Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010-2015).

abstract：INTRODUCTION:Ischemic stroke is a leading cause of death and disability, but treatment options are severely limited. Cell therapy offers an attractive strategy for regenerating lost tissues and enhancing the endogenous healing process. In this study, we investigated the use of human embryonic stem cell-derived neural p...

journal_title：Stem cell research & therapy

authors： Drury-Stewart D,Song M,Mohamad O,Guo Y,Gu X,Chen D,Wei L

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:Within the last years, the interest in physical exercise as non-invasive stimulus influencing circulating hematopoietic stem and progenitor cell (CPC) concentrations has constantly grown. Cell estimates are often derived by determining the subgroup of CPC as percent lymphocytes (LYM) or mononuclear cells (MN...

journal_title：Stem cell research & therapy

authors： Kröpfl JM,Schmid M,Di Marzio Y,Schreiber K,Spengler CM

更新日期：2019-10-17 00:00:00

abstract：INTRODUCTION:Preterm newborns often require mechanical respiratory support that can result in ventilation-induced lung injury (VILI), despite exogenous surfactant treatment. Human amnion epithelial cells (hAECs) reduce lung inflammation and resultant abnormal lung development in preterm animals; co-administration with ...

journal_title：Stem cell research & therapy

authors： McDonald CA,Melville JM,Polglase GR,Jenkin G,Moss TJ

更新日期：2014-09-04 00:00:00

abstract：INTRODUCTION:Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a wide variety of tissues. This study aims to assess the functional similarities of MPCs from differen...

journal_title：Stem cell research & therapy

authors： Djouad F,Jackson WM,Bobick BE,Janjanin S,Song Y,Huang GT,Tuan RS

更新日期：2010-05-04 00:00:00

abstract：INTRODUCTION:Mesenchymal stromal cells (MSC) have well defined immunomodulatory properties including the suppression of lymphocyte proliferation and inhibition of dendritic cell (DC) maturation involving both cell contact and soluble factors. These properties have made MSC attractive candidates for cellular therapy. Ho...

journal_title：Stem cell research & therapy

authors： Cahill EF,Tobin LM,Carty F,Mahon BP,English K

更新日期：2015-03-11 00:00:00

abstract：INTRODUCTION:Transplanting mesenchymal stromal cells (MSCs) or their derivatives into a neurodegenerative environment is believed to be beneficial because of the trophic support, migratory guidance, immunosuppression, and neurogenic stimuli they provide. SB623, a cell therapy for the treatment of chronic stroke, curren...

journal_title：Stem cell research & therapy

authors： Aizman I,Tirumalashetty BJ,McGrogan M,Case CC

更新日期：2014-02-26 00:00:00

abstract：:The proteasome is a multi-enzyme complex responsible for orchestrating protein quality control by degrading misfolded, damaged, abnormal and foreign proteins. Studies related to the association of the proteasomal system in the preservation of self-renewal in both human and mouse pluripotent cells are sparse, and there...

journal_title：Stem cell research & therapy

authors： Schröter F,Adjaye J

更新日期：2014-02-18 00:00:00

abstract：BACKGROUND:Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators of the injury response, dental pulp stem cells (DPSCs) play a critical role in pulp tissue repair and regeneration. Resolvin E1 (RvE1), a major dietary omega-3 polyunsaturated fatty-a...

journal_title：Stem cell research & therapy

authors： Chen J,Xu H,Xia K,Cheng S,Zhang Q

更新日期：2021-01-22 00:00:00

abstract：INTRODUCTION:Silk fibroin (SF) scaffolds have been shown to be a suitable substrate for tissue engineering and to improve tissue regeneration when cellularized with mesenchymal stromal cells (MSCs). We here demonstrate, for the first time, that electrospun nanofibrous SF patches cellularized with human adipose-derived ...

journal_title：Stem cell research & therapy

authors： Navone SE,Pascucci L,Dossena M,Ferri A,Invernici G,Acerbi F,Cristini S,Bedini G,Tosetti V,Ceserani V,Bonomi A,Pessina A,Freddi G,Alessandrino A,Ceccarelli P,Campanella R,Marfia G,Alessandri G,Parati EA

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal muscle sphincters, such as the external anal or urinary sphincter. However, little is known about t...

journal_title：Stem cell research & therapy

authors： Thurner M,Deutsch M,Janke K,Messner F,Kreutzer C,Beyl S,Couillard-Després S,Hering S,Troppmair J,Marksteiner R

更新日期：2020-06-12 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive accumulation of Lewy body inclusions along with selective destruction of dopaminergic (DA) neurons in the nigrostriatal tract of the brain. Genetic studies have revealed much about the pathophysiology of PD, enabling the identifi...

journal_title：Stem cell research & therapy

authors： Gibson SA,Gao GD,McDonagh K,Shen S

更新日期：2012-04-03 00:00:00

abstract：INTRODUCTION:Nervous system injuries comprise a diverse group of disorders that include traumatic brain injury (TBI). The potential of mesenchymal stem cells (MSCs) to differentiate into neural cell types has aroused hope for the possible development of autologous therapies for central nervous system injury. METHODS:I...

journal_title：Stem cell research & therapy

authors： Nichols JE,Niles JA,DeWitt D,Prough D,Parsley M,Vega S,Cantu A,Lee E,Cortiella J

更新日期：2013-01-06 00:00:00

abstract：BACKGROUND:Patients suffering from osteoporosis show an increased number of adipocytes in their bone marrow, concomitant with a reduction in the pool of human mesenchymal stem cells (hMSCs) that are able to differentiate into osteoblasts, thus leading to suppressed osteogenesis. METHODS:In order to be able to interfer...

journal_title：Stem cell research & therapy

authors： van Zoelen EJ,Duarte I,Hendriks JM,van der Woning SP

更新日期：2016-08-26 00:00:00

abstract：INTRODUCTION:Facing the challenging treatment of neurodegenerative diseases as well as complex craniofacial injuries such as those common after cancer therapy, the field of regenerative medicine increasingly relies on stem cell transplantation strategies. Here, neural crest-derived stem cells (NCSCs) offer many promisi...

journal_title：Stem cell research & therapy

authors： Greiner JF,Grunwald LM,Müller J,Sudhoff H,Widera D,Kaltschmidt C,Kaltschmidt B

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:In our previous study, a venom-based peptide named Gonearrestide (also named P13) was identified and demonstrated with an effective inhibition in the proliferation of colon cancer cells. In this study, we explored if P13 and its potent mutant M6 could promote the proliferation of human embryonic stem cells a...

journal_title：Stem cell research & therapy

authors： Ma R,Ren Z,Li B,Siu SWI,Chen G,Kwok HF

更新日期：2020-06-18 00:00:00

abstract：:The outbreak of 2019 novel coronavirus disease (COVID-19) worldwide is becoming rapidly a major concern. The number of severe cases has increased dramatically worldwide, while specific treatment options are scarce. The main pathologic features of severe or critical COVID-19 were consistent with acute lung injure (ALI)...

journal_title：Stem cell research & therapy

authors： Liu S,Peng D,Qiu H,Yang K,Fu Z,Zou L

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:The widely recognized anti-cancer potential of aspirin has created a broad interest to explore the clinical benefits of aspirin in cancer therapy. However, the current understanding of the molecular mechanisms involved in the anti-cancer potential of aspirin remains limited. METHODS:Cancer stemness assays w...

journal_title：Stem cell research & therapy

authors： Zhang X,Du R,Luo N,Xiang R,Shen W

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:Human embryonic stem cells (hESCs) hold tremendous promise for cell replacement therapies for a range of degenerative diseases. In order to provide cost-effective treatments affordable by public health systems, HLA-matched allogeneic tissue banks of the highest quality clinical-grade hESCs will be required. ...

journal_title：Stem cell research & therapy

authors： Ye J,Bates N,Soteriou D,Grady L,Edmond C,Ross A,Kerby A,Lewis PA,Adeniyi T,Wright R,Poulton KV,Lowe M,Kimber SJ,Brison DR

更新日期：2017-06-05 00:00:00

abstract：INTRODUCTION:Fallopian tube, which is normally discarded in surgical procedures, has proven to be a source of mesenchymal stem cells (MSCs) with increasing evidence. However, fallopian tube mucosa, which can be acquired via non-invasive procedures, is a previously unknown source of MSCs. In the present study, we explor...

journal_title：Stem cell research & therapy

authors： Wang J,Zhao Y,Wu X,Yin S,Chuai Y,Wang A

更新日期：2015-05-21 00:00:00

abstract：INTRODUCTION:Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease the function of MSCs during recovery from tissue and organ damage. Extracellular vesicles (EVs) released from MSCs contribute to the repair of kidney injury. We explored the influe...

journal_title：Stem cell research & therapy

authors： Wang Y,Guo YF,Fu GP,Guan C,Zhang X,Yang DG,Shi YC

更新日期：2020-07-08 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are multipotent and have been derived from various tissues. Although MSCs share many basic features, they often display subtle tissue specific differences. We previously demonstrated that bone marrow (BM) MSCs frequently become polyploid in culture. This tendency was mediated ...

journal_title：Stem cell research & therapy

authors： Ravid O,Shoshani O,Sela M,Weinstock A,Sadan TW,Gur E,Zipori D,Shani N

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have recently attracted attention as novel multipotential stem cell sources. However, their application is limited due to in vitro replicative senescence. Ectopic expression of telomerase reverse transcriptase (TERT) is a promising strategy for overcomi...

journal_title：Stem cell research & therapy

authors： Yin Z,Wang Q,Li Y,Wei H,Shi J,Li A

更新日期：2016-04-04 00:00:00

abstract：BACKGROUND:Neural stem cells for the treatment of spinal cord injury (SCI) are of particular interest for future therapeutic use. However, until now, stem cell therapies are often limited due to the inhibitory environment following the injury. Therefore, in this study, we aimed at testing a combinatorial approach with ...

journal_title：Stem cell research & therapy

authors： Butenschön J,Zimmermann T,Schmarowski N,Nitsch R,Fackelmeier B,Friedemann K,Radyushkin K,Baumgart J,Lutz B,Leschik J

更新日期：2016-01-13 00:00:00

abstract：:Periostin is a matricellular protein that is reactivated during tissue damage and repair and has been shown to be a critical regulator of multiple biological pathways involved in the repair of tissue after myocardial infarction, peripheral vascular disease, and skin wounds. The tissue repair properties attributed to p...

journal_title：Stem cell research & therapy

authors： Chow T,Rogers IM

更新日期：2015-11-04 00:00:00

abstract：INTRODUCTION:Impaction allograft with cement is a common technique used in revision hip surgeries for the last 20 years. However, its clinical results are inconsistent. Recent studies have shown that mesenchymal stem cells (MSCs) seeded onto allograft can enhance bone formation. This in vitro study investigates whether...

journal_title：Stem cell research & therapy

authors： Reissis Y,García-Gareta E,Korda M,Blunn GW,Hua J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Human induced pluripotent stem cells (hiPSCs) offer a renewable source of cells for the generation of hematopoietic cells for cell-based therapy, disease modeling, and drug screening. However, current serum/feeder-free differentiation protocols rely on the use of various cytokines, which makes the process ve...

journal_title：Stem cell research & therapy

authors： Netsrithong R,Suwanpitak S,Boonkaew B,Trakarnsanga K,Chang LJ,Tipgomut C,Vatanashevanopakorn C,Pattanapanyasat K,Wattanapanitch M

更新日期：2020-11-11 00:00:00

abstract：INTRODUCTION:Adipose-derived stroma cells (ASCs) are attractive cells for cell-based gene therapy but are generally difficult to transfect. Nucleofection has proven to be an efficient method for transfection of primary cells. Therefore, we used this technique to transfect ASCs with a vector encoding for Ambystoma mexic...

journal_title：Stem cell research & therapy

authors： Fülbier A,Schnabel R,Michael S,Vogt PM,Strauß S,Reimers K,Radtke C

更新日期：2014-10-09 00:00:00

abstract：BACKGROUND:Exploring the effects of lncRNA SNHG1 in the process of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) would provide novel therapeutic strategies for tissue regeneration. METHODS:Loss-of-function and gain-of-function assays were induced by lentivirus. The osteogenic differentiation o...

journal_title：Stem cell research & therapy

authors： Li Z,Guo X,Wu S

更新日期：2020-10-07 00:00:00

abstract：INTRODUCTION:Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and immunomodulatory ability of systemic OFSC transplantation were demonstrated in our previous wor...

journal_title：Stem cell research & therapy

authors： Lin KJ,Loi MX,Lien GS,Cheng CF,Pao HY,Chang YC,Ji AT,Ho JH

更新日期：2013-06-14 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and to suppress immune response raises questions regarding their biosafety. Our aim was to evaluate wheth...

journal_title：Stem cell research & therapy

authors： Bruna F,Plaza A,Arango M,Espinoza I,Conget P

更新日期：2018-05-11 00:00:00