Cell-free therapy with the secretome of adipose tissue-derived stem cells in rats' frozen-thawed ovarian grafts.

abstract：:Tissues characterized by constant turnover contain post-mitotic, terminally differentiated cells originating from highly proliferative progenitors, which in turn derive from a relatively small population of stem cells. At the population level, self-renewal and differentiation are the possible outcomes of stem cell pro...

journal_title：Stem cell research & therapy

authors： Sottocornola R,Lo Celso C

更新日期：2012-03-19 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from ...

journal_title：Stem cell research & therapy

authors： Boeuf S,Richter W

更新日期：2010-10-13 00:00:00

abstract：:Tendon injuries, as one of the most common orthopedic disorders, are the major cause of early retirement or wastage among sport horses which mainly affect the superficial digital flexor tendon (SDFT). Tendon repair is a slow process, and tendon tissue is often replaced by scar tissue. The current treatment options are...

journal_title：Stem cell research & therapy

authors： Shojaee A,Parham A

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue sources such as bone marrow (BM), adipose (AD), dental pulp (DP), and Wharton's jelly (WJ) are routin...

journal_title：Stem cell research & therapy

authors： Paliwal S,Chaudhuri R,Agrawal A,Mohanty S

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting its therapeutic benefit. The aim of this study is to create a new approach to treat type 2 diabetes b...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2018-12-07 00:00:00

abstract：INTRODUCTION:Increased levels of angiotensin II (Ang II) and activity of Ang II receptor type 1 (AT1R) elicit detrimental effects in cardiovascular disease. However, the role of Ang II receptor type 2 (AT2R) remains poorly defined. Mesenchymal stem cells (MSCs) replenish and repair endothelial cells in the cardiovascul...

journal_title：Stem cell research & therapy

authors： Ikhapoh IA,Pelham CJ,Agrawal DK

更新日期：2015-01-06 00:00:00

abstract：INTRODUCTION:Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and immunomodulatory ability of systemic OFSC transplantation were demonstrated in our previous wor...

journal_title：Stem cell research & therapy

authors： Lin KJ,Loi MX,Lien GS,Cheng CF,Pao HY,Chang YC,Ji AT,Ho JH

更新日期：2013-06-14 00:00:00

abstract：BACKGROUND:Inner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential source for hair cell (HC) regeneration, but several studies have shown that the regeneration ability of SCs decreases dramatically as mice age and that lost HCs cannot be regenerated in adult mice. To better understand how SCs mig...

journal_title：Stem cell research & therapy

authors： Cheng C,Wang Y,Guo L,Lu X,Zhu W,Muhammad W,Zhang L,Lu L,Gao J,Tang M,Chen F,Gao X,Li H,Chai R

更新日期：2019-12-02 00:00:00

abstract：INTRODUCTION:Studies have demonstrated that mesenchymal stromal cells (MSCs) could reverse acute and chronic kidney injury by a paracrine or endocrine mechanism, and microvesicles (MVs) have been regarded as a crucial means of intercellular communication. In the current study, we focused on the therapeutic effects of h...

journal_title：Stem cell research & therapy

authors： Zou X,Zhang G,Cheng Z,Yin D,Du T,Ju G,Miao S,Liu G,Lu M,Zhu Y

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties due to their anti-inflammatory, angiogenic, and even antibacterial properties. We have shown previously that minocycline enhances the wound healing phenotype of MSCs, and MSCs encapsulated in poly(ethylene glycol) and gelatin-base...

journal_title：Stem cell research & therapy

authors： Guerra AD,Rose WE,Hematti P,Kao WJ

更新日期：2017-07-21 00:00:00

abstract：:Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine f...

journal_title：Stem cell research & therapy

authors： Qiu G,Zheng G,Ge M,Wang J,Huang R,Shu Q,Xu J

更新日期：2019-11-28 00:00:00

abstract：BACKGROUND:Acquired aplastic anemia (AA) is characterized by deficiency or dysfunction of the bone marrow (BM) microenvironment. However, little is known about the impairment of BM-derived mesenchymal stem cells (MSCs) in AA patients. METHODS:We used Illumina HiSeqTM 2000 sequencing, quantitative real-time polymerase ...

journal_title：Stem cell research & therapy

authors： Lu S,Ge M,Zheng Y,Li J,Feng X,Feng S,Huang J,Feng Y,Yang D,Shi J,Chen F,Han Z

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involved in this effect. However, the mechanisms by which BMSC modulate neutrophil remains unknown. METHOD...

journal_title：Stem cell research & therapy

authors： Su X,Yang L,Yin Y,Huang J,Qiao F,Fang Y,Yu L,Wang Y,Zhou K,Wang J

更新日期：2018-09-26 00:00:00

abstract：BACKGROUND:miRNA expression profiles in ectopic endometrium (EC) serving as pathophysiologic genetic fingerprints contribute to determining endometriosis progression; however, the underlying molecular mechanisms remain unknown. METHODS:miRNA microarray analysis was used to determine the expression profiling of EC fres...

journal_title：Stem cell research & therapy

authors： Zhou CF,Liu MJ,Wang W,Wu S,Huang YX,Chen GB,Liu LM,Peng DX,Wang XF,Cai XZ,Li XX,Feng WQ,Ma Y

更新日期：2019-09-23 00:00:00

abstract：INTRODUCTION:Chronic wounds are a major health-care issue, but research is limited by the complexity and heterogeneity in terms of wound etiology as well as patient-related factors. A suitable animal model that replicates the situation in humans is not available. Therefore, the aim of the present work is to present a s...

journal_title：Stem cell research & therapy

authors： Wettstein R,Savic M,Pierer G,Scheufler O,Haug M,Halter J,Gratwohl A,Baumberger M,Schaefer DJ,Kalbermatten DF

更新日期：2014-01-29 00:00:00

abstract：INTRODUCTION:The bursa subacromialis (BS) provides the gliding mechanism of the shoulder and regenerates itself after surgical removal. Therefore, we explored the presence of mesenchymal stem cells (MSCs) within the human adult BS tissue and characterized the BS cells compared to MSCs from bone marrow (BMSCs) on a mole...

journal_title：Stem cell research & therapy

authors： Steinert AF,Kunz M,Prager P,Göbel S,Klein-Hitpass L,Ebert R,Nöth U,Jakob F,Gohlke F

更新日期：2015-06-03 00:00:00

abstract：AIM:Myocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. This study aims to explore the effect and mechanism of lncRNA KLF3-AS1 in exosomes secreted by human mesenc...

journal_title：Stem cell research & therapy

authors： Mao Q,Liang XL,Zhang CL,Pang YH,Lu YX

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory ...

journal_title：Stem cell research & therapy

authors： Li Y,Xu J,Shi W,Chen C,Shao Y,Zhu L,Lu W,Han X

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bone marrow (BM-MSC) have long been the most used stem cell source in cartilage tissue engineering, the...

journal_title：Stem cell research & therapy

authors： Reppel L,Schiavi J,Charif N,Leger L,Yu H,Pinzano A,Henrionnet C,Stoltz JF,Bensoussan D,Huselstein C

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects female fertility. However, with the lack of a corresponding research model, the pathology mechanism of PCOS is poorly understood. Induced pluripotent stem cell (iPSC) technology has been recognized as means to generate...

journal_title：Stem cell research & therapy

authors： Min Z,Gao Q,Zhen X,Fan Y,Tan T,Li R,Zhao Y,Yu Y

更新日期：2018-08-09 00:00:00

abstract：BACKGROUND:Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms in the organotropism of metastasis are still unclear. Adipose-derived mesenchymal stem cells (ADSCs) exhibit cancer-promoting properties that influence the tumour microenvironment; however, there is no research o...

journal_title：Stem cell research & therapy

authors： Wang Y,Chu Y,Ren X,Xiang H,Xi Y,Ma X,Zhu K,Guo Z,Zhou C,Zhang G,Chen B

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Precision or individualized medicine is increasingly pervasive across medical and surgical disciplines. However, the concept has not been introduced in regenerative medicine. MAIN BODY:Targeted and engineered cellular and acellular therapy, specific to individuals or disease states, could significantly impr...

journal_title：Stem cell research & therapy

authors： Lightner AL,Chan T

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester human umbilical cord-derived perivascular cells (FTM HUCPVCs) have multipotent characteristics and pr...

journal_title：Stem cell research & therapy

authors： Iqbal F,Szaraz P,Librach M,Gauthier-Fisher A,Librach CL

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing. METHODS:In this review, we investigated the trends in injectable scaffolds for ASC delivery in the dermis, and injectable or implantable scaffolds for ASC del...

journal_title：Stem cell research & therapy

authors： Mamsen FP,Munthe-Fog L,Kring MKM,Duscher D,Taudorf M,Katz AJ,Kølle ST

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:The dog represents an excellent large animal model for translational cell-based studies. Importantly, the properties of canine multipotent stromal cells (cMSCs) and the ideal tissue source for specific translational studies have yet to be established. The aim of this study was to characterize cMSCs derived f...

journal_title：Stem cell research & therapy

authors： Bearden RN,Huggins SS,Cummings KJ,Smith R,Gregory CA,Saunders WB

更新日期：2017-10-03 00:00:00

abstract：:Injuries of the spinal cord trigger local healing but hardly restore normal function. Spinal cord injury (SCI) has been deeply studied to develop strategies for functional recovery. The study by van Gorp and colleagues uses a rat model of acute SCI to characterize the effects of intraspinal grafting of human fetal spi...

journal_title：Stem cell research & therapy

authors： Tavares I

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing lesions in vivo. Cord blood mononuclear cells (CBMCs) have emerged as a potential cell source for regen...

journal_title：Stem cell research & therapy

authors： Kim Y,Park N,Rim YA,Nam Y,Jung H,Lee K,Ju JH

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells, including those derived from human adipose tissue (hASCs), are currently being widely investigated for cell therapy. However, when transplanted at the site of injury, the survival and engraftment rates of hASCs are low, mainly due to the harsh microenvironment they encounter, characte...

journal_title：Stem cell research & therapy

authors： Garrido-Pascual P,Alonso-Varona A,Castro B,Burón M,Palomares T

更新日期：2020-08-03 00:00:00

abstract：INTRODUCTION:Human hematopoietic stem cells (HSCs) have been clinically used for transplantation and gene and cellular therapy for more than 4 decades. However, this use is limited because of the challenges in the ex vivo culturing of HSCs. The major hurdle is to amplify these cells without losing their self-renewing p...

journal_title：Stem cell research & therapy

authors： Kaur K,Mirlashari MR,Kvalheim G,Kjeldsen-Kragh J

更新日期：2013-05-24 00:00:00

abstract：:The original article [1] contained errors in the presentation of Figure 7. ...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2019-01-08 00:00:00