Quantitative motor assessment of muscular weakness in myasthenia gravis: a pilot study.

abstract：BACKGROUND:DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It plays a crucial role in embryonic development, imprinting and genome stability, cell differentiation. The dysfunction of this group of enzymes can lead to a vari...

journal_title：BMC neurology

authors： Zheng W,Yan Z,He R,Huang Y,Lin A,Huang W,Su Y,Li S,Zhang VW,Xie H

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs). METHODS:Ex-vivo treatment of AVM tissues: Intact AVM tissues were treated with doxycycline for 48 hours. Active and total MMP-9...

journal_title：BMC neurology

authors： Hashimoto T,Matsumoto MM,Li JF,Lawton MT,Young WL,University of California, San Francisco, BAVM Study Group.

更新日期：2005-01-24 00:00:00

abstract：BACKGROUND:The clinical impact of neutralizing antibodies against interferon-beta (NAb) is controversial. Their presence can lead to a decrease in interferon-beta (IFNβ) efficacy. Fatigue reported in patients with multiple sclerosis (MS) may be associated with an unfavorable clinical course. We conducted a prospective ...

journal_title：BMC neurology

authors： Manceau P,Latarche C,Pittion S,Edan G,de Sèze J,Massart C,Debouverie M

更新日期：2014-11-30 00:00:00

abstract：BACKGROUND:Cubital tunnel syndrome is common nerve compression syndrome among peripheral nerve compression diseases. However, the syndrome caused by intraneural ganglion cysts has been rarely reported. Medical approaches, like ultrasound-guided aspiration and open surgical treatment remain to be discussed. CASE PRESEN...

journal_title：BMC neurology

authors： Li P,Lou D,Lu H

更新日期：2018-12-22 00:00:00

abstract：BACKGROUND:Prediction of clinical outcome in the acute stage of ischaemic stroke can be difficult when based on patient characteristics, clinical findings and on non-contrast CT. CT perfusion and CT angiography may provide additional prognostic information and guide treatment in the early stage. We present the study pr...

journal_title：BMC neurology

authors： van Seeters T,Biessels GJ,van der Schaaf IC,Dankbaar JW,Horsch AD,Luitse MJ,Niesten JM,Mali WP,Kappelle LJ,van der Graaf Y,Velthuis BK,DUST investigators.

更新日期：2014-02-25 00:00:00

abstract：BACKGROUND:Few studies on whether etiologic subtype can predict outcome in mild stroke are available. The study aim to explore the effect of different etiologic subtype on prognosis of these patients. METHODS:We prospectively registered consecutive cases of acute ischemic stroke from September. 01, 2009 to August. 31,...

journal_title：BMC neurology

authors： Hao Z,Liu M,Wang D,Wu B,Tao W,Chang X

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:Hydrocephalus is a common, life threatening complication of human immunodeficiency virus (HIV)-related central nervous system opportunistic infection which can be treated by insertion of a ventriculoperitoneal shunt (VPS). In HIV-infected patients there is concern that VPS might be associated with unacceptab...

journal_title：BMC neurology

authors： Loan JJM,Poon MTC,Tominey S,Mankahla N,Meintjes G,Fieggen AG

更新日期：2020-04-17 00:00:00

abstract：BACKGROUND:Intracranial hemorrhage in central nervous system lymphoma is extremely rare. T2*-weighted gradient-echo magnetic resonance imaging is of particularly use in detecting silent hemorrhage as hypointense signals due to the deposition of paramagnetic hemosiderin or mineralization. Multifocal hemosiderin depositi...

journal_title：BMC neurology

authors： Yang XZ,Ni J,Cui LY

更新日期：2014-09-25 00:00:00

abstract：BACKGROUND:Chronic fatigue syndrome (CFS) is a disabling condition that affects approximately 800,000 adult Americans. The pathophysiology remains unknown and there are no diagnostic markers or characteristic physical signs or laboratory abnormalities. Most CFS patients complain of unrefreshing sleep and many of the po...

journal_title：BMC neurology

authors： Unger ER,Nisenbaum R,Moldofsky H,Cesta A,Sammut C,Reyes M,Reeves WC

更新日期：2004-04-19 00:00:00

abstract：BACKGROUND:Patients with vascular Ehlers-Danlos syndrome (EDS) occasionally suffer from arterial dissection. Eagle syndrome, which is caused by an elongated styloid process and also causes arterial dissection, is difficult to diagnose and could sometimes be overlooked. Little is known of the coexistence of these two di...

journal_title：BMC neurology

authors： Ikenouchi H,Takagi M,Nishimura A,Yamaguchi E,Koge J,Saito K,Toyoda K,Koga M

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Falls frequency increases with age and particularly in neurogeriatric cohorts. The interplay between eye movements and locomotion may contribute substantially to the occurrence of falls, but is hardly investigated. This paper provides an overview of current approaches to simultaneously measure eye and body m...

journal_title：BMC neurology

authors： Srulijes K,Mack DJ,Klenk J,Schwickert L,Ihlen EA,Schwenk M,Lindemann U,Meyer M,Srijana KC,Hobert MA,Brockmann K,Wurster I,Pomper JK,Synofzik M,Schneider E,Ilg U,Berg D,Maetzler W,Becker C

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:The aim of this study was to examine the stability and relative validity (RV) of the Neuromuscular Disease Impact Profile (NMDIP) using criterion-related groups. In a previous study the NMDIP-scales showed good internal consistency, convergent and discriminant validity. Known-groups analysis showed that the ...

journal_title：BMC neurology

authors： Bos I,Kuks JBM,Almansa J,Kremer HPH,Wynia K

更新日期：2017-05-11 00:00:00

abstract：BACKGROUND:In children with cerebral palsy (CP), stiffness, caused by contractile and non-contractile structures, can influence motor performance. This study sought to determine whether the nerve mobility had a relevant impact on motor performance in children with CP. We hypothesized that a positive Straight Leg Raise ...

journal_title：BMC neurology

authors： Marsico P,Tal-Akabi A,van Hedel HJ

更新日期：2016-10-07 00:00:00

abstract：BACKGROUND:Admission hyperglycemia (HG) has been associated with worse outcomes among acute stroke patients. A better understanding and awareness of the potentially adverse influence of hyperglycemia on the clinical outcome of acute stroke patients would help to provide guidance for acute stroke management and preventi...

journal_title：BMC neurology

authors： Zewde YZ,Mengesha AT,Gebreyes YF,Naess H

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Deep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and factors associated with DVT in Asian patients with ischemic stroke. METHODS:Acute ischemic stroke ...

journal_title：BMC neurology

authors： Ha SH,Kim YJ,Heo SH,Chang DI,Kim BJ

更新日期：2020-06-27 00:00:00

abstract：BACKGROUND:Interleukin 36 (IL-36) cytokines belong to the IL-1 family and play an important role in some autoimmune diseases. However, the relationship between IL-36 and neuromyelitis optica spectrum disorders (NMOSD) remains unclear. METHODS:We determined serum IL-36α, IL-36β and IL-36γ levels and assessed correlatio...

journal_title：BMC neurology

authors： Yang CS,Zhang QX,Deng Y,Zhou BJ,Zhang LJ,Li LM,Qi Y,Wang J,Yang L,Shi FD

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbness and leg weakness resulting in decreased productivity and social activity. The majority of sciatic...

journal_title：BMC neurology

authors： Verheijen E,Munts AG,van Haagen O,de Vries D,Dekkers O,van den Hout W,Vleggeert-Lankamp C

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurological symptoms other than visual impairment, secondary to bilateral papilledema. Correctly recognizing ...

journal_title：BMC neurology

authors： Zhao T,Wang G,Dai J,Liu Y,Wang Y,Li S

更新日期：2018-09-29 00:00:00

abstract：BACKGROUND:Assessing primary rehabilitation needs in patients with acquired brain injury is a challenge due to case complexity and the heterogeneity of symptoms after brain injury. The Rehabilitation Complexity Scale-Extended (RCS-E) is an instrument used in assessment of rehabilitation complexity in patients with seve...

journal_title：BMC neurology

authors： Maribo T,Pedersen AR,Jensen J,Nielsen JF

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including central nervous system infections, however, Japanese encephalitis (JE, epidemic encephalitis type B) w...

journal_title：BMC neurology

authors： Jia M,Xiong N,Huang J,Wang Y,Zhang X,Zhang Z,Cao X,Lin Z,Wang T

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:Silent brain infarcts are detected by neuroimaging in up to 20% of asymptomatic patients based on population studies. They are five times more frequent than stroke in general population, and increase significantly both with advancing age and hypertension. Moreover, they are independently associated with the ...

journal_title：BMC neurology

authors： Riba-Llena I,Jarca CI,Mundet X,Tovar JL,Orfila F,López-Rueda A,Nafría C,Fernández JL,Castañé X,Domingo M,Alvarez-Sabín J,Fernández-Cortiñas I,Maisterra O,Montaner J,Delgado P

更新日期：2013-10-02 00:00:00

abstract：BACKGROUND:The time from injury to surgery (TIS) is critical in the functional recovery of individuals with traumatic acute subdural hematoma (TASDH). However, only few studies have confirmed such notion. METHODS:The data of TASDH patients who were surgically treated in Chia-Yi Christian Hospital between January 2008 ...

journal_title：BMC neurology

authors： Chen SH,Sun JM,Fang WK

更新日期：2020-06-04 00:00:00

abstract：BACKGROUND:Many Polio survivors have reduced mobility, pain and fatigue, which make access to conventional forms of aerobic exercise difficult. Inactivity leads to increased risk of health problems, many of which are prevalent among Polio survivors. Aerobic exercise programmes in Polio survivors should utilise stable m...

journal_title：BMC neurology

authors： Murray D,Meldrum D,Moloney R,Campion A,Horgan F,Hardiman O

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:Myotonic dystrophy type 1 (MD1) is one of the most prevalent neuromuscular diseases, yet very little is known about how MD1 affects the lives of couples and how they themselves manage individually and together. To better match health care to their problems, concerns and needs, it is important to understand t...

journal_title：BMC neurology

authors： Cup EH,Kinébanian A,Satink T,Pieterse AJ,Hendricks HT,Oostendorp RA,van der Wilt GJ,van Engelen BG

更新日期：2011-07-13 00:00:00

abstract：BACKGROUND:Several environmental exposures, including infection with Epstein-Barr virus, low levels of vitamin D and smoking are established risk factors for multiple sclerosis (MS). Also, high hygienic standard and infection with parasites have been proposed to influence MS risk. The aim of this study was to investiga...

journal_title：BMC neurology

authors： Gustavsen MW,Page CM,Moen SM,Bjølgerud A,Berg-Hansen P,Nygaard GO,Sandvik L,Lie BA,Celius EG,Harbo HF

更新日期：2014-10-03 00:00:00

abstract：BACKGROUND:Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular su...

journal_title：BMC neurology

authors： Wang J,Liu P,Liu Z,Tian Y,Zhang G,Guo J,Li L,Liu Z,Han Z,Lin W,Lin X,Lu Q,Liu Y,Chang Q,Wu S

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders that occur owing to the abnormalities in type 1 collagen, and is characterized by increased bone fragility and other extraskeletal manifestations. We report the case of a patient who was diagnosed with OI following subarachnoid hemo...

journal_title：BMC neurology

authors： Hirohata T,Miyawaki S,Mizutani A,Iwakami T,Yamada S,Nishido H,Suzuki Y,Miyamoto S,Hoya K,Murakami M,Matsuno A

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:There is conflicting information as to whether antiretroviral drugs with better central nervous system (CNS) penetration (neuroHAART) assist in improving neurocognitive function and suppressing cerebrospinal fluid (CSF) HIV RNA. The current review aims to better synthesise existing literature by using an inn...

journal_title：BMC neurology

authors： Cysique LA,Waters EK,Brew BJ

更新日期：2011-11-22 00:00:00

abstract：BACKGROUND:In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia. METHODS:Patients presenting with acute cerebral ischemic events were randomly assigned into aspirin (...

journal_title：BMC neurology

authors： Lee SJ,Lee JS,Choi MH,Lee SE,Shin DH,Hong JM

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI), defined as a transitional zone between normal cognition and dementia, requires a battery of formal neuropsychological tests administered by a trained rater for its diagnosis. The objective of this study was to develop a screening tool for MCI. METHODS:One hundred ninety seve...

journal_title：BMC neurology

authors： Guo QH,Zhou B,Zhao QH,Wang B,Hong Z

更新日期：2012-10-11 00:00:00