当前位置： SCI文献检索 > Stem Cell Research & Therapy期刊下所有文献 > Placental mesenchymal stem cells of fetal and maternal origins demonstrate different therapeutic potentials.

Placental mesenchymal stem cells of fetal and maternal origins demonstrate different therapeutic potentials.

Abstract：

INTRODUCTION:Therapeutic potentials of mesenchymal stem cells (MSCs) from different sources have been evaluated in pre-clinical and clinical settings. Although MSCs from different sources share MSC-specific characteristics and functions, inconsistent or controversial results of pre-clinical and clinical applications of such cells are frequently reported. This may be partially due to the fact that MSCs isolated from different origins may differentially express some functions not typical for MSCs, and hence have different therapeutic potentials. The aim of this study is to investigate the differences in human placental MSCs (P-MSCs) of fetal and maternal origins in the aspects of clinical importance. METHODS:P-MSCs of fetal and maternal origins isolated from normal term placentas were characterized for their typical phenotype as well as their expression of receptors and growth factors of clinic interests. P-MSCs that preferentially express hepatocyte growth factor (HGF) and CD200 were evaluated for their therapeutic potentials in models of angiogenesis and allogeneic skin transplantation, in comparison with their HGF and CD200 negative partners. RESULTS:Although all P-MSCs express typical MSC phenotype, fetal but not maternal P-MSCs express high levels of CD200 and HGF. Compared with HGF and CD200 negative P-MSCs, HGF and CD200 positive cells demonstrated significantly high potentials in promoting angiogenesis in vitro and increasing immunosuppressive function in vivo. These therapeutic potentials were at least in part due to their differences in HGF and CD200 expression, respectively. CONCLUSIONS:We conclude that MSC origins may have significant impact on the therapeutic potentials of such cells, and should be taken into consideration in clinical applications.

journal_name

Stem Cell Res Ther

journal_title

Stem cell research & therapy

authors

Zhu Y,Yang Y,Zhang Y,Hao G,Liu T,Wang L,Yang T,Wang Q,Zhang G,Wei J,Li Y

doi

10.1186/scrt436

subject

Has Abstract

pub_date

2014-04-10 00:00:00

pages

48

issue

2

issn

1757-6512

pii

scrt436

journal_volume

5

pub_type

杂志文章

相关文献

Stem Cell Research & Therapy文献大全
  • Discrepancy between short-term and long-term effects of bone marrow-derived cell therapy in acute myocardial infarction: a systematic review and meta-analysis.

    abstract：BACKGROUND:Bone marrow-derived cell therapy has been used to treat acute myocardial infarction. However, the therapeutic efficacy of this approach remains controversial. Here, we performed a systematic review and meta-analysis to evaluate short-term and long-term effectiveness of bone marrow-derived therapy. METHODS:W...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章,meta分析

    doi：10.1186/s13287-016-0415-z

    authors： Lee SH,Hong JH,Cho KH,Noh JW,Cho HJ

    更新日期：2016-10-20 00:00:00

  • PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity.

    abstract：BACKGROUND:Nicotinamide adenine dinucleotide (NAD+) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin 1 (SIRT1) affect cellular NAD+ levels and play essential roles in regulating metabolism. However, there has been little research on the effects of PARP1...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-018-0961-7

    authors： Zha S,Li Z,Cao Q,Wang F,Liu F

    更新日期：2018-08-23 00:00:00

  • Adipose mesenchymal stem cell transplantation alleviates spinal cord injury-induced neuroinflammation partly by suppressing the Jagged1/Notch pathway.

    abstract：BACKGROUND:The therapeutic effects of adipose-derived mesenchymal stem cell (ADSC) transplantation have been demonstrated in several models of central nervous system (CNS) injury and are thought to involve the modulation of the inflammatory response. However, the exact underlying molecular mechanism is poorly understoo...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-01724-5

    authors： Zhou Z,Tian X,Mo B,Xu H,Zhang L,Huang L,Yao S,Huang Z,Wang Y,Xie H,Xu L,Zhang H

    更新日期：2020-06-03 00:00:00

  • Human neural stem cell transplantation in spinal cord injury models: how far from clinical application?

    abstract：:Injuries of the spinal cord trigger local healing but hardly restore normal function. Spinal cord injury (SCI) has been deeply studied to develop strategies for functional recovery. The study by van Gorp and colleagues uses a rat model of acute SCI to characterize the effects of intraspinal grafting of human fetal spi...

    journal_title：Stem cell research & therapy

    pub_type： 评论,杂志文章

    doi：10.1186/scrt210

    authors： Tavares I

    更新日期：2013-06-13 00:00:00

  • Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors.

    abstract：:Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/scrt31

    authors： Boeuf S,Richter W

    更新日期：2010-10-13 00:00:00

  • Local application of IGFBP5 protein enhanced periodontal tissue regeneration via increasing the migration, cell proliferation and osteo/dentinogenic differentiation of mesenchymal stem cells in an inflammatory niche.

    abstract：BACKGROUND:Periodontitis is a widespread infectious disease ultimately resulting in tooth loss. The number of mesenchymal stem cells (MSCs) in patients with periodontitis is decreased, and MSC functions are impaired. Rescuing the impaired function of MSCs in periodontitis is the key for treatment, especially in a manne...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-017-0663-6

    authors： Han N,Zhang F,Li G,Zhang X,Lin X,Yang H,Wang L,Cao Y,Du J,Fan Z

    更新日期：2017-09-29 00:00:00

  • Activin A expression regulates multipotency of mesenchymal progenitor cells.

    abstract：INTRODUCTION:Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a wide variety of tissues. This study aims to assess the functional similarities of MPCs from differen...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/scrt11

    authors： Djouad F,Jackson WM,Bobick BE,Janjanin S,Song Y,Huang GT,Tuan RS

    更新日期：2010-05-04 00:00:00

  • Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase.

    abstract：INTRODUCTION:Delivered systemically or natively circulating mesenchymal stem cells accumulate in injured tissues. During homing mesenchymal stem cells adhere to endothelial cells and infiltrate underlying tissue. Previously we have shown that adhesiveness of endothelial cells for mesenchymal stem cells correlates with ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/scrt35

    authors： Potapova IA,Cohen IS,Doronin SV

    更新日期：2010-11-17 00:00:00

  • Challenges in the clinical application of induced pluripotent stem cells.

    abstract：:The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential...

    journal_title：Stem cell research & therapy

    pub_type： 社论

    doi：10.1186/scrt9

    authors： Sipp D

    更新日期：2010-04-12 00:00:00

  • Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro.

    abstract：BACKGROUND:We aimed to determine and compare the in vitro effects of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) and mesenchymal stem cell supernatant (MSC-Sp) on the wound healing capacity of equine corneal fibroblasts using a scratch assay. METHODS:Bone marrow aspirates and eyes were collected fr...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-017-0577-3

    authors： Sherman AB,Gilger BC,Berglund AK,Schnabel LV

    更新日期：2017-05-25 00:00:00

  • Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-β.

    abstract：BACKGROUND:Liver organoid technology holds great promises to be used in large-scale population-based drug screening and in future regenerative medicine strategies. Recently, some studies reported robust protocols for generating isogenic liver organoids using liver parenchymal and non-parenchymal cells derived from indu...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-019-1367-x

    authors： Goulart E,de Caires-Junior LC,Telles-Silva KA,Araujo BHS,Kobayashi GS,Musso CM,Assoni AF,Oliveira D,Caldini E,Gerstenhaber JA,Raia S,Lelkes PI,Zatz M

    更新日期：2019-08-15 00:00:00

  • High quality clinical grade human embryonic stem cell lines derived from fresh discarded embryos.

    abstract：BACKGROUND:Human embryonic stem cells (hESCs) hold tremendous promise for cell replacement therapies for a range of degenerative diseases. In order to provide cost-effective treatments affordable by public health systems, HLA-matched allogeneic tissue banks of the highest quality clinical-grade hESCs will be required. ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-017-0561-y

    authors： Ye J,Bates N,Soteriou D,Grady L,Edmond C,Ross A,Kerby A,Lewis PA,Adeniyi T,Wright R,Poulton KV,Lowe M,Kimber SJ,Brison DR

    更新日期：2017-06-05 00:00:00

  • Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells.

    abstract：:Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the i...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-019-1417-4

    authors： Hegyesi H,Sándor N,Sáfrány G,Lovas V,Kovács Á,Takács A,Kőhidai L,Turiák L,Kittel Á,Pálóczi K,Bertók L,Buzás EI

    更新日期：2019-10-29 00:00:00

  • Insult-dependent effect of bone marrow cell therapy on inflammatory response in a murine model of extrapulmonary acute respiratory distress syndrome.

    abstract：INTRODUCTION:Administration of bone marrow-derived cells produces beneficial effects in experimental extrapulmonary acute respiratory distress syndrome (ARDS). However, there are controversies regarding the effects of timing of cell administration and initial insult severity on inflammatory response. We evaluated the e...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/scrt334

    authors： Maron-Gutierrez T,Silva JD,Cruz FF,Alegria S,Xisto DG,Assis EF,Castro-Faria-Neto HC,Dos Santos CC,Morales MM,Rocco PR

    更新日期：2013-10-13 00:00:00

  • Development of immortalized Hertwig's epithelial root sheath cell lines for cementum and dentin regeneration.

    abstract：BACKGROUND:Hertwig's epithelial root sheath (HERS) is important in guiding tooth root formation by differentiating into cementoblasts through epithelial-mesenchymal transition (EMT) and inducing odontoblastic differentiation of dental papilla through epithelial-mesenchymal interaction (EMI) during the tooth root develo...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-018-1106-8

    authors： Li X,Zhang S,Zhang Z,Guo W,Chen G,Tian W

    更新日期：2019-01-03 00:00:00

  • Autologous bone marrow-derived mononuclear cell therapy in Chinese patients with critical limb ischemia due to thromboangiitis obliterans: 10-year results.

    abstract：BACKGROUND:For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term results of our experience treating patients with TAO with autologous bone marrow-derived mononuclear cell...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-018-0784-6

    authors： Guo J,Guo L,Cui S,Tong Z,Dardik A,Gu Y

    更新日期：2018-02-22 00:00:00

  • A novel method for banking stem cells from human exfoliated deciduous teeth: lentiviral TERT immortalization and phenotypical analysis.

    abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have recently attracted attention as novel multipotential stem cell sources. However, their application is limited due to in vitro replicative senescence. Ectopic expression of telomerase reverse transcriptase (TERT) is a promising strategy for overcomi...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-016-0309-0

    authors： Yin Z,Wang Q,Li Y,Wei H,Shi J,Li A

    更新日期：2016-04-04 00:00:00

  • Correction to: Overexpression of apelin in Wharton' jelly mesenchymal stem cell reverses insulin resistance and promotes pancreatic β cell proliferation in type 2 diabetic rats.

    abstract：:The original article [1] contained errors in the presentation of Figure 7. ...

    journal_title：Stem cell research & therapy

    pub_type： 已发布勘误

    doi：10.1186/s13287-018-1116-6

    authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

    更新日期：2019-01-08 00:00:00

  • Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers.

    abstract：BACKGROUND:The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been demonstrated to provide biological pacing in dogs with complete heart block. The mechanism appears to be the generation of the ion current (If) by the HCN2-...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-016-0326-z

    authors： Bruzauskaite I,Bironaite D,Bagdonas E,Skeberdis VA,Denkovskij J,Tamulevicius T,Uvarovas V,Bernotiene E

    更新日期：2016-04-30 00:00:00

  • In silico tandem affinity purification refines an Oct4 interaction list.

    abstract：INTRODUCTION:Octamer-binding transcription factor 4 (Oct4) is a master regulator of early mammalian development. Its expression begins from the oocyte stage, becomes restricted to the inner cell mass of the blastocyst and eventually remains only in primordial germ cells. Unearthing the interactions of Oct4 would provid...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/scrt67

    authors： Cheong CY,Lon Ng PM,Ponnampalam R,Tsai HH,Bourque G,Lufkin T

    更新日期：2011-05-13 00:00:00

  • Human serum enhances the proliferative capacity and immunomodulatory property of MSCs derived from human placenta and umbilical cord.

    abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are considered potential candidates that hold great promise in the treatment of immune-related diseases. For therapeutic applications, it is necessary to isolate and expand MSCs with procedures complying with good manufacturing practice (GMP). Recent studies reported the use ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-019-1175-3

    authors： Thaweesapphithak S,Tantrawatpan C,Kheolamai P,Tantikanlayaporn D,Roytrakul S,Manochantr S

    更新日期：2019-03-07 00:00:00

  • Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies.

    abstract：:Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies using primary NK cells are prone to manufacturing issues related to expansion and storage. Alternative cell sourc...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/s13287-020-01741-4

    authors： Shankar K,Capitini CM,Saha K

    更新日期：2020-06-16 00:00:00

  • Mouse CD146+ muscle interstitial progenitor cells differ from satellite cells and present myogenic potential.

    abstract：BACKGROUND:The skeletal muscle regeneration relays on the satellite cells which are stem cells located between basal lamina and plasmalemma of muscle fiber. In the injured muscles, the satellite cells become activated, start to proliferate, and then differentiate into myoblasts, which fuse to form myotubes and finally ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-01827-z

    authors： Mierzejewski B,Grabowska I,Jackowski D,Irhashava A,Michalska Z,Stremińska W,Jańczyk-Ilach K,Ciemerych MA,Brzoska E

    更新日期：2020-08-06 00:00:00

  • Role of VEGF-A in angiogenesis promoted by umbilical cord-derived mesenchymal stromal/stem cells: in vitro study.

    abstract：BACKGROUND:Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most acceptable, safe, and effective source for allogeneic cell therapy e.g. for therapeutic angiogenesis. In this report we describe pro-angiogenic properties...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-016-0305-4

    authors： Arutyunyan I,Fatkhudinov T,Kananykhina E,Usman N,Elchaninov A,Makarov A,Bolshakova G,Goldshtein D,Sukhikh G

    更新日期：2016-03-22 00:00:00

  • 17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway.

    abstract：INTRODUCTION:Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, the effects of estrogen on the differentiation of SCAP remain unclear. METHODS:SCAP was isolated a...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/scrt515

    authors： Li Y,Yan M,Wang Z,Zheng Y,Li J,Ma S,Liu G,Yu J

    更新日期：2014-11-17 00:00:00

  • Topological and electrical control of cardiac differentiation and assembly.

    abstract：:Tissue engineering has developed many paradigms and techniques on how to best integrate cells and extracellular matrix to create in vitro structures that replicate native tissue. The strategy best suited for building these constructs depends mainly on the target cells, tissues, and organ of interest, and how readily t...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/scrt162

    authors： Thavandiran N,Nunes SS,Xiao Y,Radisic M

    更新日期：2013-02-14 00:00:00

  • Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis.

    abstract：BACKGROUND:Multiple sclerosis is a demyelinating disease mostly of autoimmune origin that affects and damages the central nervous system, leading to a disabling condition. The aim of the present study was to investigate whether administration of mesenchymal stem cells from human periodontal ligament (hPDLSCs) could ame...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-015-0253-4

    authors： Trubiani O,Giacoppo S,Ballerini P,Diomede F,Piattelli A,Bramanti P,Mazzon E

    更新日期：2016-01-04 00:00:00

  • Curcumin-mediated bone marrow mesenchymal stem cell sheets create a favorable immune microenvironment for adult full-thickness cutaneous wound healing.

    abstract：BACKGROUND:Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-mediated tissue regeneration driven by biomaterial offers an attractive regenerative strategy for dama...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-018-0768-6

    authors： Yang Z,He C,He J,Chu J,Liu H,Deng X

    更新日期：2018-01-31 00:00:00

  • The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling.

    abstract：BACKGROUND:The Activin A and bone morphogenetic protein (BMP) pathways are critical regulators of the immune system and of bone formation. Inappropriate activation of these pathways, as in conditions of congenital heterotopic ossification, are thought to activate an osteogenic program in endothelial cells. However, if ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-016-0372-6

    authors： Barruet E,Morales BM,Lwin W,White MP,Theodoris CV,Kim H,Urrutia A,Wong SA,Srivastava D,Hsiao EC

    更新日期：2016-08-17 00:00:00

  • Transcriptome differences in adipose stromal cells derived from pre- and postmenopausal women.

    abstract：BACKGROUND:As the population ages, an increasing number of postmenopausal women are donors of adipose stromal cells (ASCs) and may benefit from autologous ASC-related treatments. However, the effect of menopausal status on ASCs has not been investigated. METHODS:RNA sequencing data were downloaded, and differentially ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-01613-x

    authors： Xie Y,Fang B,Liu W,Li G,Huang RL,Zhang L,He J,Zhou S,Liu K,Li Q

    更新日期：2020-02-28 00:00:00