Different EPHX1 methylation levels in promoter area between carbamazepine-resistant epilepsy group and carbamazepine-sensitive epilepsy group in Chinese population.

abstract：BACKGROUND:MS-pathogenesis is known to involve both multiple environmental events, and several independent genetic risk-factors. METHODS:A model of susceptibility is developed and a mathematical analysis undertaken to elucidate the nature of genetic susceptibility to MS and to understand the constraints that are place...

journal_title：BMC neurology

authors： Goodin DS

更新日期：2010-10-28 00:00:00

abstract：BACKGROUND:Ventral intermediate thalamic nucleus (VIM) deep brain stimulation (DBS) is an effective treatment for tremor, but there is limited data on long-term efficacy and mortality after VIM-DBS. Here we report the analysis of patient satisfaction and mortality in all patients treated in our center 1996-2010 with VI...

journal_title：BMC neurology

authors： Børretzen MN,Bjerknes S,Sæhle T,Skjelland M,Skogseid IM,Toft M,Dietrichs E

更新日期：2014-06-05 00:00:00

abstract：BACKGROUND:Due to lack of any curative therapy for ALS, symptomatic treatment and maintenance of quality of life (QoL) is very important. We aimed to characterize the affected domains of QoL in ALS patients and to identify factors which are associated with reduced QoL and increased depression. METHODS:159 ALS patients...

journal_title：BMC neurology

authors： Körner S,Kollewe K,Abdulla S,Zapf A,Dengler R,Petri S

更新日期：2015-05-16 00:00:00

abstract：BACKGROUND:Ropinirole prolonged release (RPR) is a once-daily formulation. However, there may be individual pharmacokinetic differences so that multiple dosing may be preferred in some individuals. This study compares once-daily and twice-daily RPR in patients with Parkinson's disease. METHODS:This study was an open-l...

journal_title：BMC neurology

authors： Yun JY,Kim HJ,Lee JY,Kim YE,Kim JS,Kim JM,Jeon BS

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:The clinical features of Alzheimer's disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four diffusion tensor imaging parameters in the white matter of patients with early stage AD, examined thei...

journal_title：BMC neurology

authors： Lee CC,Hsu SW,Huang CW,Chang WN,Chen SF,Wu MK,Chang CC,Hwang LC,Chen PC

更新日期：2017-10-06 00:00:00

abstract：BACKGROUND:Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular subtypes was not widely investigated. The relationship between molecular phenotype and histological sub...

journal_title：BMC neurology

authors： Tang Q,Lian Y,Yu J,Wang Y,Shi Z,Chen L

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:The character of upper limb disorder in computer operators is subject to debate. A peripheral nerve-involvement is suggested from the common presence of a triad of symptoms consisting of pain, paraestesiae and subjective weakness, and from physical findings suggesting neuropathy. This study aimed to examine ...

journal_title：BMC neurology

authors： Jepsen JR,Thomsen G

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Robotic devices are expected to be widely used in various applications including support for the independent mobility of the elderly with muscle weakness and people with impaired motor function as well as support for nursing care that involves heavy laborious work. We evaluated the effects of a hybrid assist...

journal_title：BMC neurology

authors： Maeshima S,Osawa A,Nishio D,Hirano Y,Takeda K,Kigawa H,Sankai Y

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not being able to give informed consent. In some nations, ethics committees will not approve of inclusion in a clinical study via consent of a legal representa...

journal_title：BMC neurology

authors： Hotter B,Ulm L,Hoffmann S,Katan M,Montaner J,Bustamante A,Meisel A

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:Anterior spinal cord herniation (aSCH) is a rare cause of myelopathy which may present as pure motor syndrome and mimic other degenerative diseases of the spinal cord. In slowly progressive cases, diagnosis may be impeded by equivocal imaging results and mistaken for evolving upper motor neuron disease. As e...

journal_title：BMC neurology

authors： Regensburger M,Schlachetzki JCM,Klekamp J,Doerfler A,Winkler J

更新日期：2020-08-29 00:00:00

abstract：BACKGROUND:Epilepsy is a major complication of stroke. We aimed to establish whether there is an association between intravenous thrombolysis, intra-arterial thrombolysis and post stroke seizure (PSS) development. Improved understanding of the relationship between reperfusion therapies and seizure development may impro...

journal_title：BMC neurology

authors： Naylor J,Thevathasan A,Churilov L,Guo R,Xiong Y,Koome M,Chen Z,Chen Z,Liu X,Kwan P,Campbell BCV

更新日期：2018-05-03 00:00:00

abstract：BACKGROUND:Chronic fatigue syndrome (CFS) is a disabling condition that affects approximately 800,000 adult Americans. The pathophysiology remains unknown and there are no diagnostic markers or characteristic physical signs or laboratory abnormalities. Most CFS patients complain of unrefreshing sleep and many of the po...

journal_title：BMC neurology

authors： Unger ER,Nisenbaum R,Moldofsky H,Cesta A,Sammut C,Reyes M,Reeves WC

更新日期：2004-04-19 00:00:00

abstract：BACKGROUND:Primary microcephaly is defined as reduced occipital-frontal circumference noticeable before 36 weeks of gestation. Large amount of insults might lead to microcephaly including infections, hypoxia and genetic mutations. More than 16 genes are described in autosomal recessive primary microcephaly. However, th...

journal_title：BMC neurology

authors： Picher-Martel V,Labrie Y,Rivest S,Lace B,Chrestian N

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI), defined as a transitional zone between normal cognition and dementia, requires a battery of formal neuropsychological tests administered by a trained rater for its diagnosis. The objective of this study was to develop a screening tool for MCI. METHODS:One hundred ninety seve...

journal_title：BMC neurology

authors： Guo QH,Zhou B,Zhao QH,Wang B,Hong Z

更新日期：2012-10-11 00:00:00

abstract：BACKGROUND:THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO...

journal_title：BMC neurology

authors： Kim HJ,Cho H,Park S,Jang H,Ryu YH,Choi JY,Moon SH,Oh SJ,Oh M,Na DL,Lyoo CH,Kim EJ,Seeley WW,Kim JS,Choi KC,Seo SW

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:This multicenter, double-blind, placebo-controlled study assessed the efficacy of rotigotine transdermal patch on apathy and motor symptoms in patients with Parkinson's disease (PD). METHODS:Patients with PD-associated apathy (Unified Parkinson's Disease Rating Scale [UPDRS] I item 4 [motivation] ≥2 and pat...

journal_title：BMC neurology

authors： Hauser RA,Slawek J,Barone P,Dohin E,Surmann E,Asgharnejad M,Bauer L

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants for the treatment of depression in patients with Parkinson's Disease (PD) but data on their efficacy are controversial. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials ...

journal_title：BMC neurology

authors： Skapinakis P,Bakola E,Salanti G,Lewis G,Kyritsis AP,Mavreas V

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:Active Rehabilitation (AR) is a community peer-based concept for people with spinal cord injury (SCI) that is primarily delivered through brief residential training programmes. Despite a plethora of positive anecdotal evidence of AR programmes as life-changing experiences, the effects of AR-programmes have n...

journal_title：BMC neurology

authors： Divanoglou A,Tasiemski T,Jörgensen S

更新日期：2020-01-11 00:00:00

abstract：BACKGROUND:Primary familial brain calcification is a rare autosomal dominant or recessive neurodegenerative disease, characterized by bilateral brain calcifications in different areas of the brain. It is a clinically heterogeneous disease and patients are reported to exhibit a wide spectrum of neurological and psychiat...

journal_title：BMC neurology

authors： Mathorne SW,Sørensen K,Fagerberg C,Bode M,Hertz JM

更新日期：2019-04-12 00:00:00

abstract：BACKGROUND:The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs). METHODS:Ex-vivo treatment of AVM tissues: Intact AVM tissues were treated with doxycycline for 48 hours. Active and total MMP-9...

journal_title：BMC neurology

authors： Hashimoto T,Matsumoto MM,Li JF,Lawton MT,Young WL,University of California, San Francisco, BAVM Study Group.

更新日期：2005-01-24 00:00:00

abstract：BACKGROUND:Recent consensus guidelines recommend pregabalin as a first-tier treatment for painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 mg/d (300 mg dosed BID) versus placebo for relieving DPN-associated neuropathic pain, and assessed its safety using objective measures of ne...

journal_title：BMC neurology

authors： Arezzo JC,Rosenstock J,Lamoreaux L,Pauer L

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:Stroke increases the risk of cognitive impairment even several years after the stroke event. The exact mechanisms of post-stroke cognitive decline are unclear, but the immunological response to stroke might play a role. The aims of the StrokeCog study are to examine the associations between immunological res...

journal_title：BMC neurology

authors： Drag LL,Mlynash M,Nassar H,Osborn E,Kim DE,Angst MS,Aghaeepour N,Buckwalter M,Lansberg MG

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Assessment of subjective quality of life (QOL) of persons with multiple sclerosis (MS) could facilitate the detection of psychosocial aspects of disease that may otherwise go unrecognized. The objectives of the study were to (i) compare the QOL ratings of relapsing remitting (RRMS) and progressive (PMS) type...

journal_title：BMC neurology

authors： Alshubaili AF,Awadalla AW,Ohaeri JU,Mabrouk AA

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is associated with vascular risk factors; brain ischemia facilitates the pathogenesis of AD. Recent studies have suggested that the reduction of AD risk with statin was achieved by decreased amyloidogenic amyloid precursor protein. METHODS:We used mitochondrial transgenic neuronal c...

journal_title：BMC neurology

authors： Jeong JH,Yum KS,Chang JY,Kim M,Ahn JY,Kim S,Lapchak PA,Han MK

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:Almost 40% of stroke patients have a poor outcome at 3 months after the index event. Predictors for stroke outcome in the early acute phase may help to tailor stroke treatment. Infection and inflammation are considered to influence stroke outcome. METHODS:In a prospective multicenter study in Germany and Sp...

journal_title：BMC neurology

authors： Mengel A,Ulm L,Hotter B,Harms H,Piper SK,Grittner U,Montaner J,Meisel C,Meisel A,Hoffmann S

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:The narcolepsy severity scale (NSS) was developed to measure the severity and consequences of symptoms in patients with narcolepsy. The scale has been validated in France, though no other studies have further validated this instrument. The current study aimed to present psychometric properties and describe t...

journal_title：BMC neurology

authors： Ouyang H,Han F,Zheng Q,Zhang J

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:Human serum paraoxonase 1 (PON1) plays a major role in the metabolism of several organophosphorus compounds. The enzyme is encoded by the polymorphic gene PON1, located on chromosome 7q21.3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative ass...

journal_title：BMC neurology

authors： Martínez C,Molina JA,Alonso-Navarro H,Jiménez-Jiménez FJ,Agúndez JA,García-Martín E

更新日期：2010-08-19 00:00:00

abstract：BACKGROUND:The etiologic determinants of stroke in young adults remain a diagnostic challenge in up to one-fourth of cases. Increasing evidences led to consider Fabry's disease (FD) as a possible cause to check up. We aimed at evaluating the prevalence of unrecognized FD in a cohort of patients with juvenile stroke in ...

journal_title：BMC neurology

authors： Fancellu L,Borsini W,Romani I,Pirisi A,Deiana GA,Sechi E,Doneddu PE,Rassu AL,Demurtas R,Scarabotto A,Cassini P,Arbustini E,Sechi G

更新日期：2015-12-12 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate and identify the risk factors for developing a new or enlarged intracranial hemorrhage (ICH) after the placement of an external ventricular drain. METHODS:A single center, nested case-control study of individuals who received an external ventricular drain from Jun...

journal_title：BMC neurology

authors： Rowe AS,Rinehart DR,Lezatte S,Langdon JR

更新日期：2018-03-07 00:00:00

abstract：BACKGROUND:Progressive Supranuclear Palsy (PSP) is the most frequent form of atypical Parkinsonism. Although there is preliminary evidence for the benefits of gait rehabilitation, balance training and oculomotor exercises in PSP, the quality of reporting of exercise therapies appears mixed. The current investigation ai...

journal_title：BMC neurology

authors： Slade SC,Underwood M,McGinley JL,Morris ME

更新日期：2019-11-29 00:00:00