Topological and electrical control of cardiac differentiation and assembly.

abstract：INTRODUCTION:Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a wide variety of tissues. This study aims to assess the functional similarities of MPCs from differen...

journal_title：Stem cell research & therapy

authors： Djouad F,Jackson WM,Bobick BE,Janjanin S,Song Y,Huang GT,Tuan RS

更新日期：2010-05-04 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) were shown to harbor therapeutic potential in models of respiratory diseases, such as bronchopulmonary dysplasia (BPD), the most common sequel of preterm birth. In these studies, cells or animals were challenged with hyperoxia or other injury-inducing agents. However, little is ...

journal_title：Stem cell research & therapy

authors： Obendorf J,Fabian C,Thome UH,Laube M

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVE:Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascularization bed. Considering the active role of adipose-derived stem cell (ADSC) in promoting angiogen...

journal_title：Stem cell research & therapy

authors： Luo Y,Yi X,Liang T,Jiang S,He R,Hu Y,Bai L,Wang C,Wang K,Zhu L

更新日期：2019-08-30 00:00:00

abstract：:Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured n...

journal_title：Stem cell research & therapy

authors： Cabral JV,Jackson CJ,Utheim TP,Jirsova K

更新日期：2020-07-21 00:00:00

abstract：INTRODUCTION:A feature which makes stem cells promising candidates for cell therapy is their ability to migrate effectively into damaged or diseased tissues. Recent reports demonstrated the increased motility of human mesenchymal stem cells (hMSC) grown under hypoxic conditions compared to normoxic cells. However, the ...

journal_title：Stem cell research & therapy

authors： Vertelov G,Kharazi L,Muralidhar MG,Sanati G,Tankovich T,Kharazi A

更新日期：2013-01-07 00:00:00

abstract：INTRODUCTION:Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Currently, the lack of a reliable and safe method to accurately and non-invasively locate the site of imp...

journal_title：Stem cell research & therapy

authors： Micci MA,Boone DR,Parsley MA,Wei J,Patrikeev I,Motamedi M,Hellmich HL

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:Human adipose-derived stromal cells (hASCs) have been gaining increasing popularity in regenerative medicine thanks to their multipotency, ease of collection, and efficient culture. Similarly to other stromal cells, their function is particularly sensitive to the culture conditions, including the composition...

journal_title：Stem cell research & therapy

authors： Kuterbekov M,Machillot P,Baillet F,Jonas AM,Glinel K,Picart C

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-mediated tissue regeneration driven by biomaterial offers an attractive regenerative strategy for dama...

journal_title：Stem cell research & therapy

authors： Yang Z,He C,He J,Chu J,Liu H,Deng X

更新日期：2018-01-31 00:00:00

abstract：INTRODUCTION:This is the first study evaluating the interactions of human adipose tissue derived stem cells (ADSCs) and human squamous cell carcinoma cells (SCCs), with regard to a prospective cell-based skin regenerative therapy and a thereby unintended co-localization of ADSCs and SCCs. METHODS:ADSCs were co-culture...

journal_title：Stem cell research & therapy

authors： Koellensperger E,Gramley F,Preisner F,Leimer U,Germann G,Dexheimer V

更新日期：2014-05-12 00:00:00

abstract：:The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential...

journal_title：Stem cell research & therapy

authors： Sipp D

更新日期：2010-04-12 00:00:00

abstract：BACKGROUND:A keloid is a fibroproliferative disorder occurring in wounds characterized by an exaggerated response to injury. To date, no effective cure has been identified. As multipotent stem cells, human adipose-derived stem cells (ADSCs) may show the possibility for curing diseases such as fibrosis. This study sough...

journal_title：Stem cell research & therapy

authors： Wang X,Ma Y,Gao Z,Yang J

更新日期：2018-02-21 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are multipotent and have been derived from various tissues. Although MSCs share many basic features, they often display subtle tissue specific differences. We previously demonstrated that bone marrow (BM) MSCs frequently become polyploid in culture. This tendency was mediated ...

journal_title：Stem cell research & therapy

authors： Ravid O,Shoshani O,Sela M,Weinstock A,Sadan TW,Gur E,Zipori D,Shani N

更新日期：2014-12-17 00:00:00

abstract：INTRODUCTION:Advances in tendon engineering with mesenchymal stem cells (MSCs) are hindered by a need for cues to direct tenogenesis, and markers to assess tenogenic state. We examined the effects of factors involved in embryonic tendon development on adult MSCs, and compared MSC responses to that of embryonic tendon p...

journal_title：Stem cell research & therapy

authors： Brown JP,Galassi TV,Stoppato M,Schiele NR,Kuo CK

更新日期：2015-05-09 00:00:00

abstract：BACKGROUND:Human embryonic stem cells (hESCs) hold tremendous promise for cell replacement therapies for a range of degenerative diseases. In order to provide cost-effective treatments affordable by public health systems, HLA-matched allogeneic tissue banks of the highest quality clinical-grade hESCs will be required. ...

journal_title：Stem cell research & therapy

authors： Ye J,Bates N,Soteriou D,Grady L,Edmond C,Ross A,Kerby A,Lewis PA,Adeniyi T,Wright R,Poulton KV,Lowe M,Kimber SJ,Brison DR

更新日期：2017-06-05 00:00:00

abstract：INTRODUCTION:Human multipotent stromal cells (MSCs) isolated from bone marrow or other tissue sources have great potential to treat a wide range of injuries and disorders in the field of regenerative medicine and tissue engineering. In particular, MSCs have inherent characteristics to suppress the immune system and are...

journal_title：Stem cell research & therapy

authors： Bellayr IH,Catalano JG,Lababidi S,Yang AX,Lo Surdo JL,Bauer SR,Puri RK

更新日期：2014-04-28 00:00:00

abstract：BACKGROUND:Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bone marrow (BM-MSC) have long been the most used stem cell source in cartilage tissue engineering, the...

journal_title：Stem cell research & therapy

authors： Reppel L,Schiavi J,Charif N,Leger L,Yu H,Pinzano A,Henrionnet C,Stoltz JF,Bensoussan D,Huselstein C

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:As a type of high-frequency electrotherapy, a short-wave can promote the fracture healing process; yet, its underlying therapeutic mechanisms remain unclear. PURPOSE:To observe the effect of Short-Wave therapy on mesenchymal stem cell (MSC) homing and relative mechanisms associated with fracture healing. M...

journal_title：Stem cell research & therapy

authors： Ye D,Chen C,Wang Q,Zhang Q,Li S,Liu H

更新日期：2020-09-07 00:00:00

abstract：:Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine f...

journal_title：Stem cell research & therapy

authors： Qiu G,Zheng G,Ge M,Wang J,Huang R,Shu Q,Xu J

更新日期：2019-11-28 00:00:00

abstract：BACKGROUND:Mesenchymal stem cell (MSC)-based cartilage tissue regeneration is a treatment with great potential. How to enhance the MSC chondrogenic differentiation is a key issue involved in cartilage formation. In the present study, we seek to expound the phenotypes and mechanisms of DLX5 in chondrogenic differentiati...

journal_title：Stem cell research & therapy

authors： Yang H,Cao Y,Zhang J,Liang Y,Su X,Zhang C,Liu H,Han X,Ge L,Fan Z

更新日期：2020-07-06 00:00:00

abstract：:The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therapeutic possibility for the ovarian graft in hypoxia. We designed the present study to evaluate whether the cell-...

journal_title：Stem cell research & therapy

authors： Damous LL,de Carvalho AETS,Nakamuta JS,Shiroma ME,Louzada ACS,Soares-Jr JM,Krieger JE,Baracat EC

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may promot...

journal_title：Stem cell research & therapy

authors： Farhana L,Nangia-Makker P,Arbit E,Shango K,Sarkar S,Mahmud H,Hadden T,Yu Y,Majumdar AP

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. lncRNA plays an essential role in microvascular dysfunction and signaling pathways in patients with diabetes. ln...

journal_title：Stem cell research & therapy

authors： Li Y,Zhi K,Han S,Li X,Li M,Lian W,Zhang H,Zhang X

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms in the organotropism of metastasis are still unclear. Adipose-derived mesenchymal stem cells (ADSCs) exhibit cancer-promoting properties that influence the tumour microenvironment; however, there is no research o...

journal_title：Stem cell research & therapy

authors： Wang Y,Chu Y,Ren X,Xiang H,Xi Y,Ma X,Zhu K,Guo Z,Zhou C,Zhang G,Chen B

更新日期：2019-06-13 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains very low due to some poorly characterized key factors. Compared with fertilized embryos, somatic donor cells lack...

journal_title：Stem cell research & therapy

authors： Qu P,Wang Y,Zhang C,Liu E

更新日期：2020-02-18 00:00:00

abstract：INTRODUCTION:The therapeutic effects of mesenchymal stem cells (MSCs) have been limited by their apoptosis induced by oxidative stress after delivery into the injured sites. Therefore, strategies designed to improve the MSC therapeutic efficacy need to be explored. Tetramethylpyrazine (TMP) can promote the proliferatio...

journal_title：Stem cell research & therapy

authors： Zhang L,Wang X,Lu X,Ma Y,Xin X,Xu X,Wang S,Hou Y

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Exosomes are nanovesicles (30-120 nm) of endosomal origin. These exosomes contain various functional proteins and RNAs that could be used for therapeutic purposes. Currently, having a standard method for exosome isolation retaining its biological properties with increased yield and purity is a major challeng...

journal_title：Stem cell research & therapy

authors： Gupta S,Rawat S,Arora V,Kottarath SK,Dinda AK,Vaishnav PK,Nayak B,Mohanty S

更新日期：2018-07-04 00:00:00

abstract：BACKGROUND:Periodontitis is a widespread infectious disease ultimately resulting in tooth loss. The number of mesenchymal stem cells (MSCs) in patients with periodontitis is decreased, and MSC functions are impaired. Rescuing the impaired function of MSCs in periodontitis is the key for treatment, especially in a manne...

journal_title：Stem cell research & therapy

authors： Han N,Zhang F,Li G,Zhang X,Lin X,Yang H,Wang L,Cao Y,Du J,Fan Z

更新日期：2017-09-29 00:00:00

abstract：BACKGROUND:Endothelial cells have been shown to mediate angiogenesis in ischemic injury sites and contribute to the repair of damaged tissues. However, the treatment of ischemic disease requires a significant number of endothelial cells, which are difficult to isolate from patients. Embryonic stem cells have been consi...

journal_title：Stem cell research & therapy

authors： Park JK,Lee TW,Do EK,Moon HJ,Kim JH

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal muscle sphincters, such as the external anal or urinary sphincter. However, little is known about t...

journal_title：Stem cell research & therapy

authors： Thurner M,Deutsch M,Janke K,Messner F,Kreutzer C,Beyl S,Couillard-Després S,Hering S,Troppmair J,Marksteiner R

更新日期：2020-06-12 00:00:00

abstract：BACKGROUND:This study explored the details of the immune response after autologous hematopoietic stem cell transplantation (AHSCT) treatment in type 1 diabetes mellitus. METHODS:Peripheral blood mononuclear cells (PBMCs) from 18 patients with type 1 diabetes mellitus were taken at baseline and 12 months after AHSCT or...

journal_title：Stem cell research & therapy

authors： Ye L,Li L,Wan B,Yang M,Hong J,Gu W,Wang W,Ning G

更新日期：2017-04-18 00:00:00