Dorsolateral medullary infarction registry: a study protocol for a prospective, multicentric registry.

Abstract:

BACKGROUND:Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular surface environment after dorsolateral medullary infarction. METHODS:This study will involve consecutive data from all medical records of patients within 7 days of acute dorsolateral medullary infarction onset at the Departments of Neurology from 10 collaborating stroke centers. Eligible patients will mainly be characterized based on detailed physical examinations, multimodal imaging, and corneal related examinations and patients will be followed-up for 2 years. Neurotrophic keratopathy after dorsolateral medullary infarction is the primary endpoint. The dynamic histological corneal innervation and ocular surface environment after dorsolateral medullary infarction will be observed during the follow-up period. DISCUSSION:This multicentric, prospective registry is the first to identify and characterize the dynamic changes of corneal innervation and the ocular surface environment after acute dorsolateral medullary infarction. The significance of the study is to emphasize that the curative effect is based on the doctors' identification of the disease in the earliest stage before irreversible damage occurs to the cornea. TRIAL REGISTRATION:The registry was registered ( ChiCTR-OPC-17,011,625 ) on June 11, 2017.

journal_name

BMC Neurol

journal_title

BMC neurology

authors

Wang J,Liu P,Liu Z,Tian Y,Zhang G,Guo J,Li L,Liu Z,Han Z,Lin W,Lin X,Lu Q,Liu Y,Chang Q,Wu S

doi

10.1186/s12883-020-02030-6

subject

Has Abstract

pub_date

2021-01-12 00:00:00

pages

18

issue

1

issn

1471-2377

pii

10.1186/s12883-020-02030-6

journal_volume

21

pub_type

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