Translating stem cell research to the clinic: a primer on translational considerations for your first stem cell protocol.

abstract：BACKGROUND:Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue sources such as bone marrow (BM), adipose (AD), dental pulp (DP), and Wharton's jelly (WJ) are routin...

journal_title：Stem cell research & therapy

authors： Paliwal S,Chaudhuri R,Agrawal A,Mohanty S

更新日期：2018-11-08 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are adult multipotent stem cells that possess regenerative and immunomodulatory properties. They have been widely investigated as therapeutic agents for a variety of disease conditions, including tissue repair, inflammation, autoimmunity, and organ transplantation. Importantly...

journal_title：Stem cell research & therapy

authors： Liu L,Zhang SX,Aeran R,Liao W,Lu M,Polovin G,Pone EJ,Zhao W

更新日期：2015-09-21 00:00:00

abstract：BACKGROUND:Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme that possesses odontogenic potential, the induction rate is relatively low. In addition, whether the...

journal_title：Stem cell research & therapy

authors： Hu X,Lee JW,Zheng X,Zhang J,Lin X,Song Y,Wang B,Hu X,Chang HH,Chen Y,Lin CP,Zhang Y

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear. Here, we hypothesized that SHED-Heps contribute to the regeneration of intrahepatic bile duct syste...

journal_title：Stem cell research & therapy

authors： Yuniartha R,Yamaza T,Sonoda S,Yoshimaru K,Matsuura T,Yamaza H,Oda Y,Ohga S,Taguchi T

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:Liver fibrosis resulting from chronic liver injury is one of the major causes of mortality worldwide. Stem cell-secreted secretome has been evaluated for overcoming the limitations of cell-based therapy in hepatic disease, while maintaining its advantages. METHODS:In this study, we investigated the effect o...

journal_title：Stem cell research & therapy

authors： Yao X,Wang J,Zhu J,Rong X

更新日期：2020-09-03 00:00:00

abstract：INTRODUCTION:Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease the function of MSCs during recovery from tissue and organ damage. Extracellular vesicles (EVs) released from MSCs contribute to the repair of kidney injury. We explored the influe...

journal_title：Stem cell research & therapy

authors： Wang Y,Guo YF,Fu GP,Guan C,Zhang X,Yang DG,Shi YC

更新日期：2020-07-08 00:00:00

abstract：INTRODUCTION:Preterm newborns often require mechanical respiratory support that can result in ventilation-induced lung injury (VILI), despite exogenous surfactant treatment. Human amnion epithelial cells (hAECs) reduce lung inflammation and resultant abnormal lung development in preterm animals; co-administration with ...

journal_title：Stem cell research & therapy

authors： McDonald CA,Melville JM,Polglase GR,Jenkin G,Moss TJ

更新日期：2014-09-04 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis is a progressive diffuse parenchymal lung disorder of unknown etiology. Mesenchymal stem cell (MSC)-based therapy is a novel approach with great therapeutic potential for the treatment of lung diseases. Despite demonstration of MSC grafting, the populations of engrafted MSCs h...

journal_title：Stem cell research & therapy

authors： Lan YW,Choo KB,Chen CM,Hung TH,Chen YB,Hsieh CH,Kuo HP,Chong KY

更新日期：2015-05-20 00:00:00

abstract：BACKGROUND:Some children who have survived cancer will be azoospermic in the future. Performing isolation and purification procedures for spermatogonial stem cells (SSC) is very critical. In this regard, performing the process of decontamination of cancerous cells is the initial step. The major objective of the present...

journal_title：Stem cell research & therapy

authors： Ashtari B,Shams A,Esmaeilzadeh N,Tanbakooei S,Koruji M,Moghadam MJ,Ansari JM,Moghadam AJ,Shabani R

更新日期：2020-05-24 00:00:00

abstract：:Mesenchymal stem cells have been used for cardiovascular regenerative therapy for decades. These cells have been established as one of the potential therapeutic agents, following several tests in animal models and clinical trials. In the process, various sources of mesenchymal stem cells have been identified which hel...

journal_title：Stem cell research & therapy

authors： Singh A,Singh A,Sen D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory ...

journal_title：Stem cell research & therapy

authors： Li Y,Xu J,Shi W,Chen C,Shao Y,Zhu L,Lu W,Han X

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:Neural stem cells for the treatment of spinal cord injury (SCI) are of particular interest for future therapeutic use. However, until now, stem cell therapies are often limited due to the inhibitory environment following the injury. Therefore, in this study, we aimed at testing a combinatorial approach with ...

journal_title：Stem cell research & therapy

authors： Butenschön J,Zimmermann T,Schmarowski N,Nitsch R,Fackelmeier B,Friedemann K,Radyushkin K,Baumgart J,Lutz B,Leschik J

更新日期：2016-01-13 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and coronary artery bypass grafting can prolong life, cardiac damage persists. In particular, cardiomyocytes have no regenerative capacity. Mesenchymal stem cells (MSCs) are attractive candidates for t...

journal_title：Stem cell research & therapy

authors： Cheng H,Chang S,Xu R,Chen L,Song X,Wu J,Qian J,Zou Y,Ma J

更新日期：2020-06-08 00:00:00

abstract：INTRODUCTION:Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue damage, and cancer. However, the use of mesenchymal stem cells (MSCs) to treat multiple myeloma (M...

journal_title：Stem cell research & therapy

authors： Atsuta I,Liu S,Miura Y,Akiyama K,Chen C,An Y,Shi S,Chen FM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most acceptable, safe, and effective source for allogeneic cell therapy e.g. for therapeutic angiogenesis. In this report we describe pro-angiogenic properties...

journal_title：Stem cell research & therapy

authors： Arutyunyan I,Fatkhudinov T,Kananykhina E,Usman N,Elchaninov A,Makarov A,Bolshakova G,Goldshtein D,Sukhikh G

更新日期：2016-03-22 00:00:00

abstract：BACKGROUND:Human adipose-derived stem cells (hASCs) are a subset of mesenchymal stem cells (MSCs); it has been regarded as one of the most promising stem cells. We previously found that fibroblast growth factor-2 (FGF-2) enhanced the proliferation and differentiation of hASC. However, the mechanisms involved in the gro...

journal_title：Stem cell research & therapy

authors： Ma Y,Kakudo N,Morimoto N,Lai F,Taketani S,Kusumoto K

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capacity. Most neural stem cells are in a quiescent state, but in response to extrinsic stimuli, they can...

journal_title：Stem cell research & therapy

authors： Li W,Wang S,He H,Qin J,Cheng X,Zhao H,Tian M,Zhang X,Jin G

更新日期：2021-01-09 00:00:00

abstract：:Temperature is an important microenvironmental factor that functions epigenetically in normal embryonic development. However, the effect of hyperthermia in the stem cells is not fully understood. Oct4 is a tightly regulated master regulator of pluripotency maintenance in stem cells and during early embryonic developme...

journal_title：Stem cell research & therapy

authors： Cheng MB,Wang X,Huang Y,Zhang Y

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:iRoot BP Plus is a novel bioceramic endodontic material. Recently, it has been considered as an alternative to MTA which is the most popular scaffold cover during regenerative endodontic therapy. This study aimed to evaluate the effects of iRoot BP Plus on the osteo/odontogenic capacity of bone marrow mesenc...

journal_title：Stem cell research & therapy

authors： Lu J,Li Z,Wu X,Chen Y,Yan M,Ge X,Yu J

更新日期：2019-07-29 00:00:00

abstract：INTRODUCTION:Endothelial dysfunction is found in different pathologies such as diabetes and renal and heart diseases, representing one of the major health problems. The reduced vasodilation of impaired endothelium starts a prothrombotic state associated with irregular blood flow. We aimed to explore the potential of am...

journal_title：Stem cell research & therapy

authors： Schiavo AA,Franzin C,Albiero M,Piccoli M,Spiro G,Bertin E,Urbani L,Visentin S,Cosmi E,Fadini GP,De Coppi P,Pozzobon M

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term recurrence are high. Thus, a new treatment strategy is still needed. In recent years, bone marrow m...

journal_title：Stem cell research & therapy

authors： Zhang H,Huang J,Liu J,Li Y,Gao Y

更新日期：2020-07-16 00:00:00

abstract：INTRODUCTION:Neural stem cells (NSCs) are among the most promising candidates for cell replacement therapy in neuronal injury and neurodegenerative diseases. One of the remaining obstacles for NSC therapy is to overcome the alloimmune response on NSCs by the host. METHODS:To investigate the mechanisms of immune modula...

journal_title：Stem cell research & therapy

authors： Lee EM,Hurh S,Cho B,Oh KH,Kim SU,Surh CD,Sprent J,Yang J,Kim JY,Ahn C

更新日期：2013-05-21 00:00:00

abstract：INTRODUCTION:Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a wide variety of tissues. This study aims to assess the functional similarities of MPCs from differen...

journal_title：Stem cell research & therapy

authors： Djouad F,Jackson WM,Bobick BE,Janjanin S,Song Y,Huang GT,Tuan RS

更新日期：2010-05-04 00:00:00

abstract：INTRODUCTION:Mesenchymal stromal cells (MSC) have well defined immunomodulatory properties including the suppression of lymphocyte proliferation and inhibition of dendritic cell (DC) maturation involving both cell contact and soluble factors. These properties have made MSC attractive candidates for cellular therapy. Ho...

journal_title：Stem cell research & therapy

authors： Cahill EF,Tobin LM,Carty F,Mahon BP,English K

更新日期：2015-03-11 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from ...

journal_title：Stem cell research & therapy

authors： Boeuf S,Richter W

更新日期：2010-10-13 00:00:00

abstract：BACKGROUND:Emerging evidence suggests that neural crest-derived cells (NCCs) present important functions in peripheral nerve regeneration to correct the insufficiency of autogenous Schwann cells. Postmigratory NCCs have been successfully isolated from adult rat bone marrow in our previous work. In this study, we aim to...

journal_title：Stem cell research & therapy

authors： Shi H,Li X,Yang J,Zhao Y,Xue C,Wang Y,He Q,Shen M,Zhang Q,Yang Y,Ding F

更新日期：2019-12-18 00:00:00

abstract：BACKGROUND:The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) can be expanded to produce adipose-derived stem cells (ADSC) which represents a combination of endothe...

journal_title：Stem cell research & therapy

authors： Chen J,Wang Y,Hu H,Xiong Y,Wang S,Yang J

更新日期：2021-01-29 00:00:00

abstract：:The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therapeutic possibility for the ovarian graft in hypoxia. We designed the present study to evaluate whether the cell-...

journal_title：Stem cell research & therapy

authors： Damous LL,de Carvalho AETS,Nakamuta JS,Shiroma ME,Louzada ACS,Soares-Jr JM,Krieger JE,Baracat EC

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:The therapeutic effect of mesenchymal stem cells (MSCs) from human adipose tissue on renal interstitial fibrosis has been demonstrated by several groups. However, the way to enhance the renoprotective effect of adipose-derived mesenchymal stem cells (AMSCs) and the possible mechanisms are still unclear. The ...

journal_title：Stem cell research & therapy

authors： Li S,Wang Y,Wang Z,Chen L,Zuo B,Liu C,Sun D

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Dystrophic epidermolysis bullosa (DEB), a rare genodermatosis, is characterized by the formation of intra-epidermal blistering and the development of chronic nonhealing skin wounds. Recently, attempts have been made to develop cell-based therapies for this currently intractable disorder. The molecular mechan...

journal_title：Stem cell research & therapy

authors： Alexeev V,Donahue A,Uitto J,Igoucheva O

更新日期：2016-08-27 00:00:00