Curcumin-mediated bone marrow mesenchymal stem cell sheets create a favorable immune microenvironment for adult full-thickness cutaneous wound healing.

abstract：:Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in different preclinical studies of central nervous system (CNS) disorders due to their immunomodulatory propertie...

journal_title：Stem cell research & therapy

authors： De Vocht N,Praet J,Reekmans K,Le Blon D,Hoornaert C,Daans J,Berneman Z,Van der Linden A,Ponsaerts P

更新日期：2013-08-22 00:00:00

abstract：BACKGROUND:Liver organoid technology holds great promises to be used in large-scale population-based drug screening and in future regenerative medicine strategies. Recently, some studies reported robust protocols for generating isogenic liver organoids using liver parenchymal and non-parenchymal cells derived from indu...

journal_title：Stem cell research & therapy

authors： Goulart E,de Caires-Junior LC,Telles-Silva KA,Araujo BHS,Kobayashi GS,Musso CM,Assoni AF,Oliveira D,Caldini E,Gerstenhaber JA,Raia S,Lelkes PI,Zatz M

更新日期：2019-08-15 00:00:00

abstract：:The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs has created the opportunity to model diseases in culture systems, with the potential to rapidly advance the drug discovery field. Current methods of drug disco...

journal_title：Stem cell research & therapy

authors： Guo Z,Higgins CA,Gillette BM,Itoh M,Umegaki N,Gledhill K,Sia SK,Christiano AM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:This prospective clinical case series aimed to investigate the safety of subretinal adipose tissue-derived mesenchymal stem cell (ADMSC) implantation in advanced stage retinitis pigmentosa (RP). METHODS:This study included 11 patients with end-stage RP who received subretinal implantation of ADMSCs. All pat...

journal_title：Stem cell research & therapy

authors： Oner A,Gonen ZB,Sinim N,Cetin M,Ozkul Y

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects female fertility. However, with the lack of a corresponding research model, the pathology mechanism of PCOS is poorly understood. Induced pluripotent stem cell (iPSC) technology has been recognized as means to generate...

journal_title：Stem cell research & therapy

authors： Min Z,Gao Q,Zhen X,Fan Y,Tan T,Li R,Zhao Y,Yu Y

更新日期：2018-08-09 00:00:00

abstract：BACKGROUND:Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester human umbilical cord-derived perivascular cells (FTM HUCPVCs) have multipotent characteristics and pr...

journal_title：Stem cell research & therapy

authors： Iqbal F,Szaraz P,Librach M,Gauthier-Fisher A,Librach CL

更新日期：2017-08-14 00:00:00

abstract：:The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential...

journal_title：Stem cell research & therapy

authors： Sipp D

更新日期：2010-04-12 00:00:00

abstract：INTRODUCTION:Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a wide variety of tissues. This study aims to assess the functional similarities of MPCs from differen...

journal_title：Stem cell research & therapy

authors： Djouad F,Jackson WM,Bobick BE,Janjanin S,Song Y,Huang GT,Tuan RS

更新日期：2010-05-04 00:00:00

abstract：INTRODUCTION:Stem cell therapy has emerged as potential therapeutic strategy for damaged heart muscles. Umbilical cord blood (UCB) cells are the most prevalent stem cell source available, yet have not been fully tested in cardiac regeneration. Herein, studies were performed to evaluate the cardiovascular safety and ben...

journal_title：Stem cell research & therapy

authors： Oommen S,Yamada S,Cantero Peral S,Campbell KA,Bruinsma ES,Terzic A,Nelson TJ

更新日期：2015-03-26 00:00:00

abstract：INTRODUCTION:Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease the function of MSCs during recovery from tissue and organ damage. Extracellular vesicles (EVs) released from MSCs contribute to the repair of kidney injury. We explored the influe...

journal_title：Stem cell research & therapy

authors： Wang Y,Guo YF,Fu GP,Guan C,Zhang X,Yang DG,Shi YC

更新日期：2020-07-08 00:00:00

abstract：INTRODUCTION:Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, the effects of estrogen on the differentiation of SCAP remain unclear. METHODS:SCAP was isolated a...

journal_title：Stem cell research & therapy

authors： Li Y,Yan M,Wang Z,Zheng Y,Li J,Ma S,Liu G,Yu J

更新日期：2014-11-17 00:00:00

abstract：INTRODUCTION:Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue damage, and cancer. However, the use of mesenchymal stem cells (MSCs) to treat multiple myeloma (M...

journal_title：Stem cell research & therapy

authors： Atsuta I,Liu S,Miura Y,Akiyama K,Chen C,An Y,Shi S,Chen FM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Induced pluripotent stem cells (iPSCs) exhibit limitless pluripotent plasticity and proliferation capability to provide an abundant cell source for tissue regenerative medicine. Thus, inducing iPSCs toward a specific differentiation direction is an important scientific question. Traditionally, iPSCs have bee...

journal_title：Stem cell research & therapy

authors： Hu Y,Chen L,Gao Y,Cheng P,Yang L,Wu C,Jie Q

更新日期：2020-02-21 00:00:00

abstract：BACKGROUND:Clinical use of mesenchymal stem cells (MSCs) requires a uniform cell population, and their harvesting is invasive and produces a limited number of cells. Human embryonic stem cell-derived MSCs (hESC-MSCs) can differentiate into three germ layers and possess immunosuppressive effects in vitro. Anticancer tre...

journal_title：Stem cell research & therapy

authors： Yoon SY,Yoon JA,Park M,Shin EY,Jung S,Lee JE,Eum JH,Song H,Lee DR,Lee WS,Lyu SW

更新日期：2020-06-26 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive accumulation of Lewy body inclusions along with selective destruction of dopaminergic (DA) neurons in the nigrostriatal tract of the brain. Genetic studies have revealed much about the pathophysiology of PD, enabling the identifi...

journal_title：Stem cell research & therapy

authors： Gibson SA,Gao GD,McDonagh K,Shen S

更新日期：2012-04-03 00:00:00

abstract：BACKGROUND:Periodontitis is a widespread infectious disease ultimately resulting in tooth loss. The number of mesenchymal stem cells (MSCs) in patients with periodontitis is decreased, and MSC functions are impaired. Rescuing the impaired function of MSCs in periodontitis is the key for treatment, especially in a manne...

journal_title：Stem cell research & therapy

authors： Han N,Zhang F,Li G,Zhang X,Lin X,Yang H,Wang L,Cao Y,Du J,Fan Z

更新日期：2017-09-29 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and to suppress immune response raises questions regarding their biosafety. Our aim was to evaluate wheth...

journal_title：Stem cell research & therapy

authors： Bruna F,Plaza A,Arango M,Espinoza I,Conget P

更新日期：2018-05-11 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from ...

journal_title：Stem cell research & therapy

authors： Boeuf S,Richter W

更新日期：2010-10-13 00:00:00

abstract：:The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therapeutic possibility for the ovarian graft in hypoxia. We designed the present study to evaluate whether the cell-...

journal_title：Stem cell research & therapy

authors： Damous LL,de Carvalho AETS,Nakamuta JS,Shiroma ME,Louzada ACS,Soares-Jr JM,Krieger JE,Baracat EC

更新日期：2018-11-21 00:00:00

abstract：INTRODUCTION:Facing the challenging treatment of neurodegenerative diseases as well as complex craniofacial injuries such as those common after cancer therapy, the field of regenerative medicine increasingly relies on stem cell transplantation strategies. Here, neural crest-derived stem cells (NCSCs) offer many promisi...

journal_title：Stem cell research & therapy

authors： Greiner JF,Grunwald LM,Müller J,Sudhoff H,Widera D,Kaltschmidt C,Kaltschmidt B

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:Ectopic expression of a defined set of transcription factors allows the reprogramming of mammalian somatic cells to pluripotency. Despite continuous progress in primate and rodent reprogramming, limited attention has been paid to cell reprogramming in domestic and companion species. Previous studies attempti...

journal_title：Stem cell research & therapy

authors： Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

更新日期：2020-12-09 00:00:00

abstract：INTRODUCTION:Adipose tissue-derived stromal cells (ADSCs) are abundant and easy to obtain, but the diversity of differentiation potential from different locations may vary with the developmental origin of their mesenchymal compartment. We therefore aim to compare the myogenic differentiation and reparative activity of ...

journal_title：Stem cell research & therapy

authors： Wang X,Zhang H,Nie L,Xu L,Chen M,Ding Z

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:In our previous study, a venom-based peptide named Gonearrestide (also named P13) was identified and demonstrated with an effective inhibition in the proliferation of colon cancer cells. In this study, we explored if P13 and its potent mutant M6 could promote the proliferation of human embryonic stem cells a...

journal_title：Stem cell research & therapy

authors： Ma R,Ren Z,Li B,Siu SWI,Chen G,Kwok HF

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investi...

journal_title：Stem cell research & therapy

authors： Tomasello L,Musso R,Cillino G,Pitrone M,Pizzolanti G,Coppola A,Arancio W,Di Cara G,Pucci-Minafra I,Cillino S,Giordano C

更新日期：2016-06-13 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains very low due to some poorly characterized key factors. Compared with fertilized embryos, somatic donor cells lack...

journal_title：Stem cell research & therapy

authors： Qu P,Wang Y,Zhang C,Liu E

更新日期：2020-02-18 00:00:00

abstract：INTRODUCTION:Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and immunomodulatory ability of systemic OFSC transplantation were demonstrated in our previous wor...

journal_title：Stem cell research & therapy

authors： Lin KJ,Loi MX,Lien GS,Cheng CF,Pao HY,Chang YC,Ji AT,Ho JH

更新日期：2013-06-14 00:00:00

abstract：BACKGROUND:The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been demonstrated to provide biological pacing in dogs with complete heart block. The mechanism appears to be the generation of the ion current (If) by the HCN2-...

journal_title：Stem cell research & therapy

authors： Bruzauskaite I,Bironaite D,Bagdonas E,Skeberdis VA,Denkovskij J,Tamulevicius T,Uvarovas V,Bernotiene E

更新日期：2016-04-30 00:00:00

abstract：:Mesenchymal stem cells have been used for cardiovascular regenerative therapy for decades. These cells have been established as one of the potential therapeutic agents, following several tests in animal models and clinical trials. In the process, various sources of mesenchymal stem cells have been identified which hel...

journal_title：Stem cell research & therapy

authors： Singh A,Singh A,Sen D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:The therapeutic effects of adipose-derived mesenchymal stem cell (ADSC) transplantation have been demonstrated in several models of central nervous system (CNS) injury and are thought to involve the modulation of the inflammatory response. However, the exact underlying molecular mechanism is poorly understoo...

journal_title：Stem cell research & therapy

authors： Zhou Z,Tian X,Mo B,Xu H,Zhang L,Huang L,Yao S,Huang Z,Wang Y,Xie H,Xu L,Zhang H

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Patients suffering from osteoporosis show an increased number of adipocytes in their bone marrow, concomitant with a reduction in the pool of human mesenchymal stem cells (hMSCs) that are able to differentiate into osteoblasts, thus leading to suppressed osteogenesis. METHODS:In order to be able to interfer...

journal_title：Stem cell research & therapy

authors： van Zoelen EJ,Duarte I,Hendriks JM,van der Woning SP

更新日期：2016-08-26 00:00:00