A novel PDGFRB sequence variant in a family with a mild form of primary familial brain calcification: a case report and a review of the literature.

abstract：BACKGROUND:Anticoagulation using vitamin K antagonists (VKAs) significantly reduces the risk of recurrent stroke in stroke patients with atrial fibrillation (AF) and is recommended by guidelines. METHODS:The German Competence NETwork on Atrial Fibrillation established a nationwide prospective registry including 9,574 ...

journal_title：BMC neurology

authors： Haeusler KG,Gerth A,Limbourg T,Tebbe U,Oeff M,Wegscheider K,Treszl A,Ravens U,Meinertz T,Kirchhof P,Breithardt G,Steinbeck G,Nabauer M,AFNET registry investigators.

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:The evidence base for the effectiveness of psychological interventions for patients with dissociative non-epileptic seizures (DS) is currently extremely limited, although data from two small pilot randomised controlled trials (RCTs), including from our group, suggest that Cognitive Behavioural Therapy (CBT) ...

journal_title：BMC neurology

authors： Goldstein LH,Mellers JD,Landau S,Stone J,Carson A,Medford N,Reuber M,Richardson M,McCrone P,Murray J,Chalder T

更新日期：2015-06-27 00:00:00

abstract：BACKGROUND:Hydrocephalus is a common, life threatening complication of human immunodeficiency virus (HIV)-related central nervous system opportunistic infection which can be treated by insertion of a ventriculoperitoneal shunt (VPS). In HIV-infected patients there is concern that VPS might be associated with unacceptab...

journal_title：BMC neurology

authors： Loan JJM,Poon MTC,Tominey S,Mankahla N,Meintjes G,Fieggen AG

更新日期：2020-04-17 00:00:00

abstract：BACKGROUND:Several environmental exposures, including infection with Epstein-Barr virus, low levels of vitamin D and smoking are established risk factors for multiple sclerosis (MS). Also, high hygienic standard and infection with parasites have been proposed to influence MS risk. The aim of this study was to investiga...

journal_title：BMC neurology

authors： Gustavsen MW,Page CM,Moen SM,Bjølgerud A,Berg-Hansen P,Nygaard GO,Sandvik L,Lie BA,Celius EG,Harbo HF

更新日期：2014-10-03 00:00:00

abstract：BACKGROUND:In this paper, seizure types, and epilepsy syndromes are elucidated as per ILAE (2010) classification. A brief outline of the antiepileptic drug regimens used and the outcome of seizure control in a two -year period is presented. The applicability of the ILAE classification in resource limited countries has ...

journal_title：BMC neurology

authors： Mohamed IN,Elseed MA,Mohamed S,Alsir A,Hamid EK,Omer IM,Elsadig SM,Gerais YM,Osman AH,Bakhiet AM,Hamed AA

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:After discharge from hospital following a stroke, prescriptions of community-based rehabilitation are often downgraded to "maintenance" rehabilitation or discontinued. This classic therapeutic behavior stems from persistent confusion between lesion-induced plasticity, which lasts for the first 6 months essen...

journal_title：BMC neurology

authors： Gracies JM,Pradines M,Ghédira M,Loche CM,Mardale V,Hennegrave C,Gault-Colas C,Audureau E,Hutin E,Baude M,Bayle N,Neurorestore Study Group.

更新日期：2019-03-12 00:00:00

abstract：BACKGROUND:Epigenetics underlying refractory epilepsy is poorly understood. DNA methylation may affect gene expression in epilepsy patients without affecting DNA sequences. Herein, we investigated the association between Carbamazepine-resistant (CBZ-resistant) epilepsy and EPHX1 methylation in a northern Han Chinese po...

journal_title：BMC neurology

authors： Lv Y,Zheng X,Shi M,Wang Z,Cui L

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disorder characterised by loss of motor neurons leading to severe weakness and death from respiratory failure within 3-5 years. Riluzole prolongs survival in ALS. A published report has suggested a dramatic effect of lithium carbonate o...

journal_title：BMC neurology

authors： Al-Chalabi A,Shaw PJ,Young CA,Morrison KE,Murphy C,Thornhill M,Kelly J,Steen IN,Leigh PN,UKMND-LiCALS.

更新日期：2011-09-21 00:00:00

abstract：BACKGROUND:To assess the feasibility of using automated capture of Electronic Medical Record (EMR) data to build predictive models for amyotrophic lateral sclerosis (ALS) outcomes. METHODS:We used an Informatics for Integrating Biology and the Bedside search discovery tool to identify and extract data from 354 ALS pat...

journal_title：BMC neurology

authors： Karanevich AG,Weisbrod LJ,Jawdat O,Barohn RJ,Gajewski BJ,He J,Statland JM

更新日期：2018-12-14 00:00:00

abstract：BACKGROUND:This multicenter, double-blind, placebo-controlled study assessed the efficacy of rotigotine transdermal patch on apathy and motor symptoms in patients with Parkinson's disease (PD). METHODS:Patients with PD-associated apathy (Unified Parkinson's Disease Rating Scale [UPDRS] I item 4 [motivation] ≥2 and pat...

journal_title：BMC neurology

authors： Hauser RA,Slawek J,Barone P,Dohin E,Surmann E,Asgharnejad M,Bauer L

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:The production of inflammatory cytokines resulting from amyloid β (Aβ) is associated with the initiation of Alzheimer's disease (AD). Atorvastatin (ATV) has been reported to improve AD, however, it is unclear how the anti-inflammatory mechanism is linked with its protection against the impairment of spatial ...

journal_title：BMC neurology

authors： Zhao L,Chen T,Wang C,Li G,Zhi W,Yin J,Wan Q,Chen L

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), which are variably expressed in the brain, has been demonstrated to reduce seizure activity in muri...

journal_title：BMC neurology

authors： Erdogan MA,Yusuf D,Christy J,Solmaz V,Erdogan A,Taskiran E,Erbas O

更新日期：2018-06-07 00:00:00

abstract：BACKGROUND:Robotic devices are expected to be widely used in various applications including support for the independent mobility of the elderly with muscle weakness and people with impaired motor function as well as support for nursing care that involves heavy laborious work. We evaluated the effects of a hybrid assist...

journal_title：BMC neurology

authors： Maeshima S,Osawa A,Nishio D,Hirano Y,Takeda K,Kigawa H,Sankai Y

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:To investigate the prognostic value of hyponatremia, defined as serum sodium level < 135 mEq/L, in radiation-induced brain necrosis (RN) patients. METHODS:We performed a retrospective analysis of the RN patients (The patients included in our study had a history of primary cancers including nasopharyngeal ca...

journal_title：BMC neurology

authors： Liao H,Zhu Z,Rong X,Wang H,Peng Y

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Malignant myoepithelioma is a relatively rare malignant tumor occurring most frequently in the salivary glands. A few isolated cases have been described in other locations, including soft tissue, bone, lung, bronchus, oral cavity, nasopharynx, larynx, and maxillary sinus. Malignant myoepithelioma, however, i...

journal_title：BMC neurology

authors： Hong Y,Guo SX,Chen S,Klebe D,Zhang JM,Wu Q

更新日期：2013-05-04 00:00:00

abstract：BACKGROUND:Facioscapulohumeral muscular dystrophy (FSHD) is a dominantly-inherited progressive muscular dystrophy caused by de-repression of the DUX4 gene, which causes disease by a toxic-gain-of-function. As molecularly targeted drugs move from preclinical testing into human trials, it is essential that we validate cl...

journal_title：BMC neurology

authors： LoRusso S,Johnson NE,McDermott MP,Eichinger K,Butterfield RJ,Carraro E,Higgs K,Lewis L,Mul K,Sacconi S,Sansone VA,Shieh P,van Engelen B,Wagner K,Wang L,Statland JM,Tawil R,ReSolve Investigators and the FSHD CTRN18.

更新日期：2019-09-10 00:00:00

abstract：BACKGROUND:A frequent disorder after stroke is neglect, resulting in a failure to report or respond to contralesional stimuli. Rehabilitation of neglect is important, given the negative influence on motor recovery, independence in self-care, transfers, and locomotion. Effects of prism adaptation (PA) to alleviate negle...

journal_title：BMC neurology

authors： Ten Brink AF,Visser-Meily JM,Nijboer TC

更新日期：2015-02-04 00:00:00

abstract：BACKGROUND:The AD etiology is yet not properly known. Interactions among environmental factors, multiple susceptibility genes and aging, contribute to AD. This study investigates the factors that play role in causing AD and how changes in cellular pathways contribute to AD. METHODS:PUBMED database, MEDLINE database an...

journal_title：BMC neurology

authors： Shafi O

更新日期：2016-11-22 00:00:00

abstract：:The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates early in the drug-discovery process, and decreased the proportion of compounds failing in clinical trials for ADMET reasons. This paper reviews the history of ADM...

journal_title：BMC neurology

authors： Tsaioun K,Bottlaender M,Mabondzo A,Alzheimer's Drug Discovery Foundation.

更新日期：2009-06-12 00:00:00

abstract：BACKGROUND:Falls frequency increases with age and particularly in neurogeriatric cohorts. The interplay between eye movements and locomotion may contribute substantially to the occurrence of falls, but is hardly investigated. This paper provides an overview of current approaches to simultaneously measure eye and body m...

journal_title：BMC neurology

authors： Srulijes K,Mack DJ,Klenk J,Schwickert L,Ihlen EA,Schwenk M,Lindemann U,Meyer M,Srijana KC,Hobert MA,Brockmann K,Wurster I,Pomper JK,Synofzik M,Schneider E,Ilg U,Berg D,Maetzler W,Becker C

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:Sarcoidosis is a multi-organ disease of unknown etiology characterised by the presence of epithelioid granulomas, without caseous necrosis. Systemic sarcoidosis is rare among children, while neurosarcoidosis in children is even rarer whether it is systemic or not. CASE PRESENTATION:We described the case of ...

journal_title：BMC neurology

authors： Shijo K,Moro N,Sasano M,Watanabe M,Yagasaki H,Takahashi S,Homma T,Yoshino A

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:Type 2 Diabetes in Mexico has a high prevalence, 16-87% of patients may experience peripheral neuropathy. Early detection can prevent or halt its progression. The performance of Sudoscan in detecting neuropathy was compared to the Michigan Neuropathy Screening Instrument (MNSI). The aim was to identificate s...

journal_title：BMC neurology

authors： Carbajal-Ramírez A,Hernández-Domínguez JA,Molina-Ayala MA,Rojas-Uribe MM,Chávez-Negrete A

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:In adults, the anastomosis between carotid and vertebrobasilar arteries is usually the posterior communicating artery, sometimes the primitive trigeminal artery. In this case, the basilar artery fed the internal carotid artery through the pontine-to-tentorial artery anastomosis after severe stenosis from tra...

journal_title：BMC neurology

authors： Liu X,Li B,Liu Y,Wu H,Zhang H,Dou L,Liu C

更新日期：2020-03-17 00:00:00

abstract：BACKGROUND:A number of emerging studies have evaluated clot composition in acute ischemic stroke. Studies of clot composition of embolic strokes of undetermined strokes are lacking. OBJECTIVES:We sought to analyze the RBC to platelet ratios in clots and correlated our findings with stroke etiology. METHODS:This was a...

journal_title：BMC neurology

authors： Nouh A,Mehta T,Hussain M,Song X,Ollenschleger M

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:There is much discourse in healthcare about the importance of client-centred rehabilitation, however in the realm of community-based therapy post-stroke there has been little investigation into the efficacy of goal-directed practice that reflects patients' valued activities. In addition, the effect of active...

journal_title：BMC neurology

authors： Graven C,Brock K,Hill K,Ames D,Cotton S,Joubert L

更新日期：2011-06-18 00:00:00

abstract：BACKGROUND:Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate. In this study, the temporal profile of ischemic stroke lesion sizes was assessed for more than one year to evaluate the effect of edaravone which m...

journal_title：BMC neurology

authors： Nakase T,Yoshioka S,Suzuki A

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbness and leg weakness resulting in decreased productivity and social activity. The majority of sciatic...

journal_title：BMC neurology

authors： Verheijen E,Munts AG,van Haagen O,de Vries D,Dekkers O,van den Hout W,Vleggeert-Lankamp C

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy population. Assessing the comorbidity between ADHD and migraine may clarify the etiopathology of bot...

journal_title：BMC neurology

authors： Hansen TF,Hoeffding LK,Kogelman L,Haspang TM,Ullum H,Sørensen E,Erikstrup C,Pedersen OB,Nielsen KR,Hjalgrim H,Paarup HM,Werge T,Burgdorf K

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is associated with vascular risk factors; brain ischemia facilitates the pathogenesis of AD. Recent studies have suggested that the reduction of AD risk with statin was achieved by decreased amyloidogenic amyloid precursor protein. METHODS:We used mitochondrial transgenic neuronal c...

journal_title：BMC neurology

authors： Jeong JH,Yum KS,Chang JY,Kim M,Ahn JY,Kim S,Lapchak PA,Han MK

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:The Migraine Disability Assessment (MIDAS) questionnaire is widely used to determine the degree of migraine-related disability of subjects. So far, and to the best of our knowledge, no Spanish version of this tool has been validated. The questionnaire comprises seven items, with the first five constituting t...

journal_title：BMC neurology

authors： Rodríguez-Almagro D,Achalandabaso A,Rus A,Obrero-Gaitán E,Zagalaz-Anula N,Lomas-Vega R

更新日期：2020-02-24 00:00:00