Abstract:
BACKGROUND:The reliable and efficient measurement of spinal cord atrophy is of growing interest in monitoring disease progression in multiple sclerosis (MS). METHODS:We compared T1- and T2-weighted MRI for measuring cervical spinal cord volume in 31 patients with MS and 18 age-matched controls (NC) from T1-weighted gradient recalled echo and T2-weighted fast spin-echo 1.5 T axial acquisitions. The two sequences were matched on slice thickness, signal averages and voxel size. An active surface software tool determined the normalized mean cervical cord cross-sectional area. RESULTS:T1-derived cord areas were higher than T2 areas in the whole cohort (estimated mean difference = 7.03 mm(2) (8.89%); 95% Confidence Interval (CI): 5.91, 8.14; p < 0.0001) and in both groups separately. There were trends for lower spinal cord areas in MS vs. NC with both sequences. For the T1 cord area, the mean difference was 3.7 mm(2) (4.55%) (95% CI: -1.36, 8.78; p = 0.15). For the T2 cord area, the difference was larger [mean difference 4.9 mm(2) (6.52%) (95% CI: -0.83, 10.67); p = 0.091]. The T1 and T2 cord areas showed similar weak to moderate correlations with measures of clinical status and T2 spinal cord lesion volume in the MS group. Superficial spinal cord T2 lesions had no apparent confounding effect on the outlining tool. The mean intra-rater and inter-rater coefficients of variation ranged from 0.27 to 0.91% for T1- and 0.66 to 0.99% for T2-derived cord areas. CONCLUSION:T2-weighted images may prove efficient for measuring cervical spinal cord atrophy in MS, with the added advantage of lesion detectability.
journal_name
BMC Neuroljournal_title
BMC neurologyauthors
Kim G,Khalid F,Oommen VV,Tauhid S,Chu R,Horsfield MA,Healy BC,Bakshi Rdoi
10.1186/s12883-015-0387-0subject
Has Abstractpub_date
2015-07-31 00:00:00pages
124issn
1471-2377pii
10.1186/s12883-015-0387-0journal_volume
15pub_type
杂志文章相关文献
BMC Neurology文献大全abstract:BACKGROUND:The Migraine Disability Assessment (MIDAS) questionnaire is widely used to determine the degree of migraine-related disability of subjects. So far, and to the best of our knowledge, no Spanish version of this tool has been validated. The questionnaire comprises seven items, with the first five constituting t...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01646-y
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:The objective of this study was to evaluate and identify the risk factors for developing a new or enlarged intracranial hemorrhage (ICH) after the placement of an external ventricular drain. METHODS:A single center, nested case-control study of individuals who received an external ventricular drain from Jun...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1030-7
更新日期:2018-03-07 00:00:00
abstract:BACKGROUND:The AD etiology is yet not properly known. Interactions among environmental factors, multiple susceptibility genes and aging, contribute to AD. This study investigates the factors that play role in causing AD and how changes in cellular pathways contribute to AD. METHODS:PUBMED database, MEDLINE database an...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/s12883-016-0765-2
更新日期:2016-11-22 00:00:00
abstract:BACKGROUND:Gall bladder cancer (GBC) is associated with abdominal pain, lump, nausea, vomiting, and jaundice due to either gall bladder mass or the involved adjacent peritoneal structures. Gall bladder cancer presenting as refractory epilepsy is rare. Here we report a young female GBC patient who presented with an atyp...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1318-2
更新日期:2019-05-10 00:00:00
abstract:BACKGROUND:There is conflicting information as to whether antiretroviral drugs with better central nervous system (CNS) penetration (neuroHAART) assist in improving neurocognitive function and suppressing cerebrospinal fluid (CSF) HIV RNA. The current review aims to better synthesise existing literature by using an inn...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/1471-2377-11-148
更新日期:2011-11-22 00:00:00
abstract:BACKGROUND:Rett syndrome (RTT) is a severe neurodevelopmental disorder mainly affecting females. One of the main clinical manifestations is hand stereotypies, which is presumed to based on dysfunction rather than on structural impairment. Reflex interictal discharge precipitated by tapping-lips in electroencephalogram ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1296-4
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Given the increasing emphasis on the community management of spinal cord injury (SCI), strategies that could be developed and implemented in order to empower and engage individuals with SCI in promoting their health and minimizing the risk of health conditions are required. A self-management program could be...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-014-0209-9
更新日期:2014-10-21 00:00:00
abstract:BACKGROUND:Road traffic accidents are known to be the main cause of traumatic brain injury (TBI). TBI is also a leading cause of death and disability. This study, by means of the idiographic approach (single-case experimental designs using multiple-baseline designs), has examined whether methylphenidate (MPH - trade na...
journal_title:BMC neurology
pub_type: 临床试验,杂志文章
doi:10.1186/s12883-020-01663-x
更新日期:2020-03-19 00:00:00
abstract:BACKGROUND:The time from injury to surgery (TIS) is critical in the functional recovery of individuals with traumatic acute subdural hematoma (TASDH). However, only few studies have confirmed such notion. METHODS:The data of TASDH patients who were surgically treated in Chia-Yi Christian Hospital between January 2008 ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01810-4
更新日期:2020-06-04 00:00:00
abstract:BACKGROUND:This study aimed to investigate the prevalence and clinical relevance of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) patients and healthy controls using extra- and intracranial colour Doppler sonography. METHODS:We examined 146 MS patients, presenting with a clinically isol...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-13-20
更新日期:2013-02-13 00:00:00
abstract:BACKGROUND:The genetic epidemiology of ischemic stroke remains relatively unstudied, and information about the genetic epidemiology of ischemic stroke in populations with significant minority representation is currently unavailable. METHODS:The Brain Attack Surveillance in Corpus Christi project (BASIC) is a populatio...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-5-20
更新日期:2005-10-31 00:00:00
abstract:BACKGROUND:Hemifacial atrophy (Parry-Romberg syndrome) is a relatively rare disease. The etiology of the disease is not clear. Some authors postulate its relation with limited scleroderma linearis. Linear scleroderma "en coup de sabre" is characterized by clinical presence of most commonly one-sided linear syndrome. In...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-9-39
更新日期:2009-07-27 00:00:00
abstract:BACKGROUND:Acceptance and Commitment Therapy (ACT), as a type of behavioral therapy, attempts to respond to changes in people's performance and their relationship to events. ACT can affect sleep quality by providing techniques to enhance the flexibility of patients' thoughts, yet maintaining mindfullness. Therefore, fo...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01883-1
更新日期:2020-08-13 00:00:00
abstract:BACKGROUND:The COVID-19 pandemic, which broke out in Wuhan in 2019, has become the global health crisis of our time. Elderly patients with certain fundamental diseases are more likely to develop severe cases. The secondary lesion following viral infection have only rarely been reported. CASE PRESENTATION:We here repor...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-02033-3
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study, effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia on focal embolic cerebral ischemia have been examined. METHODS:Focal ischemic injury was in...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-2-2
更新日期:2002-04-18 00:00:00
abstract:BACKGROUND:Recent consensus guidelines recommend pregabalin as a first-tier treatment for painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 mg/d (300 mg dosed BID) versus placebo for relieving DPN-associated neuropathic pain, and assessed its safety using objective measures of ne...
journal_title:BMC neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2377-8-33
更新日期:2008-09-16 00:00:00
abstract:BACKGROUND:In this paper, seizure types, and epilepsy syndromes are elucidated as per ILAE (2010) classification. A brief outline of the antiepileptic drug regimens used and the outcome of seizure control in a two -year period is presented. The applicability of the ILAE classification in resource limited countries has ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1514-0
更新日期:2019-11-15 00:00:00
abstract:BACKGROUND:Active Rehabilitation (AR) is a community peer-based concept for people with spinal cord injury (SCI) that is primarily delivered through brief residential training programmes. Despite a plethora of positive anecdotal evidence of AR programmes as life-changing experiences, the effects of AR-programmes have n...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1546-5
更新日期:2020-01-11 00:00:00
abstract:BACKGROUND:Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer's Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear. METHODS:Adults with chronic treated HIV disease were recruited (n = 43, aged 56.7 ± 7.9; 32% aged 60+; median ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0298-0
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Delayed post-hypoxic leukoencephalopathy (DPHL) is a demyelinating syndrome characterized by neurological relapse after an initial recovery from hypoxic brain injury. We describe a patient with impaired consciousness following DPHL, concurrent with injury of the ascending reticular activating system (ARAS) s...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-017-0917-z
更新日期:2017-07-19 00:00:00
abstract:BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants for the treatment of depression in patients with Parkinson's Disease (PD) but data on their efficacy are controversial. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials ...
journal_title:BMC neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2377-10-49
更新日期:2010-06-21 00:00:00
abstract:BACKGROUND:Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including central nervous system infections, however, Japanese encephalitis (JE, epidemic encephalitis type B) w...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-12-43
更新日期:2012-06-19 00:00:00
abstract:BACKGROUND:Central sensitization is thought to be an important contributing factor in many chronic pain disorders. The Central Sensitization Inventory (CSI) is a patient-reported measure frequently used to assess symptoms related to central sensitization. The aims of the study were to translate and cross-culturally ada...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01867-1
更新日期:2020-07-27 00:00:00
abstract:BACKGROUND:Assessment of subjective quality of life (QOL) of persons with multiple sclerosis (MS) could facilitate the detection of psychosocial aspects of disease that may otherwise go unrecognized. The objectives of the study were to (i) compare the QOL ratings of relapsing remitting (RRMS) and progressive (PMS) type...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-7-31
更新日期:2007-09-18 00:00:00
abstract:BACKGROUND:Neuroprotective strategies after cardiopulmonary resuscitation are currently the focus of experimental and clinical research. Levosimendan has been proposed as a promising drug candidate because of its cardioprotective properties, improved haemodynamic effects in vivo and reduced traumatic brain injury in vi...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-12-81
更新日期:2012-08-24 00:00:00
abstract:BACKGROUND:Myotonic dystrophy type 1 (MD1) is one of the most prevalent neuromuscular diseases, yet very little is known about how MD1 affects the lives of couples and how they themselves manage individually and together. To better match health care to their problems, concerns and needs, it is important to understand t...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-86
更新日期:2011-07-13 00:00:00
abstract:BACKGROUND:THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1434-z
更新日期:2019-08-29 00:00:00
abstract:BACKGROUND:Herpes simplex encephalitis is the most common type of sporadic encephalitis worldwide. Frank intracerebral hemorrhage complicating the disease course in herpes simplex encephalitis patients is rare, especially cases where surgical decompression is necessary. Here, we report a previously healthy female with ...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/s12883-018-1181-6
更新日期:2018-10-23 00:00:00
abstract:BACKGROUND:Cannabis therapy has been considered an effective treatment for spasticity, although clinical reports of symptom reduction in multiple sclerosis (MS) describe mixed outcomes. Recently introduced therapies of combined Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) extracts have potential for symptom ...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/1471-2377-9-59
更新日期:2009-12-04 00:00:00
abstract:BACKGROUND:Patients with vascular Ehlers-Danlos syndrome (EDS) occasionally suffer from arterial dissection. Eagle syndrome, which is caused by an elongated styloid process and also causes arterial dissection, is difficult to diagnose and could sometimes be overlooked. Little is known of the coexistence of these two di...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01866-2
更新日期:2020-07-21 00:00:00