Abstract:
BACKGROUND:Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disorder characterised by loss of motor neurons leading to severe weakness and death from respiratory failure within 3-5 years. Riluzole prolongs survival in ALS. A published report has suggested a dramatic effect of lithium carbonate on survival. 44 patients were studied, with 16 randomly selected to take LiCO3 and riluzole and 28 allocated to take riluzole alone. In the group treated with lithium, no patients had died (i.e., 100% survival) at the end of the study (15 months from entry), compared to 71% surviving in the riluzole-only group. Although the trial can be criticised on several grounds, there is a substantial rationale from other laboratory studies that lithium is worth investigating therapeutically in amyotrophic lateral sclerosis. METHODS/DESIGN:LiCALS is a multi-centre double-blind randomised parallel group controlled trial of the efficacy, safety, and tolerability of lithium carbonate (LiCO3) at doses to achieve stable 'therapeutic' plasma levels (0.4-0.8 mmol/L), plus standard treatment, versus matched placebo plus standard treatment, in patients with amyotrophic lateral sclerosis. The study will be based in the UK, in partnership with the MND Association and DeNDRoN (the Dementias and Neurodegnerative Diseases Clinical Research Network). 220 patients will be recruited. All patients will be on the standard treatment for ALS of riluzole 100 mg daily. The primary outcome measure will be death from any cause at 18 months defined from the date of randomisation. Secondary outcome measures will be changes in three functional rating scales, the ALS Functional Rating Scale-Revised, The EuroQOL (EQ-5D), and the Hospital Anxiety and Depression Scale.Eligible patients will have El Escorial Possible, Laboratory-supported Probable, Probable or Definite amyotrophic lateral sclerosis with disease duration between 6 months and 36 months (inclusive), vital capacity ≥ 60% of predicted within 1 month prior to randomisation and age at least18 years. DISCUSSION:Patient recruitment began in June 2009 and the last patient is expected to complete the trial protocol in November 2011. TRIAL REGISTRATION:Current controlled trials ISRCTN83178718.
journal_name
BMC Neuroljournal_title
BMC neurologyauthors
Al-Chalabi A,Shaw PJ,Young CA,Morrison KE,Murphy C,Thornhill M,Kelly J,Steen IN,Leigh PN,UKMND-LiCALS.doi
10.1186/1471-2377-11-111subject
Has Abstractpub_date
2011-09-21 00:00:00pages
111issn
1471-2377pii
1471-2377-11-111journal_volume
11pub_type
杂志文章,多中心研究,随机对照试验相关文献
BMC Neurology文献大全abstract:BACKGROUND:There is conflicting information as to whether antiretroviral drugs with better central nervous system (CNS) penetration (neuroHAART) assist in improving neurocognitive function and suppressing cerebrospinal fluid (CSF) HIV RNA. The current review aims to better synthesise existing literature by using an inn...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/1471-2377-11-148
更新日期:2011-11-22 00:00:00
abstract:BACKGROUND:A Transient Ischaemic Attack (TIA) bears a high risk of a subsequent ischaemic stroke. Adequate diagnosis of a TIA should be followed immediately by the start of appropriate preventive therapy, including antiplatelets. The diagnosis of a TIA based on symptoms and signs only is notoriously difficult and bioma...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0388-z
更新日期:2015-07-28 00:00:00
abstract:BACKGROUND:Taste disorder is a common symptom in the general population. Several studies have shown that patients with neurological disorders, such as amyotrophic lateral sclerosis and Parkinson's disease, develop taste disturbance. Facial onset sensory and motor neuronopathy (FOSMN) is a rare disease characterized by ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01639-x
更新日期:2020-02-29 00:00:00
abstract:BACKGROUND:To describe the clinical phenotype of paroxysmal extreme pain disorder, an autosomal dominant condition in four members in one family with the mutation NM_002977.3:c.3892G > T (p.Val1298Phe) in the SCN9A gene. Clinical examinations and details from members of one Polish family were collected, including age a...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01770-9
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:Deep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and factors associated with DVT in Asian patients with ischemic stroke. METHODS:Acute ischemic stroke ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01842-w
更新日期:2020-06-27 00:00:00
abstract:BACKGROUND:Guillain-Barré syndrome (GBS) is an autoimmune condition characterized by peripheral neuropathy. The pathogenesis of GBS is not fully understood, and the mechanism of how intravenous immunoglobulin (IVIG) cures GBS is ambiguous. Herein, we investigated lymphocyte subsets in patients with two major subtypes o...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-014-0202-3
更新日期:2014-10-15 00:00:00
abstract:BACKGROUND:Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), which are variably expressed in the brain, has been demonstrated to reduce seizure activity in muri...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1086-4
更新日期:2018-06-07 00:00:00
abstract:BACKGROUND:Chronic low back pain (CLBP) has been shown to be associated with various pathophysiological changes at several level of the sensorimotor system, pointing to a general hypersensitivity in CLBP patients. The aim of the present study was to investigate signs of generalized mechanical pain hypersensitivity in C...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-12-98
更新日期:2012-09-21 00:00:00
abstract:BACKGROUND:The narcolepsy severity scale (NSS) was developed to measure the severity and consequences of symptoms in patients with narcolepsy. The scale has been validated in France, though no other studies have further validated this instrument. The current study aimed to present psychometric properties and describe t...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1570-5
更新日期:2019-12-21 00:00:00
abstract:BACKGROUND:Epilepsy is a major complication of stroke. We aimed to establish whether there is an association between intravenous thrombolysis, intra-arterial thrombolysis and post stroke seizure (PSS) development. Improved understanding of the relationship between reperfusion therapies and seizure development may impro...
journal_title:BMC neurology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12883-018-1064-x
更新日期:2018-05-03 00:00:00
abstract:BACKGROUND:Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated with Parkinson disease (PD), multiple system atrophy (MSA), and pure autonomic failure. nOH can increase the risk of falls due to symptoms that include...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1129-x
更新日期:2018-08-25 00:00:00
abstract:BACKGROUND:The COVID-19 pandemic, which broke out in Wuhan in 2019, has become the global health crisis of our time. Elderly patients with certain fundamental diseases are more likely to develop severe cases. The secondary lesion following viral infection have only rarely been reported. CASE PRESENTATION:We here repor...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-02033-3
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs). METHODS:Ex-vivo treatment of AVM tissues: Intact AVM tissues were treated with doxycycline for 48 hours. Active and total MMP-9...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-5-1
更新日期:2005-01-24 00:00:00
abstract:BACKGROUND:Robotic devices are expected to be widely used in various applications including support for the independent mobility of the elderly with muscle weakness and people with impaired motor function as well as support for nursing care that involves heavy laborious work. We evaluated the effects of a hybrid assist...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-116
更新日期:2011-09-27 00:00:00
abstract:BACKGROUND:Cannabis therapy has been considered an effective treatment for spasticity, although clinical reports of symptom reduction in multiple sclerosis (MS) describe mixed outcomes. Recently introduced therapies of combined Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) extracts have potential for symptom ...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/1471-2377-9-59
更新日期:2009-12-04 00:00:00
abstract:BACKGROUND:Epidemiology of acute stroke in developing countries differs from that in the developed world, for example, the age at stroke, risk factors, subtypes of stroke and prognosis. Hypertension remains a dominant risk factor and prognostic indicator in patients with stroke in all communities. The risk of stroke is...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-4-1
更新日期:2004-01-06 00:00:00
abstract:BACKGROUND:Balanced Steady State Free Precession (b-SSFP) sequences and the newly developed Fast-Spin-Echo (FSE)-sequences enable an optimized visualization of neurovascular compression (NVC) in patients with trigeminal neuralgia (TN). Arterial conflicts are mostly associated with a favorable outcome of microvascular d...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01860-8
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:An Early Supported Discharge (ESD) and rehabilitation from a coordinated team in the home environment is recommended in several high-income countries for patients with mild to moderate symptoms after stroke. Returning home from the hospital takes place very early in Sweden today (12 days post stroke), thus t...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12883-015-0492-0
更新日期:2015-11-16 00:00:00
abstract:BACKGROUND:B-mode and Color Doppler ultrasonography (CDUS) are the methods of choice for screening and determining the degree of Carotid artery stenosis. The evaluation of stenosis with calcification may be hampered by a common CDUS artifact known as acoustic shadow (AS). Our objective was to assess the change in relia...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1405-4
更新日期:2019-07-29 00:00:00
abstract:BACKGROUND:BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) has been recently developed as brief, practical and universal assessment tool for cognitive impairment in MS subjects. It includes the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-2 (CVLT2) and the Brief Visu...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-014-0171-6
更新日期:2014-09-10 00:00:00
abstract:BACKGROUND:Ventral intermediate thalamic nucleus (VIM) deep brain stimulation (DBS) is an effective treatment for tremor, but there is limited data on long-term efficacy and mortality after VIM-DBS. Here we report the analysis of patient satisfaction and mortality in all patients treated in our center 1996-2010 with VI...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-14-120
更新日期:2014-06-05 00:00:00
abstract:BACKGROUND:The clinical features of Alzheimer's disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four diffusion tensor imaging parameters in the white matter of patients with early stage AD, examined thei...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-017-0970-7
更新日期:2017-10-06 00:00:00
abstract:BACKGROUND:Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed to synchronous mass activity owing the lack of inhibition. We assume that removal of exactly these frequency components from an auditory stimulus will cause the brain to reorganize ar...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2377-14-40
更新日期:2014-03-02 00:00:00
abstract:BACKGROUND:In the pathogenesis of limbic encephalitis other promoting factors besides the pure existence of autoantibodies are increasingly discussed to play a significant role. This is to our knowledge the first described patient in whom the presence of autoantibodies precedes the manifestation of limbic encephalitis ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0435-9
更新日期:2015-09-30 00:00:00
abstract:BACKGROUND:Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate. In this study, the temporal profile of ischemic stroke lesion sizes was assessed for more than one year to evaluate the effect of edaravone which m...
journal_title:BMC neurology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2377-11-39
更新日期:2011-03-30 00:00:00
abstract:BACKGROUND:Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not being able to give informed consent. In some nations, ethics committees will not approve of inclusion in a clinical study via consent of a legal representa...
journal_title:BMC neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12883-017-0989-9
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:Chest pain as the primary manifestation of epilepsy is extremely rare and has only been reported once to date. CASE PRESENTATION:We herein describe a 47-year-old woman with recurrent chest pain for 3 years. The cause of her chest pain remained elusive despite extensive investigations including comprehensive...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1575-0
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:Intravenous thrombolysis has been recently introduced in Nepal for the management of acute ischemic stroke. Pre-hospital delay is one of the main reasons that hinder thrombolytic therapy. The objective of this study was to evaluate the status of prehospital delay and thrombolysis in Nepal. METHODS:Data were...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1378-3
更新日期:2019-07-09 00:00:00
abstract:BACKGROUND:DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It plays a crucial role in embryonic development, imprinting and genome stability, cell differentiation. The dysfunction of this group of enzymes can lead to a vari...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1177-2
更新日期:2018-10-20 00:00:00
abstract:BACKGROUND:Spinal cord infarction (SCI) is rarely caused by vertebral artery dissection (VAD), which is an important cause of posterior circulation stroke in young and middle-aged patients. We report the case of a middle-aged patient without obvious risk factors for atherosclerosis who had SCI from right VAD. CASE PRE...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/s12883-019-1559-0
更新日期:2019-12-12 00:00:00