Inverse relationship between Alzheimer's disease and cancer, and other factors contributing to Alzheimer's disease: a systematic review.

abstract：BACKGROUND:Silent brain infarcts are detected by neuroimaging in up to 20% of asymptomatic patients based on population studies. They are five times more frequent than stroke in general population, and increase significantly both with advancing age and hypertension. Moreover, they are independently associated with the ...

journal_title：BMC neurology

authors： Riba-Llena I,Jarca CI,Mundet X,Tovar JL,Orfila F,López-Rueda A,Nafría C,Fernández JL,Castañé X,Domingo M,Alvarez-Sabín J,Fernández-Cortiñas I,Maisterra O,Montaner J,Delgado P

更新日期：2013-10-02 00:00:00

abstract：BACKGROUND:Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate. In this study, the temporal profile of ischemic stroke lesion sizes was assessed for more than one year to evaluate the effect of edaravone which m...

journal_title：BMC neurology

authors： Nakase T,Yoshioka S,Suzuki A

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Phase I/II placebo-controlled clinical trials of recombinant Factor VIIa (rFVIIa) suggested that administration of rFVIIa within 4 hours after onset of intracerebral hemorrhage (ICH) is safe, limits ICH growth, and improves outcomes. We sought to determine the cost-effectiveness of rFVIIa for acute ICH treat...

journal_title：BMC neurology

authors： Kissela BM,Eckman MH

更新日期：2008-05-19 00:00:00

abstract：BACKGROUND:Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is an autosomal recessive inherited disease of metabolic dysfunction clinically characterized by fluctuating proximal muscle weakness, excise intolerance, and dramatic riboflavin responsiveness. Dropped head syndrome can occasionally be observed in...

journal_title：BMC neurology

authors： Peng Y,Zhu M,Zheng J,Zhu Y,Li X,Wei C,Hong D

更新日期：2015-07-24 00:00:00

abstract：BACKGROUND:Spinal muscular atrophy (SMA) is an autosomal recessive disorder that affects the motoneurons of the spinal anterior horn, resulting in hypotonia and muscle weakness. The disease is caused by deletion or mutation in the telomeric copy of SMN gene (SMN1) and clinical severity is in part determined by the copy...

journal_title：BMC neurology

authors： Darbar IA,Plaggert PG,Resende MB,Zanoteli E,Reed UC

更新日期：2011-03-24 00:00:00

abstract：BACKGROUND:The available health resources limit the amount of therapy that may be offered to children with cerebral palsy and the amount of training in each session may be insufficient to drive the neuroplastic changes, which are necessary for functional improvements to take place. The aim of this pilot study was to pr...

journal_title：BMC neurology

authors： Bilde PE,Kliim-Due M,Rasmussen B,Petersen LZ,Petersen TH,Nielsen JB

更新日期：2011-03-09 00:00:00

abstract：BACKGROUND:In the pathogenesis of limbic encephalitis other promoting factors besides the pure existence of autoantibodies are increasingly discussed to play a significant role. This is to our knowledge the first described patient in whom the presence of autoantibodies precedes the manifestation of limbic encephalitis ...

journal_title：BMC neurology

authors： Fauser S,Uttner I,Ariño H,Scherbaum WA,Saiz A,Lewerenz J

更新日期：2015-09-30 00:00:00

abstract：BACKGROUND:We aimed to develop a tool, the hemorrhagic transformation (HT) index (HTI), to predict any HT within 14 days after middle cerebral artery (MCA) stroke onset regardless of the intravenous recombinant tissue plasminogen activator (IV rtPA) use. That is especially important in the light of missing evidence-bas...

journal_title：BMC neurology

authors： Kalinin MN,Khasanova DR,Ibatullin MM

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:Sub-cortical vascular ischaemia is the second most common etiology contributing to cognitive impairment in older adults, and is frequently under-diagnosed and under-treated. Although evidence is mounting that exercise has benefits for cognitive function among seniors, very few randomized controlled trials of...

journal_title：BMC neurology

authors： Liu-Ambrose T,Eng JJ,Boyd LA,Jacova C,Davis JC,Bryan S,Lee P,Brasher P,Hsiung GY

更新日期：2010-02-17 00:00:00

abstract：:Following publication of the original article [1], the authors reported an error in Table 2 wherein the item numbering in the first column is wrong. ...

journal_title：BMC neurology

authors： da Silva ESM,Santos GL,Catai AM,Borstad A,Furtado NPD,Aniceto IAV,Russo TL

更新日期：2019-09-13 00:00:00

abstract：BACKGROUND:The genetic epidemiology of ischemic stroke remains relatively unstudied, and information about the genetic epidemiology of ischemic stroke in populations with significant minority representation is currently unavailable. METHODS:The Brain Attack Surveillance in Corpus Christi project (BASIC) is a populatio...

journal_title：BMC neurology

authors： Lisabeth LD,Smith MA,Brown DL,Uchino K,Morgenstern LB

更新日期：2005-10-31 00:00:00

abstract：BACKGROUND:Many migraineurs who seek care in headache clinics are refractory to treatment, despite advances in headache therapies. Epidemiology is poorly characterized, because diagnostic criteria for refractory migraine were not available until recently. We aimed to determine the frequency of refractory migraine in pa...

journal_title：BMC neurology

authors： Irimia P,Palma JA,Fernandez-Torron R,Martinez-Vila E

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:A few reliable national data concerning the etiology of non-traumatic spinal cord injury (SCI) in sub-Sahara Africa exists, mainly because of the limitations of diagnostic imaging. These are both expensive and mostly unavailable in several resource-limited settings. Only a few studies have employed the magne...

journal_title：BMC neurology

authors： Musubire AK,Meya DB,Katabira ET,Meyer ACL,Bohjanen PR,Boulware DR,Minja F

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Admission hyperglycemia (HG) has been associated with worse outcomes among acute stroke patients. A better understanding and awareness of the potentially adverse influence of hyperglycemia on the clinical outcome of acute stroke patients would help to provide guidance for acute stroke management and preventi...

journal_title：BMC neurology

authors： Zewde YZ,Mengesha AT,Gebreyes YF,Naess H

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Seizures are one of the most important neurologic complications of human immuno-deficiency virus (HIV)-negative cryptococcal meningitis. A better understanding of the risk associated factors can help predict those who will require treatment. METHODS:This 22-year retrospective study enrolled 180 patients. Pr...

journal_title：BMC neurology

authors： Hung CW,Chang WN,Kung CT,Tsai NW,Wang HC,Lin WC,Huang CR,Huang CC,Tsai WC,Chang HW,Su YJ,Lin YJ,Cheng BC,Chang YT,Su CM,Lu CH

更新日期：2014-10-13 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (CMV) is an ubiquitous pathogen capable of modulating the host immune system. Immune dysfunction is common during CMV infection and includes autoimmune phenomena. Here we focus on a case of primary CMV infection associated with encephalopathy in a patient with a rudimentary spleen. We d...

journal_title：BMC neurology

authors： Xu X,Bergman P,Willows T,Tammik C,Sund M,Hökfelt T,Söderberg-Naucler C,Varani S

更新日期：2012-09-04 00:00:00

abstract：BACKGROUND:An Early Supported Discharge (ESD) and rehabilitation from a coordinated team in the home environment is recommended in several high-income countries for patients with mild to moderate symptoms after stroke. Returning home from the hospital takes place very early in Sweden today (12 days post stroke), thus t...

journal_title：BMC neurology

authors： Nordin Å,Sunnerhagen KS,Axelsson ÅB

更新日期：2015-11-16 00:00:00

abstract：BACKGROUND:Epigenetics underlying refractory epilepsy is poorly understood. DNA methylation may affect gene expression in epilepsy patients without affecting DNA sequences. Herein, we investigated the association between Carbamazepine-resistant (CBZ-resistant) epilepsy and EPHX1 methylation in a northern Han Chinese po...

journal_title：BMC neurology

authors： Lv Y,Zheng X,Shi M,Wang Z,Cui L

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Rett syndrome is a severe neurodevelopmental disorder that primarily affects females. Typical features include a loss of purposeful hand skills, development of hand stereotypies, loss of spoken language, gait abnormalities, and acquired microcephaly. However, Rett syndrome hasn't been recognized by clinical ...

journal_title：BMC neurology

authors： Lv Y,Liu C,Shi M,Cui L

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Spinal dysraphism with a hamartomatous growth (appendix) of the spinal cord is better known as herniated spinal cord. There are many arguments in favour of considering it a developmental defect. From this point of view, it is a type of neural tube disorder. Neural tube disorders can be caused by multiple fac...

journal_title：BMC neurology

authors： Bartels RHMA,Grotenhuis JA,Stegmann APA,Brunner H

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the central nervous system could lead to disease-specific PTMs detectable in the cerebrospinal fluid (C...

journal_title：BMC neurology

authors： Bäckryd E,Edström S,Gerdle B,Ghafouri B

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia. METHODS:Patients presenting with acute cerebral ischemic events were randomly assigned into aspirin (...

journal_title：BMC neurology

authors： Lee SJ,Lee JS,Choi MH,Lee SE,Shin DH,Hong JM

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs). METHODS:Ex-vivo treatment of AVM tissues: Intact AVM tissues were treated with doxycycline for 48 hours. Active and total MMP-9...

journal_title：BMC neurology

authors： Hashimoto T,Matsumoto MM,Li JF,Lawton MT,Young WL,University of California, San Francisco, BAVM Study Group.

更新日期：2005-01-24 00:00:00

abstract：BACKGROUND:Acute ischemic stroke attack with and without a recent TIA may differ in clinical risk factors, and this may affect treatment outcomes following thrombolytic therapy. We examined whether the odds of exclusion or inclusion for thrombolytic therapy are greater in ischemic stroke with TIA less than 24 h precedi...

journal_title：BMC neurology

authors： Poupore N,Strat D,Mackey T,Snell A,Nathaniel T

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Limb Girdle Muscular Dystrophy (LGMD), caused by defective α-dystroglycan (α-DG) glycosylation, was recently associated with mutations in Isoprenoid synthase domain-containing (ISPD) and GDP-mannose pyrophosphorylase B (GMPPB) genes. The frequency of ISPD and GMPPB gene mutations in the LGMD population is un...

journal_title：BMC neurology

authors： Magri F,Colombo I,Del Bo R,Previtali S,Brusa R,Ciscato P,Scarlato M,Ronchi D,D'Angelo MG,Corti S,Moggio M,Bresolin N,Comi GP

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid (Aβ) peptides in the wall of brain vasculature, commonly involving capillaries and arterioles. Also being considered a part of CAA is the Aβ deposition in leptomeninge. The cellular origin of angiopathic Aβ and the pathogenic course of C...

journal_title：BMC neurology

authors： Xue ZQ,He ZW,Yu JJ,Cai Y,Qiu WY,Pan A,Gai WP,Cai H,Luo XG,Ma C,Yan XX

更新日期：2015-05-02 00:00:00

abstract：BACKGROUND:The recent SLEEMSA study that evaluated excessive daytime sleepiness (EDS) in Caucasian patients with multiple system atrophy (MSA) demonstrated that EDS was more frequent in patients (28%) than in healthy subjects (2%). However, the prevalence and determinants of EDS in other ethnic populations have not bee...

journal_title：BMC neurology

authors： Shimohata T,Nakayama H,Tomita M,Ozawa T,Nishizawa M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Dopaminergic neuronal loss begins years before motor symptoms appear in Parkinson disease (PD). Thus, reliable biomarkers for early diagnosis and prognosis of PD are an essential pre-requisite to develop disease modifying therapies. Inflammation-derived oxidative stress is postulated to contribute to nigrost...

journal_title：BMC neurology

authors： Rathnayake D,Chang T,Udagama P

更新日期：2019-04-06 00:00:00

abstract：BACKGROUND:Patients with multiple sclerosis (MS) have a decreased frequency of CD8+ T cells reactive to their own Epstein-Barr virus (EBV) infected B cells. We have proposed that this might predispose to the development of MS by allowing EBV-infected autoreactive B cells to accumulate in the central nervous system. The...

journal_title：BMC neurology

authors： Pender MP,Csurhes PA,Pfluger CM,Burrows SR

更新日期：2011-08-03 00:00:00

abstract：BACKGROUND:The insular cortex is not routinely removed in modified functional hemispherectomy due to the risk of injury to the main arteries and to deep structures. Our study evaluates the safety and usefulness of applying intraoperative electrocorticography (ECoG) on the insular during the hemispherectomy. METHODS:We...

journal_title：BMC neurology

authors： Kim GH,Seo JH,Baumgartner JE,Ajmal F,Lee KH

更新日期：2017-08-25 00:00:00