Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?

abstract：BACKGROUND:Gait ability and cognitive function are interrelated during both normal walking (NW) and dual-task walking (DTW), and gait ability is thus adversely affected by cognitive impairment in both situations. However, this association is insufficiently understood in people with mild cognitive impairment (MCI). Here...

journal_title：BMC neurology

authors： Doi T,Shimada H,Makizako H,Tsutsumimoto K,Uemura K,Anan Y,Suzuki T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders that occur owing to the abnormalities in type 1 collagen, and is characterized by increased bone fragility and other extraskeletal manifestations. We report the case of a patient who was diagnosed with OI following subarachnoid hemo...

journal_title：BMC neurology

authors： Hirohata T,Miyawaki S,Mizutani A,Iwakami T,Yamada S,Nishido H,Suzuki Y,Miyamoto S,Hoya K,Murakami M,Matsuno A

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospital stay post ischemic stroke on mortality is unclear. We determined whether the timing of OAC initia...

journal_title：BMC neurology

authors： Palm F,Kraus M,Safer A,Wolf J,Becher H,Grau AJ

更新日期：2014-10-08 00:00:00

abstract：BACKGROUND:Anticoagulation using vitamin K antagonists (VKAs) significantly reduces the risk of recurrent stroke in stroke patients with atrial fibrillation (AF) and is recommended by guidelines. METHODS:The German Competence NETwork on Atrial Fibrillation established a nationwide prospective registry including 9,574 ...

journal_title：BMC neurology

authors： Haeusler KG,Gerth A,Limbourg T,Tebbe U,Oeff M,Wegscheider K,Treszl A,Ravens U,Meinertz T,Kirchhof P,Breithardt G,Steinbeck G,Nabauer M,AFNET registry investigators.

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:Neuroprotective strategies after cardiopulmonary resuscitation are currently the focus of experimental and clinical research. Levosimendan has been proposed as a promising drug candidate because of its cardioprotective properties, improved haemodynamic effects in vivo and reduced traumatic brain injury in vi...

journal_title：BMC neurology

authors： Roehl AB,Zoremba N,Kipp M,Schiefer J,Goetzenich A,Bleilevens C,Kuehn-Velten N,Tolba R,Rossaint R,Hein M

更新日期：2012-08-24 00:00:00

abstract：BACKGROUND:Recent consensus guidelines recommend pregabalin as a first-tier treatment for painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 mg/d (300 mg dosed BID) versus placebo for relieving DPN-associated neuropathic pain, and assessed its safety using objective measures of ne...

journal_title：BMC neurology

authors： Arezzo JC,Rosenstock J,Lamoreaux L,Pauer L

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:A frequent disorder after stroke is neglect, resulting in a failure to report or respond to contralesional stimuli. Rehabilitation of neglect is important, given the negative influence on motor recovery, independence in self-care, transfers, and locomotion. Effects of prism adaptation (PA) to alleviate negle...

journal_title：BMC neurology

authors： Ten Brink AF,Visser-Meily JM,Nijboer TC

更新日期：2015-02-04 00:00:00

abstract：BACKGROUND:Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed to synchronous mass activity owing the lack of inhibition. We assume that removal of exactly these frequency components from an auditory stimulus will cause the brain to reorganize ar...

journal_title：BMC neurology

authors： Pantev C,Rudack C,Stein A,Wunderlich R,Engell A,Lau P,Wollbrink A,Shaykevich A

更新日期：2014-03-02 00:00:00

abstract：BACKGROUND:The medical imaging to differentiate World Health Organization (WHO) grade II (ODG2) from III (ODG3) oligodendrogliomas still remains a challenge. We investigated whether combination of machine leaning with radiomics from conventional T1 contrast-enhanced (T1 CE) and fluid attenuated inversion recovery (FLAI...

journal_title：BMC neurology

authors： Zhao SS,Feng XL,Hu YC,Han Y,Tian Q,Sun YZ,Zhang J,Ge XW,Cheng SC,Li XL,Mao L,Shen SN,Yan LF,Cui GB,Wang W

更新日期：2020-02-07 00:00:00

abstract：BACKGROUND:BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) has been recently developed as brief, practical and universal assessment tool for cognitive impairment in MS subjects. It includes the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-2 (CVLT2) and the Brief Visu...

journal_title：BMC neurology

authors： Goretti B,Niccolai C,Hakiki B,Sturchio A,Falautano M,Minacapelli E,Martinelli V,Incerti C,Nocentini U,Murgia M,Fenu G,Cocco E,Marrosu MG,Garofalo E,Ambra FI,Maddestra M,Consalvo M,Viterbo RG,Trojano M,Losignore NA,

更新日期：2014-09-10 00:00:00

abstract：BACKGROUND:Detecting malingering or exaggeration of impairments in brain function after traumatic brain injury is of increasing importance in neuropsychological assessment. Lawyers involved in brain injury litigation cases routinely coach their clients how to approach neuropsychological testing to their advantage. Thus...

journal_title：BMC neurology

authors： Rüsseler J,Brett A,Klaue U,Sailer M,Münte TF

更新日期：2008-10-07 00:00:00

abstract：BACKGROUND:To assess the feasibility of using automated capture of Electronic Medical Record (EMR) data to build predictive models for amyotrophic lateral sclerosis (ALS) outcomes. METHODS:We used an Informatics for Integrating Biology and the Bedside search discovery tool to identify and extract data from 354 ALS pat...

journal_title：BMC neurology

authors： Karanevich AG,Weisbrod LJ,Jawdat O,Barohn RJ,Gajewski BJ,He J,Statland JM

更新日期：2018-12-14 00:00:00

abstract：BACKGROUND:Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy population. Assessing the comorbidity between ADHD and migraine may clarify the etiopathology of bot...

journal_title：BMC neurology

authors： Hansen TF,Hoeffding LK,Kogelman L,Haspang TM,Ullum H,Sørensen E,Erikstrup C,Pedersen OB,Nielsen KR,Hjalgrim H,Paarup HM,Werge T,Burgdorf K

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:The study aims to assess the therapeutic benefits of motor imagery training in stroke patients with persistent motor weakness. There is evidence to suggest that mental rehearsal of movement can produce effects normally attributed to practising the actual movements. Imagining hand movements could stimulate th...

journal_title：BMC neurology

authors： Ietswaart M,Johnston M,Dijkerman HC,Scott CL,Joice SA,Hamilton S,Macwalter RS

更新日期：2006-10-26 00:00:00

abstract：BACKGROUND:The mechanisms underlying the interictal habituation deficit of cortical visual evoked potentials (VEP) in migraine are not well understood. Abnormal long-term functional plasticity of the visual cortex may play a role and it can be assessed experimentally by light deprivation (LD). METHODS:We have compared...

journal_title：BMC neurology

authors： Coppola G,Crémers J,Gérard P,Pierelli F,Schoenen J

更新日期：2011-07-27 00:00:00

abstract：BACKGROUND:An Early Supported Discharge (ESD) and rehabilitation from a coordinated team in the home environment is recommended in several high-income countries for patients with mild to moderate symptoms after stroke. Returning home from the hospital takes place very early in Sweden today (12 days post stroke), thus t...

journal_title：BMC neurology

authors： Nordin Å,Sunnerhagen KS,Axelsson ÅB

更新日期：2015-11-16 00:00:00

abstract：BACKGROUND:MS-pathogenesis is known to involve both multiple environmental events, and several independent genetic risk-factors. METHODS:A model of susceptibility is developed and a mathematical analysis undertaken to elucidate the nature of genetic susceptibility to MS and to understand the constraints that are place...

journal_title：BMC neurology

authors： Goodin DS

更新日期：2010-10-28 00:00:00

abstract：BACKGROUND:Primary microcephaly is defined as reduced occipital-frontal circumference noticeable before 36 weeks of gestation. Large amount of insults might lead to microcephaly including infections, hypoxia and genetic mutations. More than 16 genes are described in autosomal recessive primary microcephaly. However, th...

journal_title：BMC neurology

authors： Picher-Martel V,Labrie Y,Rivest S,Lace B,Chrestian N

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:Effective control of (upright) body posture requires a proper representation of body orientation. Stroke patients with pusher syndrome were shown to suffer from severely disturbed perception of own body orientation. They experience their body as oriented 'upright' when actually tilted by nearly 20 degrees to...

journal_title：BMC neurology

authors： Johannsen L,Broetz D,Karnath HO

更新日期：2006-08-23 00:00:00

abstract：BACKGROUND:There is conflicting information as to whether antiretroviral drugs with better central nervous system (CNS) penetration (neuroHAART) assist in improving neurocognitive function and suppressing cerebrospinal fluid (CSF) HIV RNA. The current review aims to better synthesise existing literature by using an inn...

journal_title：BMC neurology

authors： Cysique LA,Waters EK,Brew BJ

更新日期：2011-11-22 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate and identify the risk factors for developing a new or enlarged intracranial hemorrhage (ICH) after the placement of an external ventricular drain. METHODS:A single center, nested case-control study of individuals who received an external ventricular drain from Jun...

journal_title：BMC neurology

authors： Rowe AS,Rinehart DR,Lezatte S,Langdon JR

更新日期：2018-03-07 00:00:00

abstract：BACKGROUND:Stroke survivors encounter emotional problems in the chronic phase after stroke. Post-stroke depressive symptoms have major impact on health-related quality of life (HRQol) and lead to increased hospitalization and therefore substantial healthcare costs. We present a cost-effectiveness and cost-utility evalu...

journal_title：BMC neurology

authors： van Eeden M,Kootker JA,Evers SM,van Heugten CM,Geurts AC,van Mastrigt GA

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Spinal dysraphism with a hamartomatous growth (appendix) of the spinal cord is better known as herniated spinal cord. There are many arguments in favour of considering it a developmental defect. From this point of view, it is a type of neural tube disorder. Neural tube disorders can be caused by multiple fac...

journal_title：BMC neurology

authors： Bartels RHMA,Grotenhuis JA,Stegmann APA,Brunner H

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Elevated intracranial pressure from cerebral edema is the major cause of early mortality in acute stroke. Current treatment strategies to limit cerebral edema are not particularly effective. Some novel anti-edema measures have shown promising early findings in experimental stroke models. Vasopressin antagoni...

journal_title：BMC neurology

authors： Hedna VS,Bidari S,Gubernick D,Ansari S,Satriotomo I,Khan AA,Qureshi AI

更新日期：2014-11-18 00:00:00

abstract：BACKGROUND:To evaluate the effects and optimal parameters of repetitive transcranial magnetic stimulation (rTMS) on cognition function of patients with Parkinson's disease (PD) and to estimate which cognitive function may obtain more benefits from rTMS. METHOD:The articles dealing with rTMS on cognitive function of PD...

journal_title：BMC neurology

authors： Jiang Y,Guo Z,McClure MA,He L,Mu Q

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:The stability of hypoperfused brain tissue in stroke patients with major artery occlusions is unknown. The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients with ICA or proximal MCA occlusions. METHODS:Fourteen patients with ICA and/or proximal MCA occlusio...

journal_title：BMC neurology

authors： González RG,Hakimelahi R,Schaefer PW,Roccatagliata L,Sorensen AG,Singhal AB

更新日期：2010-02-10 00:00:00

abstract：BACKGROUND:Sarcoidosis is a multi-organ disease of unknown etiology characterised by the presence of epithelioid granulomas, without caseous necrosis. Systemic sarcoidosis is rare among children, while neurosarcoidosis in children is even rarer whether it is systemic or not. CASE PRESENTATION:We described the case of ...

journal_title：BMC neurology

authors： Shijo K,Moro N,Sasano M,Watanabe M,Yagasaki H,Takahashi S,Homma T,Yoshino A

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:This study aimed to determine the risk of thromboembolic events in patients with junctional bradycardia(JB). METHODS:We retrospectively reviewed electrocardiograms(ECGs) for 380,682 patients. Those with JB on an ECG at least twice over a ≥3-month interval were included for analysis. We additionally included...

journal_title：BMC neurology

authors： Kim GS,Uhm JS,Kim TH,Lee H,Park J,Park JK,Joung B,Pak HN,Lee MH

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Partially thrombosed giant aneurysms at the basilar apex (BA) artery are challenging lesions with a poor prognosis if left untreated. Here we describe a rare case of extensive brain edema after growth of a surgically treated and thrombosed giant basilar apex aneurysm. CASE PRESENTATION:We performed a proxim...

journal_title：BMC neurology

authors： García-Pérez D,Panero I,Eiriz C,Moreno LM,Munarriz PM,Paredes I,Lagares A,Alén JF

更新日期：2020-06-06 00:00:00

abstract：BACKGROUND:The Observational Skills Assessment Score (OSAS) measures amount and quality of use of the affected hand in children with unilateral Cerebral Palsy (CP) in bimanual activities and could therefore be a valuable addition to existing assessment tools. The OSAS consists of tasks that are age appropriate and requ...

journal_title：BMC neurology

authors： Speth L,Janssen-Potten Y,Leffers P,Rameckers E,Defesche A,Geers R,Smeets R,Vles H

更新日期：2013-10-21 00:00:00