DLX5 and HOXC8 enhance the chondrogenic differentiation potential of stem cells from apical papilla via LINC01013.

abstract：BACKGROUND:Many studies have shown that long noncoding RNAs (lncRNAs) are closely related to the stimulation of osteogenic differentiation of adipose-derived stem cells (ADSCs) and the prevention of osteoporosis. Current research aimed to investigate the novel lncRNA and explored the function and molecular mechanism of...

journal_title：Stem cell research & therapy

authors： Shi ZL,Zhang H,Fan ZY,Ma W,Song YZ,Li M,Li TQ,Cao SX,Feng GJ

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-mediated tissue regeneration driven by biomaterial offers an attractive regenerative strategy for dama...

journal_title：Stem cell research & therapy

authors： Yang Z,He C,He J,Chu J,Liu H,Deng X

更新日期：2018-01-31 00:00:00

abstract：INTRODUCTION:Fetal bovine serum (FBS) is an animal product used as a medium supplement. The animal origin of FBS is a concern if cultured stem cells are to be utilized for human cell therapy. Therefore, a substitute for FBS is desirable. In this study, an industrial, xeno-free, pharmaceutical-grade supplement for cell ...

journal_title：Stem cell research & therapy

authors： Díez JM,Bauman E,Gajardo R,Jorquera JI

更新日期：2015-03-13 00:00:00

abstract：BACKGROUND:In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing. METHODS:In this review, we investigated the trends in injectable scaffolds for ASC delivery in the dermis, and injectable or implantable scaffolds for ASC del...

journal_title：Stem cell research & therapy

authors： Mamsen FP,Munthe-Fog L,Kring MKM,Duscher D,Taudorf M,Katz AJ,Kølle ST

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Liver fibrosis resulting from chronic liver injury is one of the major causes of mortality worldwide. Stem cell-secreted secretome has been evaluated for overcoming the limitations of cell-based therapy in hepatic disease, while maintaining its advantages. METHODS:In this study, we investigated the effect o...

journal_title：Stem cell research & therapy

authors： Yao X,Wang J,Zhu J,Rong X

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:A keloid is a fibroproliferative disorder occurring in wounds characterized by an exaggerated response to injury. To date, no effective cure has been identified. As multipotent stem cells, human adipose-derived stem cells (ADSCs) may show the possibility for curing diseases such as fibrosis. This study sough...

journal_title：Stem cell research & therapy

authors： Wang X,Ma Y,Gao Z,Yang J

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Multiple sclerosis is a demyelinating disease mostly of autoimmune origin that affects and damages the central nervous system, leading to a disabling condition. The aim of the present study was to investigate whether administration of mesenchymal stem cells from human periodontal ligament (hPDLSCs) could ame...

journal_title：Stem cell research & therapy

authors： Trubiani O,Giacoppo S,Ballerini P,Diomede F,Piattelli A,Bramanti P,Mazzon E

更新日期：2016-01-04 00:00:00

abstract：BACKGROUND:The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues. The objective of this study was to identify nucleus pulposus-derived progenitor cells (NPPC) and examine...

journal_title：Stem cell research & therapy

authors： Tekari A,Chan SCW,Sakai D,Grad S,Gantenbein B

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:Three-dimensional (3D) cultures recapitulate the microenvironment of tissue-resident stem cells and enable them to modulate their properties. We determined whether salivary gland-resident stem cells (SGSCs) are primed by a 3D spheroid culture prior to treating irradiation-induced salivary hypofunction using ...

journal_title：Stem cell research & therapy

authors： Shin HS,Lee S,Hong HJ,Lim YC,Koh WG,Lim JY

更新日期：2018-03-22 00:00:00

abstract：:The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential...

journal_title：Stem cell research & therapy

authors： Sipp D

更新日期：2010-04-12 00:00:00

abstract：BACKGROUND:Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term recurrence are high. Thus, a new treatment strategy is still needed. In recent years, bone marrow m...

journal_title：Stem cell research & therapy

authors： Zhang H,Huang J,Liu J,Li Y,Gao Y

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:Graft-versus-host disease (GvHD) is the main life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). Thirty to 80% of GvHD patients do not respond to first-line treatment and a second-line treatment is not universally established. Based on their immunomodulatory properties...

journal_title：Stem cell research & therapy

authors： Morata-Tarifa C,Macías-Sánchez MDM,Gutiérrez-Pizarraya A,Sanchez-Pernaute R

更新日期：2020-02-18 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) play a central role in mediating endogenous repair of cell and tissue damage. Biologic aging is a universal process that results in changes at the cellular and molecular levels. In the present study, the role of microRNA (miRNA) in age-induced molecular changes in MSCs derived...

journal_title：Stem cell research & therapy

authors： Pandey AC,Semon JA,Kaushal D,O'Sullivan RP,Glowacki J,Gimble JM,Bunnell BA

更新日期：2011-11-14 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are considered to have a modest benefit on left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). However, the optimal injection timing and dose needed to induce beneficial cardiac effects are unknown. The purpose of this meta-analysis w...

journal_title：Stem cell research & therapy

authors： Wang Z,Wang L,Su X,Pu J,Jiang M,He B

更新日期：2017-01-28 00:00:00

abstract：BACKGROUND:Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive degeneration. Cell-based IVD therapy has emerged as an area of great interest, with studies reportin...

journal_title：Stem cell research & therapy

authors： Tang R,Jing L,Willard VP,Wu CL,Guilak F,Chen J,Setton LA

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) plays a role in a number of physiological processes including stem cell differentiation and osteogenesis. Endothelial nitric oxide synthase (eNOS), one of three NO-producing enzymes, is located in a close conformation with the caveolin-1 (CAV-1WT) membrane protein which is inhibitory to NO ...

journal_title：Stem cell research & therapy

authors： Bandara N,Gurusinghe S,Lim SY,Chen H,Chen S,Wang D,Hilbert B,Wang LX,Strappe P

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:Human induced pluripotent stem cells (hiPSCs) offer a renewable source of cells for the generation of hematopoietic cells for cell-based therapy, disease modeling, and drug screening. However, current serum/feeder-free differentiation protocols rely on the use of various cytokines, which makes the process ve...

journal_title：Stem cell research & therapy

authors： Netsrithong R,Suwanpitak S,Boonkaew B,Trakarnsanga K,Chang LJ,Tipgomut C,Vatanashevanopakorn C,Pattanapanyasat K,Wattanapanitch M

更新日期：2020-11-11 00:00:00

abstract：INTRODUCTION:Increased levels of angiotensin II (Ang II) and activity of Ang II receptor type 1 (AT1R) elicit detrimental effects in cardiovascular disease. However, the role of Ang II receptor type 2 (AT2R) remains poorly defined. Mesenchymal stem cells (MSCs) replenish and repair endothelial cells in the cardiovascul...

journal_title：Stem cell research & therapy

authors： Ikhapoh IA,Pelham CJ,Agrawal DK

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting its therapeutic benefit. The aim of this study is to create a new approach to treat type 2 diabetes b...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2018-12-07 00:00:00

abstract：INTRODUCTION:Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Currently, the lack of a reliable and safe method to accurately and non-invasively locate the site of imp...

journal_title：Stem cell research & therapy

authors： Micci MA,Boone DR,Parsley MA,Wei J,Patrikeev I,Motamedi M,Hellmich HL

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and coronary artery bypass grafting can prolong life, cardiac damage persists. In particular, cardiomyocytes have no regenerative capacity. Mesenchymal stem cells (MSCs) are attractive candidates for t...

journal_title：Stem cell research & therapy

authors： Cheng H,Chang S,Xu R,Chen L,Song X,Wu J,Qian J,Zou Y,Ma J

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Expansion protocols aim at both increasing the number of umbilical cord blood (UCB) hematopoietic stem cells and progenitor cells (HSPCs) and reducing the period of neutropenia in UCB HSPC graft. Because glycosaminoglycans (GAGs) are known to be important components of the hematopoietic niche and to modulate...

journal_title：Stem cell research & therapy

authors： Faivre L,Parietti V,Siñeriz F,Chantepie S,Gilbert-Sirieix M,Albanese P,Larghero J,Vanneaux V

更新日期：2016-01-07 00:00:00

abstract：OBJECTIVE:Autologous bone marrow stem cell (ABMSC) transplantation has been considered a promising option for hepatitis B virus-related cirrhosis (HBV-C). Although an analysis of the published literature has been performed, the exact effects and safety have yet to be systematically investigated. METHODS:We conducted a...

journal_title：Stem cell research & therapy

authors： Sun A,Gao W,Xiao T

更新日期：2020-03-05 00:00:00

abstract：BACKGROUND:The widely recognized anti-cancer potential of aspirin has created a broad interest to explore the clinical benefits of aspirin in cancer therapy. However, the current understanding of the molecular mechanisms involved in the anti-cancer potential of aspirin remains limited. METHODS:Cancer stemness assays w...

journal_title：Stem cell research & therapy

authors： Zhang X,Du R,Luo N,Xiang R,Shen W

更新日期：2020-08-27 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are adult multipotent stem cells that possess regenerative and immunomodulatory properties. They have been widely investigated as therapeutic agents for a variety of disease conditions, including tissue repair, inflammation, autoimmunity, and organ transplantation. Importantly...

journal_title：Stem cell research & therapy

authors： Liu L,Zhang SX,Aeran R,Liao W,Lu M,Polovin G,Pone EJ,Zhao W

更新日期：2015-09-21 00:00:00

abstract：BACKGROUND:Human embryonic stem cells (hESCs) hold tremendous promise for cell replacement therapies for a range of degenerative diseases. In order to provide cost-effective treatments affordable by public health systems, HLA-matched allogeneic tissue banks of the highest quality clinical-grade hESCs will be required. ...

journal_title：Stem cell research & therapy

authors： Ye J,Bates N,Soteriou D,Grady L,Edmond C,Ross A,Kerby A,Lewis PA,Adeniyi T,Wright R,Poulton KV,Lowe M,Kimber SJ,Brison DR

更新日期：2017-06-05 00:00:00

abstract：BACKGROUND:Human adipose-derived stromal cells (hASCs) have been gaining increasing popularity in regenerative medicine thanks to their multipotency, ease of collection, and efficient culture. Similarly to other stromal cells, their function is particularly sensitive to the culture conditions, including the composition...

journal_title：Stem cell research & therapy

authors： Kuterbekov M,Machillot P,Baillet F,Jonas AM,Glinel K,Picart C

更新日期：2019-08-14 00:00:00

abstract：:The original article [1] contained errors in the presentation of Figure 7. ...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2019-01-08 00:00:00

abstract：:Tissue engineering has developed many paradigms and techniques on how to best integrate cells and extracellular matrix to create in vitro structures that replicate native tissue. The strategy best suited for building these constructs depends mainly on the target cells, tissues, and organ of interest, and how readily t...

journal_title：Stem cell research & therapy

authors： Thavandiran N,Nunes SS,Xiao Y,Radisic M

更新日期：2013-02-14 00:00:00

abstract：BACKGROUND:Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation. In other tissues, co-transplantation with mesenchymal stem cells has been shown to reduce damage by improving anti-inflammatory and a...

journal_title：Stem cell research & therapy

authors： Laporte C,Tubbs E,Cristante J,Gauchez AS,Pesenti S,Lamarche F,Cottet-Rousselle C,Garrel C,Moisan A,Moulis JM,Fontaine E,Benhamou PY,Lablanche S

更新日期：2019-03-12 00:00:00