High quality clinical grade human embryonic stem cell lines derived from fresh discarded embryos.

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMMSCs) are suitable cell sources for dental pulp regeneration, but the mechanism of BMMSCs differentiation into odontogenic lineage remains unknown. The aim of the present study was to reveal the role of magnesium transporter protein 1 (MagT1) and MAPK pathways in the odo...

journal_title：Stem cell research & therapy

authors： Zheng JM,Kong YY,Li YY,Zhang W

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:Within the last years, the interest in physical exercise as non-invasive stimulus influencing circulating hematopoietic stem and progenitor cell (CPC) concentrations has constantly grown. Cell estimates are often derived by determining the subgroup of CPC as percent lymphocytes (LYM) or mononuclear cells (MN...

journal_title：Stem cell research & therapy

authors： Kröpfl JM,Schmid M,Di Marzio Y,Schreiber K,Spengler CM

更新日期：2019-10-17 00:00:00

abstract：BACKGROUND:The proangiogenic capacity of adipose tissue and its derivatives has been demonstrated in a variety of studies. The paracrine mechanism of the cellular component is considered to play a critical role in the regenerative properties of these tissues. However, cell-based therapy for clinical application has bee...

journal_title：Stem cell research & therapy

authors： Yu Z,Cai Y,Deng M,Li D,Wang X,Zheng H,Xu Y,Li W,Zhang W

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Exploring the effects of lncRNA SNHG1 in the process of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) would provide novel therapeutic strategies for tissue regeneration. METHODS:Loss-of-function and gain-of-function assays were induced by lentivirus. The osteogenic differentiation o...

journal_title：Stem cell research & therapy

authors： Li Z,Guo X,Wu S

更新日期：2020-10-07 00:00:00

abstract：INTRODUCTION:Mesenchymal stromal cells (MSC) have well defined immunomodulatory properties including the suppression of lymphocyte proliferation and inhibition of dendritic cell (DC) maturation involving both cell contact and soluble factors. These properties have made MSC attractive candidates for cellular therapy. Ho...

journal_title：Stem cell research & therapy

authors： Cahill EF,Tobin LM,Carty F,Mahon BP,English K

更新日期：2015-03-11 00:00:00

abstract：INTRODUCTION:Octamer-binding transcription factor 4 (Oct4) is a master regulator of early mammalian development. Its expression begins from the oocyte stage, becomes restricted to the inner cell mass of the blastocyst and eventually remains only in primordial germ cells. Unearthing the interactions of Oct4 would provid...

journal_title：Stem cell research & therapy

authors： Cheong CY,Lon Ng PM,Ponnampalam R,Tsai HH,Bourque G,Lufkin T

更新日期：2011-05-13 00:00:00

abstract：INTRODUCTION:The therapeutic effects of mesenchymal stem cells (MSCs) have been limited by their apoptosis induced by oxidative stress after delivery into the injured sites. Therefore, strategies designed to improve the MSC therapeutic efficacy need to be explored. Tetramethylpyrazine (TMP) can promote the proliferatio...

journal_title：Stem cell research & therapy

authors： Zhang L,Wang X,Lu X,Ma Y,Xin X,Xu X,Wang S,Hou Y

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. Here, we intended to find candidate miRNAs that are involved in cardiac differentiation through regu...

journal_title：Stem cell research & therapy

authors： Kay M,Soltani BM,Aghdaei FH,Ansari H,Baharvand H

更新日期：2019-06-27 00:00:00

abstract：INTRODUCTION:Endothelial dysfunction is found in different pathologies such as diabetes and renal and heart diseases, representing one of the major health problems. The reduced vasodilation of impaired endothelium starts a prothrombotic state associated with irregular blood flow. We aimed to explore the potential of am...

journal_title：Stem cell research & therapy

authors： Schiavo AA,Franzin C,Albiero M,Piccoli M,Spiro G,Bertin E,Urbani L,Visentin S,Cosmi E,Fadini GP,De Coppi P,Pozzobon M

更新日期：2015-10-31 00:00:00

abstract：INTRODUCTION:Facing the challenging treatment of neurodegenerative diseases as well as complex craniofacial injuries such as those common after cancer therapy, the field of regenerative medicine increasingly relies on stem cell transplantation strategies. Here, neural crest-derived stem cells (NCSCs) offer many promisi...

journal_title：Stem cell research & therapy

authors： Greiner JF,Grunwald LM,Müller J,Sudhoff H,Widera D,Kaltschmidt C,Kaltschmidt B

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:Many studies have shown that long noncoding RNAs (lncRNAs) are closely related to the stimulation of osteogenic differentiation of adipose-derived stem cells (ADSCs) and the prevention of osteoporosis. Current research aimed to investigate the novel lncRNA and explored the function and molecular mechanism of...

journal_title：Stem cell research & therapy

authors： Shi ZL,Zhang H,Fan ZY,Ma W,Song YZ,Li M,Li TQ,Cao SX,Feng GJ

更新日期：2020-06-17 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) play a central role in mediating endogenous repair of cell and tissue damage. Biologic aging is a universal process that results in changes at the cellular and molecular levels. In the present study, the role of microRNA (miRNA) in age-induced molecular changes in MSCs derived...

journal_title：Stem cell research & therapy

authors： Pandey AC,Semon JA,Kaushal D,O'Sullivan RP,Glowacki J,Gimble JM,Bunnell BA

更新日期：2011-11-14 00:00:00

abstract：:Owing to the aging of the population, our society now faces an impending wave of age-related neurodegenerative pathologies, the most significant of which is Alzheimer's disease. Currently, no effective therapies for Alzheimer's disease have been developed. However, recent advances in the fields of neural stem cells an...

journal_title：Stem cell research & therapy

authors： Byrne JA

更新日期：2014-05-30 00:00:00

abstract：INTRODUCTION:Human multipotent stromal cells (MSCs) isolated from bone marrow or other tissue sources have great potential to treat a wide range of injuries and disorders in the field of regenerative medicine and tissue engineering. In particular, MSCs have inherent characteristics to suppress the immune system and are...

journal_title：Stem cell research & therapy

authors： Bellayr IH,Catalano JG,Lababidi S,Yang AX,Lo Surdo JL,Bauer SR,Puri RK

更新日期：2014-04-28 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated that intravenous administration of adipose tissue stem cells (ASCs) could significantly reduce allergic symptoms and suppress eosinophilic inflammation. METHODS:To evaluate the secretome of ASCs, we administrated culture supernatant of ASCs (ASC sup, which contains the A...

journal_title：Stem cell research & therapy

authors： Yu HS,Park MK,Kang SA,Cho KS,Mun SJ,Roh HJ

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-mediated tissue regeneration driven by biomaterial offers an attractive regenerative strategy for dama...

journal_title：Stem cell research & therapy

authors： Yang Z,He C,He J,Chu J,Liu H,Deng X

更新日期：2018-01-31 00:00:00

abstract：BACKGROUND:Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue repair in the clinic. However, the feasibility and efficacy of a combination of USCs and SIS for skin...

journal_title：Stem cell research & therapy

authors： Zhang XR,Huang YZ,Gao HW,Jiang YL,Hu JG,Pi JK,Chen AJ,Zhang Y,Zhou L,Xie HQ

更新日期：2020-04-06 00:00:00

abstract：INTRODUCTION:The bursa subacromialis (BS) provides the gliding mechanism of the shoulder and regenerates itself after surgical removal. Therefore, we explored the presence of mesenchymal stem cells (MSCs) within the human adult BS tissue and characterized the BS cells compared to MSCs from bone marrow (BMSCs) on a mole...

journal_title：Stem cell research & therapy

authors： Steinert AF,Kunz M,Prager P,Göbel S,Klein-Hitpass L,Ebert R,Nöth U,Jakob F,Gohlke F

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been demonstrated to provide biological pacing in dogs with complete heart block. The mechanism appears to be the generation of the ion current (If) by the HCN2-...

journal_title：Stem cell research & therapy

authors： Bruzauskaite I,Bironaite D,Bagdonas E,Skeberdis VA,Denkovskij J,Tamulevicius T,Uvarovas V,Bernotiene E

更新日期：2016-04-30 00:00:00

abstract：BACKGROUND:Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (H2O2). In diabetes, elevated levels of glucose (hyperglycaemia) induce H2O2 production, which causes the endothelial dysfunction that underlies...

journal_title：Stem cell research & therapy

authors： Basmaeil YS,Al Subayyil AM,Khatlani T,Bahattab E,Al-Alwan M,Abomaray FM,Kalionis B,Alshabibi MA,AlAskar AS,Abumaree MH

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation...

journal_title：Stem cell research & therapy

authors： Bueno DF,Kabayashi GS,Pinheiro CCG,Tanikawa DYS,Raposo-Amaral CE,Rocha DL,Ferreira JRM,Shibuya Y,Hokugo A,Jarrahy R,ZuK PA,Passos-Bueno MR

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Vascular injury is one of the most common detrimental effects of cancer radiotherapy on healthy tissues. Since the efficacy of current preventive and therapeutic strategies remains limited, the exploration of new approaches to treat radiation-induced vascular injury (RIV) is on high demands. The use of mesen...

journal_title：Stem cell research & therapy

authors： Tao X,Sun M,Chen M,Ying R,Su W,Zhang J,Xie X,Wei W,Meng X

更新日期：2019-03-13 00:00:00

abstract：BACKGROUND:In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing. METHODS:In this review, we investigated the trends in injectable scaffolds for ASC delivery in the dermis, and injectable or implantable scaffolds for ASC del...

journal_title：Stem cell research & therapy

authors： Mamsen FP,Munthe-Fog L,Kring MKM,Duscher D,Taudorf M,Katz AJ,Kølle ST

更新日期：2021-01-19 00:00:00

abstract：:Injuries of the spinal cord trigger local healing but hardly restore normal function. Spinal cord injury (SCI) has been deeply studied to develop strategies for functional recovery. The study by van Gorp and colleagues uses a rat model of acute SCI to characterize the effects of intraspinal grafting of human fetal spi...

journal_title：Stem cell research & therapy

authors： Tavares I

更新日期：2013-06-13 00:00:00

abstract：INTRODUCTION:Silk fibroin (SF) scaffolds have been shown to be a suitable substrate for tissue engineering and to improve tissue regeneration when cellularized with mesenchymal stromal cells (MSCs). We here demonstrate, for the first time, that electrospun nanofibrous SF patches cellularized with human adipose-derived ...

journal_title：Stem cell research & therapy

authors： Navone SE,Pascucci L,Dossena M,Ferri A,Invernici G,Acerbi F,Cristini S,Bedini G,Tosetti V,Ceserani V,Bonomi A,Pessina A,Freddi G,Alessandrino A,Ceccarelli P,Campanella R,Marfia G,Alessandri G,Parati EA

更新日期：2014-01-14 00:00:00

abstract：INTRODUCTION:No comparative study of adipose-derived stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMSCs) by using superparamagnetic iron oxide nanoparticles (SPIOs)-labeling and magnetic resonance imaging (MRI) has been performed. METHODS:We studied the biological activity and MRI of ADSCs by labeling th...

journal_title：Stem cell research & therapy

authors： Fan J,Tan Y,Jie L,Wu X,Yu R,Zhang M

更新日期：2013-04-23 00:00:00

abstract：INTRODUCTION:Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Currently, the lack of a reliable and safe method to accurately and non-invasively locate the site of imp...

journal_title：Stem cell research & therapy

authors： Micci MA,Boone DR,Parsley MA,Wei J,Patrikeev I,Motamedi M,Hellmich HL

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:Acquired aplastic anemia (AA) is characterized by deficiency or dysfunction of the bone marrow (BM) microenvironment. However, little is known about the impairment of BM-derived mesenchymal stem cells (MSCs) in AA patients. METHODS:We used Illumina HiSeqTM 2000 sequencing, quantitative real-time polymerase ...

journal_title：Stem cell research & therapy

authors： Lu S,Ge M,Zheng Y,Li J,Feng X,Feng S,Huang J,Feng Y,Yang D,Shi J,Chen F,Han Z

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may promot...

journal_title：Stem cell research & therapy

authors： Farhana L,Nangia-Makker P,Arbit E,Shango K,Sarkar S,Mahmud H,Hadden T,Yu Y,Majumdar AP

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Exosomes are nanovesicles (30-120 nm) of endosomal origin. These exosomes contain various functional proteins and RNAs that could be used for therapeutic purposes. Currently, having a standard method for exosome isolation retaining its biological properties with increased yield and purity is a major challeng...

journal_title：Stem cell research & therapy

authors： Gupta S,Rawat S,Arora V,Kottarath SK,Dinda AK,Vaishnav PK,Nayak B,Mohanty S

更新日期：2018-07-04 00:00:00