Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?

Abstract:

BACKGROUND:Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are predisposing factors. We studied the correlation between MAP and HLA. METHODS:Five hundred thirty-one patients were searched for anti-MAP2694 antibodies, DRB1-DQB1 genotyping was performed. The haplotypes were classified as predisposing, neutral or protective. RESULTS:Anti-MAP2694 were found in 23 % of subjects carrying one protective HLA versus 32 % without (p = 0.04). CONCLUSIONS:We showed a lower frequency of Abs in patients with protective HLA. These haplotypes could have a protective role for both MS and MAP.

journal_name

BMC Neurol

journal_title

BMC neurology

authors

Frau J,Cossu D,Sardu C,Mameli G,Coghe G,Lorefice L,Fenu G,Tranquilli S,Sechi LA,Marrosu MG,Cocco E

doi

10.1186/s12883-016-0669-1

subject

Has Abstract

pub_date

2016-08-23 00:00:00

pages

148

issue

1

issn

1471-2377

pii

10.1186/s12883-016-0669-1

journal_volume

16

pub_type

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