Abstract:
BACKGROUND:Autonomic nervous system (ANS) dysfunction is present in up to one third of patients with tetanus. The prognostic value of ANS dysfunction is known in severe tetanus but its value is not well established in mild to moderate tetanus. METHODS:Medical records of all patients admitted with tetanus at two academic tertiary care centers in Karachi, Pakistan were reviewed. The demographic, clinical and laboratory data was recorded and analyzed. ANS dysfunction was defined as presence of labile or persistent hypertension or hypotension and sinus tachycardia, tachyarrythmia or bradycardia on EKG. Patients were divided into two groups based on presence of ANS dysfunction (ANS group and non ANS group). Tetanus severity was classified on the basis of Ablett criteria. RESULTS:Ninety six (64 males; 32 females) patients were admitted with the diagnosis over a period of 10 years. ANS group had 31 (32%) patients while non ANS group comprised of 65 (68%) patients. Both groups matched for age, gender, symptom severity, use of tetanus immunoglobulin and antibiotics. Twelve patients in ANS group had mild to moderate tetanus (Ablett I and II) and 19 patients had severe/very severe tetanus (Ablett III and IV). Fifteen (50%) patients in ANS group required ventilation as compared to 28 (45%) in non-ANS group (p = 0.09). Fourteen (47%) patients died in ANS group as compared to 10 (15%) in non ANS group (p= 0.002). Out of those 14 patients died in ANS group, six patients had mild to moderate tetanus and eight patients had severe/very severe tetanus. Major cause of death was cardiac arrhythmias (13/14; 93%) in ANS group and respiratory arrest (7/10; 70%) in non ANS group. Ten (33%) patients had complete recovery in ANS group while in non ANS group 35(48%) patients had complete recovery (p= 0.05). CONCLUSIONS:ANS dysfunction was present in one third of our tetanus population. 40% patients with ANS dysfunction had only mild to moderate tetanus. ANS dysfunction, irrespective of the need of mechanical ventilation or severity of tetanus, predicted poor outcome.
journal_name
BMC Neuroljournal_title
BMC neurologyauthors
Wasay M,Khealani BA,Talati N,Shamsi R,Syed NA,Salahuddin Ndoi
10.1186/1471-2377-5-2keywords:
subject
Has Abstractpub_date
2005-01-31 00:00:00pages
2issue
1issn
1471-2377pii
1471-2377-5-2journal_volume
5pub_type
杂志文章相关文献
BMC Neurology文献大全abstract:BACKGROUND:Although the precise etiology of multiple sclerosis is largely unknown, there is some speculation that a prior history of surgery may be associated with the subsequent risk for developing the disease. Therefore, we aimed to examine surgery as a risk factor for the diagnosis of multiple sclerosis. METHODS:We...
journal_title:BMC neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2377-13-41
更新日期:2013-05-06 00:00:00
abstract:BACKGROUND:The Migraine Disability Assessment (MIDAS) questionnaire is widely used to determine the degree of migraine-related disability of subjects. So far, and to the best of our knowledge, no Spanish version of this tool has been validated. The questionnaire comprises seven items, with the first five constituting t...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01646-y
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:Limb Girdle Muscular Dystrophy (LGMD), caused by defective α-dystroglycan (α-DG) glycosylation, was recently associated with mutations in Isoprenoid synthase domain-containing (ISPD) and GDP-mannose pyrophosphorylase B (GMPPB) genes. The frequency of ISPD and GMPPB gene mutations in the LGMD population is un...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0428-8
更新日期:2015-09-24 00:00:00
abstract:BACKGROUND:Effective control of (upright) body posture requires a proper representation of body orientation. Stroke patients with pusher syndrome were shown to suffer from severely disturbed perception of own body orientation. They experience their body as oriented 'upright' when actually tilted by nearly 20 degrees to...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-6-30
更新日期:2006-08-23 00:00:00
abstract:BACKGROUND:DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It plays a crucial role in embryonic development, imprinting and genome stability, cell differentiation. The dysfunction of this group of enzymes can lead to a vari...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1177-2
更新日期:2018-10-20 00:00:00
abstract:BACKGROUND:Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed to synchronous mass activity owing the lack of inhibition. We assume that removal of exactly these frequency components from an auditory stimulus will cause the brain to reorganize ar...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2377-14-40
更新日期:2014-03-02 00:00:00
abstract:BACKGROUND:Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospital stay post ischemic stroke on mortality is unclear. We determined whether the timing of OAC initia...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-014-0199-7
更新日期:2014-10-08 00:00:00
abstract:BACKGROUND:Deep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and factors associated with DVT in Asian patients with ischemic stroke. METHODS:Acute ischemic stroke ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01842-w
更新日期:2020-06-27 00:00:00
abstract:BACKGROUND:Patients with vascular Ehlers-Danlos syndrome (EDS) occasionally suffer from arterial dissection. Eagle syndrome, which is caused by an elongated styloid process and also causes arterial dissection, is difficult to diagnose and could sometimes be overlooked. Little is known of the coexistence of these two di...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01866-2
更新日期:2020-07-21 00:00:00
abstract:BACKGROUND:Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular subtypes was not widely investigated. The relationship between molecular phenotype and histological sub...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-017-0961-8
更新日期:2017-09-15 00:00:00
abstract:BACKGROUND:Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP is associated with various inflammatory, infectious, and malignant diseases, such as rheumatic arthritis, sarcoidosis, anti-neutrophil cytoplasmic antibody-associated vasculitis, IgG4-rela...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-1600-3
更新日期:2020-01-09 00:00:00
abstract:BACKGROUND:Embolectomy is the standard of care in acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). Aim of this study was to compare two techniques: A Direct Aspiration First Pass Technique (ADAPT) and Stent-retriever Assisted Vacuum-locked Extraction (SAVE) stratified by the occluded vessel. METHODS...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1291-9
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:In Asia, stroke incidence varies dramatically from country to country. Little is known about stroke incidence in Asians/Pacific Islanders in the US, where regional heterogeneity in Asian/Pacific Islander sub-populations is great. We sought to characterize both the national and regional incidences of first an...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-5-21
更新日期:2005-11-10 00:00:00
abstract:BACKGROUND:Chronic headache (headache ≥ 15 days/month for at least 3 months) affects 2-5% of the general population. Medication overuse contributes to the problem. Medication-overuse headache (MOH) can be identified by using the Severity of Dependence Scale (SDS). A "brief intervention" scheme (BI) has previously been ...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2377-12-70
更新日期:2012-08-10 00:00:00
abstract:BACKGROUND:Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbness and leg weakness resulting in decreased productivity and social activity. The majority of sciatic...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12883-019-1445-9
更新日期:2019-09-03 00:00:00
abstract:BACKGROUND:The cognitive consequences of carbon monoxide (CO) poisoning are well described. However, most studies have been carried out without an ad-hoc group of control subjects. The main aim of this study was to evaluate cognitive and psychiatric outcome after CO exposure during the storm Klaus in the South West of ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-14-153
更新日期:2014-07-21 00:00:00
abstract:BACKGROUND:Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare autosomal recessive congenital anomaly characterized by horizontal gaze limitation and progressive scoliosis. We investigated the underlying pathogenesis by incorporating diffusion tensor imaging and an electrophysiological study. CASE PRESE...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1081-9
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:Balanced Steady State Free Precession (b-SSFP) sequences and the newly developed Fast-Spin-Echo (FSE)-sequences enable an optimized visualization of neurovascular compression (NVC) in patients with trigeminal neuralgia (TN). Arterial conflicts are mostly associated with a favorable outcome of microvascular d...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01860-8
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:A fraction of patients with penetrating artery infarction (PAI) experience progressive motor deficit deterioration (PMD). We sought to investigate the role of high-sensitivity C-reactive protein (hs-CRP) at admission in predicting PMD. METHODS:From January 2015 to September 2018, consecutive patients with P...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1538-5
更新日期:2019-12-29 00:00:00
abstract:BACKGROUND:Chronic fatigue syndrome (CFS) is a disabling condition that affects approximately 800,000 adult Americans. The pathophysiology remains unknown and there are no diagnostic markers or characteristic physical signs or laboratory abnormalities. Most CFS patients complain of unrefreshing sleep and many of the po...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-4-6
更新日期:2004-04-19 00:00:00
abstract:BACKGROUND:The study of muscle metabolism by near-infrared spectroscopy (NIRS) has been poorly implemented in multiple sclerosis (MS). Aims of the study were to compare resting muscle oxygen consumption (rmVO2) at gastrocnemius in MS patients and in age-matched healthy controls (HC) measured using NIRS, and to evaluate...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-13-52
更新日期:2013-05-29 00:00:00
abstract:BACKGROUND:Partially thrombosed giant aneurysms at the basilar apex (BA) artery are challenging lesions with a poor prognosis if left untreated. Here we describe a rare case of extensive brain edema after growth of a surgically treated and thrombosed giant basilar apex aneurysm. CASE PRESENTATION:We performed a proxim...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01819-9
更新日期:2020-06-06 00:00:00
abstract:BACKGROUND:Robotic devices are expected to be widely used in various applications including support for the independent mobility of the elderly with muscle weakness and people with impaired motor function as well as support for nursing care that involves heavy laborious work. We evaluated the effects of a hybrid assist...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-116
更新日期:2011-09-27 00:00:00
abstract:BACKGROUND:Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurological symptoms other than visual impairment, secondary to bilateral papilledema. Correctly recognizing ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1156-7
更新日期:2018-09-29 00:00:00
abstract:BACKGROUND:"Anarchic hand" is a rare condition characterised by non-volitional, goal-directed movements of one arm. We report a case with analysis of structural and functional connectivity. CASE PRESENTATION:A 15 year old girl developed intermittent symptoms of intermanual conflict or anarchic hand as a result of trau...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0477-z
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular su...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-02030-6
更新日期:2021-01-12 00:00:00
abstract:BACKGROUND:Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for producing γ-aminobutyric acid, and it has been suggested that antibodies against GAD play a role in neurological conditions and type 1 diabetes. However, it is not known whether dementia appears as the sole neurological manifestation associate...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-156
更新日期:2011-12-21 00:00:00
abstract:BACKGROUND:There is conflicting information as to whether antiretroviral drugs with better central nervous system (CNS) penetration (neuroHAART) assist in improving neurocognitive function and suppressing cerebrospinal fluid (CSF) HIV RNA. The current review aims to better synthesise existing literature by using an inn...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/1471-2377-11-148
更新日期:2011-11-22 00:00:00
abstract:BACKGROUND:We imaged the corticospinal tract (CST) and corticoreticular pathway (CRP) using diffusion tensor tractography (DTT) to evaluate the cause of muscle weakness in a patient who was exposed to high-voltage electricity. CASE PRESENTATION:A 39-year-old man presented with quadriparesis after high-voltage electric...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01707-2
更新日期:2020-04-13 00:00:00
abstract:BACKGROUND:In this paper, seizure types, and epilepsy syndromes are elucidated as per ILAE (2010) classification. A brief outline of the antiepileptic drug regimens used and the outcome of seizure control in a two -year period is presented. The applicability of the ILAE classification in resource limited countries has ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1514-0
更新日期:2019-11-15 00:00:00