Differences of embedding adipose-derived stromal cells in natural and synthetic scaffolds for dermal and subcutaneous delivery.

abstract：INTRODUCTION:Despite attempts to prevent brain injury during the hyperacute phase of stroke, most sufferers end up with significant neuronal loss and functional deficits. The use of cell-based therapies to recover the injured brain offers new hope. In the current study, we employed human neural stem cells (hNSCs) isola...

journal_title：Stem cell research & therapy

authors： Abeysinghe HC,Bokhari L,Quigley A,Choolani M,Chan J,Dusting GJ,Crook JM,Kobayashi NR,Roulston CL

更新日期：2015-09-29 00:00:00

abstract：BACKGROUND:The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues. The objective of this study was to identify nucleus pulposus-derived progenitor cells (NPPC) and examine...

journal_title：Stem cell research & therapy

authors： Tekari A,Chan SCW,Sakai D,Grad S,Gantenbein B

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term recurrence are high. Thus, a new treatment strategy is still needed. In recent years, bone marrow m...

journal_title：Stem cell research & therapy

authors： Zhang H,Huang J,Liu J,Li Y,Gao Y

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:As the population ages, an increasing number of postmenopausal women are donors of adipose stromal cells (ASCs) and may benefit from autologous ASC-related treatments. However, the effect of menopausal status on ASCs has not been investigated. METHODS:RNA sequencing data were downloaded, and differentially ...

journal_title：Stem cell research & therapy

authors： Xie Y,Fang B,Liu W,Li G,Huang RL,Zhang L,He J,Zhou S,Liu K,Li Q

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells derived from human umbilical cord tissue, termed UCX®, have the potential to promote a full range of events leading to tissue regeneration and homeostasis. The main goal of this work was to investigate UCX® action in experimentally induced hindlimb ischemia (HLI). METHODS:UCX®, obtain...

journal_title：Stem cell research & therapy

authors： Pereira AR,Mendes TF,Ministro A,Teixeira M,Filipe M,Santos JM,Bárcia RN,Goyri-O'Neill J,Pinto F,Cruz PE,Cruz HJ,Santos SC

更新日期：2016-09-29 00:00:00

abstract：:The proteasome is a multi-enzyme complex responsible for orchestrating protein quality control by degrading misfolded, damaged, abnormal and foreign proteins. Studies related to the association of the proteasomal system in the preservation of self-renewal in both human and mouse pluripotent cells are sparse, and there...

journal_title：Stem cell research & therapy

authors： Schröter F,Adjaye J

更新日期：2014-02-18 00:00:00

abstract：INTRODUCTION:Osteopontin (OPN) is a phosphoglycoprotein with important roles in tissue homeostasis, wound healing, immune regulation, and stress responses. It is expressed constitutively in the brain and upregulated during neuroinflammatory responses; for example, after focal cerebral ischemia. To date, its effects on ...

journal_title：Stem cell research & therapy

authors： Rabenstein M,Hucklenbroich J,Willuweit A,Ladwig A,Fink GR,Schroeter M,Langen KJ,Rueger MA

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:This study explored the details of the immune response after autologous hematopoietic stem cell transplantation (AHSCT) treatment in type 1 diabetes mellitus. METHODS:Peripheral blood mononuclear cells (PBMCs) from 18 patients with type 1 diabetes mellitus were taken at baseline and 12 months after AHSCT or...

journal_title：Stem cell research & therapy

authors： Ye L,Li L,Wan B,Yang M,Hong J,Gu W,Wang W,Ning G

更新日期：2017-04-18 00:00:00

abstract：:Ischemic heart disease is the major cause of death globally, and a recently developed stem cell transplantation is a promising therapy for myocardial infarction. Mesenchymal stem cells (MSCs) exist in a wide range of tissues, and their differentiation potential and immunoregulatory capacity make them a more optimal ca...

journal_title：Stem cell research & therapy

authors： Li Q,Wang Y,Deng Z

更新日期：2013-06-05 00:00:00

abstract：INTRODUCTION:Huntington's disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss and dysfunction of neurons in the neostriatum and cortex, leading to cognitive decline, motor dysfunction, and death, typically occurring 15 to ...

journal_title：Stem cell research & therapy

authors： Rossignol J,Fink KD,Crane AT,Davis KK,Bombard MC,Clerc S,Bavar AM,Lowrance SA,Song C,Witte S,Lescaudron L,Dunbar GL

更新日期：2015-02-19 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are multipotent and have been derived from various tissues. Although MSCs share many basic features, they often display subtle tissue specific differences. We previously demonstrated that bone marrow (BM) MSCs frequently become polyploid in culture. This tendency was mediated ...

journal_title：Stem cell research & therapy

authors： Ravid O,Shoshani O,Sela M,Weinstock A,Sadan TW,Gur E,Zipori D,Shani N

更新日期：2014-12-17 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive accumulation of Lewy body inclusions along with selective destruction of dopaminergic (DA) neurons in the nigrostriatal tract of the brain. Genetic studies have revealed much about the pathophysiology of PD, enabling the identifi...

journal_title：Stem cell research & therapy

authors： Gibson SA,Gao GD,McDonagh K,Shen S

更新日期：2012-04-03 00:00:00

abstract：INTRODUCTION:Silk fibroin (SF) scaffolds have been shown to be a suitable substrate for tissue engineering and to improve tissue regeneration when cellularized with mesenchymal stromal cells (MSCs). We here demonstrate, for the first time, that electrospun nanofibrous SF patches cellularized with human adipose-derived ...

journal_title：Stem cell research & therapy

authors： Navone SE,Pascucci L,Dossena M,Ferri A,Invernici G,Acerbi F,Cristini S,Bedini G,Tosetti V,Ceserani V,Bonomi A,Pessina A,Freddi G,Alessandrino A,Ceccarelli P,Campanella R,Marfia G,Alessandri G,Parati EA

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investi...

journal_title：Stem cell research & therapy

authors： Tomasello L,Musso R,Cillino G,Pitrone M,Pizzolanti G,Coppola A,Arancio W,Di Cara G,Pucci-Minafra I,Cillino S,Giordano C

更新日期：2016-06-13 00:00:00

abstract：:Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies using primary NK cells are prone to manufacturing issues related to expansion and storage. Alternative cell sourc...

journal_title：Stem cell research & therapy

authors： Shankar K,Capitini CM,Saha K

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester human umbilical cord-derived perivascular cells (FTM HUCPVCs) have multipotent characteristics and pr...

journal_title：Stem cell research & therapy

authors： Iqbal F,Szaraz P,Librach M,Gauthier-Fisher A,Librach CL

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:To reduce young female fertility loss, the in-vitro culture of cryopreserved ovarian cortical tissues (OCTs) is considered an effective approach without delaying treatment and undergoing stimulation medicine. However, ischemic damage and follicular loss during the in-vitro culture of OCTs are major technical...

journal_title：Stem cell research & therapy

authors： Jia Y,Shi X,Xie Y,Xie X,Wang Y,Li S

更新日期：2017-06-24 00:00:00

abstract：:Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a better understanding of molecular and cellular mechanisms of CVD as well as improved therapeutic str...

journal_title：Stem cell research & therapy

authors： Abou-Saleh H,Zouein FA,El-Yazbi A,Sanoudou D,Raynaud C,Rao C,Pintus G,Dehaini H,Eid AH

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSCs) exhibit the capacity to self-renew and differentiate into multi-lineage cell types, including osteoblasts, which are crucial regulators of fracture healing. Thus, this study aims to investigate the effect of microRNA (miR)-22-3p from BMSC-derived EVs on osteogenic d...

journal_title：Stem cell research & therapy

authors： Zhang X,Wang Y,Zhao H,Han X,Zhao T,Qu P,Li G,Wang W

更新日期：2020-06-10 00:00:00

abstract：INTRODUCTION:Degenerative retinal diseases like age-related macular degeneration (AMD) are the leading cause of blindness. Cell transplantation showed promising therapeutic effect for such diseases, and embryonic stem cell (ESC) is one of the sources of such donor cells. Here, we aimed to generate retinal progenitor ce...

journal_title：Stem cell research & therapy

authors： Qu Z,Guan Y,Cui L,Song J,Gu J,Zhao H,Xu L,Lu L,Jin Y,Xu GT

更新日期：2015-11-09 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) represents a devastating, progressive, heterogeneous, and the most common motor neuron (MN) disease. To date, no cure has been available for the condition. Studies with transgenic mice have yielded significant results that help us understand the underlying mechanisms of AL...

journal_title：Stem cell research & therapy

authors： Sun X,Song J,Huang H,Chen H,Qian K

更新日期：2018-11-15 00:00:00

abstract：:Over the last two decades, a new therapeutic paradigm has emerged which has changed the way debilitating diseases may be treated in the future. Instead of using small-molecule drugs and devices to ameliorate the symptoms of disease, clinicians may harness the therapeutic power of cells to regenerate and cure diseases ...

journal_title：Stem cell research & therapy

authors： O'Brien T,Creane M,Windebank AJ,Terzic A,Dietz AB

更新日期：2015-08-22 00:00:00

abstract：BACKGROUND:Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into cortical neurons for disease modeling and regenerative medicine. However, these procedures are hard to provide sufficient cells for their applications. Using a combination of small-molecules and growth factors, we pre...

journal_title：Stem cell research & therapy

authors： Zhao S,Duan K,Ai Z,Niu B,Chen Y,Kong R,Li T

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. Here, we intended to find candidate miRNAs that are involved in cardiac differentiation through regu...

journal_title：Stem cell research & therapy

authors： Kay M,Soltani BM,Aghdaei FH,Ansari H,Baharvand H

更新日期：2019-06-27 00:00:00

abstract：BACKGROUND:The dog represents an excellent large animal model for translational cell-based studies. Importantly, the properties of canine multipotent stromal cells (cMSCs) and the ideal tissue source for specific translational studies have yet to be established. The aim of this study was to characterize cMSCs derived f...

journal_title：Stem cell research & therapy

authors： Bearden RN,Huggins SS,Cummings KJ,Smith R,Gregory CA,Saunders WB

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Sepsis is a global inflammatory disease that causes death. It has been reported that mesenchymal stem cell (MSC) treatment can attenuate inflammatory and septic symptoms. In this study, we investigated how interactions between neutrophils and human umbilical cord blood (hUCB)-MSCs in the liver of septic mice...

journal_title：Stem cell research & therapy

authors： Ahn SY,Maeng YS,Kim YR,Choe YH,Hwang HS,Hyun YM

更新日期：2020-02-03 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis is a progressive diffuse parenchymal lung disorder of unknown etiology. Mesenchymal stem cell (MSC)-based therapy is a novel approach with great therapeutic potential for the treatment of lung diseases. Despite demonstration of MSC grafting, the populations of engrafted MSCs h...

journal_title：Stem cell research & therapy

authors： Lan YW,Choo KB,Chen CM,Hung TH,Chen YB,Hsieh CH,Kuo HP,Chong KY

更新日期：2015-05-20 00:00:00

abstract：:Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the i...

journal_title：Stem cell research & therapy

authors： Hegyesi H,Sándor N,Sáfrány G,Lovas V,Kovács Á,Takács A,Kőhidai L,Turiák L,Kittel Á,Pálóczi K,Bertók L,Buzás EI

更新日期：2019-10-29 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from ...

journal_title：Stem cell research & therapy

authors： Boeuf S,Richter W

更新日期：2010-10-13 00:00:00

abstract：:Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in different preclinical studies of central nervous system (CNS) disorders due to their immunomodulatory propertie...

journal_title：Stem cell research & therapy

authors： De Vocht N,Praet J,Reekmans K,Le Blon D,Hoornaert C,Daans J,Berneman Z,Van der Linden A,Ponsaerts P

更新日期：2013-08-22 00:00:00