Abstract:
INTRODUCTION:Neural stem cells (NSCs) are among the most promising candidates for cell replacement therapy in neuronal injury and neurodegenerative diseases. One of the remaining obstacles for NSC therapy is to overcome the alloimmune response on NSCs by the host. METHODS:To investigate the mechanisms of immune modulatory function derived from the interaction of human NSCs with allogeneic T cells, we examined the immune regulatory effects of human NSCs on allogeneic T cells in vitro. RESULTS:Significantly, NSCs induced apoptosis of allogeneic T cells, in particular CD4+ T cells. Interaction of CD70 on NSCs and CD27 on CD4(+) T cells mediated apoptosis of T cells. Thus, blocking CD70-CD27 interaction prevented NSC-mediated death of CD4(+) T cells. CONCLUSIONS:We present a rational explanation of NSC-induced immune escape in two consecutive stages. First, CD70 constitutively expressed on NSCs engaged CD27 on CD4(+) T cells, which induced Fas ligand expression on CD4(+) T cells. Second, CD4(+) T-cell apoptosis was followed by Fas-Fas ligand interaction in the CD4(+) T cells.
journal_name
Stem Cell Res Therjournal_title
Stem cell research & therapyauthors
Lee EM,Hurh S,Cho B,Oh KH,Kim SU,Surh CD,Sprent J,Yang J,Kim JY,Ahn Cdoi
10.1186/scrt206subject
Has Abstractpub_date
2013-05-21 00:00:00pages
56issue
3issn
1757-6512pii
scrt206journal_volume
4pub_type
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