Abstract:
BACKGROUND:Stroke increases the risk of cognitive impairment even several years after the stroke event. The exact mechanisms of post-stroke cognitive decline are unclear, but the immunological response to stroke might play a role. The aims of the StrokeCog study are to examine the associations between immunological responses and long-term post-stroke cognitive trajectories in individuals with ischemic stroke. METHODS:StrokeCog is a single-center, prospective, observational, cohort study. Starting 6-12 months after stroke, comprehensive neuropsychological assessment, plasma and serum, and psychosocial variables will be collected at up to 4 annual visits. Single cell sequencing of peripheral blood monocytes and plasma proteomics will be conducted. The primary outcome will be the change in global and domain-specific neuropsychological performance across annual evaluations. To explain the differences in cognitive change amongst participants, we will examine the relationships between comprehensive immunological measures and these cognitive trajectories. It is anticipated that 210 participants will be enrolled during the first 3 years of this 4-year study. Accounting for attrition, an anticipated final sample size of 158 participants with an average of 3 annual study visits will be available at the completion of the study. Power analyses indicate that this sample size will provide 90% power to detect an average cognitive change of at least 0.23 standard deviations in either direction. DISCUSSION:StrokeCog will provide novel insight into the relationships between immune events and cognitive change late after stroke.
journal_name
BMC Neuroljournal_title
BMC neurologyauthors
Drag LL,Mlynash M,Nassar H,Osborn E,Kim DE,Angst MS,Aghaeepour N,Buckwalter M,Lansberg MGdoi
10.1186/s12883-020-01897-9subject
Has Abstractpub_date
2020-08-26 00:00:00pages
313issue
1issn
1471-2377pii
10.1186/s12883-020-01897-9journal_volume
20pub_type
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