Comparative analysis of mesenchymal stem cell and embryonic tendon progenitor cell response to embryonic tendon biochemical and mechanical factors.

abstract：INTRODUCTION:Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a wide variety of tissues. This study aims to assess the functional similarities of MPCs from differen...

journal_title：Stem cell research & therapy

authors： Djouad F,Jackson WM,Bobick BE,Janjanin S,Song Y,Huang GT,Tuan RS

更新日期：2010-05-04 00:00:00

abstract：BACKGROUND:The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) can be expanded to produce adipose-derived stem cells (ADSC) which represents a combination of endothe...

journal_title：Stem cell research & therapy

authors： Chen J,Wang Y,Hu H,Xiong Y,Wang S,Yang J

更新日期：2021-01-29 00:00:00

abstract：:Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies using primary NK cells are prone to manufacturing issues related to expansion and storage. Alternative cell sourc...

journal_title：Stem cell research & therapy

authors： Shankar K,Capitini CM,Saha K

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan-increasing clinical case reports have documented that it could induce cardiotoxicity including severe arrhythmias and heart failur...

journal_title：Stem cell research & therapy

authors： Liu R,Li D,Sun F,Rampoldi A,Maxwell JT,Wu R,Fischbach P,Castellino SM,Du Y,Fu H,Mandawat A,Xu C

更新日期：2020-11-05 00:00:00

abstract：:Owing to the aging of the population, our society now faces an impending wave of age-related neurodegenerative pathologies, the most significant of which is Alzheimer's disease. Currently, no effective therapies for Alzheimer's disease have been developed. However, recent advances in the fields of neural stem cells an...

journal_title：Stem cell research & therapy

authors： Byrne JA

更新日期：2014-05-30 00:00:00

abstract：INTRODUCTION:No comparative study of adipose-derived stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMSCs) by using superparamagnetic iron oxide nanoparticles (SPIOs)-labeling and magnetic resonance imaging (MRI) has been performed. METHODS:We studied the biological activity and MRI of ADSCs by labeling th...

journal_title：Stem cell research & therapy

authors： Fan J,Tan Y,Jie L,Wu X,Yu R,Zhang M

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMMSCs) are suitable cell sources for dental pulp regeneration, but the mechanism of BMMSCs differentiation into odontogenic lineage remains unknown. The aim of the present study was to reveal the role of magnesium transporter protein 1 (MagT1) and MAPK pathways in the odo...

journal_title：Stem cell research & therapy

authors： Zheng JM,Kong YY,Li YY,Zhang W

更新日期：2019-01-31 00:00:00

abstract：:The outbreak of 2019 novel coronavirus disease (COVID-19) worldwide is becoming rapidly a major concern. The number of severe cases has increased dramatically worldwide, while specific treatment options are scarce. The main pathologic features of severe or critical COVID-19 were consistent with acute lung injure (ALI)...

journal_title：Stem cell research & therapy

authors： Liu S,Peng D,Qiu H,Yang K,Fu Z,Zou L

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involved in this effect. However, the mechanisms by which BMSC modulate neutrophil remains unknown. METHOD...

journal_title：Stem cell research & therapy

authors： Su X,Yang L,Yin Y,Huang J,Qiao F,Fang Y,Yu L,Wang Y,Zhou K,Wang J

更新日期：2018-09-26 00:00:00

abstract：OBJECTIVES:Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been developed yet. MATERIALS AND METHODS:Here, we developed the full chemical-defined medium, NBVbe med...

journal_title：Stem cell research & therapy

authors： Xu J,Lian W,Chen J,Li W,Li L,Huang Z

更新日期：2020-03-19 00:00:00

abstract：INTRODUCTION:Osteopontin (OPN) is a phosphoglycoprotein with important roles in tissue homeostasis, wound healing, immune regulation, and stress responses. It is expressed constitutively in the brain and upregulated during neuroinflammatory responses; for example, after focal cerebral ischemia. To date, its effects on ...

journal_title：Stem cell research & therapy

authors： Rabenstein M,Hucklenbroich J,Willuweit A,Ladwig A,Fink GR,Schroeter M,Langen KJ,Rueger MA

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:As a type of high-frequency electrotherapy, a short-wave can promote the fracture healing process; yet, its underlying therapeutic mechanisms remain unclear. PURPOSE:To observe the effect of Short-Wave therapy on mesenchymal stem cell (MSC) homing and relative mechanisms associated with fracture healing. M...

journal_title：Stem cell research & therapy

authors： Ye D,Chen C,Wang Q,Zhang Q,Li S,Liu H

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) from the human umbilical cord have been studied extensively due to their immunomodulatory functions. Large-conductance Ca2+-activated K+ (BKCa channels) channels are involved in many inflammatory responses, but their involvement in the anti-inflammator...

journal_title：Stem cell research & therapy

authors： Song A,Wang J,Tong Y,Fang J,Zhang Y,Zhang H,Ruan H,Wang K,Liu Y

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Hematopoietic stem cell (HSC) transplantation has been widely applied to the treatment of malignant blood diseases. However, limited number of functional HSCs hinders successful transplantation. The purpose of our current study is to develop a new and cost-efficient medium formulation that could greatly enha...

journal_title：Stem cell research & therapy

authors： Zhang Y,Shen B,Guan X,Qin M,Ren Z,Ma Y,Dai W,Ding X,Jiang Y

更新日期：2019-06-13 00:00:00

abstract：:Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the i...

journal_title：Stem cell research & therapy

authors： Hegyesi H,Sándor N,Sáfrány G,Lovas V,Kovács Á,Takács A,Kőhidai L,Turiák L,Kittel Á,Pálóczi K,Bertók L,Buzás EI

更新日期：2019-10-29 00:00:00

abstract：:The loss of neurons and degeneration of axons after spinal cord injury result in the loss of sensory and motor functions. A bridging biomaterial construct that allows the axons to grow through has been investigated for the repair of injured spinal cord. Due to the hostility of the microenvironment in the lesion, multi...

journal_title：Stem cell research & therapy

authors： Shrestha B,Coykendall K,Li Y,Moon A,Priyadarshani P,Yao L

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:As the population ages, an increasing number of postmenopausal women are donors of adipose stromal cells (ASCs) and may benefit from autologous ASC-related treatments. However, the effect of menopausal status on ASCs has not been investigated. METHODS:RNA sequencing data were downloaded, and differentially ...

journal_title：Stem cell research & therapy

authors： Xie Y,Fang B,Liu W,Li G,Huang RL,Zhang L,He J,Zhou S,Liu K,Li Q

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Mesenchymal stem cell (MSC)-based cartilage tissue regeneration is a treatment with great potential. How to enhance the MSC chondrogenic differentiation is a key issue involved in cartilage formation. In the present study, we seek to expound the phenotypes and mechanisms of DLX5 in chondrogenic differentiati...

journal_title：Stem cell research & therapy

authors： Yang H,Cao Y,Zhang J,Liang Y,Su X,Zhang C,Liu H,Han X,Ge L,Fan Z

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bone marrow (BM-MSC) have long been the most used stem cell source in cartilage tissue engineering, the...

journal_title：Stem cell research & therapy

authors： Reppel L,Schiavi J,Charif N,Leger L,Yu H,Pinzano A,Henrionnet C,Stoltz JF,Bensoussan D,Huselstein C

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucidation. This study was designed to explore whether high-dose silicate can induce a cytotoxicity effec...

journal_title：Stem cell research & therapy

authors： Li Z,Liu S,Fu T,Peng Y,Zhang J

更新日期：2019-11-27 00:00:00

abstract：:Injuries of the spinal cord trigger local healing but hardly restore normal function. Spinal cord injury (SCI) has been deeply studied to develop strategies for functional recovery. The study by van Gorp and colleagues uses a rat model of acute SCI to characterize the effects of intraspinal grafting of human fetal spi...

journal_title：Stem cell research & therapy

authors： Tavares I

更新日期：2013-06-13 00:00:00

abstract：:Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a better understanding of molecular and cellular mechanisms of CVD as well as improved therapeutic str...

journal_title：Stem cell research & therapy

authors： Abou-Saleh H,Zouein FA,El-Yazbi A,Sanoudou D,Raynaud C,Rao C,Pintus G,Dehaini H,Eid AH

更新日期：2018-07-27 00:00:00

abstract：:Tendon injuries, as one of the most common orthopedic disorders, are the major cause of early retirement or wastage among sport horses which mainly affect the superficial digital flexor tendon (SDFT). Tendon repair is a slow process, and tendon tissue is often replaced by scar tissue. The current treatment options are...

journal_title：Stem cell research & therapy

authors： Shojaee A,Parham A

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may promot...

journal_title：Stem cell research & therapy

authors： Farhana L,Nangia-Makker P,Arbit E,Shango K,Sarkar S,Mahmud H,Hadden T,Yu Y,Majumdar AP

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcomes may be helpful. Hematopoietic stem and progenitor cell (HSPC)-mediated gene therapy often requires...

journal_title：Stem cell research & therapy

authors： Bhatt KH,Rudraraju R,Brooks JF,Jung JW,Galea R,Wells JW,Steptoe RJ

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capacity. Most neural stem cells are in a quiescent state, but in response to extrinsic stimuli, they can...

journal_title：Stem cell research & therapy

authors： Li W,Wang S,He H,Qin J,Cheng X,Zhao H,Tian M,Zhang X,Jin G

更新日期：2021-01-09 00:00:00

abstract：INTRODUCTION:Ischemic stroke is a leading cause of death and disability, but treatment options are severely limited. Cell therapy offers an attractive strategy for regenerating lost tissues and enhancing the endogenous healing process. In this study, we investigated the use of human embryonic stem cell-derived neural p...

journal_title：Stem cell research & therapy

authors： Drury-Stewart D,Song M,Mohamad O,Guo Y,Gu X,Chen D,Wei L

更新日期：2013-08-08 00:00:00

abstract：INTRODUCTION:Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection of the factors that these cells secrete could be effective, but the effect of conditioned medium (C...

journal_title：Stem cell research & therapy

authors： Xing L,Cui R,Peng L,Ma J,Chen X,Xie RJ,Li B

更新日期：2014-08-21 00:00:00

abstract：INTRODUCTION:The therapeutic effects of mesenchymal stem cells (MSCs) have been limited by their apoptosis induced by oxidative stress after delivery into the injured sites. Therefore, strategies designed to improve the MSC therapeutic efficacy need to be explored. Tetramethylpyrazine (TMP) can promote the proliferatio...

journal_title：Stem cell research & therapy

authors： Zhang L,Wang X,Lu X,Ma Y,Xin X,Xu X,Wang S,Hou Y

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues. The objective of this study was to identify nucleus pulposus-derived progenitor cells (NPPC) and examine...

journal_title：Stem cell research & therapy

authors： Tekari A,Chan SCW,Sakai D,Grad S,Gantenbein B

更新日期：2016-05-23 00:00:00