Osteopontin mediates survival, proliferation and migration of neural stem cells through the chemokine receptor CXCR4.

abstract：BACKGROUND:Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucidation. This study was designed to explore whether high-dose silicate can induce a cytotoxicity effec...

journal_title：Stem cell research & therapy

authors： Li Z,Liu S,Fu T,Peng Y,Zhang J

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:miRNA expression profiles in ectopic endometrium (EC) serving as pathophysiologic genetic fingerprints contribute to determining endometriosis progression; however, the underlying molecular mechanisms remain unknown. METHODS:miRNA microarray analysis was used to determine the expression profiling of EC fres...

journal_title：Stem cell research & therapy

authors： Zhou CF,Liu MJ,Wang W,Wu S,Huang YX,Chen GB,Liu LM,Peng DX,Wang XF,Cai XZ,Li XX,Feng WQ,Ma Y

更新日期：2019-09-23 00:00:00

abstract：BACKGROUND:Bone marrow-derived cell therapy has been used to treat acute myocardial infarction. However, the therapeutic efficacy of this approach remains controversial. Here, we performed a systematic review and meta-analysis to evaluate short-term and long-term effectiveness of bone marrow-derived therapy. METHODS:W...

journal_title：Stem cell research & therapy

authors： Lee SH,Hong JH,Cho KH,Noh JW,Cho HJ

更新日期：2016-10-20 00:00:00

abstract：INTRODUCTION:Neural stem cells (NSCs) are among the most promising candidates for cell replacement therapy in neuronal injury and neurodegenerative diseases. One of the remaining obstacles for NSC therapy is to overcome the alloimmune response on NSCs by the host. METHODS:To investigate the mechanisms of immune modula...

journal_title：Stem cell research & therapy

authors： Lee EM,Hurh S,Cho B,Oh KH,Kim SU,Surh CD,Sprent J,Yang J,Kim JY,Ahn C

更新日期：2013-05-21 00:00:00

abstract：INTRODUCTION:Nervous system injuries comprise a diverse group of disorders that include traumatic brain injury (TBI). The potential of mesenchymal stem cells (MSCs) to differentiate into neural cell types has aroused hope for the possible development of autologous therapies for central nervous system injury. METHODS:I...

journal_title：Stem cell research & therapy

authors： Nichols JE,Niles JA,DeWitt D,Prough D,Parsley M,Vega S,Cantu A,Lee E,Cortiella J

更新日期：2013-01-06 00:00:00

abstract：OBJECTIVE:Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascularization bed. Considering the active role of adipose-derived stem cell (ADSC) in promoting angiogen...

journal_title：Stem cell research & therapy

authors： Luo Y,Yi X,Liang T,Jiang S,He R,Hu Y,Bai L,Wang C,Wang K,Zhu L

更新日期：2019-08-30 00:00:00

abstract：INTRODUCTION:Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Currently, the lack of a reliable and safe method to accurately and non-invasively locate the site of imp...

journal_title：Stem cell research & therapy

authors： Micci MA,Boone DR,Parsley MA,Wei J,Patrikeev I,Motamedi M,Hellmich HL

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:Patients suffering from osteoporosis show an increased number of adipocytes in their bone marrow, concomitant with a reduction in the pool of human mesenchymal stem cells (hMSCs) that are able to differentiate into osteoblasts, thus leading to suppressed osteogenesis. METHODS:In order to be able to interfer...

journal_title：Stem cell research & therapy

authors： van Zoelen EJ,Duarte I,Hendriks JM,van der Woning SP

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:MEG3 downregulated the expression in several tumors and inhibits human tumorigenesis. But so far, the mechanism of MEG3 in tumorigenesis is still unclear. METHODS:In gene infection, cellular and molecular technologies and tumorigenesis test in vitro and in vivo were performed, respectively. RESULTS:Our res...

journal_title：Stem cell research & therapy

authors： Jiang X,Wang L,Xie S,Chen Y,Song S,Lu Y,Lu D

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the second most prevalent cause of cancer-related fatality. Long non-coding RNAs (lncRNAs) have been observed to exercise functions in NSCLC. Here, the current study aimed to explore the potential mechanism of lncRNA MBNL1-AS1 in NSCLC. METHODS:Microarray analysis was p...

journal_title：Stem cell research & therapy

authors： Li P,Xing W,Xu J,Yuan D,Liang G,Liu B,Ma H

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:Induced pluripotent stem cells (iPSCs) exhibit limitless pluripotent plasticity and proliferation capability to provide an abundant cell source for tissue regenerative medicine. Thus, inducing iPSCs toward a specific differentiation direction is an important scientific question. Traditionally, iPSCs have bee...

journal_title：Stem cell research & therapy

authors： Hu Y,Chen L,Gao Y,Cheng P,Yang L,Wu C,Jie Q

更新日期：2020-02-21 00:00:00

abstract：BACKGROUND:Alveolar bone loss is a frequent occurrence. Dental pulp stem cells (DPSCs) which have invasive accessibility and high osteogenic potential is a promising source for cell-based bone regeneration. EphrinB2 is involved in bone homeostasis and osteogenesis. The aim of this study was to investigate the effect an...

journal_title：Stem cell research & therapy

authors： Wang W,Yuan C,Geng T,Liu Y,Zhu S,Zhang C,Liu Z,Wang P

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (H2O2). In diabetes, elevated levels of glucose (hyperglycaemia) induce H2O2 production, which causes the endothelial dysfunction that underlies...

journal_title：Stem cell research & therapy

authors： Basmaeil YS,Al Subayyil AM,Khatlani T,Bahattab E,Al-Alwan M,Abomaray FM,Kalionis B,Alshabibi MA,AlAskar AS,Abumaree MH

更新日期：2018-09-21 00:00:00

abstract：INTRODUCTION:Delivered systemically or natively circulating mesenchymal stem cells accumulate in injured tissues. During homing mesenchymal stem cells adhere to endothelial cells and infiltrate underlying tissue. Previously we have shown that adhesiveness of endothelial cells for mesenchymal stem cells correlates with ...

journal_title：Stem cell research & therapy

authors： Potapova IA,Cohen IS,Doronin SV

更新日期：2010-11-17 00:00:00

abstract：BACKGROUND:Mesenchymal stem cell (MSC)-based cartilage tissue regeneration is a treatment with great potential. How to enhance the MSC chondrogenic differentiation is a key issue involved in cartilage formation. In the present study, we seek to expound the phenotypes and mechanisms of DLX5 in chondrogenic differentiati...

journal_title：Stem cell research & therapy

authors： Yang H,Cao Y,Zhang J,Liang Y,Su X,Zhang C,Liu H,Han X,Ge L,Fan Z

更新日期：2020-07-06 00:00:00

abstract：INTRODUCTION:Ischemic stroke is a leading cause of death and disability, but treatment options are severely limited. Cell therapy offers an attractive strategy for regenerating lost tissues and enhancing the endogenous healing process. In this study, we investigated the use of human embryonic stem cell-derived neural p...

journal_title：Stem cell research & therapy

authors： Drury-Stewart D,Song M,Mohamad O,Guo Y,Gu X,Chen D,Wei L

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:The therapeutic effects of adipose-derived mesenchymal stem cell (ADSC) transplantation have been demonstrated in several models of central nervous system (CNS) injury and are thought to involve the modulation of the inflammatory response. However, the exact underlying molecular mechanism is poorly understoo...

journal_title：Stem cell research & therapy

authors： Zhou Z,Tian X,Mo B,Xu H,Zhang L,Huang L,Yao S,Huang Z,Wang Y,Xie H,Xu L,Zhang H

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:A keloid is a fibroproliferative disorder occurring in wounds characterized by an exaggerated response to injury. To date, no effective cure has been identified. As multipotent stem cells, human adipose-derived stem cells (ADSCs) may show the possibility for curing diseases such as fibrosis. This study sough...

journal_title：Stem cell research & therapy

authors： Wang X,Ma Y,Gao Z,Yang J

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have recently attracted attention as novel multipotential stem cell sources. However, their application is limited due to in vitro replicative senescence. Ectopic expression of telomerase reverse transcriptase (TERT) is a promising strategy for overcomi...

journal_title：Stem cell research & therapy

authors： Yin Z,Wang Q,Li Y,Wei H,Shi J,Li A

更新日期：2016-04-04 00:00:00

abstract：BACKGROUND:The therapeutic effect of mesenchymal stem cells (MSCs) from human adipose tissue on renal interstitial fibrosis has been demonstrated by several groups. However, the way to enhance the renoprotective effect of adipose-derived mesenchymal stem cells (AMSCs) and the possible mechanisms are still unclear. The ...

journal_title：Stem cell research & therapy

authors： Li S,Wang Y,Wang Z,Chen L,Zuo B,Liu C,Sun D

更新日期：2021-01-07 00:00:00

abstract：INTRODUCTION:Mesenchymal stromal cells (MSC) have well defined immunomodulatory properties including the suppression of lymphocyte proliferation and inhibition of dendritic cell (DC) maturation involving both cell contact and soluble factors. These properties have made MSC attractive candidates for cellular therapy. Ho...

journal_title：Stem cell research & therapy

authors： Cahill EF,Tobin LM,Carty F,Mahon BP,English K

更新日期：2015-03-11 00:00:00

abstract：INTRODUCTION:Adipose-derived stroma cells (ASCs) are attractive cells for cell-based gene therapy but are generally difficult to transfect. Nucleofection has proven to be an efficient method for transfection of primary cells. Therefore, we used this technique to transfect ASCs with a vector encoding for Ambystoma mexic...

journal_title：Stem cell research & therapy

authors： Fülbier A,Schnabel R,Michael S,Vogt PM,Strauß S,Reimers K,Radtke C

更新日期：2014-10-09 00:00:00

abstract：INTRODUCTION:Our previous works demonstrated that systemic orbital fat-derived stem cell (OFSC) transplantation was effective in ameliorating lipopolysaccharide (LPS)-induced extensive acute lung injury (ALI) in vivo mainly through paracrine regulation of macrophage-mediated cytokine-storm. In this study, we explore th...

journal_title：Stem cell research & therapy

authors： Lien GS,Liu JF,Chien MH,Hsu WT,Chang TH,Ku CC,Ji AT,Tan P,Hsieh TL,Lee LM,Ho JH

更新日期：2014-08-13 00:00:00

abstract：BACKGROUND:Bone marrow-derived mesenchymal stromal cells (MSCs) are multipotent cells with a high constitutive level of autophagy and low expression of CD99. Under certain conditions, MSCs may develop tumorigenic properties. However, these transformation-induced conditions are largely unknown. Recently, we have identif...

journal_title：Stem cell research & therapy

authors： Husak Z,Dworzak MN

更新日期：2017-04-18 00:00:00

abstract：BACKGROUND:Complex immunophenotypic repertoires defining discrete adipose-derived stem cell (ASC) subpopulations may hold a key toward identifying predictors of clinical utility. To this end, we sorted out of the freshly established ASCs four subpopulations (SPs) according to a specific pattern of co-expression of six ...

journal_title：Stem cell research & therapy

authors： Nielsen FM,Riis SE,Andersen JI,Lesage R,Fink T,Pennisi CP,Zachar V

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the mechanisms controlling its differentiation and function are not fully ...

journal_title：Stem cell research & therapy

authors： He F,Li N,Huang HB,Wang JB,Yang XF,Wang HD,Huang W,Li FR

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem cells, intercellular molecule exchange by the adipose tissue complex, a vast array of bioactive secret...

journal_title：Stem cell research & therapy

authors： Bellei B,Migliano E,Tedesco M,Caputo S,Papaccio F,Lopez G,Picardo M

更新日期：2018-08-09 00:00:00

abstract：INTRODUCTION:Adipose tissue-derived stromal cells (ADSCs) are abundant and easy to obtain, but the diversity of differentiation potential from different locations may vary with the developmental origin of their mesenchymal compartment. We therefore aim to compare the myogenic differentiation and reparative activity of ...

journal_title：Stem cell research & therapy

authors： Wang X,Zhang H,Nie L,Xu L,Chen M,Ding Z

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Prostate cancer is the second most frequent cancer among males worldwide, and most patients with metastatic disease eventually develop therapy-resistant disease. Recent research has suggested the existence of cancer stem-like cells, and that such cells are behind the therapy resistance and progression. METH...

journal_title：Stem cell research & therapy

authors： Ceder JA,Aalders TW,Schalken JA

更新日期：2017-04-26 00:00:00

abstract：INTRODUCTION:Fallopian tube, which is normally discarded in surgical procedures, has proven to be a source of mesenchymal stem cells (MSCs) with increasing evidence. However, fallopian tube mucosa, which can be acquired via non-invasive procedures, is a previously unknown source of MSCs. In the present study, we explor...

journal_title：Stem cell research & therapy

authors： Wang J,Zhao Y,Wu X,Yin S,Chuai Y,Wang A

更新日期：2015-05-21 00:00:00