Abstract：
BACKGROUND:The stability of hypoperfused brain tissue in stroke patients with major artery occlusions is unknown. The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients with ICA or proximal MCA occlusions. METHODS:Fourteen patients with ICA and/or proximal MCA occlusion and a diffusion/perfusion mismatch at presentation were studied. All were enrolled in a pilot randomized study of normobaric oxygen therapy. None received thrombolytic therapy; 8 received normobaric oxygen and 6 room air. Diffusion/perfusion MRI was performed at baseline, 4 hours, 24 hours, and 1 week. Abnormal DWI, ADC, and MTT volumes were determined using standard image analysis methods. RESULTS:The mean time from symptom onset to baseline MRI was 7.5 +/- 1 hours. Across all 4 time points there was a significant difference in DWI lesion (ANOVA, P < 0.0001) and abnormal MTT volumes (ANOVA, P < 0.01) with the 24 hour and 1 week abnormal volumes different from the earlier studies. However, comparing baseline and 4 hour scans, there was no significant interval change in the mean abnormal DWI volume (29.4 +/- 8.2 ml vs. 28.1 +/- 7.4 ml) or abnormal MTT volumes (137 +/- 17.7 ml vs. 130.9 +/- 13.8). By 24 hours, only 2 patients did not maintain a mismatch of 20% or greater. CONCLUSIONS:Patients who present outside the time window for thrombolytic therapy, and who have a large diffusion/perfusion mismatch on MRI may have a stable mismatch for 4 or more hours.
journal_name
BMC Neuroljournal_title
BMC neurologyauthors
González RG,Hakimelahi R,Schaefer PW,Roccatagliata L,Sorensen AG,Singhal ABdoi
10.1186/1471-2377-10-13subject
Has Abstractpub_date
2010-02-10 00:00:00pages
13issn
1471-2377pii
1471-2377-10-13journal_volume
10pub_type
杂志文章,随机对照试验相关文献
BMC Neurology文献大全abstract：BACKGROUND:The prognostic impact of preadmission use of calcium channel blockers (CCBs) and beta blockers (BBs) on stroke mortality remains unclear. We aimed to examine whether preadmission use of CCBs or BBs was associated with improved short-term mortality following ischemic stroke, intracerebral hemorrhage (ICH), or...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-015-0279-3
更新日期：2015-03-07 00:00:00
abstract：BACKGROUND:Nosocomial infection (NI) control is an important issue in neurocritical care due to secondary brain damage and the increased morbidity and mortality of primary acute neurocritical care patients. The primary aim of this study was to determine incidence of nosocomial infections and multidrug-resistant bacteri...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-018-1031-6
更新日期：2018-03-07 00:00:00
abstract：BACKGROUND:Patients often report neurocognitive difficulties after neuroborreliosis (NB). The frequency and extent of cognitive problems in European patients have been studied incompletely. METHODS:Sixty patients received a neurological and neuropsychological work-up 6 months or longer after treatment for proven NB. Q...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-015-0386-1
更新日期：2015-08-19 00:00:00
abstract：BACKGROUND:The cognitive consequences of carbon monoxide (CO) poisoning are well described. However, most studies have been carried out without an ad-hoc group of control subjects. The main aim of this study was to evaluate cognitive and psychiatric outcome after CO exposure during the storm Klaus in the South West of ...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/1471-2377-14-153
更新日期：2014-07-21 00:00:00
abstract：BACKGROUND:B-mode and Color Doppler ultrasonography (CDUS) are the methods of choice for screening and determining the degree of Carotid artery stenosis. The evaluation of stenosis with calcification may be hampered by a common CDUS artifact known as acoustic shadow (AS). Our objective was to assess the change in relia...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-019-1405-4
更新日期：2019-07-29 00:00:00
abstract：BACKGROUND:In children with cerebral palsy (CP), stiffness, caused by contractile and non-contractile structures, can influence motor performance. This study sought to determine whether the nerve mobility had a relevant impact on motor performance in children with CP. We hypothesized that a positive Straight Leg Raise ...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-016-0715-z
更新日期：2016-10-07 00:00:00
abstract：BACKGROUND:Myasthenic crisis is the most serious life-threatening event in generalized myasthenia gravis (MG) patients. The objective of this study was to assess the long-term impact of thymectomy on rate and severity of these attacks in Iranian patients. METHODS:We reviewed the clinical records from 272 myasthenic pa...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/1471-2377-4-12
更新日期：2004-09-11 00:00:00
abstract：BACKGROUND:Decision-making is an essential function of everyday life. Decision-making under explicit risk requires developing advantageous decision strategies based on fixed outcomes (e.g., probabilities of winning or losing a bet). Decision-making and its neural substrates have been rarely studied in MS. We expected p...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-015-0318-0
更新日期：2015-04-23 00:00:00
abstract：:The term paraproteinemic neuropathy describes a heterogeneous set of neuropathies characterized by the presence of homogeneous immunoglobulin in the serum. An abnormal clonal proliferation of B-lymphocytes or plasma cells, which may or may not occur in the context of a hematologic malignancy, produces the immunoglobul...
journal_title：BMC neurology
pub_type： 杂志文章,评审
doi：10.1186/s12883-016-0532-4
更新日期：2016-01-28 00:00:00
abstract：BACKGROUND:In adults, the anastomosis between carotid and vertebrobasilar arteries is usually the posterior communicating artery, sometimes the primitive trigeminal artery. In this case, the basilar artery fed the internal carotid artery through the pontine-to-tentorial artery anastomosis after severe stenosis from tra...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-020-01651-1
更新日期：2020-03-17 00:00:00
abstract：BACKGROUND:A Transient Ischaemic Attack (TIA) bears a high risk of a subsequent ischaemic stroke. Adequate diagnosis of a TIA should be followed immediately by the start of appropriate preventive therapy, including antiplatelets. The diagnosis of a TIA based on symptoms and signs only is notoriously difficult and bioma...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-015-0388-z
更新日期：2015-07-28 00:00:00
abstract：BACKGROUND:Muscular weakness in myasthenia gravis (MG) is commonly assessed using Quantitative Myasthenia Gravis Score (QMG). More objective and quantitative measures may complement the use of clinical scales and might detect subclinical affection of muscles. We hypothesized that muscular weakness in patients with MG c...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-015-0517-8
更新日期：2015-12-23 00:00:00
abstract：BACKGROUND:Primary microcephaly is defined as reduced occipital-frontal circumference noticeable before 36 weeks of gestation. Large amount of insults might lead to microcephaly including infections, hypoxia and genetic mutations. More than 16 genes are described in autosomal recessive primary microcephaly. However, th...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-020-01643-1
更新日期：2020-02-15 00:00:00
abstract：BACKGROUND:The available health resources limit the amount of therapy that may be offered to children with cerebral palsy and the amount of training in each session may be insufficient to drive the neuroplastic changes, which are necessary for functional improvements to take place. The aim of this pilot study was to pr...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/1471-2377-11-32
更新日期：2011-03-09 00:00:00
abstract：:In clinical neurology, a comprehensive understanding of consciousness has been regarded as an abstract concept--best left to philosophers. However, times are changing and the need to clinically assess consciousness is increasingly becoming a real-world, practical challenge. Current methods for evaluating altered level...
journal_title：BMC neurology
pub_type： 杂志文章,评审
doi：10.1186/1471-2377-10-11
更新日期：2010-01-29 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD) is associated with vascular risk factors; brain ischemia facilitates the pathogenesis of AD. Recent studies have suggested that the reduction of AD risk with statin was achieved by decreased amyloidogenic amyloid precursor protein. METHODS:We used mitochondrial transgenic neuronal c...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-015-0390-5
更新日期：2015-07-31 00:00:00
abstract：BACKGROUND:The insular cortex is not routinely removed in modified functional hemispherectomy due to the risk of injury to the main arteries and to deep structures. Our study evaluates the safety and usefulness of applying intraoperative electrocorticography (ECoG) on the insular during the hemispherectomy. METHODS:We...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-017-0940-0
更新日期：2017-08-25 00:00:00
abstract：BACKGROUND:Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for producing γ-aminobutyric acid, and it has been suggested that antibodies against GAD play a role in neurological conditions and type 1 diabetes. However, it is not known whether dementia appears as the sole neurological manifestation associate...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/1471-2377-11-156
更新日期：2011-12-21 00:00:00
abstract：BACKGROUND:The partial form of the complex regional pain syndrome of the hand type 1 (CRPS 1), involving only 1 to 3 fingers, is a rare condition first described in 1972. The aim of the study is to define more precisely the diagnosis workup and the prognosis of this clinical entity. METHODS:Retrospective study of CRPS...
journal_title：BMC neurology
pub_type： 杂志文章,评审
doi：10.1186/1471-2377-13-28
更新日期：2013-03-18 00:00:00
abstract：BACKGROUND:Complex Regional Pain Syndrome (CRPS) presents as chronic, continuous pain and sensory, autonomic, and motor abnormalities affecting one or more extremities. People with CRPS can also show changes in their perception of and attention to the affected body part and sensory information in the affected side of s...
journal_title：BMC neurology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12883-020-1604-z
更新日期：2020-02-19 00:00:00
abstract：BACKGROUND:Carotid angioplasty with stenting is a relatively new, increasingly used, less-invasive treatment for the treatment of symptomatic carotid artery stenosis. It is being evaluated in ongoing and nearly finished randomized trials. An important factor in the evaluation of stents is the occurrence of in-stent res...
journal_title：BMC neurology
pub_type： 杂志文章,评审
doi：10.1186/1471-2377-9-36
更新日期：2009-07-22 00:00:00
abstract：BACKGROUND:Neuromyelitis optica (NMO) includes transverse myelitis, optic neuritis and brain lesions. Recent studies have indicated that the brainstem is an important site of attack in NMO. Longitudinally extensive transverse myelitis (LETM) is an important component of the clinical diagnosis of NMO. The frequency of b...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/1471-2377-13-33
更新日期：2013-04-08 00:00:00
abstract：BACKGROUND:Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbness and leg weakness resulting in decreased productivity and social activity. The majority of sciatic...
journal_title：BMC neurology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12883-019-1445-9
更新日期：2019-09-03 00:00:00
abstract：BACKGROUND:The impact of comorbidity on multiple sclerosis (MS) is a new area of interest. Limited data on the risk factors of metabolic syndrome (MetS) is currently available. The aim of this study was to estimate the presence of comorbid conditions and MetS in a sample of adult patients with MS. METHODS:A retrospect...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-017-0914-2
更新日期：2017-07-17 00:00:00
abstract：BACKGROUND:Fatigue is a common complaint in multiple sclerosis (MS) and often interferes with daily functioning. Both clinicians and researchers may need to detect high levels of fatigue impact using a time and effort efficient tool. This study evaluates the psychometric properties of a rapid screening instrument for f...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/1471-2377-6-27
更新日期：2006-08-17 00:00:00
abstract：BACKGROUND:Past studies found that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But the reason of the concurrency remains unknown. The purpose of this study was to confirm whether angioarchitectural factors relate to the concurrence and which angioarchitectural facto...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-016-0691-3
更新日期：2016-09-22 00:00:00
abstract：BACKGROUND:Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospital stay post ischemic stroke on mortality is unclear. We determined whether the timing of OAC initia...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-014-0199-7
更新日期：2014-10-08 00:00:00
abstract：BACKGROUND:MS-pathogenesis is known to involve both multiple environmental events, and several independent genetic risk-factors. METHODS:A model of susceptibility is developed and a mathematical analysis undertaken to elucidate the nature of genetic susceptibility to MS and to understand the constraints that are place...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/1471-2377-10-101
更新日期：2010-10-28 00:00:00
abstract：BACKGROUND:Ramsay Hunt syndrome (RHS) is caused by a reactivation of varicella-zoster virus (VZV) infection, and it is characterized by the symptoms of facial paralysis, otalgia, auricular rash, and/or an oral lesion. Elderly patients or immunocompromised patients, deep pain at the initial visit and no prompt treatment...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-021-02071-5
更新日期：2021-01-28 00:00:00
abstract：BACKGROUND:Cognitive impairment commonly occurs in the acute phase post-stroke, but may persist with over half of all stroke survivors experiencing some form of long-term cognitive deficit. Recent evidence suggests that optimising secondary prevention adherence is a critical factor in preventing recurrent stroke and th...
journal_title：BMC neurology
pub_type： 杂志文章
doi：10.1186/s12883-015-0288-2
更新日期：2015-03-12 00:00:00
