Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway.

abstract：BACKGROUND:Given the increasing emphasis on the community management of spinal cord injury (SCI), strategies that could be developed and implemented in order to empower and engage individuals with SCI in promoting their health and minimizing the risk of health conditions are required. A self-management program could be...

journal_title：BMC neurology

authors： Munce SE,Fehlings MG,Straus SE,Nugaeva N,Jang E,Webster F,Jaglal SB

更新日期：2014-10-21 00:00:00

abstract：BACKGROUND:Migraine is a highly prevalent disorder. The disability provoked by its attacks results in suffering as well as considerable economic and social losses. The objective of migraine acute treatment is to restore the patient to normal function as quickly and consistently as possible. There are numerous drugs ava...

journal_title：BMC neurology

authors： Krymchantowski AV

更新日期：2004-01-28 00:00:00

abstract：BACKGROUND:A number of emerging studies have evaluated clot composition in acute ischemic stroke. Studies of clot composition of embolic strokes of undetermined strokes are lacking. OBJECTIVES:We sought to analyze the RBC to platelet ratios in clots and correlated our findings with stroke etiology. METHODS:This was a...

journal_title：BMC neurology

authors： Nouh A,Mehta T,Hussain M,Song X,Ollenschleger M

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed a...

journal_title：BMC neurology

authors： Nakamura Y,Nakajima H,Tani H,Hosokawa T,Ishida S,Kimura F,Kaneko K,Takahashi T,Nakashima I

更新日期：2017-04-19 00:00:00

abstract：BACKGROUND:IncobotulinumtoxinA (Xeomin®) is a botulinum neurotoxin type A with established efficacy in the treatment of upper-limb spasticity in adults. This retrospective case series in a university hospital setting aimed to elucidate the safety and tolerability of incobotulinumtoxinA for treatment of spasticity in ch...

journal_title：BMC neurology

authors： León-Valenzuela A,Palacios JS,Del Pino Algarrada R

更新日期：2020-04-08 00:00:00

abstract：:Leakage of the blood-brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue where it is exposed to an inflammatory milieu and tissue damage, e.g., demyelination. Once in the CNS, albumin ca...

journal_title：BMC neurology

authors： LeVine SM

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Recent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinson's disease (PD). In our previous work, we sequenced the exomes of sixteen patients from eight Chinese PD families using whole exome sequencing technology, consequently three patients from different pedig...

journal_title：BMC neurology

authors： Liao XX,Zhan ZX,Luo YY,Li K,Wang JL,Guo JF,Yan XX,Xia K,Tang BS,Shen L

更新日期：2013-12-11 00:00:00

abstract：BACKGROUND:Post-stroke depression (PSD) is a mood disorder characterized by depression and anhedonia caused by stroke. Metabolomics identified metabolites associated with PSD, but previous studies are based on gas chromatography (GC)/mass spectrometry (MS). This study aimed to perform a liquid chromatography (LC)-MS-ba...

journal_title：BMC neurology

authors： Wang M,Gui X,Wu L,Tian S,Wang H,Xie L,Wu W

更新日期：2020-06-20 00:00:00

abstract：BACKGROUND:We aimed to develop a tool, the hemorrhagic transformation (HT) index (HTI), to predict any HT within 14 days after middle cerebral artery (MCA) stroke onset regardless of the intravenous recombinant tissue plasminogen activator (IV rtPA) use. That is especially important in the light of missing evidence-bas...

journal_title：BMC neurology

authors： Kalinin MN,Khasanova DR,Ibatullin MM

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:Partially thrombosed giant aneurysms at the basilar apex (BA) artery are challenging lesions with a poor prognosis if left untreated. Here we describe a rare case of extensive brain edema after growth of a surgically treated and thrombosed giant basilar apex aneurysm. CASE PRESENTATION:We performed a proxim...

journal_title：BMC neurology

authors： García-Pérez D,Panero I,Eiriz C,Moreno LM,Munarriz PM,Paredes I,Lagares A,Alén JF

更新日期：2020-06-06 00:00:00

abstract：BACKGROUND:THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO...

journal_title：BMC neurology

authors： Kim HJ,Cho H,Park S,Jang H,Ryu YH,Choi JY,Moon SH,Oh SJ,Oh M,Na DL,Lyoo CH,Kim EJ,Seeley WW,Kim JS,Choi KC,Seo SW

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:Herpes simplex encephalitis is the most common type of sporadic encephalitis worldwide. Frank intracerebral hemorrhage complicating the disease course in herpes simplex encephalitis patients is rare, especially cases where surgical decompression is necessary. Here, we report a previously healthy female with ...

journal_title：BMC neurology

authors： Byun YH,Ha EJ,Ko SB,Kim KH

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is associated with vascular risk factors; brain ischemia facilitates the pathogenesis of AD. Recent studies have suggested that the reduction of AD risk with statin was achieved by decreased amyloidogenic amyloid precursor protein. METHODS:We used mitochondrial transgenic neuronal c...

journal_title：BMC neurology

authors： Jeong JH,Yum KS,Chang JY,Kim M,Ahn JY,Kim S,Lapchak PA,Han MK

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:A few reliable national data concerning the etiology of non-traumatic spinal cord injury (SCI) in sub-Sahara Africa exists, mainly because of the limitations of diagnostic imaging. These are both expensive and mostly unavailable in several resource-limited settings. Only a few studies have employed the magne...

journal_title：BMC neurology

authors： Musubire AK,Meya DB,Katabira ET,Meyer ACL,Bohjanen PR,Boulware DR,Minja F

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Cognitive impairment commonly occurs in the acute phase post-stroke, but may persist with over half of all stroke survivors experiencing some form of long-term cognitive deficit. Recent evidence suggests that optimising secondary prevention adherence is a critical factor in preventing recurrent stroke and th...

journal_title：BMC neurology

authors： Mellon L,Brewer L,Hall P,Horgan F,Williams D,Hickey A,ASPIRE-S study group.

更新日期：2015-03-12 00:00:00

abstract：BACKGROUND:The time from injury to surgery (TIS) is critical in the functional recovery of individuals with traumatic acute subdural hematoma (TASDH). However, only few studies have confirmed such notion. METHODS:The data of TASDH patients who were surgically treated in Chia-Yi Christian Hospital between January 2008 ...

journal_title：BMC neurology

authors： Chen SH,Sun JM,Fang WK

更新日期：2020-06-04 00:00:00

abstract：BACKGROUND:The Observational Skills Assessment Score (OSAS) measures amount and quality of use of the affected hand in children with unilateral Cerebral Palsy (CP) in bimanual activities and could therefore be a valuable addition to existing assessment tools. The OSAS consists of tasks that are age appropriate and requ...

journal_title：BMC neurology

authors： Speth L,Janssen-Potten Y,Leffers P,Rameckers E,Defesche A,Geers R,Smeets R,Vles H

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:Complications after stroke have been associated with poor outcome. Modern stroke treatment might reduce the occurrence of complications. The aim of this study was to investigate whether the frequency and type of complications during the first week after stroke has changed in patients treated in a stroke unit...

journal_title：BMC neurology

authors： Bovim MR,Askim T,Lydersen S,Fjærtoft H,Indredavik B

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:Different studies have found diminished cardiac metaiodobenzylguanidine (MIBG) uptake in Lewy body (LB) related conditions (Parkinson's disease (PD) and Lewy body dementia (LBD)). However, delayed heart/mediastinum (d-H/M) ratio diagnostic cutoff points are debated in parkinsonian syndromes. METHODS:We perf...

journal_title：BMC neurology

authors： Lamotte G,Morello R,Lebasnier A,Agostini D,Defer GL

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity. Our purpose was to investigate the association of adherence to a Mediterranean diet and severity in a prospective hospital register of AIS patient...

journal_title：BMC neurology

authors： Lavados PM,Mazzon E,Rojo A,Brunser AM,Olavarría VV

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Progressive Supranuclear Palsy (PSP) is the most frequent form of atypical Parkinsonism. Although there is preliminary evidence for the benefits of gait rehabilitation, balance training and oculomotor exercises in PSP, the quality of reporting of exercise therapies appears mixed. The current investigation ai...

journal_title：BMC neurology

authors： Slade SC,Underwood M,McGinley JL,Morris ME

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospital stay post ischemic stroke on mortality is unclear. We determined whether the timing of OAC initia...

journal_title：BMC neurology

authors： Palm F,Kraus M,Safer A,Wolf J,Becher H,Grau AJ

更新日期：2014-10-08 00:00:00

abstract：BACKGROUND:"Anarchic hand" is a rare condition characterised by non-volitional, goal-directed movements of one arm. We report a case with analysis of structural and functional connectivity. CASE PRESENTATION:A 15 year old girl developed intermittent symptoms of intermanual conflict or anarchic hand as a result of trau...

journal_title：BMC neurology

authors： Basu AP,Taylor PN,Lowther E,Forsyth EO,Blamire AM,Forsyth RJ

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurological symptoms other than visual impairment, secondary to bilateral papilledema. Correctly recognizing ...

journal_title：BMC neurology

authors： Zhao T,Wang G,Dai J,Liu Y,Wang Y,Li S

更新日期：2018-09-29 00:00:00

abstract：BACKGROUND:Anterior spinal cord herniation (aSCH) is a rare cause of myelopathy which may present as pure motor syndrome and mimic other degenerative diseases of the spinal cord. In slowly progressive cases, diagnosis may be impeded by equivocal imaging results and mistaken for evolving upper motor neuron disease. As e...

journal_title：BMC neurology

authors： Regensburger M,Schlachetzki JCM,Klekamp J,Doerfler A,Winkler J

更新日期：2020-08-29 00:00:00

abstract：BACKGROUND:The coexistence of distinct neurodegenerative diseases in single cases has recently attracted greater attention. The phenotypic co-occurrence of progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) has been documented in several cases. That said, the clinicopathological comorbidity of...

journal_title：BMC neurology

authors： Fujita K,Matsubara T,Miyamoto R,Sumikura H,Takeuchi T,Maruyama Saladini K,Kawarai T,Nodera H,Udaka F,Kume K,Morino H,Kawakami H,Hasegawa M,Kaji R,Murayama S,Izumi Y

更新日期：2019-07-18 00:00:00

abstract：BACKGROUND:Dorsolateral medullary infarction (Wallenberg syndrome) is rare in clinical practice; however, the subsequent corneal lesions are more uncommon. To our knowledge, only one such case was previously reported. We report a similar case with successful treatment and recovery, and analyse both cases to address the...

journal_title：BMC neurology

authors： Wu S,Li N,Xia F,Sidlauskas K,Lin X,Qian Y,Gao W,Zhang Q

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:To investigate the prognostic value of hyponatremia, defined as serum sodium level < 135 mEq/L, in radiation-induced brain necrosis (RN) patients. METHODS:We performed a retrospective analysis of the RN patients (The patients included in our study had a history of primary cancers including nasopharyngeal ca...

journal_title：BMC neurology

authors： Liao H,Zhu Z,Rong X,Wang H,Peng Y

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Internal jugular vein stenosis (IJVS), characterized by a series of clinical manifestations, such as head and neck symptoms, visual and ear symptoms, as well as sleep disorder, has been receiving attention in recent years. However, its' etiologies are not fully understood. CASE PRESENTATION:We report a case...

journal_title：BMC neurology

authors： Li M,Sun Y,Chan CC,Fan C,Ji X,Meng R

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is an autosomal recessive inherited disease of metabolic dysfunction clinically characterized by fluctuating proximal muscle weakness, excise intolerance, and dramatic riboflavin responsiveness. Dropped head syndrome can occasionally be observed in...

journal_title：BMC neurology

authors： Peng Y,Zhu M,Zheng J,Zhu Y,Li X,Wei C,Hong D

更新日期：2015-07-24 00:00:00