Strategies of tenogenic differentiation of equine stem cells for tendon repair: current status and challenges.

abstract：BACKGROUND:Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term recurrence are high. Thus, a new treatment strategy is still needed. In recent years, bone marrow m...

journal_title：Stem cell research & therapy

authors： Zhang H,Huang J,Liu J,Li Y,Gao Y

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation...

journal_title：Stem cell research & therapy

authors： Bueno DF,Kabayashi GS,Pinheiro CCG,Tanikawa DYS,Raposo-Amaral CE,Rocha DL,Ferreira JRM,Shibuya Y,Hokugo A,Jarrahy R,ZuK PA,Passos-Bueno MR

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Prostate cancer is the second most frequent cancer among males worldwide, and most patients with metastatic disease eventually develop therapy-resistant disease. Recent research has suggested the existence of cancer stem-like cells, and that such cells are behind the therapy resistance and progression. METH...

journal_title：Stem cell research & therapy

authors： Ceder JA,Aalders TW,Schalken JA

更新日期：2017-04-26 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit the proliferation of proinflammatory T lymphocytes, which appear responsible for causing autoimmune disease, have yet to be fully elucidated. One of ...

journal_title：Stem cell research & therapy

authors： Luz-Crawford P,Kurte M,Bravo-Alegría J,Contreras R,Nova-Lamperti E,Tejedor G,Noël D,Jorgensen C,Figueroa F,Djouad F,Carrión F

更新日期：2013-06-04 00:00:00

abstract：BACKGROUND:Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms in the organotropism of metastasis are still unclear. Adipose-derived mesenchymal stem cells (ADSCs) exhibit cancer-promoting properties that influence the tumour microenvironment; however, there is no research o...

journal_title：Stem cell research & therapy

authors： Wang Y,Chu Y,Ren X,Xiang H,Xi Y,Ma X,Zhu K,Guo Z,Zhou C,Zhang G,Chen B

更新日期：2019-06-13 00:00:00

abstract：:Adipogenesis is essential in in vitro experimentation to assess differentiation capability of stem cells, and therefore, its accurate measurement is important. Quantitative analysis of adipogenic levels, however, is challenging and often susceptible to errors due to non-specific reading or manual estimation by observe...

journal_title：Stem cell research & therapy

authors： Yuan C,Chakraborty S,Chitta KK,Subramanian S,Lim TE,Han W,Bhanu Prakash KN,Sugii S

更新日期：2019-01-22 00:00:00

abstract：:Owing to the aging of the population, our society now faces an impending wave of age-related neurodegenerative pathologies, the most significant of which is Alzheimer's disease. Currently, no effective therapies for Alzheimer's disease have been developed. However, recent advances in the fields of neural stem cells an...

journal_title：Stem cell research & therapy

authors： Byrne JA

更新日期：2014-05-30 00:00:00

abstract：:The original article [1] contains an error in Fig. 5 whereby sub-Fig. 5c, d & 5e are mistakenly mixed-up. ...

journal_title：Stem cell research & therapy

authors： Zuo R,Liu M,Wang Y,Li J,Wang W,Wu J,Sun C,Li B,Wang Z,Lan W,Zhang C,Shi C,Zhou Y

更新日期：2020-01-23 00:00:00

abstract：:Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in different preclinical studies of central nervous system (CNS) disorders due to their immunomodulatory propertie...

journal_title：Stem cell research & therapy

authors： De Vocht N,Praet J,Reekmans K,Le Blon D,Hoornaert C,Daans J,Berneman Z,Van der Linden A,Ponsaerts P

更新日期：2013-08-22 00:00:00

abstract：OBJECTIVE:Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascularization bed. Considering the active role of adipose-derived stem cell (ADSC) in promoting angiogen...

journal_title：Stem cell research & therapy

authors： Luo Y,Yi X,Liang T,Jiang S,He R,Hu Y,Bai L,Wang C,Wang K,Zhu L

更新日期：2019-08-30 00:00:00

abstract：INTRODUCTION:Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Currently, the lack of a reliable and safe method to accurately and non-invasively locate the site of imp...

journal_title：Stem cell research & therapy

authors： Micci MA,Boone DR,Parsley MA,Wei J,Patrikeev I,Motamedi M,Hellmich HL

更新日期：2015-07-21 00:00:00

abstract：:On 23 May 2013, the Italian health minister decided to endorse a law regarding controversial stem cell-based therapies in 32 young terminally ill patients, shocking many scientists. According to the international scientific community, these therapies could be dangerous because they were not rigorously tested in humans...

journal_title：Stem cell research & therapy

authors： Frati P,Frati G,Gulino M,Montanari Vergallo G,Di Luca A,Fineschi V

更新日期：2013-10-11 00:00:00

abstract：BACKGROUND:Clinical use of mesenchymal stem cells (MSCs) requires a uniform cell population, and their harvesting is invasive and produces a limited number of cells. Human embryonic stem cell-derived MSCs (hESC-MSCs) can differentiate into three germ layers and possess immunosuppressive effects in vitro. Anticancer tre...

journal_title：Stem cell research & therapy

authors： Yoon SY,Yoon JA,Park M,Shin EY,Jung S,Lee JE,Eum JH,Song H,Lee DR,Lee WS,Lyu SW

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Autologous epidermal basal cell suspension therapy has been proven to be one of the most effective treatments for full-thickness wounds. However, we found there remain obvious defects that significantly confined the utilization and function of the epidermal basal cells (EBCs), especially the epidermal stem c...

journal_title：Stem cell research & therapy

authors： Wang P,Hu Z,Cao X,Huang S,Dong Y,Cheng P,Xu H,Shu B,Xie J,Wu J,Tang B,Zhu J

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involved in this effect. However, the mechanisms by which BMSC modulate neutrophil remains unknown. METHOD...

journal_title：Stem cell research & therapy

authors： Su X,Yang L,Yin Y,Huang J,Qiao F,Fang Y,Yu L,Wang Y,Zhou K,Wang J

更新日期：2018-09-26 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from ...

journal_title：Stem cell research & therapy

authors： Boeuf S,Richter W

更新日期：2010-10-13 00:00:00

abstract：:The role of p53 as "a guardian of the genome" has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understanding the role of p53 in pluripotent stem cells and in pluripotent stem cell-like cancer stem cells. The p53 pro...

journal_title：Stem cell research & therapy

authors： Lin T,Lin Y

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:Liver organoid technology holds great promises to be used in large-scale population-based drug screening and in future regenerative medicine strategies. Recently, some studies reported robust protocols for generating isogenic liver organoids using liver parenchymal and non-parenchymal cells derived from indu...

journal_title：Stem cell research & therapy

authors： Goulart E,de Caires-Junior LC,Telles-Silva KA,Araujo BHS,Kobayashi GS,Musso CM,Assoni AF,Oliveira D,Caldini E,Gerstenhaber JA,Raia S,Lelkes PI,Zatz M

更新日期：2019-08-15 00:00:00

abstract：:The original article [1] contained errors in the presentation of Figure 7. ...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. lncRNA plays an essential role in microvascular dysfunction and signaling pathways in patients with diabetes. ln...

journal_title：Stem cell research & therapy

authors： Li Y,Zhi K,Han S,Li X,Li M,Lian W,Zhang H,Zhang X

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Dystrophic epidermolysis bullosa (DEB), a rare genodermatosis, is characterized by the formation of intra-epidermal blistering and the development of chronic nonhealing skin wounds. Recently, attempts have been made to develop cell-based therapies for this currently intractable disorder. The molecular mechan...

journal_title：Stem cell research & therapy

authors： Alexeev V,Donahue A,Uitto J,Igoucheva O

更新日期：2016-08-27 00:00:00

abstract：BACKGROUND:Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcomes may be helpful. Hematopoietic stem and progenitor cell (HSPC)-mediated gene therapy often requires...

journal_title：Stem cell research & therapy

authors： Bhatt KH,Rudraraju R,Brooks JF,Jung JW,Galea R,Wells JW,Steptoe RJ

更新日期：2017-03-09 00:00:00

abstract：INTRODUCTION:Impaction allograft with cement is a common technique used in revision hip surgeries for the last 20 years. However, its clinical results are inconsistent. Recent studies have shown that mesenchymal stem cells (MSCs) seeded onto allograft can enhance bone formation. This in vitro study investigates whether...

journal_title：Stem cell research & therapy

authors： Reissis Y,García-Gareta E,Korda M,Blunn GW,Hua J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme that possesses odontogenic potential, the induction rate is relatively low. In addition, whether the...

journal_title：Stem cell research & therapy

authors： Hu X,Lee JW,Zheng X,Zhang J,Lin X,Song Y,Wang B,Hu X,Chang HH,Chen Y,Lin CP,Zhang Y

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Bone marrow-derived cell therapy has been used to treat acute myocardial infarction. However, the therapeutic efficacy of this approach remains controversial. Here, we performed a systematic review and meta-analysis to evaluate short-term and long-term effectiveness of bone marrow-derived therapy. METHODS:W...

journal_title：Stem cell research & therapy

authors： Lee SH,Hong JH,Cho KH,Noh JW,Cho HJ

更新日期：2016-10-20 00:00:00

abstract：OBJECTIVES:Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been developed yet. MATERIALS AND METHODS:Here, we developed the full chemical-defined medium, NBVbe med...

journal_title：Stem cell research & therapy

authors： Xu J,Lian W,Chen J,Li W,Li L,Huang Z

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most acceptable, safe, and effective source for allogeneic cell therapy e.g. for therapeutic angiogenesis. In this report we describe pro-angiogenic properties...

journal_title：Stem cell research & therapy

authors： Arutyunyan I,Fatkhudinov T,Kananykhina E,Usman N,Elchaninov A,Makarov A,Bolshakova G,Goldshtein D,Sukhikh G

更新日期：2016-03-22 00:00:00

abstract：BACKGROUND:Induced pluripotent stem cells (iPSCs) exhibit limitless pluripotent plasticity and proliferation capability to provide an abundant cell source for tissue regenerative medicine. Thus, inducing iPSCs toward a specific differentiation direction is an important scientific question. Traditionally, iPSCs have bee...

journal_title：Stem cell research & therapy

authors： Hu Y,Chen L,Gao Y,Cheng P,Yang L,Wu C,Jie Q

更新日期：2020-02-21 00:00:00

abstract：BACKGROUND:One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage and loss of lung function. There are currently no effective therapies for combatting ARDS. Mesenchymal...

journal_title：Stem cell research & therapy

authors： Kaspi H,Semo J,Abramov N,Dekel C,Lindborg S,Kern R,Lebovits C,Aricha R

更新日期：2021-01-19 00:00:00

abstract：INTRODUCTION:Therapeutic potentials of mesenchymal stem cells (MSCs) from different sources have been evaluated in pre-clinical and clinical settings. Although MSCs from different sources share MSC-specific characteristics and functions, inconsistent or controversial results of pre-clinical and clinical applications of...

journal_title：Stem cell research & therapy

authors： Zhu Y,Yang Y,Zhang Y,Hao G,Liu T,Wang L,Yang T,Wang Q,Zhang G,Wei J,Li Y

更新日期：2014-04-10 00:00:00