BACKGROUND:The major difficulty in postoperative care in patients after craniotomy is to distinguish the intracranial deficits from the residual effect of general anesthesia. In present study, we used cerebral state index (CSI) monitoring in patients after craniotomy with delayed recovery, and evaluated the prediction ...

journal_title：BMC neurology

authors： Xu M,Lei YN,Zhou JX

更新日期：2011-01-27 00:00:00