Chinese version of narcolepsy severity scale: a validation study.

abstract：BACKGROUND:Among patients with relapsing-remitting multiple sclerosis, relapses are associated with increased disability and decreased quality of life. Relapses are commonly treated with corticosteroids or left untreated. We aimed to better understand patient perceptions of the adequacy of corticosteroids in resolving ...

journal_title：BMC neurology

authors： Nickerson M,Marrie RA

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impairment (MCI) and involved in their pathophysiology. METHODS:Plasma samples and clinical data were obt...

journal_title：BMC neurology

authors： Kim SM,Song J,Kim S,Han C,Park MH,Koh Y,Jo SA,Kim YY

更新日期：2011-05-12 00:00:00

abstract：BACKGROUND:Multiple sclerosis is a chronic, incurable, demyelinating disease that requires long-term treatment. Rates of non-adherence to prescribed therapy of up to 50% have been reported for chronic diseases. Strategies to improve treatment adherence are therefore of the utmost importance. This study will evaluate th...

journal_title：BMC neurology

authors： Zettl UK,Bauer-Steinhusen U,Glaser T,Hechenbichler K,Limmroth V,Study Group.

更新日期：2013-09-06 00:00:00

abstract：BACKGROUND:The stability of hypoperfused brain tissue in stroke patients with major artery occlusions is unknown. The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients with ICA or proximal MCA occlusions. METHODS:Fourteen patients with ICA and/or proximal MCA occlusio...

journal_title：BMC neurology

authors： González RG,Hakimelahi R,Schaefer PW,Roccatagliata L,Sorensen AG,Singhal AB

更新日期：2010-02-10 00:00:00

abstract：BACKGROUND:Ropinirole prolonged release (RPR) is a once-daily formulation. However, there may be individual pharmacokinetic differences so that multiple dosing may be preferred in some individuals. This study compares once-daily and twice-daily RPR in patients with Parkinson's disease. METHODS:This study was an open-l...

journal_title：BMC neurology

authors： Yun JY,Kim HJ,Lee JY,Kim YE,Kim JS,Kim JM,Jeon BS

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:Deep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and factors associated with DVT in Asian patients with ischemic stroke. METHODS:Acute ischemic stroke ...

journal_title：BMC neurology

authors： Ha SH,Kim YJ,Heo SH,Chang DI,Kim BJ

更新日期：2020-06-27 00:00:00

abstract：BACKGROUND:Limb Girdle Muscular Dystrophy (LGMD), caused by defective α-dystroglycan (α-DG) glycosylation, was recently associated with mutations in Isoprenoid synthase domain-containing (ISPD) and GDP-mannose pyrophosphorylase B (GMPPB) genes. The frequency of ISPD and GMPPB gene mutations in the LGMD population is un...

journal_title：BMC neurology

authors： Magri F,Colombo I,Del Bo R,Previtali S,Brusa R,Ciscato P,Scarlato M,Ronchi D,D'Angelo MG,Corti S,Moggio M,Bresolin N,Comi GP

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Neuromuscular electrical stimulation (NMES) is commonly used to activate skeletal muscles and reverse muscle atrophy in clinical populations. Clinical recommendations for NMES suggest the use of short pulse widths (100-200 μs) and low-to-moderate pulse frequencies (30-50 Hz). However, this type of NMES cause...

journal_title：BMC neurology

authors： Bochkezanian V,Newton RU,Trajano GS,Vieira A,Pulverenti TS,Blazevich AJ

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Postherpetic neuralgia (PHN) is a painful and difficult to treat complication of acute herpes zoster. Current treatment options provide only partial relief and are often limited by poor tolerability. We evaluated the safety and efficacy of a single 60-minute application of NGX-4010, an 8% capsaicin patch, in...

journal_title：BMC neurology

authors： Webster LR,Tark M,Rauck R,Tobias JK,Vanhove GF

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:Recovery patterns of upper extremity motor function have been described in several longitudinal studies, but most of these studies have had selected samples, short follow up times or insufficient outcomes on motor function. The general understanding is that improvements in upper extremity occur mainly during...

journal_title：BMC neurology

authors： Alt Murphy M,Persson HC,Danielsson A,Broeren J,Lundgren-Nilsson A,Sunnerhagen KS

更新日期：2011-05-25 00:00:00

abstract：BACKGROUND:Parkinsonian symptoms have been associated with increased morbidity and mortality. Several studies have reported on the prevalence of signs and symptoms. Symptoms questionnaires can identify potential PD cases for further neurological examination to save resources. They can also provide information about how...

journal_title：BMC neurology

authors： Ishihara LS,Khaw KT,Luben R,Bingham S,Welch A,Day N,Brayne C

更新日期：2005-08-24 00:00:00

abstract：BACKGROUND:Neurocysticercosis (NC) is one of the most frequent parasitic diseases of the central nervous system. Cysticidal drugs, albendazole and praziquantel, are generally effective when parasites localize in the parenchyma. In contrast, parasites lodged in the subarachnoid basal cisterns are less responsive to trea...

journal_title：BMC neurology

authors： Cárdenas G,Carrillo-Mezo R,Jung H,Sciutto E,Hernandez JL,Fleury A

更新日期：2010-03-04 00:00:00

abstract：BACKGROUND:The character of upper limb disorder in computer operators is subject to debate. A peripheral nerve-involvement is suggested from the common presence of a triad of symptoms consisting of pain, paraestesiae and subjective weakness, and from physical findings suggesting neuropathy. This study aimed to examine ...

journal_title：BMC neurology

authors： Jepsen JR,Thomsen G

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Muscular weakness in myasthenia gravis (MG) is commonly assessed using Quantitative Myasthenia Gravis Score (QMG). More objective and quantitative measures may complement the use of clinical scales and might detect subclinical affection of muscles. We hypothesized that muscular weakness in patients with MG c...

journal_title：BMC neurology

authors： Hoffmann S,Siedler J,Brandt AU,Piper SK,Kohler S,Sass C,Paul F,Reilmann R,Meisel A

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Gall bladder cancer (GBC) is associated with abdominal pain, lump, nausea, vomiting, and jaundice due to either gall bladder mass or the involved adjacent peritoneal structures. Gall bladder cancer presenting as refractory epilepsy is rare. Here we report a young female GBC patient who presented with an atyp...

journal_title：BMC neurology

authors： Pandey S,Garg RK,Malhotra HS,Uniyal R,Kumar N

更新日期：2019-05-10 00:00:00

abstract：BACKGROUND:Spinal dysraphism with a hamartomatous growth (appendix) of the spinal cord is better known as herniated spinal cord. There are many arguments in favour of considering it a developmental defect. From this point of view, it is a type of neural tube disorder. Neural tube disorders can be caused by multiple fac...

journal_title：BMC neurology

authors： Bartels RHMA,Grotenhuis JA,Stegmann APA,Brunner H

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders that occur owing to the abnormalities in type 1 collagen, and is characterized by increased bone fragility and other extraskeletal manifestations. We report the case of a patient who was diagnosed with OI following subarachnoid hemo...

journal_title：BMC neurology

authors： Hirohata T,Miyawaki S,Mizutani A,Iwakami T,Yamada S,Nishido H,Suzuki Y,Miyamoto S,Hoya K,Murakami M,Matsuno A

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It plays a crucial role in embryonic development, imprinting and genome stability, cell differentiation. The dysfunction of this group of enzymes can lead to a vari...

journal_title：BMC neurology

authors： Zheng W,Yan Z,He R,Huang Y,Lin A,Huang W,Su Y,Li S,Zhang VW,Xie H

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular su...

journal_title：BMC neurology

authors： Wang J,Liu P,Liu Z,Tian Y,Zhang G,Guo J,Li L,Liu Z,Han Z,Lin W,Lin X,Lu Q,Liu Y,Chang Q,Wu S

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Recent consensus guidelines recommend pregabalin as a first-tier treatment for painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 mg/d (300 mg dosed BID) versus placebo for relieving DPN-associated neuropathic pain, and assessed its safety using objective measures of ne...

journal_title：BMC neurology

authors： Arezzo JC,Rosenstock J,Lamoreaux L,Pauer L

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:Mechanical thrombectomy was approved by NICE as a treatment for stroke in 2016. However, most of the evidence is from studies conducted during working hours. Only few centres in the UK perform thrombectomies out-of-hours. The Royal Stoke University Hospital (RSUH) has offered thrombectomies over 24 h (24/7) ...

journal_title：BMC neurology

authors： Weddell J,Parr E,Knight S,Muddegowda G,Natarajan I,Chembala J,Ferdinand P,Ahmad N,Pencz Z,Rana S,Warusevitane A,Jadun C,Nayak S,Hashim Z,Augustine A,Sim J,Roffe C

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO...

journal_title：BMC neurology

authors： Kim HJ,Cho H,Park S,Jang H,Ryu YH,Choi JY,Moon SH,Oh SJ,Oh M,Na DL,Lyoo CH,Kim EJ,Seeley WW,Kim JS,Choi KC,Seo SW

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs). METHODS:Ex-vivo treatment of AVM tissues: Intact AVM tissues were treated with doxycycline for 48 hours. Active and total MMP-9...

journal_title：BMC neurology

authors： Hashimoto T,Matsumoto MM,Li JF,Lawton MT,Young WL,University of California, San Francisco, BAVM Study Group.

更新日期：2005-01-24 00:00:00

abstract：BACKGROUND:A few reliable national data concerning the etiology of non-traumatic spinal cord injury (SCI) in sub-Sahara Africa exists, mainly because of the limitations of diagnostic imaging. These are both expensive and mostly unavailable in several resource-limited settings. Only a few studies have employed the magne...

journal_title：BMC neurology

authors： Musubire AK,Meya DB,Katabira ET,Meyer ACL,Bohjanen PR,Boulware DR,Minja F

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Intravenous thrombolysis has been recently introduced in Nepal for the management of acute ischemic stroke. Pre-hospital delay is one of the main reasons that hinder thrombolytic therapy. The objective of this study was to evaluate the status of prehospital delay and thrombolysis in Nepal. METHODS:Data were...

journal_title：BMC neurology

authors： Nepal G,Yadav JK,Basnet B,Shrestha TM,Kharel G,Ojha R

更新日期：2019-07-09 00:00:00

abstract：BACKGROUND:Stroke increases the risk of cognitive impairment even several years after the stroke event. The exact mechanisms of post-stroke cognitive decline are unclear, but the immunological response to stroke might play a role. The aims of the StrokeCog study are to examine the associations between immunological res...

journal_title：BMC neurology

authors： Drag LL,Mlynash M,Nassar H,Osborn E,Kim DE,Angst MS,Aghaeepour N,Buckwalter M,Lansberg MG

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Surgery is a potential trigger of Guillain-Barré syndrome (GBS), a disorder which leads to an autoimmune-mediated attack of peripheral nerves. The present study was designed to explore clinical features of post-surgical GBS compared with those of general GBS in order to provide better clinical advice to pati...

journal_title：BMC neurology

authors： Gong Q,Liu S,Liu Y,Yao J,Fu X,Xiao Z,Lu Z

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:This multicenter, double-blind, placebo-controlled study assessed the efficacy of rotigotine transdermal patch on apathy and motor symptoms in patients with Parkinson's disease (PD). METHODS:Patients with PD-associated apathy (Unified Parkinson's Disease Rating Scale [UPDRS] I item 4 [motivation] ≥2 and pat...

journal_title：BMC neurology

authors： Hauser RA,Slawek J,Barone P,Dohin E,Surmann E,Asgharnejad M,Bauer L

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:Spinal cord infarction (SCI) is rarely caused by vertebral artery dissection (VAD), which is an important cause of posterior circulation stroke in young and middle-aged patients. We report the case of a middle-aged patient without obvious risk factors for atherosclerosis who had SCI from right VAD. CASE PRE...

journal_title：BMC neurology

authors： Meng YY,Dou L,Wang CM,Kong DZ,Wei Y,Wu LS,Yang Y,Zhou HW

更新日期：2019-12-12 00:00:00

abstract：BACKGROUND:Post-stroke depression (PSD) is a mood disorder characterized by depression and anhedonia caused by stroke. Metabolomics identified metabolites associated with PSD, but previous studies are based on gas chromatography (GC)/mass spectrometry (MS). This study aimed to perform a liquid chromatography (LC)-MS-ba...

journal_title：BMC neurology

authors： Wang M,Gui X,Wu L,Tian S,Wang H,Xie L,Wu W

更新日期：2020-06-20 00:00:00